Advances in Neuroimmune Biology最新文献_第9页

Novel Therapeutic Approaches to Multiple Sclerosis: Neuroprotective Drugs for Relapsing-Remitting Multiple Sclerosis 多发性硬化的新治疗方法:复发-缓解型多发性硬化的神经保护药物

Advances in Neuroimmune Biology Pub Date : 2013-01-01 DOI: 10.3233/NIB-130066

M. Pugliese, J. Espinosa-Parrilla, J. Bustos, C. Campás, M. Frias, Georgina Sorrosal

引用次数: 0

Neuroanatomy of Stress Responses 应激反应的神经解剖学

Advances in Neuroimmune Biology Pub Date : 2013-01-01 DOI: 10.3233/NIB-130054

T. Ueyama

{"title":"Neuroanatomy of Stress Responses","authors":"T. Ueyama","doi":"10.3233/NIB-130054","DOIUrl":"https://doi.org/10.3233/NIB-130054","url":null,"abstract":"The autonomic nervous system, especially the sympathetic nervous system, regulates immune responses, while cytokines produced in the immune system also affect neuronal activities. Stress-induced expression of immediate early genes, such as c-Fos in the brain, and the viral transneuronal labeling using pseudorabies virus make it possible to analyze the neurocircuitry of the stress-related central autonomic nervous system. Limbic systems (amygdala, lateral septum, infralimbic, insular, ventromedial temporal cortical regions), and several hypothalamic and brainstem nuclei have been identified as the central sites that regulate stress-induced sympathetic nervous activation. This review focuses on the involvement of the amygdala in the regulation of stress-induced sympathetic nervous responses. All amygdaloid subnuclei receive psychological information from other limbic regions, while the lateral and central subnuclei receive sensory and immune information from parabrachial nucleus and medical geniculate nucleus. Output to the hypothalamus mainly originates from the medial amygdala, while output to the bed nucleus of the stria terminalis originates from the central amygdala and the medial amygdala. Sex steroids such as estrogen and androgen can modulate the sympathetic nervous activity since their receptors are expressed in the medial amygdala.","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"4 1","pages":"13-33"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-130054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70144320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of ceramide in the physiology and pathophysiology of nervous systems 神经酰胺在神经系统生理和病理生理中的作用

Advances in Neuroimmune Biology Pub Date : 2013-01-01 DOI: 10.3233/NIB-130055

Md Shamim Hossain, M. Ifuku, T. Katafuchi

引用次数: 2

Neuroimmune Modulation by c-Src/Fyn Pathway Upon Traumatic Injury of Brain 脑外伤后c-Src/Fyn通路的神经免疫调节

Advances in Neuroimmune Biology Pub Date : 2013-01-01 DOI: 10.3233/NIB-130056

Hui Zhao, Xiaocong Zhao, Huilin Mou, Gen-cheng Wu, Xiao-ding Cao

引用次数: 0

Strategies for Reversing Age-Related Sympathetic Neuropathy Loss in Immune Organs 逆转免疫器官中与年龄相关的交感神经病变丧失的策略

Advances in Neuroimmune Biology Pub Date : 2013-01-01 DOI: 10.3233/NIB-130059

D. Bellinger, D. Lorton

引用次数: 0

Well-Being at Work and Immune Response 工作中的幸福感和免疫反应

Advances in Neuroimmune Biology Pub Date : 2012-01-01 DOI: 10.3233/NIB-012905

P. Boscolo, L. Forcella, Michela Cortini, M. Reale

引用次数: 0

Correction of Stress-induced Dysfunctions of the Immune and Neuroendocrine Systems by Peptide and Nucleotide Preparations 利用肽和核苷酸制剂纠正应激性免疫和神经内分泌系统功能障碍

