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Current Treatment Options in Pediatrics最新文献

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Updates and Opinions in Diagnosis and Treatment of Clostridiodes difficile in Pediatrics. 儿科艰难梭菌诊治进展及意见
Current Treatment Options in Pediatrics Pub Date : 2021-01-01 Epub Date: 2021-12-04 DOI: 10.1007/s40746-021-00232-9
Sanchi Malhotra, Sindhu Mohandas
{"title":"Updates and Opinions in Diagnosis and Treatment of <i>Clostridiodes difficile</i> in Pediatrics.","authors":"Sanchi Malhotra, Sindhu Mohandas","doi":"10.1007/s40746-021-00232-9","DOIUrl":"10.1007/s40746-021-00232-9","url":null,"abstract":"<p><strong>Purpose of review: </strong><i>Clostridiodes difficile</i> infection (CDI) has unique challenges for diagnosis and treatment in pediatrics. Though new antibiotics and biologics are being approved or developed for adults, most of the pediatric therapies still rely on multiple or extended antibiotic courses. This review aims to highlight emerging evidence and our clinical experience with CDI in children and can help inform readers' approach to pediatric CDI.</p><p><strong>Recent findings: </strong>Use of fidaxomicin for CDI in pediatrics has been shown to be to be non-inferior to vancomycin and is associated with higher global cure rates and decreased risk of recurrence. Fecal microbiota transplant is a successful emerging therapy with cure rates of up to 90%, though safety alerts should be noted. Diagnostic laboratory testing for <i>C. difficile</i> remains a challenge as it still cannot definitively distinguish between colonization and true infection, and this is particularly relevant to pediatric patients as they have the highest rates of colonization.</p><p><strong>Summary: </strong>The diagnosis and treatment of <i>C. difficile</i> infection in pediatrics remain challenging and recommendations lag behind advances made in the adult field. Recent data suggests that use of fidaxomicin both as treatment of first episode or recurrences may be beneficial in pediatrics just as in adults. At an experienced center, FMT is associated with high cure rates. Bezlotuxumab a monoclonal antibody to toxin B that is already recommended for use in adults is being studied in children and should be available for clinical use soon. Oral vancomycin prophylaxis is also an emerging strategy for high-risk patients. Finally, a possible vaccine may be on the horizon for pediatrics.</p>","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"7 1","pages":"203-216"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48032608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemolytic Uremic Syndrome 溶血性尿毒症综合征
Current Treatment Options in Pediatrics Pub Date : 2020-11-08 DOI: 10.1007/s40746-020-00216-1
G. Ariceta
{"title":"Hemolytic Uremic Syndrome","authors":"G. Ariceta","doi":"10.1007/s40746-020-00216-1","DOIUrl":"https://doi.org/10.1007/s40746-020-00216-1","url":null,"abstract":"","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"6 1","pages":"252 - 262"},"PeriodicalIF":0.0,"publicationDate":"2020-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40746-020-00216-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41852114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Medical and Invasive Management of Cardiac Thrombosis in Children with Congenital and Acquired Heart Disease 先天性和后天性心脏病患儿心脏血栓形成的医学和侵入性治疗
Current Treatment Options in Pediatrics Pub Date : 2020-10-19 DOI: 10.1007/s40746-020-00214-3
John S. Kim, M. Loi, M. Stone, C. VanderPluym
{"title":"Medical and Invasive Management of Cardiac Thrombosis in Children with Congenital and Acquired Heart Disease","authors":"John S. Kim, M. Loi, M. Stone, C. VanderPluym","doi":"10.1007/s40746-020-00214-3","DOIUrl":"https://doi.org/10.1007/s40746-020-00214-3","url":null,"abstract":"","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"6 1","pages":"283 - 298"},"PeriodicalIF":0.0,"publicationDate":"2020-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40746-020-00214-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47293903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crisis Resource Management in Medicine: a Clarion Call for Change 医学危机资源管理：变革的清晰呼唤
Current Treatment Options in Pediatrics Pub Date : 2020-10-05 DOI: 10.1007/s40746-020-00215-2
R. Bishop, Carlos Porges, M. Carlisle, Robert Strickland
{"title":"Crisis Resource Management in Medicine: a Clarion Call for Change","authors":"R. Bishop, Carlos Porges, M. Carlisle, Robert Strickland","doi":"10.1007/s40746-020-00215-2","DOIUrl":"https://doi.org/10.1007/s40746-020-00215-2","url":null,"abstract":"","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"6 1","pages":"299 - 316"},"PeriodicalIF":0.0,"publicationDate":"2020-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40746-020-00215-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48565114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Sepsis: an Update on Current Improvement Efforts 败血症:当前改进工作的最新进展
