NeuroPharmac Journal最新文献

Limitations of Alzheimer’s Disease Medications 阿尔茨海默病药物的局限性

NeuroPharmac Journal Pub Date : 2023-12-30 DOI: 10.37881/1.832

A. Pathan

引用次数: 0

Potential use of neuroprotective and L-DOPA-rich plants in parkinsonian therapy 神经保护植物和富含 L-DOPA 的植物在帕金森治疗中的潜在用途

NeuroPharmac Journal Pub Date : 2023-12-30 DOI: 10.37881/1.831

Jamal Arif, Yusuf Jamal, Feras Almarshad, Abdulrahman M. Alshahrani, Mohammed Atef

引用次数: 0

Stroke and migraine are leading neurological conditions on a global scale 中风和偏头痛是全球范围内主要的神经系统疾病

NeuroPharmac Journal Pub Date : 2023-08-30 DOI: 10.37881/1.822

A. Pathan

引用次数: 0

Neurological adverse effects after SARS-CoV-2 vaccinations: Etiology should be warranted 接种SARS-CoV-2疫苗后神经系统不良反应:病因学应得到保证

NeuroPharmac Journal Pub Date : 2023-08-30 DOI: 10.37881/1.821

A. Pathan, N. Logade, F. Khan

{"title":"Neurological adverse effects after SARS-CoV-2 vaccinations: Etiology should be warranted","authors":"A. Pathan, N. Logade, F. Khan","doi":"10.37881/1.821","DOIUrl":"https://doi.org/10.37881/1.821","url":null,"abstract":"The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has claimed a global health crisis of unpredictable amount. Due to its high mortality, many COVID-19 vaccines are being developed, approved, and manufactured rapidly. However, some serious neurological adverse events (AEs) were reported after the application of them.\u0000This review was conducted to collect and discuss published data about neurological side effects of SARS-CoV-2 vaccines in order to discover type, frequency, treatment, and outcome of these side effects. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. Healthcare practitioners, particularly neurologists involved in the management of patients having undergone SARS-CoV-2 vaccinations, should be aware of these side effects and should recognize them early and treat them significantly. Furthermore, some neurological conditions like headache and GBS are found in patients of COVID-19 infection and in patients after the SARS-CoV-2 vaccinations. Further studies should be warranted to differentiate the etiology.","PeriodicalId":383954,"journal":{"name":"NeuroPharmac Journal","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128271647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropharmacology of Lecanemab-irmb: A new drug granted in the treatment of Alzheimer's disease Lecanemab-irmb的神经药理学:一种治疗阿尔茨海默病的新药

NeuroPharmac Journal Pub Date : 2023-04-30 DOI: 10.37881/1.811

Fahaad Alenazi

{"title":"Neuropharmacology of Lecanemab-irmb: A new drug granted in the treatment of Alzheimer's disease","authors":"Fahaad Alenazi","doi":"10.37881/1.811","DOIUrl":"https://doi.org/10.37881/1.811","url":null,"abstract":"United state food and drug administration approved on 6 January 2023, Lecanemab-irmb via the accelerated approval pathway for the treatment of Alzheimer’s disease. Researchers evaluated Lecanemab-irmb’s efficacy in a double-blind, placebo-controlled, parallel-group, dose-finding study of 856 patients with Alzheimer’s disease. Treatment was initiated in patients with mild cognitive impairment or mild dementia stage of disease and confirmed the presence of amyloid beta pathology. Patients receiving the treatment had significant dose and time-dependent reduction of amyloid beta plaque, with patients receiving the approved dose of lecanemab, 10 milligram/kilogram every two weeks, having a statistically significant reduction in brain amyloid plaque from baseline to Week 79 compared to the placebo arm, which had no reduction of amyloid beta plaque. \u0000These results support the accelerated approval of Lecanemab-irmb, which is based on the observed reduction of amyloid beta plaque, a marker of Alzheimer’s disease. The amyloid beta plaque was quantified using positron emission tomography (PET) imaging to estimate the brain levels of amyloid beta plaque in a composite of brain regions expected to be widely affected by Alzheimer’s disease pathology compared to a brain region expected to be spared of such pathology.","PeriodicalId":383954,"journal":{"name":"NeuroPharmac Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126593062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropharmacology of Levetiracetam as Anti-epileptic Medication 左乙拉西坦抗癫痫药物的神经药理学研究

NeuroPharmac Journal Pub Date : 2022-12-30 DOI: 10.37881/1.731

Fahaad Alenazi, A. Pathan

引用次数: 0

Moderation in Asbab-e-Sitta Zarooriya (Six essential factors): A Unique Practice for Boosting Immunity 适度的Asbab-e-Sitta Zarooriya(六个基本因素):提高免疫力的独特做法

