2006 International Conference on Biomedical and Pharmaceutical Engineering最新文献

Exercise Training Improved Blood Flow Velocity and Autonomic Nervous Activity 运动训练改善血液流动速度和自主神经活动

2006 International Conference on Biomedical and Pharmaceutical Engineering Pub Date : 2006-12-01 DOI: 10.1109/ICBPE.2006.348649

A. Azhim, M. Katai, M. Akutagawa, Y. Hirao, K. Yoshizaki, S. Obara, M. Nomura, Hiroyuki Tanaka, H. Yamaguchi, Y. Kinouchi

{"title":"Exercise Training Improved Blood Flow Velocity and Autonomic Nervous Activity","authors":"A. Azhim, M. Katai, M. Akutagawa, Y. Hirao, K. Yoshizaki, S. Obara, M. Nomura, Hiroyuki Tanaka, H. Yamaguchi, Y. Kinouchi","doi":"10.1109/ICBPE.2006.348649","DOIUrl":"https://doi.org/10.1109/ICBPE.2006.348649","url":null,"abstract":"The present study aimed to investigate non-invasively the effects of a short-term 4 week aerobic training program on the resting common carotid artery (CCA) blood flow velocity waveforms and autonomic nervous activity in young sedentary healthy subjects. It was hypothesis that training-induced the enhancement of blood flow is associated with the improvement of autonomic nervous function. The CCA blood velocities were measured for 3 minutes at resting sitting posture with synchronized measurement of electrocardiogram (ECG) and brachial blood pressure (BP). Autonomic activity was assessed by low frequency (LF) power, as an index of sympathetic activity and high frequency (HF) power, as an index of parasympathetic activity obtained from power spectral of RR intervals. Training exercise-induced the significant enhancement of all blood velocity waveforms is associated with decreasing of heart rate at rest. The evidence of improvement in training was reinforced by a significant reduction in peripheral vascular resistance and increase in heart rate variability (HRV) and HF power of HRV analysis, an index of vagal tone or parasympathetic activity. However, systolic (SBP), diastolic (DBP) and its mean blood pressure (MBP) are not significantly changed with the training. We conclude that short-term aerobic exercise training could improve cardiovascular and autonomic nervous system functions in the sedentary young men. With the further study, training effect may be simply evaluated using the non-invasive measurement system of blood velocities in CCA.","PeriodicalId":382525,"journal":{"name":"2006 International Conference on Biomedical and Pharmaceutical Engineering","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115482343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Biodart - catalogue of biological data aftifact examples 生物数据库-生物数据实例目录

2006 International Conference on Biomedical and Pharmaceutical Engineering Pub Date : 2006-12-01 DOI: 10.1109/ICBPE.2006.348608

A. Vceramani, K. Gopalakiishnan, V. Brusic

引用次数: 2

Temporal and antigenic analysis of dengue virus serotype 1 genome polyprotein sequences 登革病毒血清1型基因组多蛋白序列的时间和抗原分析

2006 International Conference on Biomedical and Pharmaceutical Engineering Pub Date : 2006-12-01 DOI: 10.1109/ICBPE.2006.348604

Menaka Rajapakse, Anitha Veeramani, Kavitha Gopalakrishnan, Sivagami Ananthanarayan, Srinivasan Kn, Srinivasan Kn, J. August, Asif M. Khan, Asif M. Khan, V. Brusic

{"title":"Temporal and antigenic analysis of dengue virus serotype 1 genome polyprotein sequences","authors":"Menaka Rajapakse, Anitha Veeramani, Kavitha Gopalakrishnan, Sivagami Ananthanarayan, Srinivasan Kn, Srinivasan Kn, J. August, Asif M. Khan, Asif M. Khan, V. Brusic","doi":"10.1109/ICBPE.2006.348604","DOIUrl":"https://doi.org/10.1109/ICBPE.2006.348604","url":null,"abstract":"Dengue virus poses a significant health threat. The new emerging strains continue to cause annual epidemics. In this paper, we report results of an analysis of dengue virus serotype 1 (DV1) genome polyprotein sequences in the context of time and geographical distribution. We studied the clustering of 60 DV1 genome polyprotein sequences of different geographical distributions, reported in the past 30 years, to identify geographic and temporal patterns of genetic and antigenic variation. Our analysis showed distinct clustering of sequences into two main geographical regions: i Western and South Pacific and South-East Asian region (with three distinct sub-clusters) and ii South American region. The results provide evidence suggesting temporal changes of the isolated strains. In addition, our analysis indicated that potential T-cell epitope hotspots within DV1 are shifting with time and recurrent epidemics, resulting in disappearing of some hotspots and emerging of new hotspots.","PeriodicalId":382525,"journal":{"name":"2006 International Conference on Biomedical and Pharmaceutical Engineering","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116511779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Genomic Level Analysis of Alcohol Producing Pathways of Zymomonas mobilis 运动单胞菌产醇途径的基因组水平分析

