Translational Research in Anatomy最新文献

{"title":"Aberrant placental structure is corrected with repeated nanoparticle-mediated IGF1 treatments in a Guinea pig model of fetal growth restriction","authors":"Baylea N. Davenport ,&nbsp;Rebecca L. Wilson ,&nbsp;Alyssa A. Williams ,&nbsp;Jaimi A. Gray ,&nbsp;Edward L. Stanley ,&nbsp;Helen N. Jones","doi":"10.1016/j.tria.2025.100424","DOIUrl":"10.1016/j.tria.2025.100424","url":null,"abstract":"<div><h3>Background</h3><div>Fetal growth restriction (FGR) is most commonly due to placental insufficiency. There are currently no treatments for placental insufficiency or FGR, and the only intervention is iatrogenic pre-term delivery. We have previously shown efficacy of repeated placental nanoparticle-mediated <em>insulin-like 1 growth factor</em> (<em>IGF1</em>) treatment in improving placental efficiency (increased fetal-placental weight ratio) and correcting fetal growth in a maternal nutrient restriction (MNR) guinea pig model of FGR. We hypothesize placenta structural changes (reduced exchange area, altered vascular structure) that we and others have previously shown in the FGR/MNR placenta which lead to deficits in placental function are mitigated by our repeated nanoparticle-mediated <em>hIGF1</em> treatment.</div></div><div><h3>Methods</h3><div>Here we investigate the structural remodeling of the placenta in a maternal nutrient restriction (MNR) guinea pig model following 3 repeated intraplacental injections of nanoparticle-mediated <em>hIGF1</em> that may underpin the published improvements in placental efficiency and fetal growth. Using immunohistochemistry and Dice-CT we investigated the micro- and macrovasculature changes of the placenta structure to identify changes in FGR and treatment.</div></div><div><h3>Results</h3><div>Sham-treated MNR placentas displayed disorganized microvasculature labyrinthine exchange areas with a reduction in placental capillary number and an increase in the volume of the placenta macrovasculature. Repeated nanoparticle-mediated <em>hIGF1</em> treatment, however, resulted in an improved exchange area with normalized placental capillary number and macrovasculature volume.</div></div><div><h3>Conclusions</h3><div>This data demonstrates repeated nanoparticle-mediated <em>hIGF1</em> delivery corrects aberrant placenta structure during FGR and placental insufficiency likely leading to improved gas exchange and transfer of nutrients to the fetus restoring fetal growth.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"40 ","pages":"Article 100424"},"PeriodicalIF":0.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early white matter microstructural alterations in cerebral small vessel disease: A tract-specific diffusion tensor imaging and cardio-cerebrovascular risk perspective","authors":"Zaw Myo Hein ,&nbsp;Muhammad Danial Che Ramli ,&nbsp;Usman Jaffer ,&nbsp;Che Mohd Nasril Che Mohd Nassir","doi":"10.1016/j.tria.2025.100425","DOIUrl":"10.1016/j.tria.2025.100425","url":null,"abstract":"<div><h3>Background</h3><div>Silent cerebral small vessel disease (CSVD), marked by white matter hyperintensities (WMHs), are commonly detected incidentally on neuroimaging. Emerging evidence links early brain microstructural changes to modifiable cardio-cerebrovascular risks, even without neurological symptoms. This study aimed to explore the relationship between cardio-cerebrovascular risk, white matter tract integrity, and cognitive performance in asymptomatic adults, using QRISK3 profiling, diffusion tensor imaging (DTI), and neurocognitive evaluation.</div></div><div><h3>Methods</h3><div>Sixty neurologically asymptomatic adults (mean age: 39.8 ± 11.5 years) with low to moderate QRISK3 scores underwent standardized neurocognitive assessment 3T brain MRI, including DTI sequences. Lesion-guided region-of-interest (ROI) tractography was used to assess six bilateral white matter tracts commonly affected in CSVD: the anterior and superior corona radiata and the superior longitudinal fasciculus (SLF).</div></div><div><h3>Results</h3><div>WMHs were identified in 20 individuals (33.3 %). Their presence was significantly associated with aging, systolic blood pressure, hypertension, and QRISK3 score (<em>p</em> &lt; 0.05). While no significant cognitive impairment was observed, processing speed was negatively correlated with age and QRISK3. Although DTI metrics such as fractional anisotropy (FA) and mean diffusivity (MD) did not significantly differ across groups, tract-specific analysis revealed that higher QRISK3 scores were significantly associated with reduced white matter integrity in the left SLF.