Retina (Philadelphia, Pa.)最新文献_第7页

CHOROIDAL AMYLOID DEPOSITION: A Multicenter Study of Amyloid Lesions Identified in Late Indocyanine Green Angiography. 脉络膜淀粉样蛋白沉积:晚期吲哚菁绿血管造影发现的淀粉样蛋白病变的多中心研究。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000003551

Fukutaro Mano, Yoshihiro Yonekawa, Shinji Kakihara, Jorge Fortun, Enrico Borrelli, Francesco Bandello, Toshinori Murata, Shunji Kusaka, Angela Dispenzieri, Jose S Pulido

{"title":"CHOROIDAL AMYLOID DEPOSITION: A Multicenter Study of Amyloid Lesions Identified in Late Indocyanine Green Angiography.","authors":"Fukutaro Mano, Yoshihiro Yonekawa, Shinji Kakihara, Jorge Fortun, Enrico Borrelli, Francesco Bandello, Toshinori Murata, Shunji Kusaka, Angela Dispenzieri, Jose S Pulido","doi":"10.1097/IAE.0000000000003551","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003551","url":null,"abstract":"Purpose: To characterize choroidal amyloid angiopathy (CAA) using late-phase indocyanine green angiography (ICGA).Methods: This was a multicenter retrospective observational case series on patients with transthyretin (ATTR) and AL amyloidosis who underwent ICGA. The timing of hyperfluorescence and longitudinal changes were analyzed.Results: Thirty-two patients (27 with ATTR and 5 with AL) with mean age of 58.9 ± 17.4 years were included. Hyperfluorescent spots in the very late phases of ICGA, corresponding to CAA, were observed in 49 of 55 eyes (89%). The median time to maximal staining was 672 (95% confidence interval, 644-752) seconds, which was significantly later than the initial staining (503 [95% confidence interval, 447-521], P < 0.0001; Wilcoxon signed rank test). In seven patients with ATTR amyloidosis who underwent follow-up of ICGA, the CAA was stable in two patients and improved in five patients during treatment. However, 3 patients (43%) had worsening vitreous opacities in both eyes, and 4 patients (57%) developed secondary open-angle glaucoma.Conclusion: Most patients with amyloidosis were found to have CAA on ICGA. Up to 12.5 minutes is required for maximal ICG staining. Choroidal amyloid angiopathy improved in most patients with systemic treatment and may serve as a marker of systemic disease status.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1989-1994"},"PeriodicalIF":3.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40373981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

LRP5 BIALLELIC MUTATIONS CAUSE A HIGHER INCIDENCE OF SEVERE PHENOTYPE COMPARED WITH LRP5 MONOALLELIC MUTATION. 与Lrp5单等位基因突变相比，Lrp5双等位基因突变导致严重表型的发生率更高。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/IAE.0000000000003543

Chunli Chen, Xiang Zhang, Xiaoyan Peng, Feng Hu, Yizhe Cheng, Peiquan Zhao

{"title":"LRP5 BIALLELIC MUTATIONS CAUSE A HIGHER INCIDENCE OF SEVERE PHENOTYPE COMPARED WITH LRP5 MONOALLELIC MUTATION.","authors":"Chunli Chen, Xiang Zhang, Xiaoyan Peng, Feng Hu, Yizhe Cheng, Peiquan Zhao","doi":"10.1097/IAE.0000000000003543","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003543","url":null,"abstract":"Purpose: To analyze the clinical features of LRP5 gene mutation-related familial exudative vitreoretinopathy and explore the potential phenotype-genotype correlation on LRP5 gene.Methods: Eighty-seven familial exudative vitreoretinopathy (FEVR) families with LRP5 mutations were selected from 722 FEVR patients, which were divided into 2 groups, including 22 autosomal-recessive FEVR (ar-FEVR) families and 65 autosomal-dominant FEVR (ad-FEVR) families. Clinical and genetic data were retrospectively analyzed. The potential phenotype-genotype correlation was explored from the mutation type and inheritance pattern.Results: No significant difference between the LRP5 null mutation subgroup and the LRP5 missense mutation subgroup was observed in the proportion of FEVR stage and the ratio of ocular involvement. Instead, a significant difference between the LRP5 ar-FEVR subgroup and the LRP5 ad-FEVR subgroup was observed in the proportion of FEVR stage and the ratio of binocularly severe phenotype. The probands with LRP5 gene recessive mutation showed a higher incidence of severe phenotype. Moreover, the ratio of binocularly severe patients in ar-FEVR was nearly 3.5 times higher than that in ad-FEVR.Conclusion: The severity of phenotype was more likely to be related to the synergistic effect of the variants.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1958-1964"},"PeriodicalIF":3.3,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33440433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Intrascleral Fixation of Implantable Polypropylene Capsular Hook(s) to Reconstruct Capsular Support for Out-of-the-Bag Intraocular Lens Fixation in Vitrectomized Eyes. 玻璃体切除眼囊外人工晶状体固定中可植入式聚丙烯囊内钩囊内固定重建囊内支撑。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-09-01 DOI: 10.1097/IAE.0000000000002554

