Cardiovascular and Cardiometabolic Journal (CCJ)最新文献_第4页

Potential Biomarkers as Early Detection of Diabetic Cardiomyopathy 糖尿病性心肌病早期检测的潜在生物标志物

Cardiovascular and Cardiometabolic Journal (CCJ) Pub Date : 2021-09-30 DOI: 10.20473/CCJ.V2I2.2021.95-109

H. Hariadi, M. T. Giani, Silvia Handika Anggraeni

{"title":"Potential Biomarkers as Early Detection of Diabetic Cardiomyopathy","authors":"H. Hariadi, M. T. Giani, Silvia Handika Anggraeni","doi":"10.20473/CCJ.V2I2.2021.95-109","DOIUrl":"https://doi.org/10.20473/CCJ.V2I2.2021.95-109","url":null,"abstract":"Abstract: Diabetes mellitus (DM) is one of the most prevalent and burdensome among chronic disease worldwide. Its complications accelerate mortality rate within population. Diabetic cardiomyopathy (DCM) is one of diabetes macrovascular complications, which symptoms are frequently unforeseen. Advances in pathogenesis understanding DCM underlying mechanisms remain not fully perceived. Current diagnostic approach of DCM can hardly determine diabetic patients with asymptomatic cardiomyopathy. Previous studies suggested biomarkers might detect early stage DCM. There are numerous selective biomarkers representing several pathophysiological pathways, such as myocardial fibrosis, inflammatory response, cardiomyocyte apoptosis, and metabolic dysregulation in the development of diabetic heart anomaly It was also reported those biomarkers are useful for the prognostic assessment of the disease. However, not all biomarkers are cardiac specific and can be an auspicious diagnostic tool candidate. Recent studies show that there are certain biomarkers, such as microRNA, H-FABP, IGFBP7, and some other novel cardiac biomarkers were more specifically associated with the pathological mechanism of DCM. In this review, we aimed to discuss the role of several potential cardiac biomarkers as early detection in DCM that may predict future incident of DCM, and contribute to improving mortality prediction in patients with subclinical DCM.Keywords: Biomarker; Diabetic Cardiomyopathy","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131392081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profile of Major Risk Factors in Acute Coronary Syndrome (ACS) at Pusat Pelayanan Jantung Terpadu (PPJT) Dr. Soetomo Public Hospital Surabaya Between the Period of January-December 2019 2019年1月至12月期间泗水suetomo医生公立医院急性冠脉综合征(ACS)主要危险因素概况

Cardiovascular and Cardiometabolic Journal (CCJ) Pub Date : 2021-09-30 DOI: 10.20473/ccj.v2i2.2021.59-72

Ikhsanuddin Qothi, M. Fuadi, Agus Subagjo

{"title":"Profile of Major Risk Factors in Acute Coronary Syndrome (ACS) at Pusat Pelayanan Jantung Terpadu (PPJT) Dr. Soetomo Public Hospital Surabaya Between the Period of January-December 2019","authors":"Ikhsanuddin Qothi, M. Fuadi, Agus Subagjo","doi":"10.20473/ccj.v2i2.2021.59-72","DOIUrl":"https://doi.org/10.20473/ccj.v2i2.2021.59-72","url":null,"abstract":"Abstract: Background: Coronary heart disease (CHD) is a leading cause of death worldwide. One type of CHD that most often causes clinical manifestations and death is Acute Coronary Syndrome (ACS). In 2013 the prevalence of SKA in Indonesia reached 1.5% and it is estimated that it will continue to increase every year. Objective: This study aims to determine the profile of major risk factors for ACS sufferers in the Pusat Pelayanan Jantung Terpadu (PPJT) Dr. Soetomo Public Hospital Surabaya in the period January-December 2019. Methods: This study used a retrospective descriptive method to analyze the patient's electronic medical record (e-MR). Results: Out of 623 patients diagnosed with ACS, 429 were excluded from the research. 194 patients who met the inclusion criteria were studied with the following details: 19 APTS patients, 43 N-STEMI patients, and 132 STEMI patients. It was found that 73% of ACS patients were male, with the 55-64 years’ age group dominating by 46%. Based on blood pressure and serum cholesterol examination data, it was found that 51% of patients had hypertension and 77% of patients had dyslipidemia (40% hypercholesterolemia, 42% hypertriglyceridemia, 40% low HDL-C levels, and 34% high LDL-C levels). 60% patients had type-2 diabetes mellitus and 52% of patients had a history of smoking. Conclusion: 73% of ACS patients in this study were men. Most common age groups were 55-64 years old (46%), had hypertension by 51%, had dyslipidemia by 77% (40% hypercholesterolemia, 42% hypertriglyceridemia, 40% low HDL-C levels, 34% high LDL-C), had type-2 diabetes mellitus by 60%, and had a smoking history by 52%.","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129737660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical Manifestation and Outcomes of Thrombolytic and Consevative Therapy in Covid-19 Patients with ST-Segment Elevation Pattern: A Case Series st段抬高型Covid-19患者溶栓和保守治疗的临床表现和结果:一个病例系列

