Current Research in Bioorganic & Organic Chemistry最新文献

{"title":"Effect of Remote Polyene Bridge Methyl Substituent on Physical Properties of Dipolar Chromophores with Conformationally and Configurationally Locked Polyene Bridge","authors":"G. C. Nwokogu, S. A. Simpson","doi":"10.29011/2639-4685.100019","DOIUrl":"https://doi.org/10.29011/2639-4685.100019","url":null,"abstract":"The effect of a C-2 substituent on the success of Knoevenagel condensation of the cycloalkenone moiety, which is usually the final step in the multi-step synthesis of conformationally and configurationally locked polyene bridged Donor - π Acceptor chromophores, has been investigated. In addition, the possibility of a two-pot synthesis of polyene bridges with more than two annulated cyclohexenyl rings and the effect of a polyene bridge methyl substituent on the planarity of the chromophore have been investigated. The results of these studies show that a C-2 on the terminal cycloalkenone of the polyenone must not be substituted for successful Knoevenagel condensation in the modular synthesis of Donor-π -Acceptor dipolar chromophores. It is also demonstrated that three new rings can be annulated in a two-pot reaction sequence. A significant blue shift in λ max of prepared rigid polyene bridge chromophores indicates that a remote methyl substituent on the polyene bridge has a dramatic effect on the planarity of the chromophore. must not be substituted for successful, final step, Knoevenagel condensation to complete the synthesis of the dipolar chromophores. We also demonstrated that three new rings can be annulated in a highly abbreviated two-pot reaction sequence. Measurements of the λ max of prepared rigid polyene bridge chromophores indicate that a remote methyl substituent on the polyene bridge has a dramatic effect on the planarity of the chromophore bridge. This conclusion is based on the observed significant blue shifts in λ max . The results of the three related studies reported herein represent important contributions to the knowledge base for the synthetic optimization of the properties of chromophoric organic materials. Monomers and polymers endowed with such optimized properties are important for the development of improved fabrication components for materials science and technology. room round the mixture. insoluble and rinsed THF until washings were colorless. THF evaporated a dark cooled to -10 o C and 30 mL of 12 cooled to 0 o C was added in portions to the stirred crude product. A yellow cake formed at bottom of the reaction flask re-dissolved after it was broken up at room temperature. The aqueous acid solution was heated at 80 o C for dehydration of the alcohol to room temperature, the aqueous solution was carefully solid sodium bicarbonate until basic to litmus paper. The product precipitated out of as an ash-colored cake. The cake was broken up and suction-filtered. The resulting was rinsed with hexane to remove an oily component. The dark gray solid product weighed after additional 1.95g of product obtained from column chromatography of the ether extracts of the aqueous on silica gel using of ethyl respectively. 42.50 g (93%). Use of n-BuLi to the nucleophile the wet distillate collected in the trap was run off every time it filled up until a viscous dark mass was left in the reaction flask. The reaction mixture was then heated ","PeriodicalId":378827,"journal":{"name":"Current Research in Bioorganic & Organic Chemistry","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116919382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Chemoselective and Regioselective Hydroxylation or Chlorination onto The Aryl Ring of N-(4-Substituted-Aryl) Nitrones. Preparation of 2-Aminophenols by Regiospecific Ortho-Hydroxylation","authors":"Jing Zhang, F. Fan, Rui Xie, J. Chen, Jingxuan Li, P. Yuan","doi":"10.29011/2639-4685.100016","DOIUrl":"https://doi.org/10.29011/2639-4685.100016","url":null,"abstract":"N-(substituted-aryl) Nitrones, in the reactions with a chlorinating reagent such as trichloroacetyl chloride, oxalyl chloride, or thionyl chloride, produce a hydroxylation or a chlorination onto the aryl ring of the arylnitrones. The chemoselectivity and the region selectivity (hydroxylation or chlorination) depend largely on the nature of chlorinating reagent and on that of the 4-substituent in the aryl ring of the arylnitrones. This work provides a novel synthetic route to important intermediates: 2-aminophenols, 2-chloroanilines and 3-chloroanilines which are important industrial intermediates for pharmaceutical products (API), for azo-dye ingredients and for agricultural products.","PeriodicalId":378827,"journal":{"name":"Current Research in Bioorganic & Organic Chemistry","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132191377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile Synthesis and Biological Evaluation of Novel N-Nitro Urea Derivatives Incorporating Amino Acid Ethyl Esters","authors":"Ying-Hui Huang, Minhui Cao, Sheng‐Zhen