Nepal Journal of Health Sciences最新文献_第4页

Formulation and in-vitro Evaluation of Oro-dispersible tablets of Indomethacin 吲哚美辛口腔分散片的处方及体外评价

Nepal Journal of Health Sciences Pub Date : 2022-08-03 DOI: 10.3126/njhs.v2i1.47172

Gopal Pokhrel, Ganga Kunwar, Jun Devi Rai, Sheela Thapa, Sudip Dhakal, Prashant Basnet

{"title":"Formulation and in-vitro Evaluation of Oro-dispersible tablets of Indomethacin","authors":"Gopal Pokhrel, Ganga Kunwar, Jun Devi Rai, Sheela Thapa, Sudip Dhakal, Prashant Basnet","doi":"10.3126/njhs.v2i1.47172","DOIUrl":"https://doi.org/10.3126/njhs.v2i1.47172","url":null,"abstract":"Introduction: Oro-dispersible tablets are rapidly dissolved in saliva without the need for water and are beneficial for renal impaired, bedridden and psychiatric patients.\u0000Objective: The study aimed to formulate oro-dispersible tablets of indomethacin with reduced adverse effects, better patient compliance, faster action, and convenience for patients.\u0000Methods: Oro-dispersible tablets of indomethacin were prepared using three different super disintegrants; crospovidone, croscarmellose sodium and sodium starch glycolate with three different concentrations (2.5%, 5.2%, and 7.7%) by direct compression method. The prepared tablets were evaluated for pre and post-compression parameters including bulk density, tapped density, compressibility index, angle of repose, Hausner's ratio, hardness, friability, wetting time, in vitro disintegration time, and in vitro drug release.\u0000Results: The percentage of drug released in 5 minutes of all formulations of Oro-dispersible tablets of Indomethacin was found to be 74.36% to 80.16% and the percentage of drug released in 10 minutes was 96.18% to 100%. All formulations showed disintegration time in the range of 19-78 seconds. The tablets prepared with 7.7% crospovidone (F6) shows faster disintegration (19 seconds) as compared to tablets prepared with sodium starch glycolate and croscarmellose sodium. The in-vitro dissolution studies showed that tablets of formulations batch containing 7.7% crospovidone releases 100% of the drug after 10 minutes which was fast released as compared to sodium starch glycolate and croscarmellose sodium.\u0000Conclusions: Oro-dispersible tablets of indomethacin prepared with crospovidone showed better disintegration time and dissolution profile as compared to other superdisintegrants.","PeriodicalId":384518,"journal":{"name":"Nepal Journal of Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129186644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depression among Elderly Residing in Old-age Homes in Devghat, Nepal 尼泊尔Devghat养老院老人抑郁症调查

Nepal Journal of Health Sciences Pub Date : 2022-08-03 DOI: 10.3126/njhs.v2i1.47161

Prava Lamichhane, Shobhana Nepal, K. Dhakal

{"title":"Depression among Elderly Residing in Old-age Homes in Devghat, Nepal","authors":"Prava Lamichhane, Shobhana Nepal, K. Dhakal","doi":"10.3126/njhs.v2i1.47161","DOIUrl":"https://doi.org/10.3126/njhs.v2i1.47161","url":null,"abstract":"Introduction: Depression among the elderly is a common phenomenon that is increasing at an alarming rate in recent years. Depression among the elderly leads to various physical and psychological problems and consequently poor quality of life.\u0000Objective: This study was aimed at assessing the prevalence of depression among elderly residing in old-age homes in Devghat, Tanahun, Nepal.\u0000Methods: A cross-sectional analytical study design was adopted to assess depression among elderly residing in old-age homes of Devghat town in Tanahun district of Nepal. Non-probability enumeration sampling technique was used to collect the data. The validated Nepali translation of the Geriatric Depression Scale-15 was used to assess depression. Collected data were entered in SPSS version 22 and analyzed by using the Chi-square test.\u0000Results: Out of 155 respondents, 45.8% had mild depression followed by 36.8% who had moderate depression. A statistically significant association was found between the level of depression and marital status, educational status, asthma, and habit of smoking.\u0000Conclusions: This study showed that the prevalence of depression in old-age homes was very high. This necessitates the provision of regular screening and adequate support and initiatives from concerned authorities to uplift the mental status of these elderly people so that it does not affect their overall health and quality of life.","PeriodicalId":384518,"journal":{"name":"Nepal Journal of Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130060271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

