Human Pathology: Case Reports最新文献_第2页

Metastatic malignant solitary fibrous tumor of urinary bladder 膀胱转移性恶性孤立性纤维性肿瘤

Human Pathology: Case Reports Pub Date : 2021-09-01 DOI: 10.1016/j.ehpc.2021.200527

Gertruda Evaristo , Pierre Olivier Fiset , Wassim Kassouf , Sungmi Jung , Fadi Brimo , Oluyomi Ajise

引用次数: 0

Positive BCOR ITD high grade endometrial stromal sarcoma discovered after miscarriage 流产后发现BCOR ITD阳性高级别子宫内膜间质肉瘤

Human Pathology: Case Reports Pub Date : 2021-09-01 DOI: 10.1016/j.ehpc.2021.200525

Jacob Kilgore, Robert Bowers, Krista Denning, Nadim Bou Zgheib

{"title":"Positive BCOR ITD high grade endometrial stromal sarcoma discovered after miscarriage","authors":"Jacob Kilgore, Robert Bowers, Krista Denning, Nadim Bou Zgheib","doi":"10.1016/j.ehpc.2021.200525","DOIUrl":"10.1016/j.ehpc.2021.200525","url":null,"abstract":"<div><p>We report a case of high-grade endometrial stromal sarcoma originally assumed to be a benign leiomyoma, with BCOR internal tandem duplicates resulting in BCOR overexpression. A 34-year-old female presented to the gynecologic oncology service for recent miscarriage attributed to a large leiomyoma. She reported symptoms of vaginal bleeding and abdominal pain. Myomectomy and tissue analysis was performed which revealed BCOR internal tandem duplicates and cyclin D1 positive high grade endometrial sarcoma. Definitive treatment for the sarcoma was performed with pelvic washings, robotic assisted total laparoscopic hysterectomy with bilateral salpingo-oophorectomy, omentectomy, and pelvic lymph nodes dissection. Negative margins were obtained along with negative lymph node and omental sections. Her sarcoma was staged pT1b (FIGO 1B). At follow up, patient reported no symptoms and was informed no further treatment was indicated. It is rare for high grade endometrial stromal sarcoma (HG-ESS) to present in a 34-year-old woman, though BCOR internal tandem duplicate (ITD) high grade endometrial stromal sarcoma is more common in younger women. This patient also had a unique finding in the pathology report, positive progesterone receptor (PR) expression, making this an interesting but difficult diagnosis.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200525","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49306296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental cytokeratin-positive interstitial reticulum cell tumor of the lymph node accompanied by breast cancer: Status of YAP/TAZ expression in tumor cells 乳腺癌伴发淋巴结偶发细胞角蛋白阳性间质网细胞瘤:YAP/TAZ在肿瘤细胞中的表达状况

Human Pathology: Case Reports Pub Date : 2021-09-01 DOI: 10.1016/j.ehpc.2021.200526

Chiemi Saigo , Yusuke Kito , Masayoshi Hasegawa , Shusuke Nomura , Takuya Mikamo , Yuki Hanamatsu , Ryutaro Mori , Manabu Futamura , Kazuhiro Yoshida , Tamotsu Takeuchi

