Current Treatment Options in Pediatrics最新文献_第9页

A Review of Short Bowel Syndrome Including Current and Emerging Management Strategies 短肠综合征的综述，包括当前和新兴的管理策略

Current Treatment Options in Pediatrics Pub Date : 2021-01-11 DOI: 10.1007/s40746-020-00218-z

Colleen B. Flahive, Monique L Goldschmidt, E. Mezoff

引用次数: 1

Going Beyond Gluten-Free: a Review of Potential Future Therapies for Celiac Disease 超越无麸质:对乳糜泻潜在未来治疗方法的回顾

Current Treatment Options in Pediatrics Pub Date : 2021-01-08 DOI: 10.1007/s40746-020-00217-0

Brandon Sparks, I. Hill, Tracy R. Ediger

引用次数: 4

Management of Multisystem Inflammatory Syndrome in Children Associated with COVID-19 Infection. 新冠肺炎感染儿童多系统炎症综合征的治疗

Current Treatment Options in Pediatrics Pub Date : 2021-01-01 Epub Date: 2021-05-06 DOI: 10.1007/s40746-021-00224-9

Pei-Ni Jone, Melanie D Everitt

{"title":"Management of Multisystem Inflammatory Syndrome in Children Associated with COVID-19 Infection.","authors":"Pei-Ni Jone, Melanie D Everitt","doi":"10.1007/s40746-021-00224-9","DOIUrl":"10.1007/s40746-021-00224-9","url":null,"abstract":"Purpose of review: The purpose of this review is to summarize what is known about multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 infection.Recent findings: The timing of presentation and features of diagnosis are described. Cardiac involvement is common and is the focus of this review. Arrhythmias, heart block, acute heart failure, shock, cardiac dysfunction, and coronary dilation have all been reported. Therapies used to treat children with this hyperinflammation syndrome include supportive care and agents that modulate the immune system. Therapies commonly described include intravenous immunoglobulin, steroids, and cytokine-directed agents, particularly tumor necrosis factor-alpha blockade and interleukin receptor blockade. The threshold for diagnosing coronary involvement in MIS-C is coronary artery dimensions indexed to body surface that exceed the normative values (Z score >2). Those hospitalized with MIS-C are evaluated by electrocardiogram and echocardiogram; outpatient assessment by a cardiologist is indicated prior to sports clearance.Summary: The prognosis of treated MIS-C patients is good. Future work is needed to understand the scope of cardiac involvement associated with acute COVID-19 and MIS-C in children and to define the optimal therapeutic targets for these distinct entities.","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"7 1","pages":"119-128"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8100365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43195414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates and Opinions in Diagnosis and Treatment of Clostridiodes difficile in Pediatrics. 儿科艰难梭菌诊治进展及意见

Current Treatment Options in Pediatrics Pub Date : 2021-01-01 Epub Date: 2021-12-04 DOI: 10.1007/s40746-021-00232-9

Sanchi Malhotra, Sindhu Mohandas

{"title":"Updates and Opinions in Diagnosis and Treatment of Clostridiodes difficile in Pediatrics.","authors":"Sanchi Malhotra, Sindhu Mohandas","doi":"10.1007/s40746-021-00232-9","DOIUrl":"10.1007/s40746-021-00232-9","url":null,"abstract":"Purpose of review: Clostridiodes difficile infection (CDI) has unique challenges for diagnosis and treatment in pediatrics. Though new antibiotics and biologics are being approved or developed for adults, most of the pediatric therapies still rely on multiple or extended antibiotic courses. This review aims to highlight emerging evidence and our clinical experience with CDI in children and can help inform readers' approach to pediatric CDI.Recent findings: Use of fidaxomicin for CDI in pediatrics has been shown to be to be non-inferior to vancomycin and is associated with higher global cure rates and decreased risk of recurrence. Fecal microbiota transplant is a successful emerging therapy with cure rates of up to 90%, though safety alerts should be noted. Diagnostic laboratory testing for C. difficile remains a challenge as it still cannot definitively distinguish between colonization and true infection, and this is particularly relevant to pediatric patients as they have the highest rates of colonization.Summary: The diagnosis and treatment of C. difficile infection in pediatrics remain challenging and recommendations lag behind advances made in the adult field. Recent data suggests that use of fidaxomicin both as treatment of first episode or recurrences may be beneficial in pediatrics just as in adults. At an experienced center, FMT is associated with high cure rates. Bezlotuxumab a monoclonal antibody to toxin B that is already recommended for use in adults is being studied in children and should be available for clinical use soon. Oral vancomycin prophylaxis is also an emerging strategy for high-risk patients. Finally, a possible vaccine may be on the horizon for pediatrics.","PeriodicalId":37445,"journal":{"name":"Current Treatment Options in Pediatrics","volume":"7 1","pages":"203-216"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48032608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemolytic Uremic Syndrome 溶血性尿毒症综合征

Current Treatment Options in Pediatrics Pub Date : 2020-11-08 DOI: 10.1007/s40746-020-00216-1

G. Ariceta

引用次数: 1

Medical and Invasive Management of Cardiac Thrombosis in Children with Congenital and Acquired Heart Disease 先天性和后天性心脏病患儿心脏血栓形成的医学和侵入性治疗

Current Treatment Options in Pediatrics Pub Date : 2020-10-19 DOI: 10.1007/s40746-020-00214-3

John S. Kim, M. Loi, M. Stone, C. VanderPluym

引用次数: 0

Crisis Resource Management in Medicine: a Clarion Call for Change 医学危机资源管理：变革的清晰呼唤

Current Treatment Options in Pediatrics Pub Date : 2020-10-05 DOI: 10.1007/s40746-020-00215-2

R. Bishop, Carlos Porges, M. Carlisle, Robert Strickland

引用次数: 2

Sepsis: an Update on Current Improvement Efforts 败血症:当前改进工作的最新进展

Current Treatment Options in Pediatrics Pub Date : 2020-09-12 DOI: 10.1007/s40746-020-00212-5

Deborah Schonfeld, Raina M. Paul

引用次数: 0

Clinical Decision Support Systems: Opportunities in Pediatric Patient Safety 临床决策支持系统:儿科患者安全的机会

Current Treatment Options in Pediatrics Pub Date : 2020-09-07 DOI: 10.1007/s40746-020-00206-3

N. Saddler, G. Harvey, K. Jessa, Daniel Rosenfield

引用次数: 2

Open Hearts: Sharing Data to Improve Outcomes in Congenital Heart Disease 敞开心扉：共享数据以改善先天性心脏病的预后

Current Treatment Options in Pediatrics Pub Date : 2020-09-05 DOI: 10.1007/s40746-020-00211-6

J. Diddle, Christine M. Riley, Lisa A Hom, D. Klugman

引用次数: 0