</div></div><div><h3>Conclusion</h3><div>These findings highlight the presence of early, subclinical white matter alterations in individuals at cardio-cerebrovascular risk, even in the absence of neurological symptoms. The integration of tract-specific DTI analysis with vascular risk profiling may provide a sensitive approach for detecting preclinical CSVD and guiding early intervention strategies in at-risk populations.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"40 ","pages":"Article 100425"},"PeriodicalIF":0.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A two-trunked anatomical variance of the brachial plexus: A cadaveric case report","authors":"Catherine A. Cash ,&nbsp;Camryn Buskey ,&nbsp;Eistine Boateng ,&nbsp;Adel Maklad ,&nbsp;Hamoun Delaviz","doi":"10.1016/j.tria.2025.100422","DOIUrl":"10.1016/j.tria.2025.100422","url":null,"abstract":"<div><h3>Background</h3><div>The brachial plexus is a network of nerves connecting five spinal nerve roots (C5-C8 and T1) and is responsible for transmitting motor and sensory signals to the upper limb. The ventral rami typically form three trunks, superior (C5-C6), middle (C7), and inferior (C8-T1), where each trunk channels motor and sensory information to specific upper limb regions.</div></div><div><h3>Methods</h3><div>A unique variation of the trunks of the brachial plexus was discovered during a routine dissection of a male cadaver within an anatomy laboratory.</div></div><div><h3>Results</h3><div>We present a case of a prefixed, two trunk brachial plexus, formed by the fusion of the middle and inferior trunks, along with downstream variations in the terminal nerve branches.</div></div><div><h3>Conclusions</h3><div>While anatomical variations of the brachial plexus are documented in the literature, fusion of the middle and inferior trunks are not commonly observed in human anatomy and subsequently not documented in the literature. Furthermore, we observed a prefixed plexus and anomalous communicating branches of the musculocutaneous nerve to the median nerve as additional features of the network. Altogether, understanding these variations is crucial for physicians, as it can affect surgical procedures and clinical presentations.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"40 ","pages":"Article 100422"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining lumbosacral transitional vertebrae classification: Morphological variation in a South African population","authors":"G.J. Paton ,&nbsp;S. Nalla ,&nbsp;S.A. Williams ,&nbsp;G.J. Louw","doi":"10.1016/j.tria.2025.100423","DOIUrl":"10.1016/j.tria.2025.100423","url":null,"abstract":"<div><h3>Background</h3><div>Lumbosacral transitional vertebrae (LSTV) are common anatomical variants where the last lumbar vertebra demonstrates unilateral or bilateral enlargement of the transverse processes, with articulation or fusion to the sacrum. This radio-anatomical study sought to investigate the morphological characteristics of LSTV in the South African population and describe unique variations that enhance the traditional Castellvi classification.</div></div><div><h3>Methods</h3><div>A retrospective radiographic review was performed on 3096 consecutive thoracoabdominal pelvic radiographs from two South African hospitals. Targeted osteological appraisal was conducted on selected skeletons containing LSTV sourced from the Raymond Dart Collection of Modern Human Skeletons. The presence of LSTV was classified according to Castellvi, identifying Types II, III, and IV, unilateral and bilateral subtypes.</div></div><div><h3>Results</h3><div>The prevalence of LSTV was 10 %. Morphological distribution was as follows: Type II (67.9 %), Type III (27.6 %), and Type IV (4.5 %). Subtype frequencies were IIA (41.9 %), IIB (26.0 %), IIIB (21.8 %), and IV (5.8 %). Laterality showed a predominance of bilateral cases (47.7 %), followed by left- (26.6 %) and right-sided (21.1 %) variants. Type IV morphology could not be classified by side using traditional methods. Transverse processes at the LSTV level were significantly longer than those in matched controls (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study proposes two refinements to the Castellvi system: First, Type IV morphology should be assigned left or right at the side of the lumbosacral fusion. Second, a novel transversoiliac articulation was associated with Type II morphology, representing a previously undescribed feature in LSTV morphology. These modifications may enhance diagnostic precision, support recognition of Bertolotti syndrome, and formulate appropriate treatment strategies.