Annals of Medicine & Surgery最新文献

{"title":"Glioneuronal tumor in an autosomal-dominant polycystic kidney disease patient: A case report and literature review","authors":"Salem K. Qupp, Mohammad M. Zeidan, Hafez Nimer","doi":"10.1097/ms9.0000000000002265","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002265","url":null,"abstract":"\u0000 \u0000 The association between primary brain tumors, such as glioneuronal tumors, with autosomal-dominant polycystic kidney disease (ADPKD) remains poorly understood, with only two cases reported excluding this one. This case of an ADPKD patient diagnosed with a rosette-forming glioneuronal tumor highlights an exceptionally rare potential association warranting further investigation.\u0000 \u0000 \u0000 \u0000 A 28-year-old male with ADPKD presented with progressive ataxia, dizziness, and headache. MRI revealed a cerebellar mass and obstructive hydrocephalus. Surgical resection and histopathological examination confirmed the diagnosis of a rosette-forming glioneuronal tumor (RGNT). Postoperatively, the patient showed significant symptom improvement.\u0000 \u0000 \u0000 \u0000 The interplay between genetics and glioneuronal development is complex and underexplored. While most glioneuronal arise sporadically, rare genetic syndromes may predispose individuals to these tumors. Additionally, although more than 70 cases of ADPKD with concurrent tumors were reported, the literature on this specific association remains limited.\u0000 \u0000 \u0000 \u0000 This case underscores the need for heightened awareness of potential associations between ADPKD and tumors such as glioneuronal tumors. With limited literature on this subject, further research is imperative to understand the underlying mechanisms and clinical implications. Enhancing our knowledge in this area can improve patient outcomes and management strategies.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":" 1244","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141363826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric cardiac hydatid cysts: A diagnostic odyssey-a rare case report","authors":"S. Zahri, Yassine Ettagmouti, Soukaina Zagdan, Mehdi Belhakim, M. Haboub, Abdenasser Drighil, R. Habbal","doi":"10.1097/ms9.0000000000002093","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002093","url":null,"abstract":"","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":"104 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141362242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of oral tranexamic acid on postoperative bleeding in spinal surgery: a randomized controlled trial","authors":"Saeed Kargar-soleimanabad, Aynoor khormali, Farnaz Godazandeh, Sajjad أajafi","doi":"10.1097/ms9.0000000000001820","DOIUrl":"https://doi.org/10.1097/ms9.0000000000001820","url":null,"abstract":"\u0000 \u0000 and Objective:\u0000 This study aimed to investigate the effect of oral administration of tranexamic acid (TXA) on reducing intraoperative bleeding during spinal surgeries.\u0000 \u0000 \u0000 \u0000 The study was a single-center, double-blind, randomized, placebo-controlled clinical trial. Participants were individuals over 20 years old who underwent spinal surgery. Patients received 1.5 grams of TXA orally, 2 hours before surgery. Intraoperative bleeding volume, blood volume in the drain after surgery, length of hospital stays after surgery, incidence of nausea or vomiting, decrease in hemoglobin (Hb) level, and postoperative coagulation test results were evaluated in each group.\u0000 \u0000 \u0000 \u0000 In this study, patients were assigned to each study group based on inclusion and exclusion criteria. The mean age of patients was 69.6±6.47 years, and 65% were male. There was no significant difference in age, gender, pre-and post-operative Hb levels, prothrombin time (PT), or international normalized ratio (INR) between the study groups. Intraoperative bleeding volume and blood volume in the drain after surgery were significantly lower in the TXA group. Additionally, the length of hospital stay after surgery was significantly shorter in the TXA group. The incidence of nausea or vomiting was significantly higher in the TXA group. Furthermore, postoperative partial thromboplastin time (PTT) was significantly higher in the TXA group compared to the placebo group.\u0000 \u0000 \u0000 \u0000 Oral administration of TXA before spinal surgery leads to a significant reduction in intraoperative and postoperative bleeding without significant adverse effects and also reduces the length of hospital stay.