Synergy Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.06

E. Antonia, Militaru Marina

引用次数: 0

QUELQUES RAMIFICATIONS TANGIBLES DE LA SOCIABILITÉ EN LIGNE: UN RAPPORT ENTRE VIE RÉELLE ET VIE VIRTUELLE DANS WORLD OF WARCRAFT 网络社交的一些有形后果:魔兽世界中现实生活和虚拟生活之间的关系

Synergy Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.04

Negrici Dominic

引用次数: 0

FORGING A NEW TYPE OF FEMINIST IDENTITY: CHICANA FEMINISM, FEMININITY, AND THE INSTITUTION OF MEMORY 塑造一种新型的女性主义身份:墨西哥女性主义、女性气质和记忆制度

Synergy Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.01

Got Monica

引用次数: 0

THE TYRANNY OF MERIT: WHAT’S BECOME OF THE COMMON GOOD 功绩专制:公共利益变成了什么

Synergy Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.07

Marinescu Roxana-Elisabeta

引用次数: 217

10 SKILLS FOR EFFECTIVE BUSINESS COMMUNICATION. PRACTICAL STRATEGIES FOR THE WORLD’S GREATEST LEADERS 10个有效的商务沟通技巧。为世界上最伟大的领导人准备的实用策略

Synergy Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.08

Serban-Obrescu Anca-Teodora

引用次数: 0

PERSPECTIVES ADVANCED. STUDENT’S BOOK 视角先进。学生的书

Synergy Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.09

David Irina

引用次数: 0

MAY THE LOVE BE WITH YOU: FROM THE JOY OF LIFE TO THE TRANSCENDENCE OF EXISTENCE IN TAKAHATA ISAO’S ANIMATION WORKS 愿爱与你同在:高畑勋动画作品从生命的喜悦到存在的超越

Synergy Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.03

Grajdian Maria

{"title":"MAY THE LOVE BE WITH YOU: FROM THE JOY OF LIFE TO THE TRANSCENDENCE OF EXISTENCE IN TAKAHATA ISAO’S ANIMATION WORKS","authors":"Grajdian Maria","doi":"10.24818/SYN/2021/17/1.03","DOIUrl":"https://doi.org/10.24818/SYN/2021/17/1.03","url":null,"abstract":"From Ponpoko: The Heisei Tanuki War (1994), through My Neighbours, the Yamadas (1999), and until The Tale of Princess Kaguya (2013), the animation movies directed by the reputed animation director Takahata Isao (1935-2018) and released by Studio Ghibli since mid-1990s address the phenomenon of “life” as a meaningful endeavour towards attaining higher levels of human awareness. This occurs either by living in accordance with the flow of history, or by enjoying every moment as it comes, or, respectively, by delving into cosmic rhythms of imponderability: every single entity of existence delivers significance and comprehension, as displayed on multiple layers in the three animation works analyzed in this paper. Thus, in a phenomenological approach inspired by Julia Kristeva’s monumental publication La Révolution du langage poétique (1974) which views cultural products as mirroring channels of repression (Verdrängung) and desire (Begehren), the analysis draws on an anthropological framework in which the researcher functions as a dynamic, self-reflexive interface mediating between the self-ness of the theoretical structure (here: life and the quest for its significance) and the other-ness of the representation medium (here: Japanese animated works).","PeriodicalId":38079,"journal":{"name":"Synergy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69172288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BETWEEN ‘CELESTIAL MAIDEN’ AND ‘SACRED PROSTITUTE’: THE MYTH OF THE DEVAͲDS5 IN THE IMAGINARY OF THE CONTEMPORARY INDIAN CLASSICAL DANCE PRACTITIONERS 在“天女”与“神圣妓女”之间:当代印度古典舞从业者想象中的devaͲds5神话

Synergy Pub Date : 2021-01-01 DOI: 10.24818/SYN/2021/17/1.05

M. Angelica

{"title":"BETWEEN ‘CELESTIAL MAIDEN’ AND ‘SACRED PROSTITUTE’: THE MYTH OF THE DEVAͲDS5 IN THE IMAGINARY OF THE CONTEMPORARY INDIAN CLASSICAL DANCE PRACTITIONERS","authors":"M. Angelica","doi":"10.24818/SYN/2021/17/1.05","DOIUrl":"https://doi.org/10.24818/SYN/2021/17/1.05","url":null,"abstract":"One of the most controversial discussions in the contemporary Indian arts environment remains the connection of the post-colonial classical dance practice with the DevadƗsƯ or the MaharƯ, the temple dancing girls. Born in the Early Medieval India, amidst and in close connection to the Bhakti and the Tantric movements, abiding in the temple institution, the so-called ‘DevadƗsƯ temple system’ remains a mystery, between awe and fascination to the nowadays practitioner and connaisseur of Indian arts. While tracing back the socio-religious contexts that brought the temple dancers on the foremost place of the stage of Indian art history, the author looks for the understanding of this myth in the imaginary and the reality of contemporary practitioners, from the perspective of a foreigner researcher-cum-practitioner of an Indian art form. The paper is based on consulting the existing literary sources concerning the DevadƗsƯ system, and the research is focusing on the nowadays classical dance practitioners’ imaginary (re)construction(s) of this system. Till today, here she stands, the woman-as-dance practitioner, either Indian or from any other part of the world, at the cross-road of all myths, imaginarily rooted in the past, but living all the aspirations of the nowadays social, cultural, religious, political dynamics, neither celestial maiden, nor sacred prostitute.","PeriodicalId":38079,"journal":{"name":"Synergy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69172309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting and understanding synergistic pairwise compound combinations of Shexian Baoxin Pill (SBP) using network biology 利用网络生物学预测和理解蛇仙保心丸(SBP)的协同配对组合

