发布求助
文献互助 智能选刊 最新文献

Topics in antiviral medicine最新文献

筛选
英文 中文
Treating HCV Infection: It Doesn't Get Much Better Than This. 治疗 HCV 感染：没有比这更好的了。
Topics in antiviral medicine Pub Date : 2019-01-01
Susanna Naggie
{"title":"Treating HCV Infection: It Doesn't Get Much Better Than This.","authors":"Susanna Naggie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Direct-acting antiviral (DAA) regimens now allow treatment of previously untreated or treated (including prior DAA failures) patients with chronic hepatitis C virus (HCV) infection with 8 or 12 week regimens, largely without the use of ribavirin. Newer next-generation pan-genotypic regimens with activity against resistance-associated substitutions include glecaprevir/pibrentasvir (GLE/PIB), a combination of a nonstructural protein (NS)3 protease inhibitor and an NS5A inhibitor, and sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX), a combination of an NS5B polymerase inhibitor, NS5A inhibitor, and NS3 protease inhibitor. Both regimens have indications in DAA-experienced patients. GLE/PIB is approved for treatment of patients with genotype 1, 2, 3, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis and for the treatment of patients with genotype 1 infection previously treated with a regimen containing an NS5A inhibitor or an NS3/4A protease inhibitor, but not the combination. SOF/VEL/VOX is approved for retreatment of patients without cirrhosis or with compensated cirrhosis with genotype 1, 2, 3, 4, 5, or 6 infection previously treated with an NS5A inhibitor-containing regimen, or with genotype 1a or 3 previously treated with a SOF-containing regimen without an NS5A inhibitor. This article summarizes an IAS-USA webinar given by Susanna Naggie, MD, MHS, on August 30, 2018.</p>","PeriodicalId":38738,"journal":{"name":"Topics in antiviral medicine","volume":"26 4","pages":"104-108"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372361/pdf/tam-26-104.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36861846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forgotten but Not Gone: Learning From the Hepatitis A Outbreak and Public Health Response in San Diego. 被遗忘但未消失:从圣地亚哥甲型肝炎爆发和公共卫生应对中学到的东西。
Topics in antiviral medicine Pub Date : 2019-01-01
Darcy A Wooten
{"title":"Forgotten but Not Gone: Learning From the Hepatitis A Outbreak and Public Health Response in San Diego.","authors":"Darcy A Wooten","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The recent hepatitis A virus (HAV) outbreak in San Diego was driven by homelessness, associated sanitation conditions, and illicit drug use. As with an outbreak in Michigan, fueled by similar factors, morbidity and mortality were higher than what has been observed with post-vaccine era foodborne HAV outbreaks. Control of the outbreak in San Diego was accomplished with vaccine, sanitation, and education initiatives that targeted those at highest risk. Mass vaccination events and mobile foot teams and vans brought education and vaccine to high-risk individuals in affected areas. The homelessness crisis in San Diego and in many locales throughout the United States poses risk of increasing numbers of outbreaks of HAV and other infectious illnesses. This article summarizes an IAS-USA continuing education webinar given by Darcy A. Wooten, MD, on July 19, 2018.</p>","PeriodicalId":38738,"journal":{"name":"Topics in antiviral medicine","volume":"26 4","pages":"117-121"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372360/pdf/tam-26-117.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36861848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatitis B Virus Infection: What Is Current and New. 乙型肝炎病毒感染:什么是当前和新的。
Topics in antiviral medicine Pub Date : 2019-01-01
Marion G Peters
{"title":"Hepatitis B Virus Infection: What Is Current and New.","authors":"Marion G Peters","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hepatitis B virus (HBV) infection is a lifelong dynamic disease that can be controlled with treatment but cannot yet be cured. Risk of end-stage liver disease and hepatocellular carcinoma (HCC) increases with ongoing inflammation and HBV viremia. Initial treatments consist of tenofovir or entecavir. Patients who require treatment include those with chronic hepatitis, cirrhosis, HCC, or HIV coinfection; patients receiving immunosuppressive treatments; and women in the third trimester of pregnancy who have elevated HBV DNA level. A number of virologic and host immune approaches are being investigated with the aim of achieving HBV eradication. This article summarizes an IAS-USA webinar given by Marion G. Peters, MD, on June 14, 2018.</p>","PeriodicalId":38738,"journal":{"name":"Topics in antiviral medicine","volume":"26 4","pages":"112-116"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372357/pdf/tam-26-112.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36861847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The human microbiome: implications for health and disease, including HIV infection. 人类微生物组:对健康和疾病的影响，包括艾滋病毒感染。
Topics in antiviral medicine Pub Date : 2018-09-01
Robert T Schooley