Xu","doi":"10.29011/2639-4685.100014","DOIUrl":"https://doi.org/10.29011/2639-4685.100014","url":null,"abstract":"A novel series of N-nitro urea derivatives 6a-w containing various amino acid ethyl esters were conveniently synthesized via three steps including nitration, carbamic chlorination, and aminolysis reactions. The structures of all compounds prepared have been confirmed by 1H NMR, IR spectroscopy and elemental analyses, and a part has been identified by 13C NMR. The preliminary bioassay indicates that some of the target compounds possesses moderate herbicidal activity against Echinochloa crusgalli and Amaranthus albus. However, some of the title compounds presented high plant growth regulating activity against rice.","PeriodicalId":378827,"journal":{"name":"Current Research in Bioorganic & Organic Chemistry","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127575308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NMR-Observed Atomic Bond Length Stability Supports a Dimensionality Shift in Protein Main Chain 3D Structure Description and Representation","authors":"Wei Li","doi":"10.29011/2639-4685.100012","DOIUrl":"https://doi.org/10.29011/2639-4685.100012","url":null,"abstract":"","PeriodicalId":378827,"journal":{"name":"Current Research in Bioorganic & Organic Chemistry","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124851079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Docking of Short-Chain Glycosaminoglycan Ligands in 3D Model of Bovine Testicular Hyaluronidase","authors":"A. Maksimenko, R. Beabealashvili","doi":"10.29011/2639-4685.100011","DOIUrl":"https://doi.org/10.29011/2639-4685.100011","url":null,"abstract":"","PeriodicalId":378827,"journal":{"name":"Current Research in Bioorganic & Organic Chemistry","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131811990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction, Isolation and Chemical Modification of the Anacardic Acids from Cashew Nut Shell (Anacardium occidentale L.) and Biological Assay","authors":"F. E. D. Silva, A. Costa, P. T. Barbosa, J. P. Mota, T. L. Lemos, Emerson Almeida de Sousa, K. A. Silva, S. Morais","doi":"10.29011/2639-4685.100010","DOIUrl":"https://doi.org/10.29011/2639-4685.100010","url":null,"abstract":"","PeriodicalId":378827,"journal":{"name":"Current Research in Bioorganic & Organic Chemistry","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134377417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Some Coumarin Hybrids and Evaluating Their Anticancer Activity","authors":"E. Abdel‐Latif, M. Abou-Elzahab, M. Ibrahim, Nivien E. Maarouf, M. Abdel-Mogib","doi":"10.29011/2639-4685.100009","DOIUrl":"https://doi.org/10.29011/2639-4685.100009","url":null,"abstract":"","PeriodicalId":378827,"journal":{"name":"Current Research in Bioorganic & Organic Chemistry","volume":"539 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116395422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothesis: Heat Transfer and Elementary Carriers of Heat Energy","authors":"Utelbaeev Bolysbek Toychibekovich, Suleimenov Esen Nurgalievich, Utelbayeva Akmaral Bolysbekovna","doi":"10.29011/2639-4685.100022","DOIUrl":"https://doi.org/10.29011/2639-4685.100022","url":null,"abstract":"Energy is one of the basic concepts of natural science and is inextricably linked with the idea of the transformation of one form of motion of matter into another. In turn, technological advances encourage science to make new discoveries that make it possible to use all types of energy efficiently: master the energy of the subsoil, the sun’s rays, tides, sea waves, control thermonuclear energy, etc. All this requires fundamental knowledge of the mechanism of energy transfer. Currently, it is argued that the “phlogiston theory” is over, but in a hidden form it is widely used in practice to explain the heat transfer as Fourier’s equation:","PeriodicalId":378827,"journal":{"name":"Current Research in Bioorganic & Organic Chemistry","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127914324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile Synthesis of Excellent Anti-Corrosive Bi-Layer Structure Composite Coatings On Mg Alloys","authors":"Sung-Nam Pak, Kyong-Sik Ju, Chang-Son Ok, Kwang-Won Nam, Chang-Su Pak","doi":"10.29011/2639-4685.100021","DOIUrl":"https://doi.org/10.29011/2639-4685.100021","url":null,"abstract":"","PeriodicalId":378827,"journal":{"name":"Current Research in Bioorganic & Organic Chemistry","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114937221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of Students Taking Hybrid General Organic and Chemistry Course at A Community College","authors":"Sumeyra Yumak, H. Yumak, O. Ecevit","doi":"10.29011/2639-4685.100017","DOIUrl":"https://doi.org/10.29011/2639-4685.100017","url":null,"abstract":"","PeriodicalId":378827,"journal":{"name":"Current Research in Bioorganic & Organic Chemistry","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124778121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}