External Dacryocystorhinostomy Surgery at Biratnagar Eye Hospital, Nepal 尼泊尔Biratnagar眼科医院的外部泪囊鼻腔造口术

Nepal Journal of Health Sciences Pub Date : 2022-08-03 DOI: 10.3126/njhs.v2i1.47155

P. A. Kafle, D. Hamal, K. Thakur, Sharmila Chaudhary

{"title":"External Dacryocystorhinostomy Surgery at Biratnagar Eye Hospital, Nepal","authors":"P. A. Kafle, D. Hamal, K. Thakur, Sharmila Chaudhary","doi":"10.3126/njhs.v2i1.47155","DOIUrl":"https://doi.org/10.3126/njhs.v2i1.47155","url":null,"abstract":"Introduction: Nasolacrimal duct obstruction at the junction of the lacrimal sac and nasolacrimal duct causes acute or chronic dacryocystitis. Dacryocystorhinostomy (DCR) is the treatment of choice and has a high success rate.\u0000Objective: To analyze the success rate of external DCR surgery and its influencing factors at our hospital.\u0000Methods: It is a hospital-based descriptive study of cases that underwent external DCR surgery from June 2016 to February 2017 at Biratnagar eye hospital. The demographic data were recorded and the successful outcome of the surgery along with its influencing factors -tube status, operating surgeons, and gender was analyzed. The main outcome measure was defined as a patent lacrimal passage on syringing at 6 months postoperatively. Chi-square and Fisher’s exact test were used for statistical analysis.\u0000Results: In total 317 patients, the mean age of the patients was 38.46 (SD ± 13.6) years. The male to female ratio was 1:2.5. The commonest presenting symptom was watering with discharge in 224 (70.6%) patients. Of the total, 195(61.5%) had undergone the DCR surgery with intubation and 122 (38.5%) without intubation. Only 114 (35.9%) patients were followed up for 6 months. The success rate was 86.8%. Postoperative wound infection, bleeding or cheese wiring of the punctum was not seen. No statistically significant factors were seen to influence the success rate of DCR surgery.\u0000Conclusions: External DCR surgery has a high success rate and no significant influencing factors were found to define its success in this study.","PeriodicalId":384518,"journal":{"name":"Nepal Journal of Health Sciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114175109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Glycated Haemoglobin and Lipid Profile in Type-2 Diabetes Mellitus 2型糖尿病糖化血红蛋白及血脂的研究

Nepal Journal of Health Sciences Pub Date : 2022-08-03 DOI: 10.3126/njhs.v2i1.47157

T. Yadav, M. V. Bhaskar, Jayendra Bajracharya, S. Sharma, Nikky Maharjan, Sushma Bhadeshwar

{"title":"Study of Glycated Haemoglobin and Lipid Profile in Type-2 Diabetes Mellitus","authors":"T. Yadav, M. V. Bhaskar, Jayendra Bajracharya, S. Sharma, Nikky Maharjan, Sushma Bhadeshwar","doi":"10.3126/njhs.v2i1.47157","DOIUrl":"https://doi.org/10.3126/njhs.v2i1.47157","url":null,"abstract":"Introduction: Diabetes Mellitus is characterized by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, insulin action, or both.\u0000Objective: To compare the biochemical parameters which included glycated hemoglobin, serum total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol of people with diabetes mellitus and matched nondiabetic controls.\u0000Methods: The cross-sectional hospital-based study was conducted among 60 diabetics and 30 nondiabetic patients. Fasting blood samples of 5 ml were collected from both the study sample and control sample. Biochemical parameters like glycated hemoglobin, serum total cholesterol, serum triglyceride, serum high-density lipoprotein cholesterol, and serum low-density lipoprotein cholesterol were analyzed with the help of a semi-automated analyzer, Erba Chem5, and Colorimeter-Systronic. Means of glycated hemoglobin, total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein were estimatedamong the cases and controls. The student`s t-test was used to compare the mean values.\u0000Results: A statistically significant difference was observed in mean glycated hemoglobin, total cholesterol, triglyceride, high density lipoprotein and low-density lipoprotein among the cases and controls (p-value<0.05).\u0000Conclusions: This study concluded that there was a significant difference in mean glycated hemoglobin, total cholesterol, triglyceride, high-density cholesterol, and low-density cholesterol among the cases and controls. It is suggestive that lipid profile must be considered among diabetic patients which could be beneficial to prevent the risk of cardiovascular complications.","PeriodicalId":384518,"journal":{"name":"Nepal Journal of Health Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115066271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Spectrum of Oral Cavity Lesions and its Clinico-Histopathological Correlation 口腔病变谱及其临床-组织病理学相关性研究