NeuroPharmac Journal Pub Date : 2022-08-30 DOI: 10.37881/1.714

N. Khan, Rizwan Khan, Abdul Aziz Khan

{"title":"Moderation in Asbab-e-Sitta Zarooriya (Six essential factors): A Unique Practice for Boosting Immunity","authors":"N. Khan, Rizwan Khan, Abdul Aziz Khan","doi":"10.37881/1.714","DOIUrl":"https://doi.org/10.37881/1.714","url":null,"abstract":"Objective: Asbab-e-Sitta Zarooriya is the six essential factors proposed by the Unani sages, testified by time and human experiences that moderation/balance in these lifestyle factors can play an imperative role to accentuate and boost immunity. The present study is designed to identify the various ways of moderation and modifications in these six indispensable factors of Asbab-e-Sitta Zarooriya to enhance immunity.\u0000Methodology: The present study is an empirical review of the classical concept of Asbab-e-Sitta Zarooriya (the six essential life factors) described in original classical texts (English translations) and a critical constructive analysis of the available literature on the topic. It is an attempt to validate the old conceptual claims with help of recent studies and to appraise the significant role of balanced Asbab-e-Sitta Zarooriya in regulating and boosting immunity and how modifications in these factors can play a pivotal role in the prevention of various disease conditions. Conclusion: The study concludes that protecting ourselves from outside by various precautionary measures will not suffice to combat the present health challenges rather we also require defending ourselves beginning right from within our body by strengthening the immune system. The immune system is quite complicated and to a great extent, influenced by the extrinsic factors surrounding us. Many aspects impact the working of the immune system. A healthy lifestyle (balanced Asbab-e- Sitta Zarooriya) includes eating nutritious food and practicing good habits involving walking and exercising regularly, maintaining good emotional and mental health, and taking adequate rest. All these six essential factors play a significant role in regulating and boosting immunity.","PeriodicalId":383954,"journal":{"name":"NeuroPharmac Journal","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131183468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Journey of mesenchymal stem cells in biomedical research: Current aspects and scenario 间充质干细胞在生物医学研究中的历程:现状和前景

NeuroPharmac Journal Pub Date : 2022-04-30 DOI: 10.37881/1.712

Sumaiya Akhlaq

{"title":"Journey of mesenchymal stem cells in biomedical research: Current aspects and scenario","authors":"Sumaiya Akhlaq","doi":"10.37881/1.712","DOIUrl":"https://doi.org/10.37881/1.712","url":null,"abstract":"Mesenchymal stem cells (MSCs) are adult stem cells that can be isolated from humans or animals. Human MSCs are multipotent stem cells that have a great potential to differentiate into mesoderm as well as endoderm lineage. Human mesenchymal stem cells (HMSCs) can be cultured for a long time purpose in cell-specific media without any abnormalities. Up to now, MSCs are isolated from different tissues including adipose tissue, amniotic fluid, endometrium, dental tissues, umbilical cord, and Wharton's jelly. MSCs possess low immunogenicity and strong immunomodulation potential; they secrete cytokines and use immune receptor which keeps the check on the microenvironment within the tissue. Their multilineage potential, immunomodulation, and production of anti-inflammatory molecules made MSCs use in clinical research and treatments. Their differential potential together with the property to secrete soluble factors and release extracellular vesicles like exosomes and microvesicles enable them to serve the purpose of tissue repair. Recent studies suggested that extracellular vesicles that serve as the cargo of mRNA, miRNA, and proteins are responsible for the therapeutic effects of MSCs. MSCs are now widely considered as the best tool for regenerating tissues due to their fast self-renewal property, their easy accessibility with a lesser ethical concern for clinical applications. MSCs clinical applications include cartilage and bone repair, tissue healing, heart, and neuronal regeneration, and treatment of different immune disorders including graft versus host disease (GvHD). Their great potential allows them to treat even many incurable diseases. This review gives detailed information on MSCs, their sources, definite properties, biomarkers, and applications. The wide potential of MSCs in today’s scenario is seen in the field of toxicology studies and cancer research.","PeriodicalId":383954,"journal":{"name":"NeuroPharmac Journal","volume":"188 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122110583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The methods of biofuel generation by using microalgae: A review 利用微藻生产生物燃料的方法综述

NeuroPharmac Journal Pub Date : 2022-04-30 DOI: 10.37881/1.710

Hanoof Alkhodairy

引用次数: 0

Effect of heavy-load eccentric calf muscle training as a rehabilitation protocol in soccer players with persistent Achilles tendinosis 大负荷偏心小腿肌肉训练作为足球运动员持续性跟腱病康复方案的效果

NeuroPharmac Journal Pub Date : 2022-04-30 DOI: 10.37881/1.711

Shadab Uddin, Mohammed Qasheesh, Waseem Mumtaz Ahamed, R. Beg

引用次数: 0