Annals of Clinical and Medical Case Reports最新文献

Mesenchymal Hamartoma: A Review of Literature 间充质错构瘤:文献综述

Annals of Clinical and Medical Case Reports Pub Date : 2021-11-19 DOI: 10.47829/ACMCR.2021.6202

S. Bernardino

引用次数: 1

Female Emotional Processing: Hydrogen Peroxide & Alzheimer’s Disease 女性情绪处理:过氧化氢与阿尔茨海默病

Annals of Clinical and Medical Case Reports Pub Date : 2021-03-24 DOI: 10.47829/acmcr.2020.5304

C. Pte

{"title":"Female Emotional Processing: Hydrogen Peroxide & Alzheimer’s Disease","authors":"C. Pte","doi":"10.47829/acmcr.2020.5304","DOIUrl":"https://doi.org/10.47829/acmcr.2020.5304","url":null,"abstract":"The SARS-CoV 2 pandemic is now responsible for over 48 million infections and one million deaths worldwide. Pandemics impact population growth not only by excessive mortality, but also by preventing births. In previous pandemics occurring in the 20th and 21st centuries, a trend towards birth rate reduction was observed 9 months later (Figure 1). After the 1918-20 HIN1 influenza pandemic, birth rates dropped by 5 to 15% in comparison to average rates before the pandemic [1]. This drop was related to higher death rates in pregnant patients (case fatality rate of 27%),\u0000as well as miscarriages and stillbirths (increased by 0.4% and 2.2% respectively as compared to prior average rates) [1,2]. A rebound in birth rates, however, occurred 1-2 years after this decline [3]. Moreover, several studies have shown that children born in 1919, and thus exposed to the H1N1 virus in utero, experienced worse health and socioeconomic outcomes in older ages than surrounding birth cohorts [4]. SARS-CoV and Ebola were also associated with similar trends in birth rates during and after the pandemics in 2004 and 2015, respectively. In Brazil, the Zika virus pandemic led to a 10 to 20% drop in birth rates [5].","PeriodicalId":380321,"journal":{"name":"Annals of Clinical and Medical Case Reports","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132883939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Conventional COVID Treatment Methods 19 非常规治疗方法

Annals of Clinical and Medical Case Reports Pub Date : 2021-02-01 DOI: 10.47829/ACMCR.2021.51002

A. Adamski

引用次数: 0

Dynamics of the COVID-19 Comparison between the Theoretical Predictions and the Real Data, and Predictions about Returning to Normal Life 新冠肺炎疫情动态:理论预测与实际数据对比及回归生活预测

Annals of Clinical and Medical Case Reports Pub Date : 2020-03-30 DOI: 10.47829/acmcr.2020.4902

G. Sonnino, P. Nardone

{"title":"Dynamics of the COVID-19 Comparison between the Theoretical Predictions and the Real Data, and Predictions about Returning to Normal Life","authors":"G. Sonnino, P. Nardone","doi":"10.47829/acmcr.2020.4902","DOIUrl":"https://doi.org/10.47829/acmcr.2020.4902","url":null,"abstract":"A new coronavirus disease, called COVID-19, appeared in the Chinese region of Wuhan at the end of last year; since then the virus spread to other countries, including most of Europe. We propose a differential equation governing the evolution of the COVID-19. This dynamic equation also describes the evolution of the number of infected people for 13 common respiratory viruses (including the SARS-CoV-2). We validate our theoretical predictions with experimental data for Italy, Belgium and Luxembourg, and compare them with the predictions of the logistic model. We find that our predictions are in good agreement with the real world since the beginning of the appearance of the COVID-19; this is not the case for the logistic model that only applies to the first days. The second part of the work is devoted to modelling the descending phase, i.e. the decrease of the number of people tested positive for COVID-19. Also in this case, we propose a new set of dynamic differential equations that we solved numerically. We use our differential equations parametrised with experimental data to make several predictions, such as the date when Italy, Belgium, and Luxembourg will reach a peak number of SARS-CoV-2 infected people. The descending curves provide valuable information such as the duration of the COVID-19 epidemic in a given Country and therefore when it will be possible to return to normal life. The study of the the dynamics of COVID-19 when the population have been subject to less restrictive measures is beyond the scope of this work and it will be matter of future works.","PeriodicalId":380321,"journal":{"name":"Annals of Clinical and Medical Case Reports","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121467287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Euglycemic Ketoacidosis and an Absence Seizure in A Type 2 Diabetic On SGLT2 Inhibitors: Case Report and Review of the Literature 使用SGLT2抑制剂的2型糖尿病患者的正糖酮症酸中毒和癫痫发作:病例报告和文献回顾

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2021.8301

Gevaert J, Willems M, Sabbe M

{"title":"Euglycemic Ketoacidosis and an Absence Seizure in A Type 2 Diabetic On SGLT2 Inhibitors: Case Report and Review of the Literature","authors":"Gevaert J, Willems M, Sabbe M","doi":"10.47829/acmcr.2021.8301","DOIUrl":"https://doi.org/10.47829/acmcr.2021.8301","url":null,"abstract":"1. Abstract 1.1. Introduction: In recent years, many new antidiabetic drugs have been developed. One class of these new antidiabetic drugs are sodium-glucose cotransporter 2 inhibitors (SGLT2i). SGLT2i are associated with an increased risk of euglycemic ketoacidosis (euDKA). Case report: We describe an 81-year-old male with type 2 diabetes mellitus (T2DM), who arrived at the emergency department (ED) after a suspected absence seizure. An arterial blood gas (ABG) demonstrated a high anion gap metabolic acidosis. Subsequently, the diagnosis of euDKA was made. A computed tomography (CT) of the brain and electroencephalography (EEG) could not provide a substrate for his seizure. We started with intravenous levetiracetam, an anticonvulsant. He left the hospital in a good condition, 5 days later. Conclusion: Health care professionals should be aware that a patient can be in diabetic ketoacidosis without having elevated levels of blood glucose. Such a euDKA often has a more atypical presentation due to different underlying pathophysiological mechanisms. In animal models, ketonemia exerts anti-seizure effects, but this has yet to be proven in clinical trials. As such, in our patient, a link between his absence seizure and euDKA remains unclear.","PeriodicalId":380321,"journal":{"name":"Annals of Clinical and Medical Case Reports","volume":"120 19","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120826231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NF1 Mutated Metastatic Melanoma and Response to Immune Checkpoint Inhibitor Therapy: A Retrospective Analysis NF1突变转移性黑色素瘤和对免疫检查点抑制剂治疗的反应:回顾性分析