2006 International Conference on Biomedical and Pharmaceutical Engineering Pub Date : 2006-12-01 DOI: 10.1109/ICBPE.2006.348638

A. Ranjan, C. Prasad, G. P. Agarwal, S. Ramachandran

{"title":"A Genomic Level Analysis of Alcohol Producing Pathways of Zymomonas mobilis","authors":"A. Ranjan, C. Prasad, G. P. Agarwal, S. Ramachandran","doi":"10.1109/ICBPE.2006.348638","DOIUrl":"https://doi.org/10.1109/ICBPE.2006.348638","url":null,"abstract":"The need of alternative energy source has intensified the efforts to produce bio-ethanol and study the efficiency of its industrial processes using microorganisms. Our work intends to study and analyze the alcohol producing pathways of bacteria, signifying the importance of regulatory sequence, on genomic level. Zymomonas mobilis, considered as a potent future organism for alcohol production, was chosen for this study. The pathway was analysed on the basis of promoter regulation, a key factor for synthesis of enzymes. It was found that the second TA base pair could be central to the binding of TATA box-binding protein (TBP) to TATA box. The length of the TATA box, based on analysis of bending stiffness energy ratio of left sequence to right sequence of central base pair, is proposed to be 10. A mathematical model for the prediction of promoter strength was developed based on bending stiffness energy of flanking sequence of TATA box. The relative promoter strengths of all the genes, of the enzymes that take part in alcohol production, were predicted using this model. Results were analyzed and the predictions of the model for the bacteria, Zymomonas mobilis, were supported by available experimental literature.","PeriodicalId":382525,"journal":{"name":"2006 International Conference on Biomedical and Pharmaceutical Engineering","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116324091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High intensity ultrasound phased array for surgical applications 外科应用的高强度超声相控阵

2006 International Conference on Biomedical and Pharmaceutical Engineering Pub Date : 2006-12-01 DOI: 10.1109/ICBPE.2006.348658

M. T. Tan, Chang Min Chu, S. Chauhan

引用次数: 1

Dynamic Intrameniscal Stresses Measurement in the Porcine Knee 猪膝关节内膜动态应力测量

2006 International Conference on Biomedical and Pharmaceutical Engineering Pub Date : 2006-12-01 DOI: 10.1109/ICBPE.2006.348581

P.K. Goh, F. Fuss, T. Yanai, A. C. Ritchie

引用次数: 1

Performance Evaluation of MULTIEPD1 on Prediction of MHC Class I Binders MULTIEPD1在MHC I类结合物预测中的性能评价

2006 International Conference on Biomedical and Pharmaceutical Engineering Pub Date : 2006-12-01 DOI: 10.1109/ICBPE.2006.348605