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"40 ","pages":"Article 100423"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberrant origin of left vertebral artery: A molecular embryological perspective","authors":"Connor Lee McCoy ,&nbsp;John Joseph Cichewicz ,&nbsp;Rainevan Miller ,&nbsp;Soumya Sharma ,&nbsp;Adel Maklad ,&nbsp;Eistine Boateng","doi":"10.1016/j.tria.2025.100421","DOIUrl":"10.1016/j.tria.2025.100421","url":null,"abstract":"<div><h3>Background</h3><div>Variation in the origin and course of the left vertebral artery have surgical and clinical implications in the management of medical conditions. Here, we show variant origin of the left vertebral artery in cadavers and propose potential causes for future molecular investigations.</div></div><div><h3>Method</h3><div>The aortic arches of 32 donors were dissected and observed for anomalous origin of the left vertebral artery in the cadaver laboratory at the University of Toledo, Ohio, USA.</div></div><div><h3>Results</h3><div>Out of 32 donors dissected during laboratory sessions, we observed two cases of the left vertebral artery originating directly from the aortic arch, medial to the left subclavian artery.</div></div><div><h3>Conclusion</h3><div>The study aims to stimulate discussions and future investigations into the molecular embryology of vasculogenesis concomitant with preconceptional and <em>in utero</em> exposures to understand the underlying causes of aberrant origin of the left vertebral artery. Additionally, we speculate that parental and embryonic environmental exposures influence the epigenetic landscape in germ cells and early embryos, thereby contributing to the programming of variant origin of blood vessels.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"40 ","pages":"Article 100421"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex determination and stature estimation using logistic and linear regression models: A population-specific study of tibia and Fibula in Northeastern Thais","authors":"Suthat Duangchit ,&nbsp;Chanasorn Poodendaen ,&nbsp;Phetcharat Phetnui ,&nbsp;Pornpimol Tasu ,&nbsp;Worrawit Boonthai ,&nbsp;Nareelak Tangsrisakda ,&nbsp;Sitthichai Iamsaard","doi":"10.1016/j.tria.2025.100420","DOIUrl":"10.1016/j.tria.2025.100420","url":null,"abstract":"<div><h3>Background</h3><div>Sex determination and stature estimation from skeletal remains are basic components of forensic anthropological analysis, particularly when fragmentary remains limit conventional approaches. This study aimed to establish the population-specific standards for Northeastern Thais using tibial and fibular measurements.</div></div><div><h3>Materials and methods</h3><div>The study examined 200 identified adult skeletons (100 males, 100 females). The nine osteometric parameters (six tibial and three fibular) were measured bilaterally. All specimens were systematically documented for age, sex, and stature.</div></div><div><h3>Results</h3><div>For sex determination, the results showed that univariate logistic regression models achieved the accuracy rates up to 87.50 %, with maximum proximal epiphyseal breadth of the tibia demonstrating highest discriminatory power. Multivariate approaches could significantly enhance the accuracy to 91.30 % for left tibial parameters, with age-related variation revealing optimal results in the 45–59 age group. Fibular measurements showed lower accuracy but still maintained statistical significance, particularly for fibular weight. For stature estimation, the maximum tibial length served as the most reliable univariate predictor (SEE = 6.66 cm, R = 0.572), while multivariate equations incorporating complementary parameters from both tibia and fibula improved the accuracy. Age-stratified analysis demonstrated diminished accuracy in older cohorts, especially for fibular measurements.</div></div><div><h3>Conclusion</h3><div>The findings align with the previous studies while reflecting distinct patterns unique to Northeastern Thai populations with their specific genetic ancestry. These population-specific equations can enhance the biological profiling capabilities in forensic investigations when the conventional methods are inapplicable due to fragmentary remains.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"40 ","pages":"Article 100420"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric analysis of circulus arteriosus cerebri variations in a South African cadaveric sample","authors":"Jessica Garlick,&nbsp;Graham Louw,&nbsp;Kentse Mpolokeng","doi":"10.1016/j.tria.2025.100419","DOIUrl":"10.1016/j.tria.2025.100419","url":null,"abstract":"<div><h3>Introduction</h3><div>The <em>circulus arteriosus cerebri</em> (CAC), or Circle of Willis, exhibits significant anatomical variability, with fewer than 50 % of cases displaying the conventional configuration. CAC variations are associated with intracranial aneurysm (IA) formation and subsequent haemorrhagic stroke. Due to limited data on CAC variations in South Africa, this study aimed to assess the prevalence and types of arterial variations in a South African cadaveric sample and to document associated IAs.