Nepal Journal of Health Sciences Pub Date : 2021-12-31 DOI: 10.3126/njhs.v1i2.42378

Deepshikha Gaire, A. D. Pant, Daisy Maharjan, U. Manandhar

{"title":"Spectrum of Oral Cavity Lesions and its Clinico-Histopathological Correlation","authors":"Deepshikha Gaire, A. D. Pant, Daisy Maharjan, U. Manandhar","doi":"10.3126/njhs.v1i2.42378","DOIUrl":"https://doi.org/10.3126/njhs.v1i2.42378","url":null,"abstract":"Introduction: Oral cavity lesions comprise a wide spectrum of diseases that varies from non-neoplastic to neoplastic. The clinical evaluation alone is insufficient for proper diagnosis in most cases. So, histopathological examination is the gold standard method for diagnosis and management of patients accordingly.\u0000Objective: The present study was done to evaluate the histopathological spectrum of oral cavity lesions and compare them in relation to age, sex, site, clinical features, risk factors, and clinical diagnoses.\u0000Methods: This prospective cross-sectional study enrolled 127 cases of oral biopsies which were received at the Department of Pathology, Tribhuvan University and Teaching Hospital, Kathmandu Nepal, from May 2018 to April 2019 for histopathological examination. Specimens were fixed in 10% formalin and subjected for tissue processing and Hematoxylin and Eosin stained sections. Data entry and analysis were done by using SPSS 24 version where frequency and percentile were calculated.\u0000Results: Total cases were 127 with slight female predilection and the age group of 50-60 years (mean age of 44.24 years) were commonly affected. The tongue being the most common site, frequently lesions presented as swelling. Most of the lesions were non-neoplastic comprising 45% whereas malignant lesions comprised 23.6%. Smoking increased the risk of malignancy by 2 fold. The most common benign lesions were squamous papilloma & fibroepithelial polyp whereas the malignant lesion was squamous cell carcinoma. Sixty percent of clinical diagnoses didn’t show correlation.\u0000Conclusions: Oral cavity lesions have a wide spectrum of distribution in age, sex, site, and clinical presentation. Initially, oral lesions may present with subtle symptoms which may cause underdiagnosis. Thus, histopathological diagnosis is a must to rule out malignancy.\u0000Keywords: Clinical presentation; correlation; oral cavity; risk factors.","PeriodicalId":384518,"journal":{"name":"Nepal Journal of Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129355994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peri-implantitis: A Classification Update 种植体周围炎:分类更新

Nepal Journal of Health Sciences Pub Date : 2021-12-31 DOI: 10.3126/njhs.v1i2.42384

Rejina Shrestha, A. Bhochhibhoya

引用次数: 0

One Health in Nepal- An Overview 尼泊尔的同一个健康——概述

Nepal Journal of Health Sciences Pub Date : 2021-07-30 DOI: 10.3126/njhs.v1i1.38738