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine & Surgery","volume":" 633","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141364213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing sucrose solution with distilled water for pain management in premature infant venipuncture: randomized clinical trial","authors":"Hossein Habibzadeh, Maryam Salamat Bakhsh, Mina Hosseini, H. Khalkhali","doi":"10.1097/ms9.0000000000002227","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002227","url":null,"abstract":"\u0000 \u0000 Managing pain is critical, especially for premature infants undergoing frequent painful procedures. Uncontrolled pain can lead to lasting harm in growth, cognitive development, and future pain responses.\u0000 \u0000 \u0000 \u0000 A double blinded clinical investigation involving 150 premature infants was performed in a neonatal intensive care unit. They were randomly divided into three groups: Sucrose 20% (50 infants), distilled water (50 infants), and a control group (50 infants). The infants’ behavioral responses were assessed using an infant pain measurement tool before, at 2, and 7 minutes after the intervention through direct observation.\u0000 \u0000 \u0000 \u0000 The study revealed that mean pain scores before, 2 minutes after, and 7 minutes after the intervention in the sucrose group were (4.78±0.91), (3.18±1.15), and (2±1.02), respectively. In the distilled water group, scores were (4.66±0.89), (3.04±1.15), and (3.08±1.10), while in the control group, they were (4.0±0.79), (4.94±0.79), and (4.72±0.96). The trend of pain scores varied among the groups over time, with a significant difference in mean pain scores at different time points (P<0.001). Initially comparable, pain scores notably decreased after two minutes in the sucrose and distilled water groups (P<0.001), differing from the control group.\u0000 \u0000 \u0000 \u0000 The study indicated that 20% sucrose and distilled water equally reduce infant pain post-venipuncture, suggesting their viability for clinical pain management. Distilled water, however, provides additional benefits, including economic considerations and ease of preparation.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine &amp; Surgery","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141365041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated expression of ELK1 promotes breast cancer cell growth and correlates with poor prognosis of breast cancer patients","authors":"Xiuping Xu, Yanan Wang, Qing Wang, Shanmei Lv, Guofeng Mao","doi":"10.1097/ms9.0000000000002256","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002256","url":null,"abstract":"\u0000 \u0000 Breast cancer is the most common tumor in women and poses a serious threat to women’s physical and mental health. The ETS-like gene 1 (ELK1), upregulated in various malignancies, serves as a transcription regulatory factor. This study primarily investigates the biological functions and prognostic significance of ELK1 in breast cancer.\u0000 \u0000 \u0000 \u0000 We conducted an analysis of ELK1 expression in breast cancer and adjacent tissues using data from The Cancer Genome Atlas (TCGA), and validated these findings with clinical specimens. Additionally, we employed siRNA transfection, proliferation and apoptosis assays to elucidate the roles of ELK1 in breast cancer cells. Furthermore, we assessed the correlations between ELK1 expression and the tumor microenvironment, as well as tumor-infiltrating immune cells (TIICs), utilizing the ESTIMATE and CIBERSORT algorithms. Finally, we used Kaplan-Meier plots and COX regressions to identify prognostic factors, and developed a predictive alignment diagram to evaluate the prognostic significance of ELK1 in breast cancer.\u0000 \u0000 \u0000 \u0000 A marked increase in ELK1 expression is evident in breast cancer tissues (P<0.01). Experimental findings demonstrate that silencing ELK1 suppresses proliferation and promotes apoptosis in breast cancer cells. ELK1 plays a pivotal role in regulating the immune microenvironment of breast cancer. Furthermore, the alignment diagram indicates that ELK1 may serve as an independent prognostic factor for breast cancer patients.\u0000 \u0000 \u0000 \u0000 Our study reveals that ELK1 exhibits high expression level in breast cancer tissues and is associated with disease progression and poor prognosis.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine &amp; Surgery","volume":" 59","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141365405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The migraine epidemic among medical students: A call for action","authors":"Muhammad Saeed, Muhammad Usman Farooq, Mohammad Najaf Ali Abbas, Faheemullah Khan, Djabo Eric Adrien Tangmi, Gaurav Mittal","doi":"10.1097/ms9.0000000000002241","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002241","url":null,"abstract":"Migraine is characterized by recurrent headaches of moderate-to-severe intensity and poses a significant challenge for medical students. This is a narrative literature review using PubMed and Scopus databases. This