Annals of Clinical and Medical Case Reports最新文献_第5页

Plea for an Air-Microbubbles and Air-Blood Interface Free Hemodialysis 空气-微气泡和空气-血液界面自由血液透析的请求

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2021.7902

Stragier A, Jadoul M

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Genetic Polymorphic Impact of Metabolizing Enzyme (CYP3A4 and UGT1A4 genes) on Anastrazole Response in Iraqi Breast Cancer Women 代谢酶(CYP3A4和UGT1A4基因)基因多态性对伊拉克乳腺癌妇女阿纳特唑反应的影响

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2022.8701

Abed Sn, Sahib As, Kadum Maa

{"title":"Genetic Polymorphic Impact of Metabolizing Enzyme (CYP3A4 and UGT1A4 genes) on Anastrazole Response in Iraqi Breast Cancer Women","authors":"Abed Sn, Sahib As, Kadum Maa","doi":"10.47829/acmcr.2022.8701","DOIUrl":"https://doi.org/10.47829/acmcr.2022.8701","url":null,"abstract":"1.1. Background and Objective: Anastrazole is an aromatase inhibitor used widely in therapy of breast cancer and has been metabolized by CYP3A4 and UGT1A4 in liver. Breast cancer is the most common cancer type in worldwide and the second causes of death after lung cancer and the one of therapy that use in its treatment is aromatase inhibiter, anastrazole has been indicated CYP3A1 and UGT1A4 are the main metabolizing enzyme, so the interindividual variation in anastrazole response are due to polymorphism of these gene. We have aimed to determine whether CYP3A4*22 and UGT1A4*2 single nucleotide polymorphisms can have affected on the response of anastrazole. 1.2. Method: 100 Iraqi females with hormone positive breast cancer were included in this study. patients were genotyped for SNPs in the CYP3A1 and UGT1A4 genes to research for response to anastrazole thought measured serum level of estradiol (E2) and tumor marker CA15.3. Highly polymorphic CYP3A4*22 (rs35599367) and UGT1A4*2 (rs6755571) were detected with different genotypes in variable percentage in Iraqi breast cancer women. 1.3. Results: For rs35599367 found that the wild genotype(GG) and for rs6755571 the mutant genotype (TT) were most abounded in 100 breast cancer women and also (AA) another mutant genotype of rs6755571 detected but in low percent. Non –significant association between different detected genotype of both SNPs and serum estradiol level, elevation of serum CA15.3 level and development of arthralgia. 1.4. Conclusion: Both SNPs suggesting had no effect on the serum levels of E2 and CA15.3 and development of arthralgia.","PeriodicalId":380321,"journal":{"name":"Annals of Clinical and Medical Case Reports","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122494862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Evaluation of Clinical Significance of Vitamin B12 Status in Patients Admitted with Acute Febrile Illness Thrombocytopenia at Tertiary Care Hospital 三级医院急性发热性血小板减少症患者维生素B12水平的临床意义评价

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2023.102403

Gupta Bk, Singh G, Gupta J, Meena SL, Dara N, Thankom SKC, Garwa NK

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Therapeutic Challenges in Post-Transplant Lymphoproliferative Disorder of the Esophagus with Central Nerve System Involvement Complicated by an Esophagotracheal Fistula: A Case Report 食道淋巴增生性疾病伴中枢神经系统受累并发食管气管瘘1例的治疗挑战