{"title":"Incidental cytokeratin-positive interstitial reticulum cell tumor of the lymph node accompanied by breast cancer: Status of YAP/TAZ expression in tumor cells","authors":"Chiemi Saigo , Yusuke Kito , Masayoshi Hasegawa , Shusuke Nomura , Takuya Mikamo , Yuki Hanamatsu , Ryutaro Mori , Manabu Futamura , Kazuhiro Yoshida , Tamotsu Takeuchi","doi":"10.1016/j.ehpc.2021.200526","DOIUrl":"10.1016/j.ehpc.2021.200526","url":null,"abstract":"<div><p>Approximately 24 cases of cytokeratin-positive interstitial reticulum cell tumors have been reported in English literature. In this paper, we report a case of cytokeratin-positive interstitial reticulum cell tumor that was localized in the parafollicular region of the axillary lymph node and was an incidental finding in a patient with breast cancer. A 50 year-old woman underwent a mastectomy and lymph node dissection following a preoperative diagnosis of bilateral breast cancer. Histopathological examination revealed that the patient had non-invasive and invasive ductal carcinoma in the right and left mammary glands. Although we could not detect breast cancer metastasis in the lymph nodes, one of eight right axillary lymph nodes harbored an 11 × 8 mm discohesive sheet of large polygonal epithelioid tumor cells in the parafollicular area. Tumor cells were immunoreactive for AE1/AE3, CAM5.2, CK18 and l-caldesmon and negative for CD1a, CD21, CD23, CD31, CD68, and S‑100 protein markers. Based on these findings, the lesion was diagnosed as a cytokeratin-positive interstitial reticulum cell tumor of the lymph node. Notably, this early-stage cytokeratin-positive interstitial reticulum cell tumor demonstrated focal nuclear YAP/TAZ proto-oncogene products, which were recently identified as critical for differentiation, maturation, and function of fibroblastic reticular cells. To the best of our knowledge, this is the first report to describe nuclear YAP/TAZ immunoreactivity in cytokeratin-positive interstitial reticulum cell tumors.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200526","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44779492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Xanthogranulomatous salpingo-oophoritis associated with diverticular perforation 黄色肉芽肿性输卵管卵巢炎伴憩室穿孔

Human Pathology: Case Reports Pub Date : 2021-09-01 DOI: 10.1016/j.ehpc.2021.200539

Bistees George , Cecilia G. Clement

引用次数: 2

Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands: Two additional cases not harboring MAML2 gene rearrangement 伴有唾液腺嗜酸性粒细胞增多症的硬化性黏液表皮样癌：两例无MAML2基因重排的病例

Human Pathology: Case Reports Pub Date : 2021-09-01 DOI: 10.1016/j.ehpc.2021.200546

Hiroshi Harada , Masashi Takeda , Yohko Kohno , Shin-ichi Nakatsuka , Kenji Mishima , Akira Kurose

{"title":"Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands: Two additional cases not harboring MAML2 gene rearrangement","authors":"Hiroshi Harada , Masashi Takeda , Yohko Kohno , Shin-ichi Nakatsuka , Kenji Mishima , Akira Kurose","doi":"10.1016/j.ehpc.2021.200546","DOIUrl":"10.1016/j.ehpc.2021.200546","url":null,"abstract":"<div><p>Sclerosing mucoepidermoid carcinoma with eosinophilia (SMCE) is a rare subgroup of mucoepidermoid carcinoma characterized by dense stromal sclerosis and marked eosinophil infiltration. We herein describe two Japanese cases of SMCE. The patients were a 60 year-old female and a 67 year-old female, and each had a tumor of the parotid and upper lip, both of which were successfully removed with no signs of recurrence or metastasis. Histologically, the tumors consisted of round or polygonal, and partly spindle-shaped squamous cells with generally scant keratinization, which formed small and large invasive nests in the background of dense sclerotic stroma with marked eosinophil infiltration. Only a small number of mucus-producing cells and cytoplasmic mucin vacuoles were observed. The second case was unique in its presentation of melanin pigmentation, which is rarely found in oral tumors. Fluorescence in situ hybridization for <em>MAML2</em> was performed, but no clear split signals were confirmed in either case. The histogenesis of SMCE, which is possibly different to that of ordinary mucoepidermoid carcinoma or the other counterpart of sclerosing mucoepidermoid carcinoma lacking eosinophilia, is further discussed comparing their genetic backgrounds. Their pathological features and diagnostic problems are also detailed.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46522310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absence of dense platelet granules and ceroid-laden macrophages: Investigating the diversity of clinical presentations in Hermansky-Pudlak syndrome 缺乏致密血小板颗粒和含铈巨噬细胞：Hermansky-Pudlak综合征临床表现多样性的研究

