Yulia V. Lifanova, Natalia V. Eliseeva, A. Spasov, Mikhail V. Maltsev, E. B. Lavrova, Lyubov I. Bugaeva
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Influence of kappa-agonist of opioid receptors compound RU-1205 on the generative function of male rats
The effect of a new kappa-opioid agonist benzimidazole derivative (compound RU-1205) on the generative function of outbred male rats was studied after oral administration for 2 months at doses of 5 mg/kg – experimentally proven therapeutic dose (TD) and 500 mg/kg (the highest dose is 100 TD). The absence of a damaging effect of the compound RU-1205 on the motivational sexual behavior of males and the processes of spermatogenesis was established.
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