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2022.8801

De Backer C, Laenen A, Bechter O

{"title":"NF1 Mutated Metastatic Melanoma and Response to Immune Checkpoint Inhibitor Therapy: A Retrospective Analysis","authors":"De Backer C, Laenen A, Bechter O","doi":"10.47829/acmcr.2022.8801","DOIUrl":"https://doi.org/10.47829/acmcr.2022.8801","url":null,"abstract":"1.1. Background: Based on molecular profiling, malignant melanoma is classified in four different groups. NF1-mutated tumors are a small subgroup occurring with a frequency of 13% of all malignant melanomas, usually harboring a high tumor mutational burden (TMB). Considering TMB as being a prerequisite for the effectiveness of immune checkpoint inhibitor therapy, we were wondering if this rare subtype is associated with a higher response rate to immunotherapy than it is known for the general melanoma population. 1.2. Methods: We analyzed a small cohort of 14 NF1 mutated metastatic melanoma patients and retrospectively assessed the response rate (RR) according to RECIST 1.1, Progression Free Survival (PFS) and Overall Survival (OS). We compared our results with outcome data reported in several clinical trials with immune checkpoint inhibitors. 1.3. Results: For our cohort, we noticed an objective response rate of 64%, which is higher than the response rate generally reported for anti-PD1 based therapy in a population of melanoma patients. The PFS rate at twelve months was 62%, next to an OS rate at twelve months of approximately 84%. Additional mutations co-occur in NF1-mutated patients. Although we did not find an association between the number of additional mutations and response in general, we did notice a significant correlation between mutations in TERT promotor region and tumor response (p-value 0.027). 1.4. Conclusion: Despite the small patient group, we observed a higher response rate for NF1 mutated metastatic melanoma patients treated with immunotherapy. In addition, a significant correlation between response rate and the presence of hTERT promotor mutations was observed","PeriodicalId":380321,"journal":{"name":"Annals of Clinical and Medical Case Reports","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124763425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of the Pharmacist in Patient Care (Book Review) 药剂师在病人护理中的角色(书评)

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/ACMCR.2021.5901

Mohiuddin Ak

引用次数: 0

Annals of Clinical and Medical Case Reports 临床和医学病例报告年鉴

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr

Hiroshi Mori

{"title":"Annals of Clinical and Medical Case Reports","authors":"Hiroshi Mori","doi":"10.47829/acmcr","DOIUrl":"https://doi.org/10.47829/acmcr","url":null,"abstract":"1.1. Objective: Gitelman syndrome (GS) is an autosomal recessive tubular disorder characterized by metabolic alkalosis, hypokalemia, hypomagnesemia and hypocalciuria. GS is mostly caused by inactivating mutations of the SLC12A3 gene. The purpose of this study was to describe the clinical features of a GS patient and investigate the underlying mutations of SLC12A3 gene in the pedigree. 1.2. Methods: A patient suffering from muscle weakness was clinically diagnosed as GS. Clinical data of the proband were studied retrospectively. All of his family members were screened for SLC12A3 gene mutations. 26 exons and exon-intron boundaries of SLC12A3 gene were amplified by Polymerase Chain Reaction(PCR). PCR products were sequenced directly. 1.3. Results: The proband had hyperreninemia but hypoaldosteronemia, which was distinct from the cases previously reported. The proband and his sick brother were found to have the same compound heterozygous mutations (c.917C>T and IVS 14-8T>C) of SLC12A3 gene. Each mutation was detected in paternal and maternal genomic DNA, respectively. The proband’s healthy brother had one mutation (c.917C>T) only. IVS 14-8T>C was a novel splicing site mutation that had never been reported. 1.4. Conclusion: Hypoaldosteronemia was found in a GS patient. A novel heterozygous splicing site mutation of the SLC12A3 gene was reported, expanding the spectrum of SLC12A3 gene mutations.","PeriodicalId":380321,"journal":{"name":"Annals of Clinical and Medical Case Reports","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125390836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastasis to Brain and Lung in Carcinosarcoma of the Parotid Gland - A Case Report and Review of Literatures 腮腺癌肉瘤脑肺转移1例及文献复习

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2021.7701

Yang Sh, Buryanek J, Guo S, Karni Rj, Shepard S, Zhu Jj, B. A.

引用次数: 0

Clinical and Genetic Analysis of Multi-System Pseudohypoaldosteronism Type 1 Caused by a Novel Splice Site Mutation of the Beta Subunit Gene of Epithelial Sodium Channel (Enac) 上皮钠通道β亚基基因剪接位点突变致1型多系统假性醛固酮增多症的临床和遗传学分析

Annals of Clinical and Medical Case Reports Pub Date : 1900-01-01 DOI: 10.47829/acmcr.2021.61101

H. S, Y. H, L. C, J. Q, Qiao L, H. C, Li T

引用次数: 0