</div></div><div><h3>Methods</h3><div>This retrospective, cross-sectional and quantitative study had a sample size of 64. The CAC was dissected, removed from the base of the brain, photographed, and analysed morphologically. Variations were classified using the Ayre et al. (2021) system and recorded individually.</div></div><div><h3>Results</h3><div>The intact samples (n = 40) were classified according to Ayre et al. (2021) and 22.5 % of the sample displayed the conventional configuration. The predominant pattern of variation was group 5 (miscellaneous patterns), and variations were commonly observed in both the anterior and posterior circulations (55 %). Individual variations were observed (n = 64 brains; 81 variations). The leading variations were unilateral posterior communicating artery (PcoA) hypoplasia (17.3 %) and aplasia (14.8 %). The anterior communicating artery (AcoA) was the most variable artery (44.4 %), with short fusion of the anterior cerebral arteries (ACAs) being the most common variation (13.6 %) affecting the AcoA. Rare findings include type 4 and 5 PcoA terminations (double P2), not previously reported in South Africa. IA frequency was insufficient for analysis.</div></div><div><h3>Conclusions</h3><div>These variations may increase stroke and IA risk. Knowledge of CAC variations can support neurosurgical planning and execution. Further studies in a South African setting are recommended.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"40 ","pages":"Article 100419"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical investigation of elongated styloid processes (Eagle syndrome) with micro-CT analysis and clinical review","authors":"Joseph X. Anders ,&nbsp;William Srinivasan ,&nbsp;Maggie M. Minett ,&nbsp;Susan P. Bare ,&nbsp;Mohammed P. Akhter ,&nbsp;Ethan L. Snow","doi":"10.1016/j.tria.2025.100418","DOIUrl":"10.1016/j.tria.2025.100418","url":null,"abstract":"<div><h3>Introduction</h3><div>Eagle syndrome is a rare disease that causes elongation (&gt;30 mm) of the temporal styloid process (SP) through osteogenesis (Type I) or ossification of the stylohyoid ligament (SHL) (Type II). Eagle syndrome implicates the styloid apparatus and can cause difficulty with swallowing, pain with neck movement, dissection of the internal carotid artery, and stroke. Reports investigating the Eagle syndrome gross anatomy and SP microstructure are scarce. This study seeks to investigate a case of Eagle syndrome SPs in a human cadaver with gross and micro-CT analysis and discuss its clinical significance.</div></div><div><h3>Methods</h3><div>The case was discovered during routine academic dissection of an adult male human cadaver. The styloid apparatus was examined bilaterally for any non-typical morphologies. The SPs were stripped of extraneous tissue and photographed. Linear and angular dimensions of the SPs were measured, and micro-CT analysis was performed on a section of the right SP. A comprehensive review of Eagle syndrome etiology, epidemiology, symptomology, diagnostic parameters, subtype descriptions, and treatment was compiled from current literature as a basis for clinical discussion.</div></div><div><h3>Results</h3><div>The long axes of the right and left SPs measured 41.4 mm and 33.0 mm, respectively, and the proximal, middle, and distal SP diameters averaged 4.2 mm, 3.5 mm, and 1.7 mm, respectively. Both SPs exhibited a mid-shaft tubercle, after which they decreased diameter by over 25% within 2 mm distance, increased angle of descent by more than 20.0° in the sagittal plane and exhibited noticeably different surface characteristics. Micro-CT analysis revealed relatively consistent trabeculae and cortical structure throughout the SP.</div></div><div><h3>Conclusions</h3><div>Clinical understanding of SP hyperplasia vs. SHL metaplasia as it applies to Eagle syndrome etiology and subsequent implications to the styloid apparatus is important for Eagle syndrome diagnosis, treatment, and patient outcomes. As Eagle syndrome can present with broad symptomology, this report may benefit primary care physicians, dentists, neurologists, radiologists, otorhinolaryngologists, and other medical professionals with information that can be used to improve diagnostic testing and treatment approaches in patients with Eagle syndrome.