Alexander A. Ozerov, Lyudmila V. Naumenko, Alyona S. Taran, Dmitry S. Yakovlev, Alina M. Chebanko, Maria S. Pshenichnikova, Nadezhda M. Shcherbakova, G. N. Solodunova, D. Merezhkina, Александр A. Spasov
{"title":"Synthesis of new heterocyclic derivatives (benzodioxane-2-yl)methanol and their effect on rat intraocular pressure","authors":"Alexander A. Ozerov, Lyudmila V. Naumenko, Alyona S. Taran, Dmitry S. Yakovlev, Alina M. Chebanko, Maria S. Pshenichnikova, Nadezhda M. Shcherbakova, G. N. Solodunova, D. Merezhkina, Александр A. Spasov","doi":"10.19163/1994-9480-2023-20-4-127-135","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-127-135","url":null,"abstract":"Objective: Synthesis of new compounds, melatonin isosters, and study of their ability to reduce intraocular pressure. \u0000Materials and methods: Based on the previously made forecast and on the similarity with the selected compounds, the synthesis of new compounds was carried out – melatonin isosters having a 2,3-dihydro-1,4-benzodioxin cycle connected by a linker of various chemical structure with a nitrogen-containing heterocyclic core. The structure of the synthesized compounds was proved by 1H- and 13C- NMR spectroscopy, purity and individuality – by chromatographic methods. Intraocular pressure in laboratory animals was measured using a contact veterinary tonometer Tonovet (Finland). Cytotoxicity was assessed using MTT test on normal rat skin fibroblasts. \u0000Results: Derivatives (benzodioxane-2-yl)methanol reduced the level of IOP in varying degrees of severity. The VMA-22-37 compound showed the greatest activity. With topical application of a 0.4% solution, the compound reduced the intraocular pressure of intact rats by 26.6%, while not affecting the control eye. This compound also has low cytotoxicity. \u0000Conclusion: Derivatives (benzodioxane-2-yl)methanol is promising for the search for compounds capable of reducing increased intraocular pressure.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"166 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140492434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Shkarin, Andrey I. Perepelkin, O. S. Chepuryaeva
{"title":"Modern aspects of physiology of muscle contraction","authors":"V. Shkarin, Andrey I. Perepelkin, O. S. Chepuryaeva","doi":"10.19163/1994-9480-2023-20-4-10-15","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-10-15","url":null,"abstract":"A lot of works have been devoted to the physiology of muscle contraction. Since ancient times, scientists have been studying the physiological processes, structure, organization and function of the human body. After all, only by studying in detail the structure and normal physiology of a person, it is possible to separate the norm from pathology, learn to diagnose various functional pathologies and ways to restore function. Much attention is paid to the physiology of muscle contraction, since human life itself, activity, motor function is associated with the work of muscles. In different periods of the development of medicine, approaches to the study and ideas about muscle contraction, the work of human muscles were different. In our opinion, it is very promising to study the problems and features of the physiology of muscle contraction.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"75 1-2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140491794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yulia V. Lifanova, Natalia V. Eliseeva, A. Spasov, Mikhail V. Maltsev, E. B. Lavrova, Lyubov I. Bugaeva
{"title":"Influence of kappa-agonist of opioid receptors compound RU-1205 on the generative function of male rats","authors":"Yulia V. Lifanova, Natalia V. Eliseeva, A. Spasov, Mikhail V. Maltsev, E. B. Lavrova, Lyubov I. Bugaeva","doi":"10.19163/1994-9480-2023-20-4-152-156","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-152-156","url":null,"abstract":"The effect of a new kappa-opioid agonist benzimidazole derivative (compound RU-1205) on the generative function of outbred male rats was studied after oral administration for 2 months at doses of 5 mg/kg – experimentally proven therapeutic dose (TD) and 500 mg/kg (the highest dose is 100 TD). The absence of a damaging effect of the compound RU-1205 on the motivational sexual behavior of males and the processes of spermatogenesis was established.