Journal of Volgograd State Medical University最新文献

Synthesis of new heterocyclic derivatives (benzodioxane-2-yl)methanol and their effect on rat intraocular pressure 新杂环衍生物（苯并二恶烷-2-基）甲醇的合成及其对大鼠眼压的影响

Journal of Volgograd State Medical University Pub Date : 2024-01-27 DOI: 10.19163/1994-9480-2023-20-4-127-135

Alexander A. Ozerov, Lyudmila V. Naumenko, Alyona S. Taran, Dmitry S. Yakovlev, Alina M. Chebanko, Maria S. Pshenichnikova, Nadezhda M. Shcherbakova, G. N. Solodunova, D. Merezhkina, Александр A. Spasov

{"title":"Synthesis of new heterocyclic derivatives (benzodioxane-2-yl)methanol and their effect on rat intraocular pressure","authors":"Alexander A. Ozerov, Lyudmila V. Naumenko, Alyona S. Taran, Dmitry S. Yakovlev, Alina M. Chebanko, Maria S. Pshenichnikova, Nadezhda M. Shcherbakova, G. N. Solodunova, D. Merezhkina, Александр A. Spasov","doi":"10.19163/1994-9480-2023-20-4-127-135","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-127-135","url":null,"abstract":"Objective: Synthesis of new compounds, melatonin isosters, and study of their ability to reduce intraocular pressure. \u0000Materials and methods: Based on the previously made forecast and on the similarity with the selected compounds, the synthesis of new compounds was carried out – melatonin isosters having a 2,3-dihydro-1,4-benzodioxin cycle connected by a linker of various chemical structure with a nitrogen-containing heterocyclic core. The structure of the synthesized compounds was proved by 1H- and 13C- NMR spectroscopy, purity and individuality – by chromatographic methods. Intraocular pressure in laboratory animals was measured using a contact veterinary tonometer Tonovet (Finland). Cytotoxicity was assessed using MTT test on normal rat skin fibroblasts. \u0000Results: Derivatives (benzodioxane-2-yl)methanol reduced the level of IOP in varying degrees of severity. The VMA-22-37 compound showed the greatest activity. With topical application of a 0.4% solution, the compound reduced the intraocular pressure of intact rats by 26.6%, while not affecting the control eye. This compound also has low cytotoxicity. \u0000Conclusion: Derivatives (benzodioxane-2-yl)methanol is promising for the search for compounds capable of reducing increased intraocular pressure.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"166 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140492434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modern aspects of physiology of muscle contraction 肌肉收缩生理学的现代方面

Journal of Volgograd State Medical University Pub Date : 2024-01-27 DOI: 10.19163/1994-9480-2023-20-4-10-15

V. Shkarin, Andrey I. Perepelkin, O. S. Chepuryaeva

引用次数: 0

Influence of kappa-agonist of opioid receptors compound RU-1205 on the generative function of male rats 阿片受体卡巴激动剂化合物 RU-1205 对雄性大鼠生殖功能的影响

Journal of Volgograd State Medical University Pub Date : 2024-01-27 DOI: 10.19163/1994-9480-2023-20-4-152-156

Yulia V. Lifanova, Natalia V. Eliseeva, A. Spasov, Mikhail V. Maltsev, E. B. Lavrova, Lyubov I. Bugaeva

引用次数: 0

Dynamics of intraocular pressure in patients with refractory glaucoma after transscleral cyclophotocoagulation in micropulse mode 微脉冲模式下经巩膜环形光凝术后难治性青光眼患者眼压的动态变化

Journal of Volgograd State Medical University Pub Date : 2024-01-27 DOI: 10.19163/1994-9480-2023-20-4-69-72

A. D. Chuprov, Anna V. Fomenko

引用次数: 0

Neural network modeling of the dependence of RAGE inhibitory activity of chemical compounds on the energy spectrum of multiple docing 化學化合物的 RAGE 抑制活性依賴於多個 docing 能譜的神經網絡模型

Journal of Volgograd State Medical University Pub Date : 2024-01-27 DOI: 10.19163/1994-9480-2023-20-4-157-161

P. M. Vasiliev, Maxim A. Perfiliev, Andrey N. Kochetkov

引用次数: 0

The clinical case of the patient’s treatment with avascular necrosis of the femoral and tibiral condyles by the method of intraosseous injection of autological bone marrow aspirate concentrate 采用自体骨髓抽吸物浓缩液骨内注射法治疗股骨髁和胫骨髁无血管坏死的临床病例

Journal of Volgograd State Medical University Pub Date : 2024-01-27 DOI: 10.19163/1994-9480-2023-20-4-86-93

Vladimir V. Kondrashenko, Dmitry A. Malanin, M. V. Demeshchenko, Valentina N. Perfilova, Alexander V. Borisov

引用次数: 0

Correlation analysis of clinical and laboratory markers in COVID-19 and acute cerebrovascular accident COVID-19 与急性脑血管意外中临床和实验室指标的相关性分析

Journal of Volgograd State Medical University Pub Date : 2024-01-27 DOI: 10.19163/1994-9480-2023-20-4-136-141