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2021.8201

Kruis Eah, Zander Tj, A. S., Muller B

{"title":"Therapeutic Challenges in Post-Transplant Lymphoproliferative Disorder of the Esophagus with Central Nerve System Involvement Complicated by an Esophagotracheal Fistula: A Case Report","authors":"Kruis Eah, Zander Tj, A. S., Muller B","doi":"10.47829/acmcr.2021.8201","DOIUrl":"https://doi.org/10.47829/acmcr.2021.8201","url":null,"abstract":".1 Background: Post-transplant lymphoproliferative disorder (PTLD) is a known complication following solid organ or hematopoietic stem cell transplantation. It’s a heterogeneous group of lymphoid and/or plasmocytic proliferations as a result of immunosuppression and is frequently associated with Epstein-Barr Virus. The clinical presentation is nonspecific and highly variable depending on the localization. We discuss the therapeutic challenges in this rare case of a male suffering PTLD with esophageal involvement complicated by an esophagotracheal fistula. 1.2 Case Report: A 55-year-old man under immunosuppression after kidney transplantation, presented with progressive cough and fever after elective upper endoscopy. Following the diagnosis of diffuse large B cell lymphoma-type PTLD with esophagotracheal fistula. The reduction of immunosuppression was unable to control the progression of disease with involvement of the CNS. Endoscopic repair of the fistula was unsuccessful. The need for surgical repair of the fistula delayed therapy with rituximab by one month. Despite brain radiation therapy, the patient passed away 3.5 months after diagnosis. 1.3 Conclusion: In patients with esophagotracheal fistula both aspiration pneumonia and treatment of the fistula can delay effective treatment of the underlying malignant disease. In patients with PTLD reduction in immunosuppression is the primary treatment strategy, followed by monotherapy with the monoclonal antibody rituximab in the case of incomplete response. Newer therapeutic approaches prefer the sequential treatment with rituximab followed by chemotherapy in case of incomplete response, or consolidation therapy with rituximab in case of complete response. Radiotherapy is recommended in case of CNS involvement.","PeriodicalId":380321,"journal":{"name":"Annals of Clinical and Medical Case Reports","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131555047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chest Imaging of COVID-19 Pneumonia COVID-19肺炎的胸部影像学

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2021.7801

Richardson Ac, Reubens Rr, O’Connor Am, Blosser Km

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Emergencies in Parkinsonism 帕金森症的紧急情况

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2022.8901

A. Ekladious, Ramana Waran

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Filiform Polyposis: Just an Ibd’s Shade or More? 丝状息肉病:只是Ibd的阴影还是更多?

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2021.8202

Miriam Palmieri, L. Pepi, Giovanni Biondini, M. Fianchini, A. Mandolesi, C. Marmorale

{"title":"Filiform Polyposis: Just an Ibd’s Shade or More?","authors":"Miriam Palmieri, L. Pepi, Giovanni Biondini, M. Fianchini, A. Mandolesi, C. Marmorale","doi":"10.47829/acmcr.2021.8202","DOIUrl":"https://doi.org/10.47829/acmcr.2021.8202","url":null,"abstract":"1.1. Introduction Postinflammatory polyps (PIPs) are non-neoplastic lesions originating from the mucosa after repeated periods of inflammation and ulceration connected with excessive healing processes. This pattern is usually associated with Inflammatory Bowel Diseases (IBD), but rarely they can be related to different clinical conditions. PIPs can be classified into: localized, multiple, giant, generalized and filiform polyposis (FP). FP is characterized by numerous finger‑like inflammatory polyps, lined by normal colonic mucosa. If they reach up to 100 mm forming bridges and tumor-like mass, they can be defined Giant Polyposis (GP). To date, FP has not the tumoral transforming potentiality. 1.2. Results The first presented case is a 52-year-old man with a past clinical history of Ulcerative Colitis (UC) who underwent rectosigmoidoscopy for distal sigmoid obstruction and an Hartmann’s procedure was performed; the histological findings suggested a pattern consistent with an active fase of UC with a lumen obstruent FP. The other patient is a 40-year-old man who suffered from colonic substenotic episodes; the colonscopy revealed an increase in number and dimension of mucosal polyps with bridge formation. The patient underwent resection of ileum and recto-sigmoid junction with an ileocolic anastomosis T-T; the surgical specimen showed a large polypous tumor-like mass with finger-like projections with non-specific inflammatory changes and without epithelial dysplasia or neoplastic lesion. 1.3. Conclusions This short case series points out how eterogenous the presentation of FP could be: there is no certain link between IBD and FP; in addiction, these polyps can form in a generalized condition of bowel inflammation.","PeriodicalId":380321,"journal":{"name":"Annals of Clinical and Medical Case Reports","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121716202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Stuttering 口吃

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.4135/9781483380810.n598

C. Pte

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Rectal Cancer Watch and Wait Approach: A Promising Rectal Salvaging Strategy 直肠癌观察和等待方法:一种有前途的直肠抢救策略

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2022.81102

Juma IM, Saeed MF, Almahmeed EA, Elhennawy RYG, Varkey RG

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Delirium Care Pathway Model Design: STOP DELIRIUM 谵妄护理通路模型设计:停止谵妄

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2021.71402

Alhussaini Anhar, Altoub Abdulaziz, Henry Dane, Mukuha Carolyne, Nessim Doris, Otto Morkel Jacques, Watson Mary-Lynn

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