Tuberculosis and Lung Diseases最新文献_第3页

Certain Aspects of Mast Cell Carboxypeptidase A3 Involvement in the Pathogenesis of COVID-19 肥大细胞羧肽酶 A3 参与 COVID-19 发病机制的某些方面

Tuberculosis and Lung Diseases Pub Date : 2024-03-20 DOI: 10.58838/2075-1230-2024-102-1-26-33

A. Budnevskiy, S. N. Avdeev, E. S. Ovsyannikov, N. Alekseeva, V. V. Shishkina, I. Savushkina, I. M. Perveeva, V. R. Drobysheva

{"title":"Certain Aspects of Mast Cell Carboxypeptidase A3 Involvement in the Pathogenesis of COVID-19","authors":"A. Budnevskiy, S. N. Avdeev, E. S. Ovsyannikov, N. Alekseeva, V. V. Shishkina, I. Savushkina, I. M. Perveeva, V. R. Drobysheva","doi":"10.58838/2075-1230-2024-102-1-26-33","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-1-26-33","url":null,"abstract":"The objective: to determine the involvement of lung mast cell carboxypeptidase A3 (SPA3) in the pathogenesis of COVID-19. Subjects and Methods. Samples of autopsy specimens from the lungs of patients who died of severe COVID-19 and patients who died of external causes were examined. On day 2 after the patient's death, the autopsy was performed and autopsy specimens were collected. Histological samples were prepared to analyze the degranulation activity of CPA3-positive mast cells (MCs). Correlations between protease profile and clinical and laboratory parameters were analyzed.Results. In the patients died of COVID-19, the total numbers of CPA3-positive MCs, CPA3-positive MCs with signs of degranulation, and coadjacent CPA3-positive MCs (two CPA3-positive MCs sharing a common cytoplasm) were statistically significantly higher versus the patients from Control Group. Positive correlations were established between the total number of CPA3-positive MCs and CPA3-positive MCs with signs of degranulation with blood hemoglobin level (r = 0.491; p = 0.008; r = 0.521; p = 0.004), between the total number of CPA3-positive MCs degranulating CPA3-positive MCs and adjacent CPA3-positive MCs with total blood protein (r = 0.431, p = 0.020; r = 0.449, p = 0.015; r = 0.456, p = 0.013), and between CPA3-positive MCs with signs of degranulation and total number of CPA3-positive MCs with aPTT level (r = 0.428; p = 0.021; r = 0.374; p = 0.045). Negative correlations were established between the total number of CPA3-positive MCs and the level of INR (r = 0.812; p = 0.050), separately lying CPA3-positive MCs with the number of monocytes (r = 0.384; p = 0.044), jointly adjacent CPA3-positive Mcs with blood eosinophils (r = 0.420, p = 0.023).","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"9 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140226296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subtotal Thrombosis of the Left Pulmonary Artery Trunk as a Complication of COVID-19: a Clinical Case 作为 COVID-19 并发症的左肺动脉主干半完全血栓形成：一个临床病例

Tuberculosis and Lung Diseases Pub Date : 2024-03-20 DOI: 10.58838/2075-1230-2024-102-1-66-71

T. I. Kalenchits, S. Kabak, I. V. Korenevskaya

引用次数: 0

Strategy of the Host-Directed Therapy for Tuberculosis: the Importance of Interferon-Gamma in the Pathogenesis and Therapy of Tuberculosis Infection 宿主引导的结核病治疗策略：干扰素-γ 在结核病感染的发病机制和治疗中的重要性

Tuberculosis and Lung Diseases Pub Date : 2024-03-20 DOI: 10.58838/2075-1230-2024-102-1-72-81

G. Mozhokina, A. G. Samoylova, A. Abramchenko, M. I. Romanova, I. A. Vasilyeva

引用次数: 0

Difficulties in Diagnosing Pulmonary Nodular Lymphoid Hyperplasia 诊断肺结节性淋巴样增生症的难点