Haiying Jin, Qi Zhang, Peiquan Zhao, Jiao Lyv

引用次数: 2

RETINAL THICKNESS AND FOVEAL HYPOPLASIA IN ADULTS BORN PRETERM WITH AND WITHOUT RETINOPATHY OF PREMATURITY: The Gutenberg Prematurity Eye Study. 伴有或不伴有早产儿视网膜病变的早产儿视网膜厚度和中央凹发育不全:古腾堡早产儿眼研究。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-09-01 DOI: 10.1097/IAE.0000000000003501

Achim Fieß, Anna Pfisterer, Sandra Gißler, Christina Korb, Eva Mildenberger, Michael S Urschitz, Fred Zepp, Bernhard Stoffelns, Norbert Pfeiffer, Alexander K Schuster

{"title":"RETINAL THICKNESS AND FOVEAL HYPOPLASIA IN ADULTS BORN PRETERM WITH AND WITHOUT RETINOPATHY OF PREMATURITY: The Gutenberg Prematurity Eye Study.","authors":"Achim Fieß, Anna Pfisterer, Sandra Gißler, Christina Korb, Eva Mildenberger, Michael S Urschitz, Fred Zepp, Bernhard Stoffelns, Norbert Pfeiffer, Alexander K Schuster","doi":"10.1097/IAE.0000000000003501","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003501","url":null,"abstract":"Purpose: This study analyses whether prematurity, retinopathy of prematurity (ROP), and associated factors lead to altered foveal shape in adulthood and whether these alterations are associated with visual acuity.Methods: The Gutenberg Prematurity Eye Study is a German cohort study with a prospective ophthalmologic examination (participants aged 18-52 years) of individuals born preterm and full-term that were examined with spectral domain optical coherence tomography. Participants were grouped according to gestational age (GA) and postnatal ROP status. Multivariable linear regression analyses for foveolar retinal thickness, foveal hypoplasia, and posterior vitreous status were performed.Results: A total of 755 eyes of 414 preterm and full-term individuals were included (aged 28.6 ± 8.6 years, 233 female individuals). Central foveal retinal thickness increased as GA decreased. The prevalence of foveal hypoplasia was 2% (control group), 9% (GA 33-36), 18% (GA 29-32), 48% (GA ≤28), 50% (ROP without treatment), and 82% of eyes (with ROP requiring treatment). In multivariable analyses, central foveal thickness was independently associated with GA and advanced stages of ROP requiring treatment while foveal hypoplasia was only associated with GA. Posterior vitreous was more frequently visible as partially detached in full-term than in preterm individuals. Lower distant-corrected visual acuity correlated with increased foveolar thickness (rho = 0.08; P = 0.03) and with foveal hypoplasia (rho = 0.15, P < 0.001).Conclusion: Our findings indicate that there are fetal origins affecting foveal shape, resulting in foveal hypoplasia potentially affecting the visual acuity in adulthood.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1716-1728"},"PeriodicalIF":3.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40434775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Anterior Chamber Fluid-Gas Exchange. 前房液气交换。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-09-01 DOI: 10.1097/IAE.0000000000002548

Kotaro Tsuboi, Motohiro Kamei

引用次数: 0

Management of Dislocated Crystalline Lens With Vitrectomy, Perfluorocarbon Liquid, and Phacoemulsification, Combined With Modified Capsular Tension Ring and in-the-Bag Intraocular Lens Implantation. 玻璃体切除、全氟碳液、超声乳化联合改良荚膜张力环及袋式人工晶状体植入术治疗晶状体脱位。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-09-01 DOI: 10.1097/IAE.0000000000002536

Yuan Zong, Kaicheng Wu, Guohua Deng, Wangyi Fang, Jian Yu, Chunhui Jiang, Haohao Zhu, Gezhi Xu

引用次数: 3

VALIDATION OF AN AUTOMATED FLUID ALGORITHM ON REAL-WORLD DATA OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION OVER FIVE YEARS. 五年来新生血管性年龄相关性黄斑变性真实数据的自动流体算法验证。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-09-01 DOI: 10.1097/IAE.0000000000003557

Bianca S Gerendas, Amir Sadeghipour, Martin Michl, Felix Goldbach, Georgios Mylonas, Anastasiia Gruber, Thomas Alten, Oliver Leingang, Stefan Sacu, Hrvoje Bogunovic, Ursula Schmidt-Erfurth