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"74 10-11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140491795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dynamics of intraocular pressure in patients with refractory glaucoma after transscleral cyclophotocoagulation in micropulse mode","authors":"A. D. Chuprov, Anna V. Fomenko","doi":"10.19163/1994-9480-2023-20-4-69-72","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-69-72","url":null,"abstract":"A retrospective analysis of IOP values was carried out in 38 patients (38 eyes) with refractory glaucoma stage III–IV after transscleral micropulse cyclophotocoagulation (mCPC) using the Cyclo G6 IRIDEX device on the next day after the procedure, after 1 month, 6, 12 and 24 months after surgery. The dynamics of IOP in the postoperative period largely depends on the initial values of the clinical parameter and does not depend on the patient’s age (p = 0.32), glaucoma stage (p = 0.46), history of antiglaucoma surgery (p = 0.34), the number of used drugs (p = 0.72). After mCPC, patients with lower baseline IOP values have a higher decrease in the indicator (-36 %) and a gradual increase by the follow-up period of 12–24 months compared with patients with high baseline IOP values.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"17 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140493217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. M. Vasiliev, Maxim A. Perfiliev, Andrey N. Kochetkov
{"title":"Neural network modeling of the dependence of RAGE inhibitory activity of chemical compounds on the energy spectrum of multiple docing","authors":"P. M. Vasiliev, Maxim A. Perfiliev, Andrey N. Kochetkov","doi":"10.19163/1994-9480-2023-20-4-157-161","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-157-161","url":null,"abstract":"Simple and multiple docking into the RAGE receptor of its known inhibitors have been carried out. For these compounds, the energies of simple docking into the specific binding site and the energy spectra of multiple docking throughout the entire volume of the RAGE receptor were calculated. A model of the dependence of the level of RAGE inhibitory activity of chemical compounds on the energy of their simple docking into the specific binding site has been constructed. A neural network model of the dependence of the level of RAGE inhibitory activity on the energy spectrum of multiple docking of chemical compounds has been formed. It is shown that the accuracy of the neural network model based on multiple docking significantly exceeds the accuracy of the model based on simple docking. The found model is used in the directed search for new compounds with RAGE inhibitory activity, which will become the basis for the creation of innovative drugs for the treatment of complications in diabetes mellitus.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140492857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vladimir V. Kondrashenko, Dmitry A. Malanin, M. V. Demeshchenko, Valentina N. Perfilova, Alexander V. Borisov
{"title":"The clinical case of the patient’s treatment with avascular necrosis of the femoral and tibiral condyles by the method of intraosseous injection of autological bone marrow aspirate concentrate","authors":"Vladimir V. Kondrashenko, Dmitry A. Malanin, M. V. Demeshchenko, Valentina N. Perfilova, Alexander V. Borisov","doi":"10.19163/1994-9480-2023-20-4-86-93","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-86-93","url":null,"abstract":"According to statistics, from 5 to 17 % of endoprothesis is performed for avascular necrosis. This article demonstrates the use of autologous bone marrow aspirate concentrate as an orthobiological material in the treatment of developed stage 2 avascular necrosis while taking glucocorticosteroids for Covid-19 applying the example of a clinical case. The patient’s complaints, the results of laboratory and instrumental investigations, the technique for performing intraosseous injection are described. The functional state of the knee joint was assessed before treatment and after 3, 6 and 12 months. The case study testifies to the effectiveness of the use of an orthobiological preparation and explains the need for further study of the presented methodic.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"5 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Vedenin, O. V. Shatalova, Andrey A. Shatalov, A. Oreshkin, Alexander S. Nazaruk
{"title":"Correlation analysis of clinical and laboratory markers in COVID-19 and acute cerebrovascular accident","authors":"Y. Vedenin, O. V. Shatalova, Andrey A. Shatalov, A. Oreshkin, Alexander S. Nazaruk","doi":"10.19163/1994-9480-2023-20-4-136-141","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-136-141","url":null,"abstract":"Coagulopathies developing with COVID-19 are a serious problem. Increased fibrinogen levels, activation of coagulation, a direct damaging effect of the virus on the endothelium, and increased interaction of the platelet with the vascular endothelium play an important role in the development of thrombotic complications and the occurrence of acute cerebral circulatory disorders. Case histories of COVID-19 patients and those with secondary CHF were analysed. Among the biochemical blood parameters in COVID-19, an increased level of D-dimer, which reflects the severity of the course of coronavirus infection, as well as CRP and ferritin were revealed more