2013 8th EUROSIM Congress on Modelling and Simulation最新文献_第6页

Modelling of DHEA Effect on CYP1A2 Expression in LNCaP and MCF-7 Cell Lines 脱氢表雄酮对LNCaP和MCF-7细胞系CYP1A2表达的影响

2013 8th EUROSIM Congress on Modelling and Simulation Pub Date : 2013-09-10 DOI: 10.1109/EUROSIM.2013.114

A. Belic, D. Rozman, M. Temesvári, K. Tóth, K. Monostory, R. Vrzal, Z. Dvořák

{"title":"Modelling of DHEA Effect on CYP1A2 Expression in LNCaP and MCF-7 Cell Lines","authors":"A. Belic, D. Rozman, M. Temesvári, K. Tóth, K. Monostory, R. Vrzal, Z. Dvořák","doi":"10.1109/EUROSIM.2013.114","DOIUrl":"https://doi.org/10.1109/EUROSIM.2013.114","url":null,"abstract":"CYP1A2 enzyme is involved in several metabolic processes that may produce substances with carcinogenic or mutagenic activity. Most commonly it metabolizes the charcoaled food components, polycyclic aromatic hydrocarbons (PAHs) or heterocyclic aromatic amines (HAAs) into mutagenic and cytotoxic substances. Dehydroepiandrosterone (DHEA) is formed endogenously from cholesterol and is a precursor of sex hormones. At pharmacological dosage as food supplement DHEA has several known chemo-protective functions. This study is dedicated to modelling of DHEA action in CYP1A2 expression. Based on the experimental data, a hypothesis was formed that DHEA interacts with CYP1A2 mRNA through androgene receptor (AR). To provide evidence for the hypothesis, dedicated experiments in LNCaP and MCF-7 cell lines were performed. First, the cells were exposed to 3-methylcholantrene (MC) as strong CYP1A2 inducer, MC and DHEA, and MC, DHEA and bicalutamide (BC) a known antagonist of AR in three separate experiments. Next, the physiology based model was constructed and validated on the experimental data. The model suggested that AR can play a role in post-transcriptional phase of CYP1A2 expression regulation. Follow-up experiments with actinomycin D, a strong transcription inhibitor were performed and the results confirmed that DHEA is affecting post-transcriptional phase of CYP1A2 expression and that AR is most likely involved in the mechanism.","PeriodicalId":386945,"journal":{"name":"2013 8th EUROSIM Congress on Modelling and Simulation","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114766948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-legged Walking Robot Modelling in MATLAB/SimmechanicsTM and Its Simulation 多足步行机器人MATLAB/SimmechanicsTM建模及仿真

2013 8th EUROSIM Congress on Modelling and Simulation Pub Date : 2013-09-10 DOI: 10.1109/EUROSIM.2013.50

M. Silva, R. Barbosa, T. Castro

{"title":"Multi-legged Walking Robot Modelling in MATLAB/SimmechanicsTM and Its Simulation","authors":"M. Silva, R. Barbosa, T. Castro","doi":"10.1109/EUROSIM.2013.50","DOIUrl":"https://doi.org/10.1109/EUROSIM.2013.50","url":null,"abstract":"Legged robots are being the target of several studies and research. The idea is to develop machines that present characteristics approximate to the ones observed in biological living creatures. However this objective is still relatively far away and the development of prototypes for these studies is expensive and time consuming, which leads to the creation of models that allow the realization of the intended studies in software. These models should include the main characteristics of biological creatures relevant for locomotion studies. Given this, the presented work describes the development of a quadruped robot model in MATLAB/Simmechanics TM. This model is intended to be used in the development of gaits for legged robots based on Central Pattern Generators. With this purpose in mind, the model was developed in a way to accept different gaits by direct introduction of the angular positions of the knee and hip joints. Various parameters of the robot are also easily changed through a configuration file that accompanies the model. This paper presents the model of a robot with flexible body, its legs and its hip and knee joints. The model of a feet-ground interaction was also modelled using a theoretic model described in the literature.","PeriodicalId":386945,"journal":{"name":"2013 8th EUROSIM Congress on Modelling and Simulation","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116672930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

SIP Signaling and QoS for ROHC Based Next Generation MANETs Reactive Routing Protocols 基于ROHC的下一代MANETs响应路由协议的SIP信令和QoS

