ORAL and Implantology最新文献

{"title":"Three-point bending test simulation on implant fpds with a bio-faithful model.","authors":"V Vertucci,&nbsp;M Montani,&nbsp;C Arcuri,&nbsp;P Cardelli","doi":"10.11138/orl/2017.10.1.053","DOIUrl":"https://doi.org/10.11138/orl/2017.10.1.053","url":null,"abstract":"<p><strong>Aim of the study: </strong>It is well known by previous important studies that mandible flexes during different jaw movements. According to this assumption it is very important to know how implant supported fixed partial dentures could restrict mandibular movements and, could lead to excess strain accumulation that could modify the resolution of implant treatment. The aim of our project is to create a bio-faithful model able to recreate mandibular movements, during three point bending test methods of (FIXED -PARTIAL -DENTURES) FPDs, to avoid a not flexible metal base, where models' properties doesn't allow to obtain a bio-faithful simulation during testing phases.</p><p><strong>Materials and methods: </strong>2 implants (premium Sweden and Martina®) were embedded in mandible resin section to mimic osteointegrated implants in premolar and molar areas, in order to recreate a Kennedy Class II configuration. Our mandible test simulator was creating according to the measurement obtained according to the study of Schwartz-Dabney and Dechow (2002). Sample so created is tested with testing machine (Instron 5566^®, UK) adopting the three point bending mechanical tests configuration.</p><p><strong>Discussion and conclusion: </strong>We can admit that oral cavity is a bio-dynamic system, where different variables incurr, so it's very important that experimental conditions simulate clinical environment. Experimentation should be based on the correlation between the failure mechanisms exhibited for <i>in vitro</i> samples and those observed in fractured clinical prostheses made of the same composition and processing conditions. A bio-faithful model could reduce this wide range between <i>in vitro</i> and <i>in vivo</i> study experimentation.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 1","pages":"53-58"},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516424/pdf/53-58.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35277235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic susceptibility and periodontal disease: a retrospective study on a large italian sample.","authors":"L Tettamanti,&nbsp;R M Gaudio,&nbsp;A Iapichino,&nbsp;D Mucchi,&nbsp;A Tagliabue","doi":"10.11138/orl/2017.10.1.020","DOIUrl":"https://doi.org/10.11138/orl/2017.10.1.020","url":null,"abstract":"<p><strong>Background: </strong>Periodontal disease (PD) is a multifactorial illness in which environment and host interact. The genetic component plays a key role in the onset of PD. In fact the genetic compound can modulate the inflammation of the mucous membranes and the loss of alveolar bone. The genetics of PD is not well understood. Previous studies suggest a strong association between PD occurrence and individual genetic profile. The role of genetic susceptibility could impact on the clinical manifestations of PD, and consequently on prevention and therapy.</p><p><strong>Materials and methods: </strong>Genetic polymorphisms of VRD, IL6 and IL10 were investigated in Italian adults affected by PD. 571 cases classified according the criteria of the American Academy of Periodontology were included. All patients were Italian coming from three areas according to italian institute of statistics (ISTAT) (www.istat.it/it/archivio/regioni). The sample comprised 379 patients from North (66%), 152 from Central (26%) and 40 of South (8%).</p><p><strong>Results: </strong>No significant differences were found among allele distribution.</p><p><strong>Conclusion: </strong>Chronic PD is a complex disease caused by a combination of genetic susceptibility, patients habits (oral hygiene, smoking, alcohol consumption) and oral pathogens. In our report no differences were detected among three Italian regions in allele distribution.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 1","pages":"20-27"},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.1.020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35277231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of antibacterial and anti-inflammatory effects of mouthrinse containing tea tree oil.","authors":"C Salvatori,&nbsp;L Barchi,&nbsp;F Guzzo,&nbsp;M Gargari","doi":"10.11138/orl/2017.10.1.059","DOIUrl":"https://doi.org/10.11138/orl/2017.10.1.059","url":null,"abstract":"<p><p>The study evaluated the antibacterial and anti-inflammatory efficacy, domiciliary oral hygiene, of a mouthrinse containing Tea Tree Oil (TTO) comparing it with two mouthrinses containing chlorhexidine 0,12% respectively and essential oils, and a placebo.</p><p><strong>Materials and methods: </strong>A pilot study, randomized 4 × 4, controlled, cross-over, double-blind. 16 subjects with gingivitis (7 males and 9 females) aged 21-37 years, were randomly divided into four groups based on mouthwash that had to be used for domiciliary oral hygiene: mouthwash with essential oils, mouthwash with chlorhexidine 0,12 %, mouthwash containig tea tree oil and mouthwash placebo. Clinical evaluation was performed by: Full Mouth Plaque Score (FMPS), Full Mouth Bleeding Score (FMBS), Gingival Index (GI), discolorations, language examination and alteration of taste. The data were recorded before and 2 weeks after treatment.