Advances in Neuroimmune Biology Pub Date : 2012-01-01 DOI: 10.3233/NIB-012902

E. Rybakina, S. N. Shanin, E. Fomicheva, E. Dmitrienko, T. A. Filatenkova, E. Korneva

{"title":"Correction of Stress-induced Dysfunctions of the Immune and Neuroendocrine Systems by Peptide and Nucleotide Preparations","authors":"E. Rybakina, S. N. Shanin, E. Fomicheva, E. Dmitrienko, T. A. Filatenkova, E. Korneva","doi":"10.3233/NIB-012902","DOIUrl":"https://doi.org/10.3233/NIB-012902","url":null,"abstract":"The authors analyzed the effects of short synthetic peptides and native DNA preparations on the function of the immune and neuroendocrine systems under various stress conditions. These preparations of peptides and nucleotides are known to be effective modulators of the immune and neuroendocrine systems. Here we discuss a new concept, which suggests that endogenous short peptides and their synthetic analogs bind to specific sequences of nucleotides in DNA strands. These site-specific peptide- DNA interactions modulate cellular genetic functions and form the basis of molecular-genetics of stress-protective short synthetic peptides. Protective action of nucleotide preparations on impaired functions of the immune and neuroendocrine systems was shown. It seems that these effects are based on the ability of nucleotides to penetrate cells and subsequently splitting into nucleotides, which, after releasing from the cell, bind to purinergic P2 receptors. The results indicate that short synthetic peptides and native DNA preparations are capable of correcting stress induced impairment of neuroimmune function.","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"3 1","pages":"353-360"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-012902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70143756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress and My Life 压力与我的生活

Advances in Neuroimmune Biology Pub Date : 2012-01-01 DOI: 10.3233/NIB-012918

I. Bérczi

{"title":"Stress and My Life","authors":"I. Bérczi","doi":"10.3233/NIB-012918","DOIUrl":"https://doi.org/10.3233/NIB-012918","url":null,"abstract":"Hans Selye, the father of stress concept has never really defined stress. The best he could do was to say that stress induced a general adaptation syndrome. Adapted animals resisted stress [1]. However, stress also had to do with disease and this was the aspect which Selye emphasized since 1955, when he published in Science the article Stress and disease [2]. Apparently if stress was causing disease it was highly fundable by granting agencies. So I herd about this aspect of stress only in the Selye Institute and this has been transmitted to the public conscience, as well. Nowadays people are “stressed out” when things are going really bad. Selye saw the thymus shrink, but in those days he had no knowledge of what the thymus was doing. It was not known either what the spleen was doing or that the pituitary gland was connected to the hypothalamus. Despite of these difficulties he was very sure of the significance of his findings on stress. I was in his laboratory in 1966–67. By that time I was an Immunologist and prior to coming to Canada, I worked as a Research Fellow at the Hungarian Academy of Sciences. The function of the thymus has been just elucidated a few years earlier by Miller in 1962 [3]. It was shown to be a central immune organ of generating thymus derived (T) lymphocytes. T lymphocytes were characterized as important in immunoregulation and in cell mediated and humoral immunity. That the spleen contains antibody producing","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"3 1","pages":"229-234"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-012918","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70144432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Trophic Actions of Prolactin in the Central Nervous System 催乳素在中枢神经系统中的营养作用

Advances in Neuroimmune Biology Pub Date : 2012-01-01 DOI: 10.3233/NIB-2012-012035

T. Morales, M. Cerbón

引用次数: 0

Stress System Regulation of Chronic Low-grade Inflammation 慢性低度炎症的应激系统调节

Advances in Neuroimmune Biology Pub Date : 2012-01-01 DOI: 10.3233/NIB-012904

N. Rohleder

{"title":"Stress System Regulation of Chronic Low-grade Inflammation","authors":"N. Rohleder","doi":"10.3233/NIB-012904","DOIUrl":"https://doi.org/10.3233/NIB-012904","url":null,"abstract":"Chronic stress is an important predictor of morbidity and mortality in humans. While research has made major advances in understanding the biological pathways between long-term stress exposure and pathophysiological mechanisms underlying adverse health outcomes, one major issue remains: Alterations of major stress systems hypothalamus pituitary adrenal (HPA) axis and sympathetic nervous system (SNS) are not consistently found, and/or are insufficient in explaining the stress-disease link. Chronic, and systemic low-grade inflammation has emerged as a promising pathway, because inflammation is more consistently found elevated in conditions of chronic psychosocial stress, and these alterations of inflammatory activity can be directly related with specific pathophysiological mechanisms underlying important diseases associated with chronic stress, such as cardiovascular disease. However, increased inflammation is theoretically incompatible with the frequent finding of unchanged, or decreased basal HPA axis activity. It has therefore been suggested that one of the major changes in chronic stress manifests itself in the ability of the inflammatory tissues to adequately respond to anti-inflammatory signaling of stress systems. The aim of this review article is to summarize our current knowledge about the ability of the stress systems HPA axis, sympathetic, and parasympathetic nervous system to control inflammation.","PeriodicalId":38645,"journal":{"name":"Advances in Neuroimmune Biology","volume":"3 1","pages":"265-276"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/NIB-012904","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70143899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1