Cardiovascular and Cardiometabolic Journal (CCJ) Pub Date : 2021-09-30 DOI: 10.20473/ccj.v2i2.2021.73-76

Raditya Rizki Muhammad, Nadya Anisah, A. Kurniawan, Hairudi Hairudi

引用次数: 0

Simple Risk Stratification based on Killip Classification and the Six-minute Walk Test Borg Scale for Outcomes of Acute Coronary Syndrome for Papuanese People in Rural Hospital 基于Killip分级和6分钟步行测试Borg量表的乡村医院巴布亚人急性冠状动脉综合征预后简单风险分层

Cardiovascular and Cardiometabolic Journal (CCJ) Pub Date : 2021-03-27 DOI: 10.20473/CCJ.V2I1.2021.10-15

Ahmad Alhamid, H. Yulidia, Intan Iriani Supriatna

{"title":"Simple Risk Stratification based on Killip Classification and the Six-minute Walk Test Borg Scale for Outcomes of Acute Coronary Syndrome for Papuanese People in Rural Hospital","authors":"Ahmad Alhamid, H. Yulidia, Intan Iriani Supriatna","doi":"10.20473/CCJ.V2I1.2021.10-15","DOIUrl":"https://doi.org/10.20473/CCJ.V2I1.2021.10-15","url":null,"abstract":"Background: Accurate risk stratification for untoward outcomes after acute coronary syndrome patients may help clinicians guide the type and intensity of therapy. Unfortunately, most of the Papuanese people face difficulties in accessing sophisticated medical treatment. Aims: The aim of this study was to determine the simplest but most accurate risk stratification for ACS patients treated in rural hospital. Methods: This was a cross-sectional study conducted in Sele Be Solu Regional Hospital at Sorong Regency in West Papua Province. Fifteen unselected patients from September 2019 to March 2020 period with ACS were prospectively studied. All the data were collected from medical records. Results: Subject characteristics mostly were male (80%) and mean age was 54 years, (13,3%) subjects were age less than 45 years. The most diagnosed ACS type was STEMI (73,3%). Conclusion:In Papuanese patients with ACS in rural hospital, those at highest risk can be identified using Killip classification and The Six-minute Walk Test Borg Scale as short term predictor for ACS patients’ outcome. ","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116025992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Aorto Femoral Bypass Graft in Chronic Limb Ischemia Patient 慢性肢体缺血患者的主动脉-股动脉旁路移植术

Cardiovascular and Cardiometabolic Journal (CCJ) Pub Date : 2021-03-27 DOI: 10.20473/CCJ.V2I1.2021.41-49

R. M. Budiarto, MD, Muhammad Hasan

引用次数: 1

Reperfusion Therapy for ST-Elevation Myocardial Infarction at Dr. Soetomo General Academic Hospital Surabaya suetomo博士综合学术医院st段抬高型心肌梗死的再灌注治疗

Cardiovascular and Cardiometabolic Journal (CCJ) Pub Date : 2021-03-27 DOI: 10.20473/CCJ.V2I1.2021.82-90