</p><p><strong>Results: </strong>Statistical analysis shows that treatments with tea tree oil, essential oils and chlorhexidine are effective. Comparing treatments should be noted that the tea tree oil gives a greater improvement in the GI and FMBS, while it is the least effective in the control of bacterial plaque.</p><p><strong>Conclusion: </strong>Although further studies are needed, the anti-inflammatory properties of the mouthwash made from TTO would seem to be a valuable non-toxic adjunct in the management of gingivitis.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 1","pages":"59-70"},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.1.059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35279232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between parodontal indexes and orthodontic retainers: prospective study in a group of 16 patients.","authors":"D DI Venere, F Pettini, G M Nardi, A Laforgia, G Stefanachi, V Notaro, B Rapone, F R Grassi, M Corsalini","doi":"10.11138/orl/2017.10.1.078","DOIUrl":"10.11138/orl/2017.10.1.078","url":null,"abstract":"<p><strong>Purpose: </strong>Fixed retainers are used to stabilize dental elements after orthodontic treatment. Being it a permanent treatment, it is necessary to instruct patients about a constant and continuous monitoring of their periodontal conditions and a correct oral hygiene. The aim of this study was to highlight the possible adverse effects of bonded retainers on parameters correlated to the health conditions of periodontal tissues.</p><p><strong>Materials and methods: </strong>We selected 16 patients, under treatment in the Orthodontics Department of University of Bari Dental School, who had undergone a lingual retainer insertion at the end of the orthodontic treatment. The patients were then divided into two groups (Control Group and Study Group) and monitored for 3 and 36 months, respectively. The following indexes were taken into consideration: gingival index (GI), plaque index (PI) and the presence of calculus (Calculus Index, CI), the probing depth and the presence of gingival recession on the six inferior frontal dental elements.</p><p><strong>Results: </strong>After the observation was carried out, any of the patients showed periodontal sockets and gingival recession. In the Study Group, only 1 patient had a PI score=3, the 7 left had scores between 0.66 and 2.83. In the Control Group, one patient had score=0, the other ones showed values between 0.5 and 1.66. The mean GI in the Study Group peaked at a score of 2.83, the minimum was 0.66; whereas in the Control Group the maximum value was 2 and the minimum 0.66. The CI in the Group Study was between 1 and 2. In the Control Group it was absent in only 1 patient, whereas in the remaining 7, it had a value between 0.3 and 1. The clinical data were studied by means of the Wilcoxon test. We found a statistically significant difference for what concerns the Plaque Indexes (PI) (P>0.05) and Calculus Indexes (CI) (P>0.1) in both groups, with higher scores in the Study Group, having retainers for 36 months. Any statistically significant difference was calculated for the GI.</p><p><strong>Conclusions: </strong>We can therefore conclude that patients with lingual retainers need periodontal hygiene and treatment as to prevent, in the course of time, periodontal damages non-detectable in short-term.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 1","pages":"78-86"},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516425/pdf/78-86.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35279236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of periodontal pathogens among italian patients with chronic periodontitis: a retrospective study on 2992 patients.","authors":"L Tettamanti,&nbsp;R M Gaudio,&nbsp;F Cura,&nbsp;D Mucchi,&nbsp;N Illuzzi,&nbsp;A Tagliabue","doi":"10.11138/orl/2017.10.1.028","DOIUrl":"https://doi.org/10.11138/orl/2017.10.1.028","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the present study was to evaluate the prevalence of some periodontal pathogens in Italian adults with chronic periodontitis.</p><p><strong>Materials and methods: </strong>The sample consisted of 2992 patients with a clinical diagnosis of chronic periodontitis, based on the criteria of the American Academy of Periodontology, sampled in the period 2013-2016: 2108 patients were from Northern, 690 from Central and 194 from Southern Italy. <i>Porphyromonas gengivalis, Treponema denticola,</i> and <i>Tannerella forsythia</i> were investigated in all patients of the present study, while <i>Campylobacter rectus, Fusobacterium nucleatum</i> and <i>Aggregatibacter actinomycetemcomitans</i> only in 2514 (84%) patients. Subgingival plaque samples of the four sites of greatest probing depth in each patient were used to obtain subgingival microbiota and then processed by quantitative polymerase chain reaction.</p><p><strong>Results: </strong>Periodontal pathogens had the following presence respect to all amount of patients: <i>Aggregatibacter actinomycetemcomitans</i> 16.1%, <i>Campylobacter rectus</i> 73.4%, <i>Fusobacterium nucleatum</i> 93.8%, <i>Porphyromonas gengivalis</i> 65.5%, <i>Treponema denticola</i> 66.4%, and Tannerella forsythia 72.7%. There are no significant statistical differences among geographic areas both for the total bacterial and the single species except for <i>T. Denticola</i> and <i>C. Rectus,</i> which prevalence was significantly higher in Southern Italy (P value <.05). The other investigated species were equally distributed among different regions. <i>A. actinomycetemcomitans</i> was the rarer species detected in this study, while <i>F. nucleatum</i> was the commonest. No differences among areas where observed as regard of the mean bacterial load except for F. Nucleatum whose prevalence in Northern Italy was lower then both in Central and Southern Italy (P value <.05).