Indian Journal of Transplantation最新文献_第8页

Apolipoprotein L1 Genetic Testing in Prospective Kidney Donors: Have We Reached a Breakthrough or an Impasse? 潜在肾供者的载脂蛋白L1基因检测:我们是取得了突破还是陷入了僵局?

Indian Journal of Transplantation Pub Date : 2023-01-01 DOI: 10.4103/ijot.ijot_66_23

Subashri Mohanasundaram, M. Edwin Fernando

{"title":"Apolipoprotein L1 Genetic Testing in Prospective Kidney Donors: Have We Reached a Breakthrough or an Impasse?","authors":"Subashri Mohanasundaram, M. Edwin Fernando","doi":"10.4103/ijot.ijot_66_23","DOIUrl":"https://doi.org/10.4103/ijot.ijot_66_23","url":null,"abstract":"Export Molecular testing, including apolipoprotein L1 (APOL1) sequencing, has recently become more accessible for use in the clinical setting. Although there is a strong association between APOL1 and kidney disease, only a small minority of African American kidney disease patients are estimated to have an APOL1 high-risk genotype. In addition, the lifetime risk for developing kidney disease among individuals with two risk alleles is estimated to be very low. The low prevalence suggests that it follows a two-hit model, where a secondary factor, such as environmental or genomic modifiers, is required to develop kidney disease. We still have a limited appreciation of factors that can act as a “second hit,” and it is unclear whether the hyperfiltration that follows donor nephrectomy constitutes as a “second hit” for the disease. One does not yet know the burden of APOL1 risk alleles among prospective living donors. Now that APOL1 genetic testing is available, and in the absence of prospective data, the role of APOL1 genotyping in live kidney donor candidate selection remains uncertain. There are several ethical issues concerning the use of genetic testing to determine donor eligibility, which can impact the development of policy around APOL1 genetic testing, release of results, and counseling.","PeriodicalId":37455,"journal":{"name":"Indian Journal of Transplantation","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graft-derived Cell-free DNA as a Rejection Biomarker and a Monitoring Tool for Immunosuppression in Liver Transplantation 移植物来源的无细胞DNA作为肝移植排斥生物标志物和免疫抑制监测工具

Indian Journal of Transplantation Pub Date : 2023-01-01 DOI: 10.4103/ijot.ijot_56_23

V. U. Lakshmi, Dinesh Balakrishnan, Manzoor Koyakutty, M. P. Narmadha

{"title":"Graft-derived Cell-free DNA as a Rejection Biomarker and a Monitoring Tool for Immunosuppression in Liver Transplantation","authors":"V. U. Lakshmi, Dinesh Balakrishnan, Manzoor Koyakutty, M. P. Narmadha","doi":"10.4103/ijot.ijot_56_23","DOIUrl":"https://doi.org/10.4103/ijot.ijot_56_23","url":null,"abstract":"Export Graft-derived cell-free DNA (gd-cfDNA) can be referred to as short fragments of DNA originating from the necrosis or apoptosis of allograft cells, released into the blood. Circulating free DNA, or cell-free DNA, is a pioneering biomarker with various potentials in medical diagnosis, including the early detection of prenatal birth defects in pregnancy, cancer, and its recurrence, and allograft dysfunction in various types of transplantation. Gd-cfDNA has a short half-life (<1.5 h), and this helps detect graft injury promptly. The quantity of gd-cfDNA depends on the size of the grafted organ as well as its integrity. The principles for differentiating the donor-derived cfDNA from the recipient-derived one include a selection of single-nucleotide polymorphism, then targeted amplification and sequencing of the cfDNA in the sample. Then, the heterozygous genome in the recipient’s sample is analyzed statistically and the level of dd-cfDNA is estimated. In liver transplantation, it can be applied to detect common complications such as acute rejection, personalize the immunosuppression doses according to the patient’s condition, and diagnose infections associated with the transplantation. In this narrative review, we spotlight the relevance of gd-cfDNA in liver transplant, the methods used to quantify it, different types of rejections, the exclusion criteria for gd-cfDNA, and its future perspectives.","PeriodicalId":37455,"journal":{"name":"Indian Journal of Transplantation","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating Parvovirus Triggered Refractory Hemolytic Anemia with Rituximab in Renal Transplant Recipients - A Report of Two Cases. 用利妥昔单抗治疗肾移植受者帕罗病毒引发的难治性溶血性贫血--两个病例的报告。