Tuberculosis and Lung Diseases Pub Date : 2024-03-20 DOI: 10.58838/2075-1230-2024-102-1-59-65

I. D. Lagkueva, O. P. Bliznyukov, N. Chernichenko, M. M. Dzhigkaeva, Y. Murzin

引用次数: 0

Comparative Characteristics of Tuberculosis and Mycobacteriosis in Two Regions of the Russian Federation: Mari El Republic and Vladimir Region 俄罗斯联邦两个地区结核病和分枝杆菌病的比较特征：马里埃尔共和国和弗拉基米尔地区

Tuberculosis and Lung Diseases Pub Date : 2024-03-20 DOI: 10.58838/2075-1230-2024-102-1-52-58

E. Beloborodova, V. N. Zimina, E. Kulabukhova, Т. A. Kuznetsova, O. V. Fesenko

{"title":"Comparative Characteristics of Tuberculosis and Mycobacteriosis in Two Regions of the Russian Federation: Mari El Republic and Vladimir Region","authors":"E. Beloborodova, V. N. Zimina, E. Kulabukhova, Т. A. Kuznetsova, O. V. Fesenko","doi":"10.58838/2075-1230-2024-102-1-52-58","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-1-52-58","url":null,"abstract":"The objective: to study the regional prevalence of mycobacteriosis and the types of non-tuberculous mycobacteria causing mycobacteriosis in Mari El Republic and Vladimir Region, to conduct a comparative clinical and radiological analysis of mycobacteriosis and tuberculosis.Subjects and Methods. Cultures of non-tuberculous mycobacteria available in the bank of the bacteriological laboratory of two regions were analyzed: 182 cultures in the Republic of Mari El and 44 cultures in Vladimir Region. Medical records and X-ray archives of patients who were found to be positive for non-tuberculous mycobacteria were retrospectively studied.Results. The incidence of mycobacteriosis in Vladimir Region and Mari El Republic made 1.5 and 4.3 cases per 100,000 population, respectively. Cultures of non-tuberculous mycobacteria that caused mycobacteriosis belonged to diverse species, and M.avium-complex was the most common (76% of cases). There were no statistically significant differences in the location and extent of lesions in patients with mycobacteriosis and tuberculosis (p > 0.05). The frequency of positive results of Mantoux test with 2TU was comparable Positive results of TRA test were found significantly more often among patients with tuberculosis versus patients with mycobacteriosis (15/19 (78.9%) and 9/24 (37.5%), respectively; p < 0.05). However, this is insufficient for differential diagnosis of these diseases.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"9 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140227289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency and Structure of Drug Resistance of M. tuberculosis in Pulmonary and Extrapulmonary Tuberculosis 肺结核和肺外结核中结核杆菌耐药性的频率和结构

Tuberculosis and Lung Diseases Pub Date : 2024-03-20 DOI: 10.58838/2075-1230-2024-102-1-40-45