</p><p><strong>Conclusions: </strong>The results of our study didn't show different geographic distribution of periodontal pathogens among Italian population of the three areas investigated. The homogeneity of the results could be related to genetic and environmental factors.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 1","pages":"28-36"},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.1.028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35277232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cleft palate only: current concepts.","authors":"L Tettamanti,&nbsp;A Avantaggiato,&nbsp;M Nardone,&nbsp;J Silvestre-Rangil,&nbsp;A Tagliabue","doi":"10.11138/orl/2017.10.1.045","DOIUrl":"https://doi.org/10.11138/orl/2017.10.1.045","url":null,"abstract":"<p><p>Cleft palate only (CPO) is one of the most common congenital malformations worldwide. The etiopathogenesis of CPO is not completely understood. Environmental factors, such as smoking, alcohol consumption, intake of drugs during pregnancy, advanced paternal age, have been demonstrated to be a risk of CPO, but conflicting results have also been published. Insufficient intake of folic acid during the pregnancy has been suggested to increase the risk for CPO. The demonstrated risk for siblings and the higher risk for monozygotic twins suggest a genetic etiopathogenesis for CPO. In some cases of CPO a prevalent mode of inheritance has been reported, but oligogenic models with reduced penetrance, and the risk related to environmental factors have also been proved. One of the first manifestations associated with CPO is difficulty with feeding. Aerophagia is a problem in these infants with CPO and requires more frequent burping and slower feeding. The inability to generate intraoral breath pressure due to nasal air emission in CPO children frequently manifests as articulation difficulties, particularly consonant weakness, and unintelligible speech. Hearing disorders are prevalent among individuals with CPO, as a result of chronic otitis media with effusion due to eustachian tube dysfunction. A multidisciplinary team is essential to manage the many aspects of CPO. In treating CPO, the reconstructive surgeon works in cooperation with otolaryngologists, dentists and orthodontists, speech pathologists, audiologists, geneticists, psychiatrists, maxillofacial surgeons, social workers, and prosthodontists. CPO can be considered a genetically complex disease, but new knowledge and new therapeutic approaches have greatly improved the quality of life of these children. Prenatal diagnosis is an important step in the treatment of this disease.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.1.045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35277236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a new coating of implant-abutment connections in reducing bacterial loading: an <i>in vitro</i> study.","authors":"D Lauritano,&nbsp;C A Bignozzi,&nbsp;D Pazzi,&nbsp;F Cura,&nbsp;F Carinci","doi":"10.11138/orl/2017.10.1.001","DOIUrl":"https://doi.org/10.11138/orl/2017.10.1.001","url":null,"abstract":"<p><strong>Background: </strong>Titanium is the gold standard for dental implants, since it has demonstrated excellent biocompatibility and osseointegration properties. The rate of osseointegration is however affected by the surface morphology and peri-implant infections may affect fixture and the long-term osseointegration outcome. Thus chemical composition of a coating at the implant-abutment junction (IAJ) surface is expected to play a key role in preventing bacterial infection.</p><p><strong>Purpose: </strong>In the present study a new antimicrobial polysiloxane coating functionalized with chlorexidine digluconate (PXT) has been tested in an <i>in vitro</i> model.</p><p><strong>Materials and methods: </strong>Twenty implants were coated in the internal chamber with PXT and twenty were used as controls.</p><p><strong>Results and conclusions: </strong>Ten of the coated implants, preliminarily tested against Gram positive and negative bacteria and fungi, showed a complete inactivation of the microbial species after a 15 min contact. On the remaining ten treated implants a series of microbiological tests and PCR analysis, after contamination of the implant external medium, in which the implant have been immersed, with genetic modified <i>Tannerella forsythia</i> (TF) and <i>Porphyromonas Gingivalis</i> (PG), leads to the conclusion that the coating is capable of inactivating the microbial species penetrating the internal of the implant through the implant abutment junction.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516421/pdf/1-10.