{"title":"The human microbiome: implications for health and disease, including HIV infection.","authors":"Robert T Schooley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our increased understanding of the human microbiome has brought insight into the role it plays in health and disease, including HIV infection. Studies have shown that the gut microbiome is less diverse in individuals with HIV infection than in noninfected control subjects. Efforts to modify the microbiome to bolster immune reconstitution in people with HIV infection have so far been unsuccessful. The vaginal microbiome affects risk of HIV acquisition, with Lactobacillus dominance being protective compared with vaginosis characterized by larger populations of Gardnerella. The vaginal microbiome might also affect efficacy of topical tenofovir disoproxil fumarate preexposure prophylaxis. This article summarizes a presentation by Robert T. Schooley, MD, at the IAS-USA continuing education program held in San Francisco in May 2018.</p>","PeriodicalId":38738,"journal":{"name":"Topics in antiviral medicine","volume":"26 3","pages":"75-78"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291299/pdf/tam-26-075.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36626746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurring and emerging questions related to management of HIV-related opportunistic infections. 与艾滋病毒相关的机会性感染管理有关的反复出现的问题。
Topics in antiviral medicine Pub Date : 2018-09-01
Henry Masur
{"title":"Recurring and emerging questions related to management of HIV-related opportunistic infections.","authors":"Henry Masur","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The incidence of HIV-related opportunistic infections (OIs) has dramatically declined with the ability to achieve viral suppression and immune reconstitution with potent antiretroviral therapy. However, a large number of patients remain at risk for OIs because they are diagnosed at late stages of HIV disease, fail to stay in treatment, or fail to maintain viral suppression. Clinicians should remain vigilant for OIs and for changes in recommended management strategies. Issues that often arise in this regard include how to interpret polymerase chain reaction diagnostic results in individuals with HIV infection; whether primary prophylaxis for Mycobacterium avium complex is still needed; whether clinicians should screen asymptomatic patients for cryptococcal antigen; and need for amphotericin B in treatment regimens for cryptococcal meningitis. This article summarizes a presentation by Henry Masur, MD, at the IAS-USA continuing education program held in Washington, DC, in April 2018.</p>","PeriodicalId":38738,"journal":{"name":"Topics in antiviral medicine","volume":"26 3","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291295/pdf/tam-26-079.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36626747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opioid addiction, opioid addiction treatment, and HIV infection. 阿片类药物成瘾、阿片类药物成瘾治疗和艾滋病毒感染。
Topics in antiviral medicine Pub Date : 2018-09-01
R Douglas Bruce
{"title":"Opioid addiction, opioid addiction treatment, and HIV infection.","authors":"R Douglas Bruce","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Available data indicate that opioid substitution treatment can successfully reduce rates of HIV transmission and that patients receiving such treatment can adhere to therapies for HIV, hepatitis C, and tuberculosis infection. Integration of opioid substitution treatment into the HIV clinic setting can make such treatment easier and improve retention in treatment. This article summarizes a presentation by R. Douglas Bruce, MD, MA, MS, at the IAS-USA continuing education program held in Chicago, Illinois, in May 2018.</p>","PeriodicalId":38738,"journal":{"name":"Topics in antiviral medicine","volume":"26 3","pages":"89-92"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291298/pdf/tam-26-089.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36626749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Policy and advocacy for the HIV practitioner. 针对艾滋病毒从业者的政策和宣传。
Topics in antiviral medicine Pub Date : 2018-09-01
Carlos Del Rio, Wendy S Armstrong
{"title":"Policy and advocacy for the HIV practitioner.","authors":"Carlos Del Rio,&nbsp;Wendy S Armstrong","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In no field of medicine has advocacy, including physician advocacy, been more crucial in shaping policy for delivery of care than in HIV/AIDS. Although the historic tradition is strong, there is an urgent need to re-energize advocacy efforts nationally and internationally to support programs that fund care, change policies that perpetuate stigma and discrimination, and change the public perception that the HIV/AIDS crisis is over. Established programs that require ongoing advocacy attention include the Ryan White Comprehensive AIDS Resources Emergency Act, a US program that serves as a payer of last resort for care for patients with HIV infection, and international programs like the President's Emergency Plan for AIDS Relief (PEPFAR) and the Global Fund to Fight AIDS, Tuberculosis and Malaria. Newer issues have emerged, including the need to ensure fair drug pricing and guarantee sustained access to care and medications. Amidst the opioid epidemic, the preservation and establishment of policies to support syringe services programs take on new urgency, and ongoing efforts are necessary to decrease stigma about HIV infection, maintain protection of LGBTQ rights, and reform HIV criminalization laws. All stakeholders in the HIV community, including practitioners, individuals with HIV infection, and professional organizations, need to make their voices heard as they have done in the past in order to effectively continue to address the epidemic. This commentary was submitted by Carlos del Rio, MD, and Wendy S. Armstrong, MD, in March, 2018, and accepted in July, 2018.</p>","PeriodicalId":38738,"journal":{"name":"Topics in antiviral medicine","volume":"26 3","pages":"94-95"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291296/pdf/tam-26-094.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36626750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human papillomavirus-related malignancies in HIV infection: anal and oropharyngeal cancers. 人乳头瘤病毒在HIV感染中的相关恶性肿瘤:肛门和口咽癌。
