{"title":"Tumor Transformation: Case of conversion of Ossifying Fibroma to Osteosarcoma post-excision in a young male","authors":"Sagar Rane, Nitin Bhola, Chetan Gupta","doi":"10.1016/j.omsc.2025.100409","DOIUrl":"10.1016/j.omsc.2025.100409","url":null,"abstract":"<div><div>Ossifying fibroma (OF) is a benign fibro-osseous tumor characterized by slow growth and a low recurrence risk, primarily affecting the mandible in young females. Although OF is typically non-invasive, rare cases demonstrate locally aggressive behavior, requiring surgical resection. Post-surgical transformation of into osteosarcoma, a rare malignancy with a prevalence of 0.7 per million in the jaw, is exceptionally uncommon. This report presents a rare case of a 28-year-old male initially diagnosed with ossifying fibroma, managed surgically through excision and reconstruction with an iliac crest graft. Despite achieving negative margins, the lesion underwent malignant transformation into fibroblastic osteosarcoma within a month, presenting diagnostic and therapeutic challenges.</div><div>The malignant transformation was confirmed through histopathological and immunohistochemical evaluations, revealing a high Ki-67 labeling index (60 %), indicative of aggressive tumor behavior. Following multidisciplinary tumor board discussions, the patient underwent extensive surgical management, including composite resection, segmental mandibulectomy, neck dissection, and microvascular reconstruction with a free fibula osteocutaneous flap. Despite its rarity, this case highlights the need for vigilant follow-up and comprehensive diagnostic workups for recurrent or progressive lesions post-OF resection.</div><div>This report contributes to the limited literature on malignant transformation in fibro-osseous lesions, emphasizing the importance of differentiating benign conditions from low-grade malignancies and discussing the role of surgical intervention in such transformations. Further research is required to elucidate the mechanisms of transformation, optimize management strategies, and improve outcomes for patients with similar rare pathologies.</div></div>","PeriodicalId":38030,"journal":{"name":"Oral and Maxillofacial Surgery Cases","volume":"11 3","pages":"Article 100409"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Flávio Fidêncio de Lima , Maria Carolina de Sousa Melo , Thamyryz Rafaela Almeida Simões , David Fischer , Luiz Carlos Magno Filho
{"title":"Enhanced fixation techniques in orthognathic surgery for improved nasal aesthetics","authors":"Flávio Fidêncio de Lima , Maria Carolina de Sousa Melo , Thamyryz Rafaela Almeida Simões , David Fischer , Luiz Carlos Magno Filho","doi":"10.1016/j.omsc.2025.100410","DOIUrl":"10.1016/j.omsc.2025.100410","url":null,"abstract":"","PeriodicalId":38030,"journal":{"name":"Oral and Maxillofacial Surgery Cases","volume":"11 3","pages":"Article 100410"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary sclerosing fibroinflammatory pseudotumor of the maxillary sinus misdiagnosed as migraine: A case report","authors":"Safwan Salih, Sadeq Qanah, Fadi Nahhab","doi":"10.1016/j.omsc.2025.100411","DOIUrl":"10.1016/j.omsc.2025.100411","url":null,"abstract":"<div><div>The head and neck region is a complex anatomical area where overlapping structures and nonspecific symptoms often make accurate diagnosis challenging. Facial pain, in particular, is a common yet ambiguous symptom frequently attributed to prevalent conditions like migraine, which can delay recognition of less common but clinically significant diseases. One such condition is Primary Sclerosing Fibroinflammatory Pseudotumor—a rare, benign lesion that can mimic malignancy both clinically and radiologically.We present the case of an 18-year-old female with chronic facial pain and globe displacement, misdiagnosed as migraine for four years. Imaging revealed a mass in the maxillary sinus with bone erosion and orbital involvement. A core needle biopsy was inconclusive, and definitive diagnosis was achieved only after surgical excision. Histopathological and immunohistochemical analysis confirmed Primary Sclerosing Fibroinflammatory Pseudotumor. The patient experienced substantial clinical improvement following combined surgical and corticosteroid therapy. This case highlights the importance of including rare pathologies in the differential diagnosis of maxillofacial masses and demonstrates the value of thorough investigation when symptoms persist despite standard treatment<strong>.</strong></div></div>","PeriodicalId":38030,"journal":{"name":"Oral and Maxillofacial Surgery Cases","volume":"11 3","pages":"Article 100411"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gustavo Andres Grimaldi Finol , Ammar Khalafalla , Mohamed Amir , Saba Hawamdeh , Moustafa Al Khalil , Ismail Farag , Ayoub Alaud