{"title":"VALIDATION OF AN AUTOMATED FLUID ALGORITHM ON REAL-WORLD DATA OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION OVER FIVE YEARS.","authors":"Bianca S Gerendas, Amir Sadeghipour, Martin Michl, Felix Goldbach, Georgios Mylonas, Anastasiia Gruber, Thomas Alten, Oliver Leingang, Stefan Sacu, Hrvoje Bogunovic, Ursula Schmidt-Erfurth","doi":"10.1097/IAE.0000000000003557","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003557","url":null,"abstract":"Background/purpose: To apply an automated deep learning automated fluid algorithm on data from real-world management of patients with neovascular age-related macular degeneration for quantification of intraretinal/subretinal fluid volumes in optical coherence tomography images.Methods: Data from the Vienna Imaging Biomarker Eye Study (VIBES, 2007-2018) were analyzed. Databases were filtered for treatment-naive neovascular age-related macular degeneration with a baseline optical coherence tomography and at least one follow-up and 1,127 eyes included. Visual acuity and optical coherence tomography at baseline, Months 1 to 3/Years 1 to 5, age, sex, and treatment number were included. Artificial intelligence and certified manual grading were compared in a subanalysis of 20%. Main outcome measures were fluid volumes.Results: Intraretinal/subretinal fluid volumes were maximum at baseline (intraretinal fluid: 21.5/76.6/107.1 nL; subretinal fluid 13.7/86/262.5 nL in the 1/3/6-mm area). Intraretinal fluid decreased to 5 nL at M1-M3 (1-mm) and increased to 11 nL (Y1) and 16 nL (Y5). Subretinal fluid decreased to a mean of 4 nL at M1-M3 (1-mm) and remained stable below 7 nL until Y5. Intraretinal fluid was the only variable that reflected VA change over time. Comparison with human expert readings confirmed an area under the curve of >0.9.Conclusion: The Vienna Fluid Monitor can precisely quantify fluid volumes in optical coherence tomography images from clinical routine over 5 years. Automated tools will introduce precision medicine based on fluid guidance into real-world management of exudative disease, improving clinical outcomes while saving resources.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1673-1682"},"PeriodicalIF":3.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40434774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

High-Resolution Spectral Domain Optical Coherence Tomography of Congenital Grouped Albinotic Spots. 先天性成组白化斑的高分辨率光谱域光学相干断层扫描。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-09-01 DOI: 10.1097/IAE.0000000000003552

Prithvi Ramtohul, Diogo Cabral, Christine A Curcio, K Bailey Freund

引用次数: 1

A Novel Technique of Internal Scleral Fixation of Posteriorly Dislocated Intraocular Lens. 一种后侧脱位人工晶状体巩膜内固定新技术。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-09-01 DOI: 10.1097/IAE.0000000000002529

Madhu Kumar Rajanna, Vinaya Kumar Konana, Ashok Kanakamedla, Pradeep Sagar, Jayamadhury Gudimetla

引用次数: 1

ANOMALIES OF CHOROIDAL VENOUS STRUCTURE IN HIGHLY MYOPIC EYES. 高度近视眼脉络膜静脉结构异常。

IF 3.3

Retina (Philadelphia, Pa.) Pub Date : 2022-09-01 DOI: 10.1097/IAE.0000000000003529

Hongshuang Lu, Ran Du, Shiqi Xie, Jianping Xiong, Changyu Chen, Muka Moriyama, Tae Igarashi-Yokoi, Hiroyuki Takahashi, Koju Kamoi, Kengo Uramoto, Noriko Nakao, Kyoko Ohno-Matsui

{"title":"ANOMALIES OF CHOROIDAL VENOUS STRUCTURE IN HIGHLY MYOPIC EYES.","authors":"Hongshuang Lu, Ran Du, Shiqi Xie, Jianping Xiong, Changyu Chen, Muka Moriyama, Tae Igarashi-Yokoi, Hiroyuki Takahashi, Koju Kamoi, Kengo Uramoto, Noriko Nakao, Kyoko Ohno-Matsui","doi":"10.1097/IAE.0000000000003529","DOIUrl":"https://doi.org/10.1097/IAE.0000000000003529","url":null,"abstract":"Purpose: To identify anomalies of choroidal venous structure in highly myopic (HM) eyes.Methods: Widefield indocyanine green angiographic images of 175 HM eyes (refractive error ≤ -6.0D diopters or axial length >26.5 mm) and 100 control eyes taken between January 2014 and December 2018 were reviewed.Results: There were no significant differences in age and gender between HM patients and controls. Three types of changes of large choroidal veins were found in 103 HM eyes (58.86%): Asymmetry of vortex veins in 44 eyes (25.14%), isolated long vein across the macula in 58 eyes (33.14%), and intervortex anastomoses in 25 eyes (14.29%). Similar changes in controls were found in 12 eyes (12%), 0 eye (0%), and 2 eyes (2%), respectively, which were significantly lower than those in the HM group (all P < 0.05). The patterns of asymmetry were affected by steeper staphyloma edges and anastomoses were observed through large trunks and terminal venules. In two eyes with large trunk anastomosis, attenuation of the less dominant vortex vein was observed afterward.Conclusion: Choroidal venous anomalies are more common in HM eyes than controls. Choroidal venous structure in HM eyes may be altering continuously, and such changes may underlie the development of myopic maculopathy.","PeriodicalId":377573,"journal":{"name":"Retina (Philadelphia, Pa.)","volume":" ","pages":"1655-1664"},"PeriodicalIF":3.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40434302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3