2013 8th EUROSIM Congress on Modelling and Simulation Pub Date : 2013-09-10 DOI: 10.1109/EUROSIM.2013.103

M. Alshamrani, H. Cruickshank, Zhili Sun

{"title":"SIP Signaling and QoS for ROHC Based Next Generation MANETs Reactive Routing Protocols","authors":"M. Alshamrani, H. Cruickshank, Zhili Sun","doi":"10.1109/EUROSIM.2013.103","DOIUrl":"https://doi.org/10.1109/EUROSIM.2013.103","url":null,"abstract":"In this paper, an evaluation of SIP signaling and voice QoS for SIP based VoIP using GSM voice codec system over IPv6 MANETs with Static, and Random mobility models. This evaluation study considered two types of reactive routing protocols, AODV and DSR. The study examined IPv4, IPv6, and Robust Header Compression (ROHC) as a compression/decompression system for IPv6 headers. The evaluation results show that SIP signaling and VoIP traffic are acting poorly over IPv6 even when applying ROHC. In general, AODV has low performance over different types of Random mobility models for MANET nodes, while DSR shows better performance with Static mobility models and bad performance with Random mobility models. When using ROHC for TCP traffic, a level of enhanced performance had shown for SIP based VoIP calls over IPv6 MANET. However ROHC still has longer delays and poor performance compared with SIP based VoIP over IPv4 MANET. Therefore, the SIP signaling for IPv6 MANET reactive protocols require further enhancements for SIP/TCP registration and retransmission timers to be able to employ the capabilities of IPv6 and ROHC system for SIP based VoIP and real-time applications over MANET.","PeriodicalId":386945,"journal":{"name":"2013 8th EUROSIM Congress on Modelling and Simulation","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123766666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Educational Development Tools for Software and Hardware Processor Design 软件和硬件处理器设计教育开发工具

2013 8th EUROSIM Congress on Modelling and Simulation Pub Date : 2013-09-10 DOI: 10.1109/EUROSIM.2013.108

A. J. Salim, S. I. Salim, N. R. Samsudin, Y. Soo

引用次数: 4

A Methodology Combining Optimization and Simulation for Real Applications of the Stochastic Aircraft Recovery Problem 飞机随机回收问题的优化与仿真相结合的实际应用方法

2013 8th EUROSIM Congress on Modelling and Simulation Pub Date : 2013-09-10 DOI: 10.1109/EUROSIM.2013.55

P. Arias, Daniel Guimarans, Miguel Mujica Mota, Geert Boosten

引用次数: 16

Compression Techniques for Medical Images Transmission over Multi Core Optical Fiber Using CDMA 基于CDMA的多芯光纤医学图像传输压缩技术

2013 8th EUROSIM Congress on Modelling and Simulation Pub Date : 2013-09-10 DOI: 10.1109/EUROSIM.2013.73

A. Abche, Alaa Salam, E. Inaty, E. Karam

{"title":"Compression Techniques for Medical Images Transmission over Multi Core Optical Fiber Using CDMA","authors":"A. Abche, Alaa Salam, E. Inaty, E. Karam","doi":"10.1109/EUROSIM.2013.73","DOIUrl":"https://doi.org/10.1109/EUROSIM.2013.73","url":null,"abstract":"In this work, an approach that incorporates the compression of images to transmit high resolution medical images is presented. It is based on a double blind CDMA technology. The proposed approach assumes that several users (medical practitioners, doctors) are transmitting images from one location to another simultaneously. The images are encoded using two-steps procedure: 1) coding the pixels (users) using spatial Optical Orthogonal Signature Patterns (OOSPs) and 2) coding the bits using time orthogonal basis functions. The encoding procedure follows the compression of images to reduce the occurrence of ghost pulses and to increase the transmission rate. Then, the encoded images are combined using a multiplexer and the results are transmitted over multi-core optical fiber. The aim of this approach is to achieve a fast transmission (parallel transmission). At the receiver end, the information is collected and is de-multiplexed to identify the user and to reconstruct the original images i.e. is decoded using the same double blind Orthogonal Signatures and compression techniques that are implemented for encoding purposes. The performance is quantitatively evaluated using Monte-Carlo simulation techniques by studying different criteria: Bit Error Rate, Root Mean Square Error and Pixel Error Rate.","PeriodicalId":386945,"journal":{"name":"2013 8th EUROSIM Congress on Modelling and Simulation","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123045875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution of Ecosystems as Successions: Discrete Switching in Continuous Models 作为演替的生态系统演化:连续模型中的离散切换