Topics in antiviral medicine Pub Date : 2018-09-01
Timothy J Wilkin
{"title":"Human papillomavirus-related malignancies in HIV infection: anal and oropharyngeal cancers.","authors":"Timothy J Wilkin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human papillomavirus (HPV)-related cancers, including anal cancer and oropharyngeal cancer, occur more frequently in individuals living with HIV infection than in the general population. Strategies for prevention among individuals with HIV infection include HPV vaccination, anal cancer screening programs, and early initiation of antiretroviral therapy (ART). HPV vaccination is not yet optimally used; a stronger and more persistent effort is needed to increase vaccination rates. Although anal cancer screening is not recommended by all authorities, there is a least some evidence that screening and treatment of anal high-grade squamous intraepithelial lesions may prevent progression to cancer. However, more definitive evidence is needed. Early initiation of ART reduces the risk of infection-related cancers, with some evidence of benefit in preventing HPV-associated cancer in individuals with HIV infection. This article summarizes a presentation by Timothy J. Wilkin, MD, MPH, at the IAS-USA continuing education program held in Los Angeles, California in April 2018.</p>","PeriodicalId":38738,"journal":{"name":"Topics in antiviral medicine","volume":"26 3","pages":"85-88"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291297/pdf/tam-26-085.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36626748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies for Linkage to and Engagement With Care: Focus on Intervention. 与护理联系和参与的战略:关注干预。
Topics in antiviral medicine Pub Date : 2018-06-01
Thomas P Giordano
{"title":"Strategies for Linkage to and Engagement With Care: Focus on Intervention.","authors":"Thomas P Giordano","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Retention of HIV-infected patients in care is crucial to optimizing individual patient outcomes and reducing transmission of HIV. A number of strategies are available to improve linkage to care; among them, the AntiRetroviral Treatment and Access Services intervention should be considered standard of care at the clinic level. With regard to retention in care, the Retention Through Enhanced Personal Contact intervention has been shown to improve retention rates and the Centers for Disease Control and Prevention Data to Care program has been successful in assisting public health authorities to locate and return to treatment patients presumed to be lost to follow-up. Patient satisfaction with initial physician and clinic encounters also improves retention. There are some data to support same-day or rapid start of antiretroviral therapy in the clinic setting as a method to immediately establish care and more data on this approach are needed. This article summarizes a presentation by Thomas P. Giordano, MD, MPH, at the Ryan White HIV/AIDS Program Clinical Conference held in San Antonio, Texas, in August 2017.</p>","PeriodicalId":38738,"journal":{"name":"Topics in antiviral medicine","volume":"26 2","pages":"62-65"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017130/pdf/tam-26-062.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36227452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New and Noteworthy in Tuberculosis Diagnostics and Treatment. 结核病诊断和治疗方面的新进展和值得注意的问题。
Topics in antiviral medicine Pub Date : 2018-06-01
Susan Swindells
{"title":"New and Noteworthy in Tuberculosis Diagnostics and Treatment.","authors":"Susan Swindells","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>People with HIV infection with latent tuberculosis (TB) infection (LTBI) are at a 10-fold greater risk of developing active disease. Interferon gamma release assays and tuberculin skin testing have approximately 65% to 70% specificity for diagnosing LTBI in HIV-infected patients. LTBI can be successfully treated with isoniazid preventive therapy and early antiretroviral therapy (ART). Rapid molecular diagnostics have approximately 88% sensitivity and 98% specificity for identifying active TB. ART should be started early in patients with TB. A number of ART regimens are recommended in co-treatment that minimize the risk of drug-drug interactions. Although progress has been made, better diagnostics and TB regimens with lower risks of drug-drug interactions and shorter treatment durations are still needed. This article summarizes a presentation by Susan Swindells, MBBS, at the Ryan White HIV/AIDS Program Clinical Care Conference held in San Antonio in August 2017.</p>","PeriodicalId":38738,"journal":{"name":"Topics in antiviral medicine","volume":"26 2","pages":"58-61"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017128/pdf/tam-26-058.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36227016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信