P. Yablonskiy, B. Vishnevskiy, N. S. Solovyova, V. B. Galkin

{"title":"Frequency and Structure of Drug Resistance of M. tuberculosis in Pulmonary and Extrapulmonary Tuberculosis","authors":"P. Yablonskiy, B. Vishnevskiy, N. S. Solovyova, V. B. Galkin","doi":"10.58838/2075-1230-2024-102-1-40-45","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-1-40-45","url":null,"abstract":"The objective: to assess changes in the data on drug resistance of M. tuberculosis for 2015-2021 and compare it with data for 2012-2014.Subjects and Methods. Using continuous sampling, the frequency of drug resistance of Mycobacterium tuberculosis (MTB DR) was studied in isolates from 151 pulmonary tuberculosis (PTB) patients and isolates from 805 extrapulmonary tuberculosis (EPTB) patients, who were treated at the clinic of St. Petersburg Research Institute of Phthisiopulmonology in 2015-2021. The results were compared with similar data for 2012-2014 which was published in 2016.Results. In 2015-2021 versus 2012-2014, the overall frequency of MTB DR decreased by 4.2% in pulmonary tuberculosis patients (from 90.1 to 85.9%) and by 2.9% in extrapulmonary tuberculosis patients (from 80.2 to 77.4%). The structure of MTB DR in pulmonary tuberculosis changed insignificantly, the frequency of MDR decreased from 42.5 to 36.5%, and XDR (as per the definitions before 2022) remained the same – 39.5%. In extrapulmonary tuberculosis, the structure of MTB DR deteriorated due to lower frequency of MDR (from 66.3 to 48.3%) and higher frequency of XDR (from 3.2 to 19.0%, p<0.01).","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"23 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140226249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment with Inhaled Antibiotics as One of the Measures to Combat Bacterial Resistance (Cystic Fibrosis is Used as an Example) 吸入式抗生素治疗是对抗细菌耐药性的措施之一（以囊性纤维化为例）

Tuberculosis and Lung Diseases Pub Date : 2024-03-20 DOI: 10.58838/2075-1230-2024-102-1-82-86

A. V. Takhtamysheva

引用次数: 0

Improvement of Organizational Measures for Detection and Diagnosing of Tuberculous Infection and Tuberculosis in Adolescents in the Republic of Kazakhstan 完善哈萨克斯坦共和国青少年结核感染和结核病检测与诊断的组织措施

Tuberculosis and Lung Diseases Pub Date : 2024-03-20 DOI: 10.58838/2075-1230-2024-102-1-46-51

L. T. Eralieva, K. S. Serikbaeva, A. Rakisheva, Z. S. Bekbenbetova, O. G. Prikhodchenko

{"title":"Improvement of Organizational Measures for Detection and Diagnosing of Tuberculous Infection and Tuberculosis in Adolescents in the Republic of Kazakhstan","authors":"L. T. Eralieva, K. S. Serikbaeva, A. Rakisheva, Z. S. Bekbenbetova, O. G. Prikhodchenko","doi":"10.58838/2075-1230-2024-102-1-46-51","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-1-46-51","url":null,"abstract":"The objective: to improve organizational measures for detection and diagnosing of tuberculous infection and tuberculosis in adolescents in the Republic of Kazakhstan.Subjects and Methods. Screening was conducted among 27,648 adolescents aged 15-17 years from regions of the Republic of Kazakhstan with a high burden of tuberculosis. It was planned to use TRA tests and fluorography in parallel, while local doctors, district and school nurses, and nurses in vaccination rooms were preliminary trained by pediatric phthisiologists to perform the test, evaluate its results and monitor manifestations of adverse events (AEs) caused by TRA test.Results. 27,648 adolescents (aged 15-17 years) were given TRA test. No adverse events were observed during TRA skin test. Latent tuberculous infection was diagnosed in 320 (1.2%) adolescents. During further examination, 10 patients were diagnosed with drug susceptible pulmonary tuberculosis with no bacillary excretion. Based on the study results, to detect LTBI and tuberculosis in adolescents, in addition to fluorography examination, it is necessary to use TRA skin test with in the groups facing a high risk of tuberculosis.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"23 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140226054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Nosocomial Venous Thromboembolic Complications in New Tuberculosis Patients and Relapses: Data from the Moscow City Registry (A Multicenter Study) 新发肺结核患者和复发患者的静脉血栓栓塞并发症发病率：来自莫斯科市登记处的数据（一项多中心研究）

Tuberculosis and Lung Diseases Pub Date : 2024-03-19 DOI: 10.58838/2075-1230-2024-102-1-12-19

D. Plotkin, A. I. Titomer, K. Lobastov, M. N. Reshetnikov, M. V. Sinitsyn, R. V. Maltsev, N. Demchenkov, A. M. Abdurakhmanov, S. Sterlikov, E. M. Bogorodskaya