Rosavelina Sintaasih Budihardjo, Agus Subagjo, S. Prajitno

{"title":"Reperfusion Therapy for ST-Elevation Myocardial Infarction at Dr. Soetomo General Academic Hospital Surabaya","authors":"Rosavelina Sintaasih Budihardjo, Agus Subagjo, S. Prajitno","doi":"10.20473/CCJ.V2I1.2021.82-90","DOIUrl":"https://doi.org/10.20473/CCJ.V2I1.2021.82-90","url":null,"abstract":"Background: Cardiovascular disease is the number one cause of death in the world by killing 17,9 million people every year. The most frequent cardiovascular disease occurs as STEMI which related to the depiction of persistent depiction of EKG elevation with ST segment. This research is aiming for figure out the profile of reperfusion therapy at Dr. Soetomo General Academic Hospital, Surabaya. Methods: In this research, the data is collected using observation method, without any treatment applied with descriptive statistical analysis using table. The data collection techniques used is simple random sampling. Results: The STEMI patients at Dr. Soetomo General Academic Hospital Surabaya are dominated by referral patients (79,2%) from approximately 40 hospitals in East Java. Most of the patients were male, the ages between 51 – 60 years old with the most frequent risk factors was the combination of type 2 diabetes mellitus, hypertension, and smoking. The reperfusion therapy given was PCI with a door to balloon <120 minutes was 59.6%. Fibrinolytic that was done in <12 hours after onset was 82.9%. Patients with STEMI managed at Dr. Soetomo General Academic Hospital Surabaya, had mortality rates around 12.2%. Conclusion: Most of the STEMI patients in Dr. Sutomo General Academic Hospital Surabaya was a referral patient and had sufficiently good PCI and fibrinolytic reperfusion therapy, resulting in a low mortality rate.","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131180916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Suspected COVID-19-associated Myocarditis Case Mimicking Life-threatening STEMI: a Shark Fin Appearance 疑似与covid -19相关的心肌炎病例模拟危及生命的STEMI:鱼翅外观

Cardiovascular and Cardiometabolic Journal (CCJ) Pub Date : 2021-03-27 DOI: 10.20473/CCJ.V2I1.2021.23-29

Ratna Mariana Tamba, A. Sitepu

{"title":"A Suspected COVID-19-associated Myocarditis Case Mimicking Life-threatening STEMI: a Shark Fin Appearance","authors":"Ratna Mariana Tamba, A. Sitepu","doi":"10.20473/CCJ.V2I1.2021.23-29","DOIUrl":"https://doi.org/10.20473/CCJ.V2I1.2021.23-29","url":null,"abstract":"Some cases of myocarditis have been reported associated to Covid-19. The presence of proinflammatory response from immune cells suggested occurs by binding to membrane protein ACE-2 leading to myocardial damage. Our hospital got a refferal from a non-PCI-capable hospital with a 51-years-old woman chest pain and progressive heavy breath with history of fever two days ago. She was diagnosed with anterior STEMI and cardiogenic shock on vassopressors. Her electrocardiogram showed shark fin appearance suggesting life-threatening STEMI. Her rapid test for covid-19 are non-reactive for both IgM and IgG. Her NCCT-thorax showed ground glass opacity in both lungs. Her laboratories finding showed elevated inflammatory markers and elevated cardiac biomarker. We took her naso-oro-pharingeal swab in the same day and process her with emergency PCI. Surprisingly, her angiography showed normal coronary artery without any significant stenosis. From There was no SARS-CoV-2 detected. In myocarditis, patient can mimick the same symptoms as STEMI such as chest pain and heavy breath with elevated cardiac biomarker, but the electrocardiogram usually shows widespread concave ST-elevation with PR-segment depression. Shark fin appearance is usually seen in life-threatening STEMI. In our patient, the NCCT-thorax showed GGO suggested Covid-19 involvement. But, the first swab was negative for SARS-CoV-2. Unfortunately, the patient was discharged without doctor’s consent, so we can not process the second swab and echocardiography to evaluate the function of myocardium. We still can not confirmed this case if it is true myocarditis-associated covid-19 and how was the involvement of the myocardium creating a shark fin mimicking life-threatening STEMI.","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133636668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac Pacemaker in Pregnancy: How to Manage? 妊娠期心脏起搏器:如何管理?