2013 8th EUROSIM Congress on Modelling and Simulation Pub Date : 2013-09-10 DOI: 10.1109/EUROSIM.2013.17

S. Chernyshenko, R. Ruzich

引用次数: 2

Dynamic Estimation Algorithm for Markovian Model for Packet Loss 丢包马尔可夫模型的动态估计算法

2013 8th EUROSIM Congress on Modelling and Simulation Pub Date : 2013-09-10 DOI: 10.1109/EUROSIM.2013.106

Islam Amro

{"title":"Dynamic Estimation Algorithm for Markovian Model for Packet Loss","authors":"Islam Amro","doi":"10.1109/EUROSIM.2013.106","DOIUrl":"https://doi.org/10.1109/EUROSIM.2013.106","url":null,"abstract":"In this Paper, we worked on the modeling of packet loss in EUMEDConnect Network (network connects 6 Arab countries) from the Palestinian side. This research exploited a data set of 72 hours. each country was expressed by a randomly selected 12-hour dataset, each dataset was divided into two-hour segments, each segment was modeled as a binary time series. From the 36 segments, 26 segments were found stationary. For Stationary segments, the research investigated the segment correlation and used it as a modeling reference. 11 segments were modeled using Bernoulli model, 12 segments were modeled using 2-state Markov chain and 5 segments showed k-th order Markov chain tendencies with orders 2, 3, 8, 27, 38. The models were built under 0.05 threshold in average filter condition of stationary and with confidence of 95% for lag dependency selection. After modeling each segment independently, an average loss model for each country was calculated using its modeled segments. confidence of these models were 95%. Afterward, we suggested a cumulative modeling algorithm through making a higher segmentation on shorter intervals less than 2 hours and give expectation for the models value for a given segment dynamically and cumulatively, this was achieved with error less than 0.001 for single segment.","PeriodicalId":386945,"journal":{"name":"2013 8th EUROSIM Congress on Modelling and Simulation","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130946877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water Quality Modelling and Control in a Water Treatment Process 水处理过程中的水质模拟与控制

2013 8th EUROSIM Congress on Modelling and Simulation Pub Date : 2013-09-10 DOI: 10.1109/EUROSIM.2013.31

J. Tomperi, E. Juuso, K. Leiviska

{"title":"Water Quality Modelling and Control in a Water Treatment Process","authors":"J. Tomperi, E. Juuso, K. Leiviska","doi":"10.1109/EUROSIM.2013.31","DOIUrl":"https://doi.org/10.1109/EUROSIM.2013.31","url":null,"abstract":"Drinking water quality is an important issue around the world since the low quality water causes health-related problems and economic losses. To ensure high quality water an efficient monitoring and control of a water treatment process is essential. In this study, two common quality variables of treated water, turbidity and residual aluminium, are modelled using the cross-validation method. Selected variables for developing the models are easy and reliable to measure on-line from raw water source. The linguistic equation (LE) approach based on nonlinear scaling and linear interactions produces models, which can be used in addition to predicting the water quality, for monitoring and controlling the water treatment process. The goal of the control simulation was to minimize the turbidity by controlling the coagulation chemical dose and see how this affects the residual aluminium level in drinking water. The results showed that the developed models were accurate and followed the changes in measured water quality variable. Results of the control simulation suggest that the water quality can be improved by proper control and optimizing the chemical dosing, as minimizing the turbidity reduces the residual aluminium level.","PeriodicalId":386945,"journal":{"name":"2013 8th EUROSIM Congress on Modelling and Simulation","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130911859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multiple Forecasting Algorithms for Demand Forecasting in the Fashion Industry 时尚行业需求预测的多重预测算法

2013 8th EUROSIM Congress on Modelling and Simulation Pub Date : 2013-09-10 DOI: 10.1109/EUROSIM.2013.122

A. Bruzzone, F. Longo, Letizia Nicoletti, A. Chiurco, Christian Bartolucci

引用次数: 6