Gastroenterologie a Hepatologie最新文献

{"title":"Two years of the COVID-19 pandemic in the population of Czech patients with inflammatory bowel disease treated with biological therapy – experience of the tertiary IBD center","authors":"K. Černá, M. Lukáš","doi":"10.48095/ccgh202314","DOIUrl":"https://doi.org/10.48095/ccgh202314","url":null,"abstract":"Summary: Background: Inflammatory bowel disease (IBD) may be associated with a more severe course of infections and a different response to vaccination, especially in complicated IBD course and in association with immune-modifying IBD treatment. The aim of this study was to describe COVID-19 pandemic during years 2020–2022 in IBD patients with long-term bio­logical therapy. Methods: A retrospective analysis of SARS-CoV-2 infection incidence in the population of 1,177 IBD (Crohn’s disease or ulcerative colitis) patients with long-term bio­logical therapy (IBD cohort) was performed. The incidence rate, crude incidence rate and standardized incidence ratio of COVID-19 in the IBD cohort, the odds ratio of infection depending on the type of bio­logic therapy administered, the dynamics of COVID-19 incidence depending on the predominant SARS-CoV-2 variant in the population and the current vaccination coverage of the IBD cohort were calculated. Results: From January 2020 to April 2022, 548 confirmed cases of COVID-19 (46.6%) were reported in the IBD cohort, with 39% share of PCR positivity in vaccinated individuals and with 95% occurrence of infection in unvaccinated part of the IBD cohort. Standardized incidence rate ratio of COVID-19 was 27% higher in the IBD cohort compared to the general Czech population. The dynamics of the development of the number of positive cases of COVID-19 in the IBD cohort was identical to the situation in the entire country. A higher odds ratio of the chances of infection was demonstrated in patients treated with tumor necrosis factor inhibitors, but not in patients treated with anti-integrins or monoclonal antibodies against interleukins. In the IBD cohort, 85.2% of patients were properly vaccinated, which was significantly more than the vaccination rate of the entire Czech population. Discussion and conclusion: During the two pandemic years, the incidence of COVID-19 in patients with severe IBD and long-term bio­logical treatment was higher compared to the general Czech population, despite the favorable vaccination coverage of this high-risk patients’ group. A higher risk was associated with tumor necrosis factor inhibitor therapy. Key words: inflammatory bowel disease – Crohn’s disease – ulcerative colitis – COVID-19 – SARS-CoV-2 – vaccination – bio­logical therapy","PeriodicalId":38577,"journal":{"name":"Gastroenterologie a Hepatologie","volume":"340 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79740198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary signet ring cell adenocarcinoma as a rare cause of colonic stenosis in a young patient with Crohn’s disease – the case report","authors":"B. Pipek, Kateřina Prokešová, R. Kotásek, M. Štěpán, P. Fojtík","doi":"10.48095/ccgh202321","DOIUrl":"https://doi.org/10.48095/ccgh202321","url":null,"abstract":"Summary: Signet ring cell carcinoma (SRCC) is a rare type of highly malignant adenocarcinoma that produces mucin and predominantly affects the stomach, ovaries, and the small intestine. Primary localisation in the colon is rare, and the prognosis of this type of adenocarcinoma is very poor. We present a case report of a 44-year-old woman who suffered from Crohn‘s disease beginning in the year 2000. During the last three years of her treatment, she was treated using bio­logical therapy with ustekinumab. The treatment led to clinical, laboratory, and endoscopic remission. In February 2021, she had widely metastatic primary signet ring cell carcinoma of the colon, which mimicked the IBD activity in the case of her colon obstruction. Because of the extensive infiltration of her liver and peritoneum at the time of the dia­gnosis, in addition to the symptoms of the passage disorders she was experiencing, she proceeded with an end ileostomy and palliative treatment was started. The patient‘s prognosis was unfavourable, and she died within 5 months of the dia­gnosis in hospice care. Key words: primary signet ring cell carcinoma – colon cancer – Crohn‘s disease – colonic stenosis","PeriodicalId":38577,"journal":{"name":"Gastroenterologie a Hepatologie","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83924279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal dysfunctions and their infl uence on the quality of life in aging adults with spinal cord injury","authors":"Jarmila Štěpánová, Kateřina Raisová, Petr Pliska","doi":"10.48095/ccgh202338","DOIUrl":"https://doi.org/10.48095/ccgh202338","url":null,"abstract":"Summary: Background: People with spinal cord injury in the chronic stage of disability have several permanent health problems that get worse during aging. Among them, there are gastrointestinal complications, which have a significant negative impact on their quality of life. Objective: The purpose of this study was to evaluate the impact of the period since the incidence of the injury, level of spinal cord injury and Body Mass Index on the level of bowel dysfunction and on the quality of life of chronic patients. Method: Proceeding from a questionnaire-based survey, 42 adults with complete and incomplete spinal cord injuries completed the standardized questionnaire Neurogenic bowel dysfunction score (NBD Score), the standardized questionnaire Irritable Bowel Syndrome – Quality of Life survey (IBS-QOL) and non-standardized Czech version questionnaire Burwood Questionnaire. Results: A statistically significant positive linear correlation was evaluated between the period of time since the incidence of the injury and NBD score. The Pearson correlation coefficient was 0.6 (P = 0.02). However, there was no statistically significant linear correlation between the period of time since the incidence of the injury and value of IBS-QOL (–0.47; P = 0.47). Neither was there any statistically significant positive linear correlation with the