{"title":"Revolutionizing maxillofacial care: Exploring denosumab's impact on giant cell granuloma – A comprehensive case series and literature review","authors":"Gustavo Andres Grimaldi Finol , Ammar Khalafalla , Mohamed Amir , Saba Hawamdeh , Moustafa Al Khalil , Ismail Farag , Ayoub Alaud","doi":"10.1016/j.omsc.2025.100408","DOIUrl":"10.1016/j.omsc.2025.100408","url":null,"abstract":"<div><div>Giant cell lesions (GCLs) of the maxillofacial complex present a therapeutic challenge due to their aggressive nature and potential for recurrence. Traditional treatment modalities often includes surgical intervention with varying degrees of success and associated morbidities. In recent years, denosumab, a monoclonal antibody targeting the RANK ligand pathway, has emerged as a promising alternative in the management of GCLs. This article provides a comprehensive overview of denosumab's efficacy, safety profile, and clinical outcomes in treating GCLs through a meticulous analysis of case series and literature review. We describe denosumab's potential as a novel therapeutic option, offering improved outcomes and reduced morbidity for patients with GCLs in the maxillofacial region with the presentation of two cases using a comprenhesive diagnosis and management. On the other hand, this article highlights the need for further prospective studies to stablish optimal dosing regimens, long-term efficacy, and potential adverse effects, for enhanced patient care and management strategies in this challenging clinical scenario.</div></div>","PeriodicalId":38030,"journal":{"name":"Oral and Maxillofacial Surgery Cases","volume":"11 3","pages":"Article 100408"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Iatrogenic intra-temporomandibular joint emphysema during injection: A case report","authors":"Asaad Shehada, Mazen Zenati","doi":"10.1016/j.omsc.2025.100405","DOIUrl":"10.1016/j.omsc.2025.100405","url":null,"abstract":"<div><div>The temporomandibular joint has a variation in its atmospheric pressure during the mouth movement, although the intra-articular injection is widely used as one of the management strategies for reducing the pain and enhancing the mouth movement range, there are atmospheric fluctuations in the joint space due to make a passage between this closed spaces and the external medium when the needle inserted into the joint capsule. This report presents iatrogenic emphysema in two cases, while this emphysema is absent in a different case.</div></div>","PeriodicalId":38030,"journal":{"name":"Oral and Maxillofacial Surgery Cases","volume":"11 3","pages":"Article 100405"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Occult papillary thyroid carcinoma presenting as parapharyngeal space mass: A case report and literature review","authors":"Fawaz Alotaibi , Harish Tummala , Mitchell Naito , Yousef Alshamrani","doi":"10.1016/j.omsc.2025.100402","DOIUrl":"10.1016/j.omsc.2025.100402","url":null,"abstract":"<div><div>Papillary thyroid carcinoma presenting as a parapharyngeal mass is uncommon clinical presentation<sup>1,2</sup>. Papillary thyroid cancer is the most common primary thyroid cancer (80–90 % of cases)<sup>17</sup>. 20–50 % of cases have lymph node metastasis<sup>4</sup>. Superior thyroid lesions usually metastasize through superior pretracheal and cervical nodes while inferior thyroid and isthmus drainage travel via the paratracheal and deep cervical nodes<sup>17</sup>. Parapharyngeal space (PPS) tumors are rare and represent about 0.5 % of all head and neck tumors<sup>1,2</sup>. We report a case of 59 years-old man who presented initially with left parapharyngeal mass for about four months and a chief complaint of dysphagia. Exam revealed a submucosal 4 cm mass in the oropharyngeal wall, no tumor was palpable in the neck and his physical examination was otherwise unremarkable. Preoperative work up was completed, and Fine Needle Aspiration (FNA) was inconclusive. The mass was excised via transcervical-mandibular swing approach and a diagnosis of papillary thyroid carcinoma was rendered. Subsequently, the patient underwent a total thyroidectomy and neck dissection. This case report highlights the unusual metastasis to parapharyngeal space from occult papillary thyroid carcinoma, reviews the lymphatic drainage system of the head and neck responsible for this route of metastasis, recommendations for preoperative imaging, surgical treatment, and adjuvant treatment of this uncommon presentation.</div></div>","PeriodicalId":38030,"journal":{"name":"Oral and Maxillofacial Surgery Cases","volume":"11 3","pages":"Article 100402"},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unusual displacement of maxillary lateral incisor into the orbital floor after panfacial trauma: A case report","authors":"Mojtaba Salehi Karizmeh, Farnaz Keyhanlou","doi":"10.1016/j.omsc.2025.100406","DOIUrl":"10.1016/j.omsc.2025.100406","url":null,"abstract":"<div><div>Panfacial trauma often involves extensive fractures across the facial skeleton and is frequently associated with dentoalveolar injuries. In cases with missing teeth, extra caution is needed, as avulsed teeth or fragments may be displaced into adjacent structures such as the maxillary sinus, nasal cavity, airway, or even the gastrointestinal tract. This report presents a rare case of a maxillary lateral incisor displaced into the orbital floor following panfacial trauma. The case highlights the critical importance of thorough clinical and radiographic assessment, particularly with CT imaging, to ensure accurate diagnosis, prevent complications, and achieve optimal management in panfacial trauma.</div></div>","PeriodicalId":38030,"journal":{"name":"Oral and Maxillofacial Surgery Cases","volume":"11 2","pages":"Article 100406"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brett A. Wilson, Jeffrey H. Brooks, Sloan B. Ashabranner, Franklin B. Ivers