Synergy Pub Date : 2020-12-01 DOI: 10.1016/j.synres.2021.100073

Siti Zuraidah Mohamad Zobir , Ran Joo Choi , Dezso Modos , Tai-Ping Fan , Andreas Bender

{"title":"Predicting and understanding synergistic pairwise compound combinations of Shexian Baoxin Pill (SBP) using network biology","authors":"Siti Zuraidah Mohamad Zobir , Ran Joo Choi , Dezso Modos , Tai-Ping Fan , Andreas Bender","doi":"10.1016/j.synres.2021.100073","DOIUrl":"10.1016/j.synres.2021.100073","url":null,"abstract":"<div>The Traditional Chinese Medicine (TCM) formulation Shexiang Baoxin Pill (SBP) is commonly used in the treatment of coronary heart disease (CHD) in East Asia and regarded to promote the regulation of angiogenesis and to improve endothelial function. SBP comprises of seven TCM materials; however, the interactions of their effects in a biological system are unknown. In this work we developed an algorithm to predict the synergy of pairwise combinations of 22 compounds present in SBP. The algorithm is based on the targets of the compounds network properties in an angiogenesis- and CHD-specific network. We evaluated our synergy score prospectively by testing the 20 highest-ranked and the 20 lowest-ranked compound combinations for their synergistic potential to promote cell proliferation of human umbilical vascular endothelial cells. Results showed that 70 % of the 20 highest-ranked combinations increased cell proliferation synergistically, while only 30 % of the 20 lowest-ranked combinations had a synergistic effect. Based on the target and pathway predictions for the combinations, we hypothesized that two complementary pathways are responsible for the synergistic effect, apoptosis through caspase-3 and caspase-8 and cell growth through the proto-oncogene c-Fos and fibroblast growth factor 1. Hence, in this work we introduce an algorithm which was able to increase the probability of identifying compound pairs from SBP exhibiting synergy, which was experimentally validated in a disease-relevant model. Furthermore, we were able, based on this model, to provide a hypothesis for interactions causing synergy to promote endothelial cell growth.</div>","PeriodicalId":38079,"journal":{"name":"Synergy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.synres.2021.100073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45667063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synergistic anti-cancer effect of pristimerin and docetaxel on human colorectal HCT-116 cells pritimerin和docetaxel对人结直肠癌HCT-116细胞的协同抗癌作用

Synergy Pub Date : 2020-12-01 DOI: 10.1016/j.synres.2020.100068

Bashir A. Yousef , Hozeifa M. Hassan , Muhanad Elhafiz , Luyong Zhang , Zhenzhou Jiang

{"title":"Synergistic anti-cancer effect of pristimerin and docetaxel on human colorectal HCT-116 cells","authors":"Bashir A. Yousef , Hozeifa M. Hassan , Muhanad Elhafiz , Luyong Zhang , Zhenzhou Jiang","doi":"10.1016/j.synres.2020.100068","DOIUrl":"10.1016/j.synres.2020.100068","url":null,"abstract":"<div>Pristimerin is a quinonemethide triterpenoid compound that exerts anticancer activities against different cancer cells, including colorectal cancer. The current study aimed to study the cytotoxic and apoptosis-inducing effects of pristimerin alone or in combination with docetaxel on HCT-116 human colorectal cancer cell line. The cytotoxicity of pristimerin, or docetaxel, or the combination on HCT-116 cells were measured using the MTT method. The combination index (CI) was calculated using the isobologram method of Chou and Talalay. Annexin V/PI double staining was used to assess the apoptosis-inducing effect of these agents. Our results showed that both pristimerin and docetaxel showed potent cytotoxic effects against HCT-116 cells in dose-dependent manners. Moreover, the efficacy of docetaxel combined pristimerin was significantly increased, compared to individual treatment. The CI value was (0.55 to 0.89) that indicated the synergistic interaction between two agents to inhibit cell growth of CRC cells. Furthermore, Annexin V/PI assay showed that both agents induced apoptosis in HCT-116 in cancer cells. While treatment with combination resulted in a significant enhancement in apoptosis rates compared to individual treatment. Collectively, the data indicated that pristimerin potentiated the anticancer activities of docetaxel in colon cancer cells by reducing cell viability and promoting apoptosis.</div>","PeriodicalId":38079,"journal":{"name":"Synergy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.synres.2020.100068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45096747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synergy最新文献