variables the level of spinal cord injury and Body Mass Index. What most decrease the quality of life of disabled patients with gastrointestinal complications are concerns for their own health, depressive feelings, and diet routines. Conclusion: All medical staff should not neglect the need of dia­gnostic and therapy of the gastrointestinal problems in the aging subpopulation of people with spinal cord injury. Key words: spinal cord injury – neurogenic bowel dysfunction – questionnaire-based survey – quality of life – aging","PeriodicalId":38577,"journal":{"name":"Gastroenterologie a Hepatologie","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74382284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune hepatitis after vaccination against COVID-19","authors":"Veronika Pítová, J. Sperl, P. Taimr, O. Fabian, T. Miřejovský, L. Janousek, J. Chlupac, J. Spicak, S. Fraňková","doi":"10.48095/ccgh202352","DOIUrl":"https://doi.org/10.48095/ccgh202352","url":null,"abstract":"Summary: In this case report, we present a 61-year-old patient admitted to the hospital because of tiredness and jaundice less than three weeks after vaccination against SARS-CoV-2 with the first dose of the Comirnaty vaccine (Pfizer/BioNTech). Based on the patient’s medical history, laboratory data, imaging methods and liver bio­psy, we dia­gnosed autoimmune hepatitis. The patient developed acute liver failure, and his liver function did not improve after corticosteroid administration. Therefore, the patient was enrolled in the waiting list and underwent a successful orthotopic liver transplantation. Key words: autoimmune hepatitis – COVID-19 – vaccination – liver failure","PeriodicalId":38577,"journal":{"name":"Gastroenterologie a Hepatologie","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76498847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complicated course of IBD in pregnancy","authors":"V. Štěpánek, Z. Šerclová, M. Kasalický, M. Bortlík","doi":"10.48095/ccgh202330","DOIUrl":"https://doi.org/10.48095/ccgh202330","url":null,"abstract":"Summary: We present a case report of a young female patient with complicated course of inflammatory bowel disease with severe luminal, as well as perianal symptoms. The patient was initially dia­gnosed with ulcerative colitis and underwent proctocolectomy with ileopouch-anal anastomosis. One year after oostomy closure she got pregnant and, at the same time, she developed perianal abscess and fistula. The dia­gnosis was thus changed to Crohn’s disease. During pregnancy, she underwent repeated perianal fistula drainages, surgical revision of ileus and treatment with ustekinumab was started. The patient delivered a healthy boy in November 2022 at 38th gestational week. Key words: Crohn’s disease – perianal Crohn’s disease – ustekinumab – pregnancy","PeriodicalId":38577,"journal":{"name":"Gastroenterologie a Hepatologie","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81578341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Titanlax – medical device profile","authors":"Vilma Vranová","doi":"10.48095/ccgh2022519","DOIUrl":"https://doi.org/10.48095/ccgh2022519","url":null,"abstract":"Summary: Constipation is a very common disease, usually solved by self-medication. There is a considerable number of drugs and medical devices on the market with diff erent compositions and mechanisms of action, while not all of them are suitable for long-term use. The composition of the medical device Titanlax (macrogol [PEG], psyllium, simethicone) refl ects the positions of the Society of General Medicine expressed in the Recommended Practices and combines dietary measures and active substances of fi rst choice, i.e. psyllium, PEG and simethicone, and is suitable for long-term use. Key words: constipation – IBS – macrogol – psyllium – simethicone","PeriodicalId":38577,"journal":{"name":"Gastroenterologie a Hepatologie","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82704644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dificlir – fidaxomicin – an effective treatment option for C. difficile infections in children","authors":"K. Zárubová","doi":"10.48095/ccgh2022515","DOIUrl":"https://doi.org/10.48095/ccgh2022515","url":null,"abstract":"","PeriodicalId":38577,"journal":{"name":"Gastroenterologie a Hepatologie","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79660422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perforation of colon sigmoideum as a delayed complication of ERCP","authors":"Polina Politová, L. Douda, Lukáš Štrincl, Z. Zádorová","doi":"10.48095/ccgh2022504","DOIUrl":"https://doi.org/10.48095/ccgh2022504","url":null,"abstract":"Summary: Pancreatobiliary stent migration is not a common complication, mostly without serious consequences, but sometimes causing intestinal perforation. The authors describe migration of the DB stent into the sigmoid with subsequent completely asymptomatic perforation of the bowel wall. Due to the patient’s clinical condition and age, the perforation was successfully treated endoscopically. Key words: biliary stent – ERCP – migration – complications – perforation","PeriodicalId":38577,"journal":{"name":"Gastroenterologie a Hepatologie","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78224643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life in patients with Crohn’s disease in the Czech Republic","authors":"J. Bielik, A. Němcová, V. Meluš, K. Gerlichová, Pavel Svoboda","doi":"10.48095/ccgh2022508","DOIUrl":"https://doi.org/10.48095/ccgh2022508","url":null,"abstract":"","PeriodicalId":38577,"journal":{"name":"Gastroenterologie a Hepatologie","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83497150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment: „Obesity in patients younger than ͼͶ years is a risk factor for Covid-ͷͿ hospital admission“ (Clinical Infectious Diseases)","authors":"J. Kral","doi":"10.48095/ccgh2022512","DOIUrl":"https://doi.org/10.48095/ccgh2022512","url":null,"abstract":"","PeriodicalId":38577,"journal":{"name":"Gastroenterologie a Hepatologie","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75993093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}