{"title":"Prevalence of Nosocomial Venous Thromboembolic Complications in New Tuberculosis Patients and Relapses: Data from the Moscow City Registry (A Multicenter Study)","authors":"D. Plotkin, A. I. Titomer, K. Lobastov, M. N. Reshetnikov, M. V. Sinitsyn, R. V. Maltsev, N. Demchenkov, A. M. Abdurakhmanov, S. Sterlikov, E. M. Bogorodskaya","doi":"10.58838/2075-1230-2024-102-1-12-19","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-1-12-19","url":null,"abstract":"The objective: to evaluate VTEC in new tuberculosis patients and relapses, to determine main factors influencing its development (according to data of the patients admitted to Moscow tuberculosis hospitals)Subjects and Methods. Based on the data of epidemiological tuberculosis monitoring system of Moscow, treatment outcomes of 4609 tuberculosis patients admitted to tuberculosis hospitals from 2020 to 2022 were retrospectively analyzed. The incidence of VTEC was estimated.Results. Totally 214/4609 cases of VTEC were identified (4.6%; 95% CI 4.1-5.3%), among which the incidence of DVT made 3.5% (95% CI 3.0-4.1%), SVP 1.5% (95% CI 1.2-1.9%), and PATE 0.6% (95% CI 0.4-0.8%). The most significant risk factors of thrombotic complications in tuberculosis patients were identified, those factors included HIV infection (RR 3.8; 95% CI 2.7-4.5) and fibrous cavernous form of pulmonary tuberculosis (RR 9.1; 95% CI 4.7-17.6). The overall prevalence of VTEC in tuberculosis hospitals was 3 or more times higher than in general clinics (according to the published data).Conclusion. The data obtained indicate that patients hospitalized for pulmonary tuberculosis face a high risk of VTEC development that requires prediction and prevention.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"14 3‐4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Predictive Model of the HIV Infection Course 艾滋病毒感染过程的预测模型

Tuberculosis and Lung Diseases Pub Date : 2024-03-19 DOI: 10.58838/2075-1230-2024-102-1-6-11

E. Veselova, G. Kaminskiy, K. A. Kocharyan, A. B. Peregudova, O. V. Lovacheva, A. G. Samoylova

{"title":"A Predictive Model of the HIV Infection Course","authors":"E. Veselova, G. Kaminskiy, K. A. Kocharyan, A. B. Peregudova, O. V. Lovacheva, A. G. Samoylova","doi":"10.58838/2075-1230-2024-102-1-6-11","DOIUrl":"https://doi.org/10.58838/2075-1230-2024-102-1-6-11","url":null,"abstract":"The course of HIV infection depends on the degree of HIV suppression during ART.The objective: to evaluate feasibility of using three factors: viral load (VL), HIV reservoir and CD8 T cells before ART initiation to estimate future levels of “residual” viremia and develop a predictive model.Subjects and Methods. 74 naive patients with HIV infection were enrolled in the study. The HIV reservoir, VL and CD4, CD8 counts were tested before ART initiation and then every 6 months. The patients were followed up for 12 months. Discriminant analysis was used.Results. After 12 months of ART, 69/74 (93.2%) patients had undetectable VL including 14 patients with residual viremia (RV) and 55 in whom no virus was detected. The probability of persisting RV after 12 months of ART was assessed first by one factor – VL prior to ART, after that by three factors – VL, HIV reservoir (HIV DNA), CD8 count prior to ART. A predictive model formula was generated using those factors: D = -5.288-0.001 CD8+1.342VL+0.08 HIV DNA. With discriminant function D>0.065, the patient has a high probability of RV after 12 months of ART; with D ≤0.065, the probability of RV is low. This prognosis should be taken into account when choosing an ART regimen ensuring its maximum optimization.","PeriodicalId":37828,"journal":{"name":"Tuberculosis and Lung Diseases","volume":"60 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0