IF 0.2

Indian Journal of Transplantation Pub Date : 2023-01-01 DOI: 10.4103/ijot.ijot_34_22

Chilaka Rajesh, Utkarsh Mishra, Anna Valsan, Elenjickal Elias John, Jeethu Joseph Eapen, Athul Thomas, Sabina Yusuf, Suceena Alexander, Vinoi George David, Santosh Varughese

{"title":"Treating Parvovirus Triggered Refractory Hemolytic Anemia with Rituximab in Renal Transplant Recipients - A Report of Two Cases.","authors":"Chilaka Rajesh, Utkarsh Mishra, Anna Valsan, Elenjickal Elias John, Jeethu Joseph Eapen, Athul Thomas, Sabina Yusuf, Suceena Alexander, Vinoi George David, Santosh Varughese","doi":"10.4103/ijot.ijot_34_22","DOIUrl":"10.4103/ijot.ijot_34_22","url":null,"abstract":"<p><p>Parvovirus B19 is a small (26 nm), nonenveloped, single-stranded DNA (5.6-kb) virus. The only known host for parvovirus B19 is humans. Parvovirus B19 is directly cytotoxic to erythroid precursor cells of the colony- and burst-forming units. Human parvovirus B19 is the etiologic agent of erythema infectiosum and chronic pure red cell aplasia in immunocompromised individuals. Acute parvovirus B19 infection should be suspected in immunocompromised patients, who present with reticulocytopenic hemolytic anemia and thrombocytopenia. Intravenous immunoglobulin (IVIg) is the standard treatment for parvovirus-induced cytopenias. We report two cases of postrenal transplant who presented with reticulocytopenic anemia and were found to have parvovirus infection. They did not respond to conventional treatment with intravenous gamma globulin. Both patients were treated with rituximab with which they had improvement in clinical and hematological parameters. There was no previous documentation of using rituximab in the treatment of parvovirus-triggered autoimmune hemolytic anemia postrenal transplant patients. This article illustrates how rituximab will be helpful in this setting, of course, it is a new thought but requires further studies and validation.</p>","PeriodicalId":37455,"journal":{"name":"Indian Journal of Transplantation","volume":"1 1","pages":"139-142"},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70754990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curbing proteastasis to combat antibody-mediated rejection post lung transplant 抑制蛋白酶转移对抗肺移植后抗体介导的排斥反应

IF 0.3

Indian Journal of Transplantation Pub Date : 2023-01-01 DOI: 10.4103/ijot.ijot_33_21

N. Sharma, Dhruva Sharma, K. Subramaniam

引用次数: 0

Spectrum of infections in renal transplant recipients, factors affecting long term patient and graft outcomes over 10 years including COVID pandemic periods 肾移植受者感染谱、10年内包括COVID大流行期间影响长期患者和移植结果的因素

IF 0.3

Indian Journal of Transplantation Pub Date : 2023-01-01 DOI: 10.4103/ijot.ijot_128_21

Abhisek Gautam, H. Mahapatra, N. Kaur, L. Pursnani, B. Muthukumar, Amandeep Singh, S. Patil, M. Prabhakaran

引用次数: 0

Knowledge and Attitude of Health-Care Professionals toward Organ Donation in Bahrain 巴林卫生保健专业人员对器官捐献的知识和态度

IF 0.3

Indian Journal of Transplantation Pub Date : 2023-01-01 DOI: 10.4103/ijot.ijot_86_21

AmgadEl-Baz El-Agroudy, ShamikH Shah, K. Sridharan, A. Alalwan, Khadija M Alshehabi, Fadhel Alsitri, Ali Alaradi

引用次数: 0

Can donor demography or anthropometry be used as a screening tool for identifying potential low ABO-Titer plasma? 供体人口统计学或人体测量学能否作为鉴别潜在低abo -效价血浆的筛选工具?