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"40 ","pages":"Article 100418"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of online educational modules on learning musculoskeletal anatomy for health professionals. A systematic review","authors":"Nikita Bandekar,&nbsp;Mohandas Rao K.G.,&nbsp;Ashwini Aithal P.,&nbsp;Anniesmitha K.,&nbsp;Bincy M. George","doi":"10.1016/j.tria.2025.100417","DOIUrl":"10.1016/j.tria.2025.100417","url":null,"abstract":"<div><h3>Background</h3><div>Musculoskeletal (MSK) anatomy is fundamental to clinical practice in various healthcare disciplines, including medicine, physiotherapy, and orthopedics. Advancements in technology have led to an increased focus on online learning tools, providing alternatives to traditional teaching methods.</div></div><div><h3>Objective</h3><div>This systematic review assesses the impact of online learning (e-learning) modules on musculoskeletal anatomy education among health professionals.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted across Scopus, PubMed, Cochrane, Web of Science, and CINAHL. The eligibility criteria included studies involving health professionals and students in anatomy education using online learning interventions such as video lectures, 3D models, and virtual labs. The risk of bias of the studies was evaluated via the JBI Checklist.</div></div><div><h3>Results</h3><div>Out of 947 records, 18 studies were included in this review. This review included 8 quasi experimental, 7 cross-sectional, 1 case‒control, and 2 randomized controlled trials (RCTs). A total of 78 % of the studies incorporated multiple online interventions, such as video tutorials, interactive 3D models, and virtual laboratories. Additionally, 67 % of the studies indicated that learners preferred hybrid models that combined online and in-person teaching, as they significantly enhanced the learning experience compared with traditional methods in improving anatomical knowledge and musculoskeletal competency. Modules that incorporated practical elements significantly increased learners’ confidence in handling musculoskeletal cases. The pandemic accelerated the adoption of online anatomy education, with many studies demonstrating that digital platforms successfully replaced traditional methods while achieving comparable educational outcomes.</div></div><div><h3>Conclusions</h3><div>Online educational modules offer a beneficial alternative to traditional anatomy teaching methods, particularly when interactive and hybrid models are in use. They enhance MSK knowledge retention, clinical skills, and learner satisfaction. Future studies should aim to optimize these technologies to integrate theoretical knowledge with clinical practices and patient education.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"40 ","pages":"Article 100417"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cadaveric investigation of the radial artery origin and its anatomical variations","authors":"Aleisha J. Singh ,&nbsp;Rohen Harrichandparsad ,&nbsp;Lelika Lazarus","doi":"10.1016/j.tria.2025.100416","DOIUrl":"10.1016/j.tria.2025.100416","url":null,"abstract":"<div><h3>Introduction</h3><div>According to standard anatomical description, the radial artery typically originates as one of two terminal branches of the brachial artery within the cubital fossa. Despite the common embryological process of the upper limb arteries, there are anatomical variations in the origin of the radial artery such as the radial artery originating from the axillary artery or from the brachial artery in the arm. The present study aimed to investigate the origin of the radial artery within a select adult cadaveric South African sample.</div></div><div><h3>Methods</h3><div>A total of thirty adult cadaveric specimens (n = 60 upper limbs) were dissected at the University of KwaZulu-Natal (BREC/00006978/2024).</div></div><div><h3>Results</h3><div>The radial artery originated from the brachial artery in the cubital fossa as per standard anatomical description in 90 % of the upper limb specimens. In 10 % of the sample, the aberrant radial artery originated from the axillary artery (four unilaterally, and one bilaterally in an 80-year-old male cadaver). The aberrant radial arteries originated an average 172 ± 20.81 mm above the inter-epicondylar line of the humerus, with external and internal diameters of 5.45 ± 1.71 mm, and 3.10 ± 0.70 mm respectively.</div></div><div><h3>Conclusion</h3><div>This study reports an incidence of 10 % of the sample in which the radial artery originated from the axillary artery. Knowledge of the variations in the origin of the radial artery within this select South African population may assist the clinician during coronary and neuro-interventional procedures.</div></div>","PeriodicalId":37913,"journal":{"name":"Translational Research in Anatomy","volume":"40 ","pages":"Article 100416"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}