Human Pathology: Case Reports Pub Date : 2021-09-01 DOI: 10.1016/j.ehpc.2021.200535

Lanny T. DiFranza , Dong Chen , Charles C. Marboe , Alex J. Rai

引用次数: 0

Atypical spindle cell/pleomorphic lipomatous tumor of the stomach: A case report 胃非典型梭形细胞/多形性脂肪瘤1例

Human Pathology: Case Reports Pub Date : 2021-09-01 DOI: 10.1016/j.ehpc.2021.200540

Raima Memon , Mohamed M. Abdelfatah , Chirag Patel , Deepti Dhall , Sameer Al Diffalha , J Bart Rose , Shi Wei , Goo Lee

引用次数: 6

Solitary fibrous tumor presenting as a colonic polyp: Report of a case and literature review 孤立性纤维瘤表现为结肠息肉：1例报告及文献复习

Human Pathology: Case Reports Pub Date : 2021-09-01 DOI: 10.1016/j.ehpc.2021.200547

Roula Katerji, Diana Agostini-Vulaj

引用次数: 2

Primary bilateral adrenal lymphoma masquerading as a metastatic melanoma: An unusual presentation of a rare disease 伪装成转移性黑色素瘤的原发性双侧肾上腺淋巴瘤:罕见疾病的不寻常表现

Human Pathology: Case Reports Pub Date : 2021-09-01 DOI: 10.1016/j.ehpc.2021.200536

J. Stephen Stalls , Anas Mohamed , Masood Hassan , Kim Geisinger , Anuradha Kanungo , Moiz Vora , Anokhi Patel , Andrew Weil

{"title":"Primary bilateral adrenal lymphoma masquerading as a metastatic melanoma: An unusual presentation of a rare disease","authors":"J. Stephen Stalls , Anas Mohamed , Masood Hassan , Kim Geisinger , Anuradha Kanungo , Moiz Vora , Anokhi Patel , Andrew Weil","doi":"10.1016/j.ehpc.2021.200536","DOIUrl":"10.1016/j.ehpc.2021.200536","url":null,"abstract":"<div><p>This report describes a 70-year-old male with bilateral primary adrenal lymphoma (PAL) characterized as non-germinal center diffuse large B-cell lymphoma (DLBCL). PAL is a very rare, aggressive disease with a poor prognosis. Our patient presented with B symptoms, chills, and nausea. Imaging studies of his abdomen revealed rapidly enlarging bilateral adrenal masses. Computed tomography (CT) guided left adrenal mass core biopsy showed diffuse sheets of neoplastic cells with irregular nuclear contours, vesicular to hyperchromatic chromatin, and prominent nucleoli. The neoplastic cells demonstrated an immunohistochemistry (IHC) profile consistent with DLBCL. Markers assessing for melanoma and neuroendocrine tumors were negative. Fluorescence in situ hybridization (FISH) revealed BCL6 rearrangement. The diagnosis of primary adrenal DLBCL, non-germinal center subtype, was rendered. The patient’s chemotherapy is ongoing; six cycles of R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) induced significant clinical and radiological response.</p><p>The differential diagnosis is broad in patients with adrenal insufficiency and bilateral adrenal masses, and our case clinically centered on metastatic melanoma in the differential. Thorough pathologic evaluation of tissue, including an extensive IHC panel, was warranted for this patient due to the rarity of PAL and due to the morphologic overlap between melanoma and DLBCL.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41554398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-osseous sclerosing epithelioid fibrosarcoma of the mandible: A case report and review of the literature 下颌骨骨内硬化性上皮样纤维肉瘤1例报告及文献复习

Human Pathology: Case Reports Pub Date : 2021-09-01 DOI: 10.1016/j.ehpc.2021.200532

Joshua Allen , Daniel Hovander , Dolphine Oda , Erica Kao , Robert W. Ricciotti

引用次数: 0