study examines how common migraine is in this group and suggests working together to address how it affects students’ well-being and chances of succeeding as a medical professional in the future. Early diagnosis by licensed medical specialists is essential for effective management of migraine. To address this, we propose a multifaceted strategy. By including direct education on migraines in medical school curricula, future doctors will be better prepared to treat patients with comparable problems and manage their own migraines. Students with migraines can also benefit greatly from creating a supportive learning environment through staff training, accommodating academic policies, and providing easily available healthcare resources. In addition, this technology may be helpful. Apps for relaxation and migraine tracking can help students better manage their condition. Long-term success requires cooperation among all parties. By promoting cooperation among medical schools, student associations, healthcare practitioners, and governmental organizations, we can raise public awareness of migraine, make pertinent resources easier to access, and create evidence-based solutions specially designed to meet the needs of medical students who experience migraine. In the end, putting student well-being first and working together to put these solutions into practice can enable aspiring doctors to succeed at both personal and professional levels.","PeriodicalId":373451,"journal":{"name":"Annals of Medicine &amp; Surgery","volume":"114 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141361053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential for and challenges of menstrual blood as a non-invasive diagnostic specimen: Current status and future directions","authors":"Amna Zaheer, Aqsa Komel, Mohammad Baraa Abu Bakr, Achit Kumar Singh, Alen Sam Saji, Manahil Mansha Kharal, Areeba Ahsan, Muhammad Hamza Khan, Anum Akbar","doi":"10.1097/ms9.0000000000002261","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002261","url":null,"abstract":"Menstrual blood, which is often discarded as a waste product, has emerged as a valuable source of health information. The components of menstrual blood, such as endometrial cells, immune cells, proteins, and microbial signatures, provide insights into health. Studies have shown encouraging results for using menstrual blood to diagnose a variety of conditions, including hormonal imbalances, cervical cancer, endometriosis, chlamydia, diabetes, and other endocrine disorders. This review examines the potential of menstrual blood as a non-invasive diagnostic specimen, exploring its composition, promising applications, and recent advances. This review also discusses challenges to utilizing menstrual blood testing, including ethical considerations, the lack of standardized collection protocols, extensive validation studies, and the societal stigma around menstruation. Overcoming these challenges will open new avenues for personalized medicine and revolutionize healthcare for individuals who menstruate.","PeriodicalId":373451,"journal":{"name":"Annals of Medicine &amp; Surgery","volume":"124 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141361517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and attitude of medical students towards artificial intelligence in ophthalmology in Riyadh, Saudi Arabia: A cross-sectional study","authors":"Zainudheen Faroog, Q. Dirar, Abdul Rehman Zia Zaidi, Mohammad Salman Khan, Golam Mahamud, Saad Rahman Ambia, Salwa Alhazzaa","doi":"10.1097/ms9.0000000000002238","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002238","url":null,"abstract":"\u0000 \u0000 The use of artificial intelligence (AI) in ophthalmology represents a transformative leap in healthcare. AI-powered technologies, such as machine learning and computer vision, enhance the accuracy and efficiency of ophthalmic diagnosis and treatment.\u0000 \u0000 \u0000 \u0000 This study aimed to determine medical students’ awareness and attitudes towards the use of artificial intelligence in ophthalmology.\u0000 \u0000 \u0000 \u0000 This cross-sectional, questionnaire-based study was conducted between November 2022 and January 2023 using online questionnaires. Data collection was carried out using convenience sampling among medical students at the University. IBM SPSS version 23 was used to analyze the data.\u0000 \u0000 \u0000 \u0000 The current finding shows that most of the participants N=309 (89.6%) had heard of the use of AI in medicine, and N=294 (85.2%) heard of the use of AI in ophthalmology. 