Y. Vedenin, O. V. Shatalova, Andrey A. Shatalov, A. Oreshkin, Alexander S. Nazaruk

{"title":"Correlation analysis of clinical and laboratory markers in COVID-19 and acute cerebrovascular accident","authors":"Y. Vedenin, O. V. Shatalova, Andrey A. Shatalov, A. Oreshkin, Alexander S. Nazaruk","doi":"10.19163/1994-9480-2023-20-4-136-141","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-136-141","url":null,"abstract":"Coagulopathies developing with COVID-19 are a serious problem. Increased fibrinogen levels, activation of coagulation, a direct damaging effect of the virus on the endothelium, and increased interaction of the platelet with the vascular endothelium play an important role in the development of thrombotic complications and the occurrence of acute cerebral circulatory disorders. Case histories of COVID-19 patients and those with secondary CHF were analysed. Among the biochemical blood parameters in COVID-19, an increased level of D-dimer, which reflects the severity of the course of coronavirus infection, as well as CRP and ferritin were revealed more frequently. \u0000Results: Among biochemical blood parameters in COVID-19, an increase in D-dimer level, which reflects the severity of the course of coronavirus infection, as well as CRP and ferritin, is more frequently detected. In correlation analysis, a positive correlation was observed between the level of ferritin, CRP and stage of CT as well as between the level of D-dimer and the number of platelets","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"9 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the electromyographic study of masticatory muscles using kinesiotape in patients with bruxism 利用运动带对磨牙症患者咀嚼肌进行肌电图研究的评估

Journal of Volgograd State Medical University Pub Date : 2024-01-27 DOI: 10.19163/1994-9480-2023-20-4-54-57

M. V. Vologina, Ksenia A. Kiba

引用次数: 0

Pharmacogenetic predictors associated with reduced risk of secondary to enalapril cough 与依那普利咳嗽继发风险降低相关的药物遗传学预测因素

Journal of Volgograd State Medical University Pub Date : 2024-01-27 DOI: 10.19163/1994-9480-2023-20-4-109-116

I. Sychev, N. P. Denisenko, A. Kachanova, A. Lapshtaeva, S. P. Abdullaev, L. N. Goncharova, K. Mirzaev, D. Sychev

{"title":"Pharmacogenetic predictors associated with reduced risk of secondary to enalapril cough","authors":"I. Sychev, N. P. Denisenko, A. Kachanova, A. Lapshtaeva, S. P. Abdullaev, L. N. Goncharova, K. Mirzaev, D. Sychev","doi":"10.19163/1994-9480-2023-20-4-109-116","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-109-116","url":null,"abstract":"Currently, the wide prevalence of the development of secondary to ACEIs cough (3.8 to 48 % based on different findings) is one of the core causes of the dramatic impairment of the patients’ quality of life, followed by drug discontinuation. The study had the purpose of revealing the pharmacogenetic predictors associated with the reduced risk of the dry cough AEs secondary to ACEIs, in particular enalapril. The study involved 217 patients with the diagnosis of \"essential arterial hypertension\", who took enalapril. The patients were assigned to 2 groups: Group 1 (study group): 104 patients without secondary to enalapril adverse drug reactions; and Group 2 (control group): 113 patients with secondary to enalapril cough. All the patients underwent pharmacogenetic testing. The analysis of the distribution of frequencies of the polymorphisms rs4149056 of gene SLCO1B1, rs4459610 of gene ACE, rs1799722 of gene BDKRB2, and rs62151109 of gene CLASP1 has revealed no differences between the group without adverse drug reactions and that with secondary to enalapril dry cough. The study has revealed a statistically significant association between the absence of adverse drug reactions and the presence of the genotype AG of gene SLCO1B1 rs2306283, genotype GG of gene ABO rs8176746 and rs495828.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"11 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics of parameters of human cardiovascular and respiratory systems under the influence of speleoclimat 岩洞气候影响下人类心血管和呼吸系统参数的动态变化

Journal of Volgograd State Medical University Pub Date : 2024-01-27 DOI: 10.19163/1994-9480-2023-20-4-64-68

V. Semiletova, Egor A. Kardashov

{"title":"Dynamics of parameters of human cardiovascular and respiratory systems under the influence of speleoclimat","authors":"V. Semiletova, Egor A. Kardashov","doi":"10.19163/1994-9480-2023-20-4-64-68","DOIUrl":"https://doi.org/10.19163/1994-9480-2023-20-4-64-68","url":null,"abstract":"Speleotherapy uses the conditions of salt mines and caves to treat diseases of the skin and respiratory systems, to restore patients after illnesses, to maintain health, and stimulate the immune system. The purpose of this study is to study the dynamics of the parameters of the cardiovascular and respiratory systems of a person under the influence of speleoclimate. The study involved studens of 1–2 courses of the Voronezh State Medical University. N.N. Burdenko. Every day for 10 days of speleotherapy after the end of speleotherapy, blood pressure, pulse, oxygen saturation, respiratory rate, and lung capacity were measured. The analysis of the obtained data was carried out using Excel and StatPlus Pro programs. It was revealed that human adaptation to the speleoclimate occurs both due to the frequency and strength of the heart contraction. The dynamics of the parameters of the respiratory system under the influence of speleoclimate reflects the adaptation of the study participants to the speleoclimate mainly due to the depth of breathing, to a lesser extent – due to the frequency of breathing. Mobilization of adaptive resources and the state of tension of the cardiovascular and respiratory systems during the development of the anxiety stage under the influence of speleoclimate is formed mainly due to intersystem mechanisms. Tension in the cardiovascular system persists after the 10th speleo procedure. It is shown that the speleoclimate has the ability to restore the vegetative status of a person. Differences in the dynamics of breathing parameters in girls and boys under the influence of speleoclimate were revealed.","PeriodicalId":377653,"journal":{"name":"Journal of Volgograd State Medical University","volume":"3 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0