{"title":"Large intraosseous xanthoma of the mandible – A case report","authors":"Brett A. Wilson, Jeffrey H. Brooks, Sloan B. Ashabranner, Franklin B. Ivers","doi":"10.1016/j.omsc.2025.100404","DOIUrl":"10.1016/j.omsc.2025.100404","url":null,"abstract":"<div><div>Xanthoma is derived from the Greek word xanthos, meaning yellow, and is related to the altered metabolism of lipids resulting in their accumulation in skin, tendon sheaths, and internal organs. Xanthomas manifest as yellowish papules, plaques, or nodules and are characterized by lipid-laden macrophages (foam cells). Xanthoma of bone is extremely rare and, when present, is often secondary to dyslipidemias or endocrine disorders. The former would be considered a secondary intraosseous xanthoma of bone. A xanthoma that is identified within bone in the absence of dyslipidemia or endocrine disease is considered a primary intraosseous xanthoma. When a xanthoma presents in the maxilla or mandible, it is considered an intraosseous xanthoma of the jaw. The first intraosseous xanthoma of the jaw was reported in 1964 and was referred to as a xanthogranuloma of the mandible. Since that initial report, less than 60 total cases have been reported in the English literature. The cases reported are typically small in size and amenable to enucleation and curettage. Our report contributes to the existing literature by providing a unique case example, highlighting the potential for these lesions to progress to a considerable size, impact adjacent anatomical structures, and necessitate more aggressive treatment.</div></div>","PeriodicalId":38030,"journal":{"name":"Oral and Maxillofacial Surgery Cases","volume":"11 2","pages":"Article 100404"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily DuBuc , Russell Arellanes , Greta Guillette , Changxing Liu
{"title":"Osteocutaneous radial forearm free flap with islanded bony segments for maxilla reconstruction: A case report","authors":"Emily DuBuc , Russell Arellanes , Greta Guillette , Changxing Liu","doi":"10.1016/j.omsc.2025.100401","DOIUrl":"10.1016/j.omsc.2025.100401","url":null,"abstract":"<div><div>Maxillofacial LeFort 1 surgery is a widely used procedure for correcting midface deformities, but it can occasionally result in rare and destructive complications such as non-union of osteotomy gaps and maxillary necrosis. Addressing these complications requires careful consideration of their severity, the surgeon's expertise, and the patient's desired outcomes. Comprehensive imaging, a detailed surgical history, and thorough preoperative planning are essential. We present the case of a 61-year-old Caucasian male referred to the otolaryngology – head and neck surgery clinic for bilateral oroantral fistulas, with multiple failed repair attempts following LeFort I osteotomy for midfacial deformity correction. Reconstruction was performed using an osteocutaneous radial forearm free flap with two separate osteotomy segments to fill the bony defect and seal the fistulas, resulting in full resolution of symptoms.</div></div>","PeriodicalId":38030,"journal":{"name":"Oral and Maxillofacial Surgery Cases","volume":"11 2","pages":"Article 100401"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamdem Benedikta , Sala Nathalie , Broome Martin , May Laurence
{"title":"Maxillary angiosarcoma: a case report and literature review","authors":"Kamdem Benedikta , Sala Nathalie , Broome Martin , May Laurence","doi":"10.1016/j.omsc.2025.100403","DOIUrl":"10.1016/j.omsc.2025.100403","url":null,"abstract":"<div><div>Angiosarcoma is a rare and aggressive malignant mesenchymal neoplasia developing from endothelial cells, comprising only 2 % of soft tissues sarcomas. While primarily affecting soft tissues and skin, its occurrence in the oral cavity is exceptionally rare (1.6 %). We present the case of a 78-year-old woman with a nodular gingival lesion initially suspected as squamous cell carcinoma. Despite an uneventful postoperative course following maxillectomy, the histological examination revealed angiosarcoma. Discussion highlights the diagnostic challenges due to its varied clinical and histological presentation, often mimicking other lesions. Treatment involves complete surgical excision, followed by adjuvant chemotherapy and radiotherapy. However, the prognosis remains poor, with a high recurrence rate and metastatic potential. Our case underscores the importance of accurate diagnosis through comprehensive clinical, radiological, and histological evaluation, emphasizing the need for early detection and multidisciplinary management to improve outcomes in angiosarcoma patients.</div></div>","PeriodicalId":38030,"journal":{"name":"Oral and Maxillofacial Surgery Cases","volume":"11 2","pages":"Article 100403"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}