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35277229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of biomaterials for bone augmentation of jaws: clinical outcomes and <i>in vitro</i> studies.","authors":"L Tettamanti, M Andreasi Bassi, G Trapella, V Candotto, A Tagliabue","doi":"10.11138/orl/2017.10.1.037","DOIUrl":"10.11138/orl/2017.10.1.037","url":null,"abstract":"<p><p>Partially or totally edentulous jaws frequently undergoes from moderate to severe bone atrophy with problems of prosthetic rehabilitation. The inability to make a prosthetic rehabilitation on implants may led to the use of a partial or total removable denture with difficulties in eating and speech, ulcerations of the oral mucosa and loss of facial vertical dimension. These problems may be solved performing bone augmentation procedures. Bone grafts and distraction osteogenesis brought implant dentistry from an experimental practice to become a consolidate dental procedure. Bone grafts, in particular, are currently a valuable treatment modality for the prosthetic rehabilitation. Numerous biomaterials have been developed for the rehabilitation of partially or totally edentulous jaws with fixed or removable dentures. The aim of this paper is to describe biomaterials for bone augmentation. Biomaterials are gradually resorbed by the osteoclasts and replaced by new bone formed through osteoblastic activity. Many biomaterials have been studied, but the most common are as follows: Allogro®, Algipore®, Osteobiol®, Peptide-15, Engipore®, Medpore®, Osteoplant®, Calcium sulfate, Perioglass®, Bio-Oss®, Calcium phosphate.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 1","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516426/pdf/37-44.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35277233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postextraction computer-guided implant surgery in partially edentate patients with metal restorations: a case report.","authors":"A Pinto,&nbsp;C Raffone","doi":"10.11138/orl/2017.10.1.071","DOIUrl":"https://doi.org/10.11138/orl/2017.10.1.071","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to describe a postextraction, computer-guided protocol for implant-prosthetic rehabilitations in partially edentate patients with metal restorations.</p><p><strong>Methods: </strong>A 60-year-old man with a loose FDP (fixed dental prosthesis) in the first quadrant was selected for a postextraction computer guided implantology according with the 2-piece radiographic template protocol. A two components radiographic template was produced, with the teeth setup portion based on the wax-up. CBCT (cone beam computed tomography) scans of the patient, wearing the base portion of the radiographic template and of the assembled radiographic template alone, were accomplished. The CBCT volume were imported in a dedicated software (NobelClinician, Nobel-Biocare, Kloten, Switzerland) and a surgical template was produced from the digital planning. The surgery was performed with a flap approach, as a bone regeneration procedure was carried out. A delayed loading protocol was chosen to allow a healing free of masticatory stress. A mobile partial denture was delivered to the patient to grant function and social life until the delivery of the definitive FDP.</p><p><strong>Results: </strong>The surgery was performed rapidly and free of obstacles. A good primary stability of the implants was achieved. The patient referred an acceptable postoperative pain and swelling.</p><p><strong>Conclusions: </strong>The 2-piece radiographic template protocol was evaluated as smooth, complication-free and suitable for patients who want to maintain their teeth until the day of implant surgery. A good command of the computer-guided software as well as a comprehensive learning curve in computer-guided implantology is necessary to obtain predictable results.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 1","pages":"71-77"},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.1.071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35279234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights in orofacial cleft: epidemiological and genetic studies on italian samples.","authors":"L Tettamanti,&nbsp;A Avantaggiato,&nbsp;M Nardone,&nbsp;A Palmieri,&nbsp;A Tagliabue","doi":"10.11138/orl/2017.10.1.011","DOIUrl":"https://doi.org/10.11138/orl/2017.10.1.011","url":null,"abstract":"<p><p>Cleft of the lip and/or palate (CL±P) is the most common congenital craniofacial anomaly affecting around 1 in 700 live births worldwide. Clefts of the human face can be classified anatomically as cleft lip only (CL), cleft palate only (CP), cleft lip and palate (CLP) or a combined group of cleft lip with or without cleft palate (CL±P), based on differences in embryologic development. CL±P has a genetic base and several linkage and association analyses have been performed in order to obtain important information about the role of candidate genes in its onset; not less important are gene-environment interactions that play an increasing role in its aetiology. In CL±P, several loci have been seen associated with the malformation, and, in some cases, a specific gene mapping in a locus has also been identified as susceptibility factor. In CP, one gene has been found, but many more are probably involved. In this short review the genetic studies carried out on CL±P, and the interaction with environmental factors (alcohol, smoking, drugs) are discussed.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 1","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2017-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516428/pdf/11-19.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35277230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}