frequently. \u0000Results: Among biochemical blood parameters in COVID-19, an increase in D-dimer level, which reflects the severity of the course of coronavirus infection, as well as CRP and ferritin, is more frequently detected. In correlation analysis, a positive correlation was observed between the level of ferritin, CRP and stage of CT as well as between the level of D-dimer and the number of platelets","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"9 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the electromyographic study of masticatory muscles using kinesiotape in patients with bruxism","authors":"M. V. Vologina, Ksenia A. Kiba","doi":"10.19163/1994-9480-2023-20-4-54-57","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-54-57","url":null,"abstract":"In this paper, an analysis of the electromyographic study of masticatory muscles before taping and after the use of kinesiotapes in patients with bruxism was carried out.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Sychev, N. P. Denisenko, A. Kachanova, A. Lapshtaeva, S. P. Abdullaev, L. N. Goncharova, K. Mirzaev, D. Sychev
{"title":"Pharmacogenetic predictors associated with reduced risk of secondary to enalapril cough","authors":"I. Sychev, N. P. Denisenko, A. Kachanova, A. Lapshtaeva, S. P. Abdullaev, L. N. Goncharova, K. Mirzaev, D. Sychev","doi":"10.19163/1994-9480-2023-20-4-109-116","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-109-116","url":null,"abstract":"Currently, the wide prevalence of the development of secondary to ACEIs cough (3.8 to 48 % based on different findings) is one of the core causes of the dramatic impairment of the patients’ quality of life, followed by drug discontinuation. The study had the purpose of revealing the pharmacogenetic predictors associated with the reduced risk of the dry cough AEs secondary to ACEIs, in particular enalapril. The study involved 217 patients with the diagnosis of \"essential arterial hypertension\", who took enalapril. The patients were assigned to 2 groups: Group 1 (study group): 104 patients without secondary to enalapril adverse drug reactions; and Group 2 (control group): 113 patients with secondary to enalapril cough. All the patients underwent pharmacogenetic testing. The analysis of the distribution of frequencies of the polymorphisms rs4149056 of gene SLCO1B1, rs4459610 of gene ACE, rs1799722 of gene BDKRB2, and rs62151109 of gene CLASP1 has revealed no differences between the group without adverse drug reactions and that with secondary to enalapril dry cough. The study has revealed a statistically significant association between the absence of adverse drug reactions and the presence of the genotype AG of gene SLCO1B1 rs2306283, genotype GG of gene ABO rs8176746 and rs495828.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"11 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dynamics of parameters of human cardiovascular and respiratory systems under the influence of speleoclimat","authors":"V. Semiletova, Egor A. Kardashov","doi":"10.19163/1994-9480-2023-20-4-64-68","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-64-68","url":null,"abstract":"Speleotherapy uses the conditions of salt mines and caves to treat diseases of the skin and respiratory systems, to restore patients after illnesses, to maintain health, and stimulate the immune system. The purpose of this study is to study the dynamics of the parameters of the cardiovascular and respiratory systems of a person under the influence of speleoclimate. The study involved studens of 1–2 courses of the Voronezh State Medical University. N.N. Burdenko. Every day for 10 days of speleotherapy after the end of speleotherapy, blood pressure, pulse, oxygen saturation, respiratory rate, and lung capacity were measured. The analysis of the obtained data was carried out using Excel and StatPlus Pro programs. It was revealed that human adaptation to the speleoclimate occurs both due to the frequency and strength of the heart contraction. The dynamics of the parameters of the respiratory system under the influence of speleoclimate reflects the adaptation of the study participants to the speleoclimate mainly due to the depth of breathing, to a lesser extent – due to the frequency of breathing. Mobilization of adaptive resources and the state of tension of the cardiovascular and respiratory systems during the development of the anxiety stage under the influence of speleoclimate is formed mainly due to intersystem mechanisms. Tension in the cardiovascular system persists after the 10th speleo procedure. It is shown that the speleoclimate has the ability to restore the vegetative status of a person. Differences in the dynamics of breathing parameters in girls and boys under the influence of speleoclimate were revealed.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"3 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}