98.6% (n=340) of respondents believed AI would be a helpful tool in ophthalmology. Along this line of questioning, a significant majority of respondents, 332 (96.2%) selected screening, 332 (96.2%) selected diagnosis, and 293 (84.9%) selected prevention as a usage of AI ophthalmology. However, the majority, 76.5%) of students had little understanding of the development of AI in ophthalmology. In addition, a significant relationship between sex, academic year, cumulative GPA (cGPA), and awareness of AI in ophthalmology (P<0.001) was found in this study.\u0000 \u0000 \u0000 \u0000 Overall, medical students in Saudi Arabia appear to have favorable thoughts about AI and positive perceptions towards AI in ophthalmology. However, the findings of this study emphasize the limited understanding and low confidence levels of medical students in Saudi Arabia regarding the use of AI in ophthalmology. As a result, early exposure to AI-related materials in medical curricula is crucial for addressing these challenges through comprehensive AI education and practical exposure to prepare future ophthalmologists.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine &amp; Surgery","volume":"114 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141363074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meckel’s diverticulum complicated by acute intestinal obstruction : a case report","authors":"A. Niasse, Abdoulaye Ndiaye, Papa Souleymane Dieng, Mactar Dieng, A. Ndong, Mamadou Cissé, M. Dieng, Ibrahima Konaté","doi":"10.1097/ms9.0000000000002263","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002263","url":null,"abstract":"\u0000 \u0000 Meckel’s diverticulum is a rare congenital intestinal anomaly that can cause sometimes serious complications. Our aim is to review the literature on this condition by reporting the clinical case of a young adult with Meckel’s diverticulum complicated by acute intestinal obstruction.\u0000 \u0000 \u0000 \u0000 this was a 24-year-old young man, operated on for open bladder stones, received for occlusive syndrome. Abdominal CT suggested a flange occlusion. Surgical exploration found a Meckel’s diverticulum creating a flange around the last one. An intestinal resection was performed with direct anastomosis with simple consequences.\u0000 \u0000 \u0000 \u0000 Meckel’s diverticulum is a rare congenital intestinal anomaly. It is discovered incidentally or in the face of serious complications such as intestinal obstruction. Intestinal resection with one-stage anastomosis emerges as a standard and safe management approach.\u0000 \u0000 \u0000 \u0000 A Meckel’s diverticulum can be complicated by acute intestinal obstruction mimicking a postoperative flange that can err the diagnosis.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine &amp; Surgery","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141366413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between atrial fibrillation and coeliac disease: A comprehensive review","authors":"Rasish Subedi, Amna Soulat, Samia Rauf Butt, Anmol Mohan, Muhammad Danish Butt, Suneel Arwani, Gulzar Ahmed, Koushik Majumder, Priyanka Mohan Lal, Vikash Kumar, Usha Tejwaney, Nanik Ram, Sarwan Kumar","doi":"10.1097/ms9.0000000000002259","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002259","url":null,"abstract":"\u0000 \u0000 This paper aims to provide a comprehensive overview of the pathophysiology of Atrial Fibrillation (AF) and Coeliac Disease (CD) individually, while also exploring the emerging evidence of a potential association between the two conditions.\u0000 \u0000 \u0000 \u0000 The pathophysiology of AF, the most prevalent arrhythmia globally, and CD, an autoimmune condition triggered by gluten consumption, is examined. Genetic, structural, electrophysiological, and inflammatory factors contributing to their development are explored.\u0000 \u0000 \u0000 \u0000 AF involves irregular atrial activity leading to electrical and structural remodeling of the atrium. CD is characterized by an immune response to gluten, primarily associated with HLA-DQ2 and HLA-DQ8 genetic mutations, resulting in damage to intestinal tissue. Emerging research suggests a link between AF and CD, possibly mediated through inflammation, fibrosis, and electromechanical delays in the atrium.\u0000 \u0000 \u0000 \u0000 Understanding the association between AF and CD carries significant clinical implications. Recognition of this relationship can assist in identifying individuals at higher risk for AF and inform proactive management strategies. Additionally, it underscores the importance of comprehensive care for CD patients, considering potential cardiac implications. Further research is warranted to elucidate precise mechanisms and explore potential therapeutic interventions targeting common pathways, opening avenues for enhanced patient care and future investigations.\u0000","PeriodicalId":373451,"journal":{"name":"Annals of Medicine &amp; Surgery","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141365014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}