Current Treatment Options in Pediatrics Pub Date : 2020-09-12 DOI: 10.1007/s40746-020-00212-5
Deborah Schonfeld, Raina M. Paul
{"title":"Sepsis: an Update on Current Improvement Efforts","authors":"Deborah Schonfeld, Raina M. Paul","doi":"10.1007/s40746-020-00212-5","DOIUrl":"https://doi.org/10.1007/s40746-020-00212-5","url":null,"abstract":"","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"6 1","pages":"366 - 376"},"PeriodicalIF":0.0,"publicationDate":"2020-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40746-020-00212-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49143544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Decision Support Systems: Opportunities in Pediatric Patient Safety 临床决策支持系统:儿科患者安全的机会
Current Treatment Options in Pediatrics Pub Date : 2020-09-07 DOI: 10.1007/s40746-020-00206-3
N. Saddler, G. Harvey, K. Jessa, Daniel Rosenfield
{"title":"Clinical Decision Support Systems: Opportunities in Pediatric Patient Safety","authors":"N. Saddler, G. Harvey, K. Jessa, Daniel Rosenfield","doi":"10.1007/s40746-020-00206-3","DOIUrl":"https://doi.org/10.1007/s40746-020-00206-3","url":null,"abstract":"","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"6 1","pages":"325 - 335"},"PeriodicalIF":0.0,"publicationDate":"2020-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40746-020-00206-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44488530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Open Hearts: Sharing Data to Improve Outcomes in Congenital Heart Disease 敞开心扉：共享数据以改善先天性心脏病的预后
Current Treatment Options in Pediatrics Pub Date : 2020-09-05 DOI: 10.1007/s40746-020-00211-6
J. Diddle, Christine M. Riley, Lisa A Hom, D. Klugman
{"title":"Open Hearts: Sharing Data to Improve Outcomes in Congenital Heart Disease","authors":"J. Diddle, Christine M. Riley, Lisa A Hom, D. Klugman","doi":"10.1007/s40746-020-00211-6","DOIUrl":"https://doi.org/10.1007/s40746-020-00211-6","url":null,"abstract":"","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"6 1","pages":"263 - 273"},"PeriodicalIF":0.0,"publicationDate":"2020-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40746-020-00211-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49324083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current Treatment Options for Catheter-Based Pulmonary Valve Replacement in Children 目前儿童导管肺动脉瓣置换术的治疗选择
Current Treatment Options in Pediatrics Pub Date : 2020-08-28 DOI: 10.1007/s40746-020-00209-0
Jenny E. Zablah, G. Morgan
{"title":"Current Treatment Options for Catheter-Based Pulmonary Valve Replacement in Children","authors":"Jenny E. Zablah, G. Morgan","doi":"10.1007/s40746-020-00209-0","DOIUrl":"https://doi.org/10.1007/s40746-020-00209-0","url":null,"abstract":"","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"6 1","pages":"274 - 282"},"PeriodicalIF":0.0,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40746-020-00209-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44843059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neurological Status Deterioration in Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State 糖尿病酮症酸中毒和高渗高血糖状态的神经状态恶化
Current Treatment Options in Pediatrics Pub Date : 2020-08-26 DOI: 10.1007/s40746-020-00210-7
Zuazaga Marcela, Fustiñana Ana, Pellegrini Solana, Arpi Lucrecia, P. Mariana, Martínez Carolina, K. Gabriela
{"title":"Neurological Status Deterioration in Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State","authors":"Zuazaga Marcela, Fustiñana Ana, Pellegrini Solana, Arpi Lucrecia, P. Mariana, Martínez Carolina, K. Gabriela","doi":"10.1007/s40746-020-00210-7","DOIUrl":"https://doi.org/10.1007/s40746-020-00210-7","url":null,"abstract":"","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"6 1","pages":"377 - 386"},"PeriodicalIF":0.0,"publicationDate":"2020-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40746-020-00210-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45407501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation and Treatment of Disorders of Magnesium Balance 镁平衡紊乱的评估与治疗
Current Treatment Options in Pediatrics Pub Date : 2020-08-26 DOI: 10.1007/s40746-020-00204-5
A. Weinstein
{"title":"Evaluation and Treatment of Disorders of Magnesium Balance","authors":"A. Weinstein","doi":"10.1007/s40746-020-00204-5","DOIUrl":"https://doi.org/10.1007/s40746-020-00204-5","url":null,"abstract":"","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"6 1","pages":"241 - 251"},"PeriodicalIF":0.0,"publicationDate":"2020-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40746-020-00204-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41743604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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