A. Khatiwada, Alina Karna, N. Bhat, S. Deo

{"title":"One Health in Nepal- An Overview","authors":"A. Khatiwada, Alina Karna, N. Bhat, S. Deo","doi":"10.3126/njhs.v1i1.38738","DOIUrl":"https://doi.org/10.3126/njhs.v1i1.38738","url":null,"abstract":"In order to meet today’s complex health and environmental challenges, multi-disciplinary research has never been more exigent. Nepal is in the early stages of adopting One Health (OH), but it is continuously expanding. Various initiatives have been taken by the Government of Nepal (GoN) to combat problems such as antimicrobial resistance, highly pathogenic avian influenza and rabies using an integrated health approach, but several challenges remain in their implementation. A few of the major obstacles to implementing OH in Nepal include weak organizational structure to support the initiative, no legal framework required to implement OH, insufficient technical expertise, lack of intersectoral data sharing mechanisms, a limited budget, and poor legislative understanding. To address these gaps and prioritize the health problems where OH will lead to the best outcome, we encourage GoN to address the gaps. To control the ongoing COVID-19 pandemic, the rational application of the One Health strategy should be our utmost priority. The One Health paradigm can help healthcare professionals and researchers improve the public’s health in response to the coming wave of COVID-19 pandemic and prepare for future pandemics.","PeriodicalId":384518,"journal":{"name":"Nepal Journal of Health Sciences","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127807572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated Cutaneous Tuberculosis like Fungal Sporotrichosis Successfully Treated With Terbinafine: A Rare Case Report 特比萘芬成功治疗弥散性皮肤结核样真菌孢子菌病:罕见病例报告

Nepal Journal of Health Sciences Pub Date : 2021-07-30 DOI: 10.3126/njhs.v1i1.38737

A. Gautam, Bijay Subedi, J. Awasthi, S. Adhikari

引用次数: 0

Burkholderia Cepacia in Patients with Diabetes Mellitus - An unusal Presentation 糖尿病患者中的洋葱伯克氏菌-一种不寻常的表现

Nepal Journal of Health Sciences Pub Date : 2021-07-30 DOI: 10.3126/njhs.v1i1.38736

N. Bhat, Alina Karna, S. Dutta

引用次数: 0

Knowledge, Attitude and Practice Regarding Personal Protective Equipment During COVID–19 Pandemic Among Healthcare Workers in Hetauda 新冠肺炎大流行期间赫托达市医护人员对个人防护装备的知识、态度和实践

Nepal Journal of Health Sciences Pub Date : 2021-07-30 DOI: 10.3126/njhs.v1i1.38733

Susmita Bhattarai, Srijana Pradhan

{"title":"Knowledge, Attitude and Practice Regarding Personal Protective Equipment During COVID–19 Pandemic Among Healthcare Workers in Hetauda","authors":"Susmita Bhattarai, Srijana Pradhan","doi":"10.3126/njhs.v1i1.38733","DOIUrl":"https://doi.org/10.3126/njhs.v1i1.38733","url":null,"abstract":"Introduction: Personal protective equipment (PPE) is one of the effective measures to protect health care workers while caring confirmed or suspected patients with COVID-19. \u0000Objective: To assess the knowledge, attitude, and practice regarding the use of PPE among healthcare workers (HCWs) in Hetauda during COVID-19 pandemic. \u0000Methods: A descriptive cross-sectional study was conducted among 138 HCWs from three hospitals in Hetauda: Hetauda Hospital, Makwanpur Sahakari hospital and Hetauda Orthopedic Hospital between December 2020 and January 2021 for two weeks. A validated self-administered questionnaire, Likert scale and Observational checklist were used for data collection. The simple descriptive statistics (percentage, mean) and inferential statistics (Chi-square test) were used for the data analysis. \u0000Results: The findings of the study showed that the mean age of the respondents was 26.54 years. Half of the total respondents 70 (50.7%) had adequate knowledge, half 69 (50%) had positive attitude and more than half of the respondents had poor practice 60 (60%) regarding the use of PPE during COVID-19 pandemic. There was significant association of knowledge regarding the use of PPE with training, continue education, profession and attitude at p<0.05 level of significance. \u0000Conclusion: This study concludes that the periodic training program for newly recruited HCWs and refresher training/ continue education for old HCWs to update about the proper use of PPE would enhance the knowledge, attitude and practice of the HCWs. The hospitals should follow the standard PPE guidelines by CDC or WHO while donning and doffing the PPE during the care of Covid patients.","PeriodicalId":384518,"journal":{"name":"Nepal Journal of Health Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124459516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0