IF 0.3

Indian Journal of Transplantation Pub Date : 2023-01-01 DOI: 10.4103/ijot.ijot_131_21

P. Pandey, S. Ranjan, D. Setya, Supriya Kumari

引用次数: 0

Chylous ascites following laparoscopic donor nephrectomy: Report of a case and a brief overview 腹腔镜供肾切除术后乳糜腹水:报告一例及简要概述

IF 0.3

Indian Journal of Transplantation Pub Date : 2023-01-01 DOI: 10.4103/ijot.ijot_67_22

C. Sheela, R. Thomas, Manishkumar D. Yadav, K. Sasidharan

引用次数: 0

An Unusual Case of Early Cytomegalovirus Retinitis with UTI, Invasive Pulmonary Aspergillosis, Klebsiella Pneumonia in a Renal Allograft Recipient 异体肾移植受者早期巨细胞病毒性视网膜炎合并尿路感染、侵袭性肺曲菌病、肺炎克雷伯氏菌一例

Indian Journal of Transplantation Pub Date : 2023-01-01 DOI: 10.4103/ijot.ijot_74_22

Preeti Chaudhary, Himansu Sekhar Mahapatra

{"title":"An Unusual Case of Early Cytomegalovirus Retinitis with UTI, Invasive Pulmonary Aspergillosis, Klebsiella Pneumonia in a Renal Allograft Recipient","authors":"Preeti Chaudhary, Himansu Sekhar Mahapatra","doi":"10.4103/ijot.ijot_74_22","DOIUrl":"https://doi.org/10.4103/ijot.ijot_74_22","url":null,"abstract":"Cytomegalovirus (CMV) remains the most common opportunistic infection after a kidney transplant. CMV retinitis is a rare manifestation of CMV invasive disease and is potentially threatening to vision in immunocompromised individuals. Invasive aspergillosis (IA) is one of the major causes of invasive fungal infection in kidney transplant recipients. Posttransplant CMV significantly increases the risk of IA in solid organ transplants. However, simultaneous or superadded opportunistic infections are rare and often delay the diagnosis. We report a case of early CMV retinitis in a renal transplant recipient, who initially developed extended-spectrum beta-lactamase-positive Escherichia coli cystitis at 2 weeks posttransplant. At 4 weeks posttransplant, he developed CMV retinitis managed with intravenous and intravitreal ganciclovir. At around 6 weeks, he developed persistent low-grade fever and pancytopenia without any specific systemic symptoms with initial sterile cultures sterile and normal imaging except for high-resolution computed tomography chest, which was suggestive of fungal pneumonia. Bronchoscopy and bronchoalveolar lavage were done, which came positive for aspergillus colonies. The patient improved with Amphotericin B, which was later changed to oral voriconazole. A few days later, the patient again deteriorated with new-onset fever, cough, and expectoration, which were diagnosed with Klebsiella pneumonia by imaging supported by sputum culture, which was managed by appropriate antibiotics. CMV and IA are both uncommon opportunistic infections and simultaneous or superadded infection with bacterial pneumonia is very rare. In the presence of persistent symptoms, early suspicion of another infection is crucial for patient management and long-term prognosis.","PeriodicalId":37455,"journal":{"name":"Indian Journal of Transplantation","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135838174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum of COVID-19 infections in renal transplant recipients: A single-center case series 肾移植受者COVID-19感染谱:单中心病例系列

IF 0.3

Indian Journal of Transplantation Pub Date : 2023-01-01 DOI: 10.4103/ijot.ijot_52_22

T. Mukherjee, R. Bonu, G. Prakash, Sundar Sankaran, S. Ballal

引用次数: 0