Cardiovascular and Cardiometabolic Journal (CCJ) Pub Date : 2021-03-27 DOI: 10.20473/CCJ.V2I1.2021.30-35

Dian Paramita Kartikasari, R. Julario

{"title":"Cardiac Pacemaker in Pregnancy: How to Manage?","authors":"Dian Paramita Kartikasari, R. Julario","doi":"10.20473/CCJ.V2I1.2021.30-35","DOIUrl":"https://doi.org/10.20473/CCJ.V2I1.2021.30-35","url":null,"abstract":"Despite the increasing use of permanent cardiac pacemakers in a younger patient population, there are little data related to pregnancy. Normal physiologic alterations of pregnancy need to be taken into account in the management of the pregnant woman with a pacemaker in place. Similarly, gestational events including the potential for surgical intervention require a basic knowledge of pacemaker technology and monitoring. We present a case of a patient with junctional escape rhythm and was implanted pacemaker during pregnancy. A 24 years old women referred from obstetric outpatient clinic with asymptomatic bradycardia and cryptogenic stroke 2 years earlier. ECG shows sinus arrest with junctional escape rhythm. After multi-disciplinary discussion, team decided to implant double chamber pacemaker implantation. The pacemaker setting is adjusted to prepare caesarean section at 39 weeks gestation with delivery of an aterm infant. The postoperative course was uneventful. Pre-pregnancy pacemaker settings were re-established after the postpartum period. The current literature on managing pregnant patients with pacemakers is quite limited. Such patients require a multidisciplinary approach to care. Electromagnetic Interference (EMI) should be noticed. ","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132070900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Atherosclerosis Effect of Soy Milk in Rats Fed an Atherogenic Diet 豆浆对致动脉粥样硬化大鼠的抗动脉粥样硬化作用

Cardiovascular and Cardiometabolic Journal (CCJ) Pub Date : 2021-03-27 DOI: 10.20473/CCJ.V2I1.2021.97-103

F. Azima

{"title":"Anti-Atherosclerosis Effect of Soy Milk in Rats Fed an Atherogenic Diet","authors":"F. Azima","doi":"10.20473/CCJ.V2I1.2021.97-103","DOIUrl":"https://doi.org/10.20473/CCJ.V2I1.2021.97-103","url":null,"abstract":"Abstract: Atherosclerosis is a problem of cardiovascular disease. Consuming food containing excessive fat is a risk factor for atherosclerosis. Soy milk has been studied for its isoflavones which has antihyperlipidemic effect on the development of atherosclerosis. The aim of this study was to find out the effect of soy milk (Glycine max (L.) Merr.) administration on aortic’s histopathology profile (the length of wall thickness and number of foam cells) in male white rats (Rattus norvegicus) which were given the atherogenic diet that consists of goat’s fat and quail egg yolk. Material and Methods: A total of 30 rats were used in the true laboratory experiment which were distributed into 5 groups (n=6) using post-test only design, there were a normal diet group, an atherogenic diet group, an atherogenic and simvastatin 10 mg group, and another 2 groups that were given an atherogenic diet with soy milk doses variation of 12.5 g and 25 g respectively. Aortic’s histopathology was prepared with the paraffin method and stained with Hematoxylin-Eosin. Results: ANOVA test showed that soy milk variation dose were significantly (p<0.05) reduce the aortic wall thickness and foam cell. Conclusion: Providing soy milk with a certain dose is able to decrease the aortic’s wall thickness and foam cells in rats fed an atherogenic diet.","PeriodicalId":371103,"journal":{"name":"Cardiovascular and Cardiometabolic Journal (CCJ)","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125253715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inferior Myocardial Infarction and Total AV Block in a Patient with Single Ostium in the Right Sinus of Valsava (A Rare Congenital Coronary Anomaly) 右瓣膜窦单口下壁心肌梗死及全房室传导阻滞1例(罕见的先天性冠状动脉异常)

Cardiovascular and Cardiometabolic Journal (CCJ) Pub Date : 1900-01-01 DOI: 10.20473/ccj.v2i1.2021.36-40

Imam Mahbub Zam Zami

引用次数: 0