G. Zhang, C. Kwoh, J. August, V. Brusic

{"title":"Performance Evaluation of MULTIEPD1 on Prediction of MHC Class I Binders","authors":"G. Zhang, C. Kwoh, J. August, V. Brusic","doi":"10.1109/ICBPE.2006.348605","DOIUrl":"https://doi.org/10.1109/ICBPE.2006.348605","url":null,"abstract":"Identification of T-cell epitopes (parts of antigenic proteins to which the T-cells receptor respond) is important in the development of vaccines and immunotherapeutics. We developed MULTIPRED1 (http://antigen.i2r.a-star.edu.sg/multipred1/), a Web-based computational system for prediction of peptides (protein fragments) that bind multiple related human leukocyte antigen (HLA) molecules (the human major histocompatibility complex - MHC molecules). In this paper, the performance of MULTIPRED1 in predicting individual 9-mer binders to HLA-A2 and A3 molecules was compared with five other publicly available prediction tools, SFYPEITHI, BIMAS, SMM, RANKPEP and SVMHC. The results show that MULTIPRED1 is both sensitive and specific for prediction of binders to individual HLA alleles and demonstrates comparable accuracy as those of other prediction tools. Majority voting was applied to combine the strength of the three prediction models of MULTIPRED1 and results indicate that better prediction performance can be achieved. MULTIPRED1 is useful in the selection of key antigenic regions to minimize the number of experiments required for mapping of promiscuous T-cell epitopes.","PeriodicalId":382525,"journal":{"name":"2006 International Conference on Biomedical and Pharmaceutical Engineering","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122215990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Time-Dependent Change of Load Sharing between Two Non-Linear Visco-Elastic Materials: Experiment and Model 两种非线性粘弹性材料载荷分担随时间的变化:实验与模型

2006 International Conference on Biomedical and Pharmaceutical Engineering Pub Date : 2006-12-01 DOI: 10.1109/ICBPE.2006.348585

F. Fuss, P.K. Goh, T. Yanai, A. C. Ritchie

引用次数: 0

Measurement of blood flow velocity waveforms in the carotid, brachial and femoral arteries during postural change 体位变化时颈动脉、肱动脉和股动脉血流速度波形的测量

2006 International Conference on Biomedical and Pharmaceutical Engineering Pub Date : 2006-12-01 DOI: 10.1109/ICBPE.2006.348631

A. Azhim, M. Katai, M. Akutagawa, Y. Hirao, K. Yoshizaki, S. Obara, M. Nomura, Hiroyuki Tanaka, H. Yamaguchi, Y. Kinouchi

{"title":"Measurement of blood flow velocity waveforms in the carotid, brachial and femoral arteries during postural change","authors":"A. Azhim, M. Katai, M. Akutagawa, Y. Hirao, K. Yoshizaki, S. Obara, M. Nomura, Hiroyuki Tanaka, H. Yamaguchi, Y. Kinouchi","doi":"10.1109/ICBPE.2006.348631","DOIUrl":"https://doi.org/10.1109/ICBPE.2006.348631","url":null,"abstract":"The purpose of this study was to measure blood flow velocities in carotid, brachial and femoral arteries simultaneously during passive postural change using our developed telemetry measurement system. This system was implemented with synchronized measurement of electrocardiogram (ECG). The velocity waveforms and ECG were continuously measured in six putatively healthy young subjects for 130 s during passive postural changes in supine and 90 degrees head-up-tilt (HUT), respectively. Peak systolic SI and end-diastolic d velocities were obtained from the velocity waveforms in 3 arteries, and using these velocities as an index of d/Sl to assess the velocity waveforms during the postural change. The velocity waveforms of 3 arteries, heart rate (HR), and blood pressure (BP) were assessed for 20 s at the stages of postural change. As a result, HTJT-induced increase in HR was more pronounced in the young subjects. The index of d/Sl in carotid was significantly decreased during HUT, whereas the index of that in brachial and femoral arteries were significantly increased. There was significant increase in diastolic BP but, a non significant change in systolic BP to tilt. The decreased of the blood flow index in the carotid artery was expected to be the effect of cerebral autoregulation (CA) to control blood flow to the brain. In contrast, the blood flow in the brachial and femoral was more influenced of venous pressure (VP) in postural change. In conclusion, HUT produced larger changes in the 3 arteries, particularly in brachial and femoral, and also in HR and diastolic BP. This study demonstrated that synchronized measurement of blood flow velocity waveforms in carotid, brachial, and femoral in HUT postural change using our telemetry measurement device was attainable. Thus, this method could prove to be a useful tool for investigating cardiovascular disease (CD) risk with further research and development.","PeriodicalId":382525,"journal":{"name":"2006 International Conference on Biomedical and Pharmaceutical Engineering","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131843608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ultrasound Mediated Gene Delivery using Bubble Containing Lipoplexes 超声介导的含脂泡基因传递

2006 International Conference on Biomedical and Pharmaceutical Engineering Pub Date : 2006-12-01 DOI: 10.1109/ICBPE.2006.348642

Jun Hua Mail, Rui Liu, Xiaohui Wei, Yanbin Yao, Yuhong Xul

引用次数: 0