Sleep Medicine: X最新文献

{"title":"Prevalence of pulmonary hypertension in children with obstructive sleep apnea living at high altitude","authors":"Elida Duenas-Meza ,&nbsp;Diego Fernando Severiche-Bueno ,&nbsp;Carolina Santos Quintero ,&nbsp;Jenny Talani Ochoa ,&nbsp;Miguel Ronderos Dummit ,&nbsp;Claudia Stapper ,&nbsp;Carlos Granados G","doi":"10.1016/j.sleepx.2024.100106","DOIUrl":"https://doi.org/10.1016/j.sleepx.2024.100106","url":null,"abstract":"<div><h3>Introduction</h3><p>The prevalence of obstructive sleep apnea (OSA) is 1–4 %. Some reports describe its association with pulmonary hypertension (PH), but its prevalence is unknown. No studies at high altitude have determined the relationship between OSA and PH. The aim of this study was to establish the prevalence of PH in children diagnosed with OSA living in a high-altitude city at 2640 m above sea level.</p></div><div><h3>Methods</h3><p>Children between 2 and 16 years of age referred to the Sleep Laboratory of the Fundación Neumológica Colombiana in Bogotá with a positive polysomnogram for OSA were included, and a two-dimensional transthoracic echocardiogram (TTE) was performed to evaluate PH. Statistical analysis was performed using median, interquartile range, chi-squared test, and Kruskall-Wallis test.</p></div><div><h3>Results</h3><p>Of the 55 patients (n: 55), 63.6 % were male, with a median age of 6 years, 14 children (25.5 %) were overweight; 12 children (21.8 %) had mild OSA, 12 (21.8 %) had moderate OSA and 31 (56.4 %) severe OSA. In patients with severe OSA, the minimum saturation during events was 78 % with a desaturation index (DI) of 33.8/hour (p &lt; 0.01). T90 and T85 increased proportionally with OSA severity (p &lt; 0.05). Of the 55 patients with OSA, none had PH according to echocardiography; 4 patients (7.2 %) had pulmonary artery systolic pressure (PASP) at the upper limit of normal (ULN), and it was not related to a higher body mass index (BMI).</p></div><div><h3>Conclusions</h3><p>We found no association between OSA and PH in children with OSA at high altitude.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"7 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142724000041/pdfft?md5=1081403ed663c1da6140248af8f439bb&pid=1-s2.0-S2590142724000041-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139699334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in sleep latency with extended-release once-nightly sodium oxybate for the treatment of adults with narcolepsy: Analysis from the phase 3 REST-ON clinical trial","authors":"Michael J. Thorpy ,&nbsp;Clete A. Kushida ,&nbsp;Richard Bogan ,&nbsp;John Winkelman ,&nbsp;Maurice M. Ohayon ,&nbsp;Colin M. Shapiro ,&nbsp;Jennifer Gudeman","doi":"10.1016/j.sleepx.2024.100113","DOIUrl":"https://doi.org/10.1016/j.sleepx.2024.100113","url":null,"abstract":"<div><h3>Background</h3><p>In the REST-ON clinical trial (NCT02720744), mean sleep latency on the Maintenance of Wakefulness Test (MWT) was significantly improved with extended-release once-nightly sodium oxybate (ON-SXB) vs placebo (<em>P</em> &lt; 0.001) in participants with narcolepsy. This post hoc analysis assessed response to treatment and improvement in excessive daytime sleepiness.</p></div><div><h3>Methods</h3><p>Participants with narcolepsy aged ≥16 years were randomized 1:1 to receive ON-SXB (4.5 g, week 1; 6 g, weeks 2–3; 7.5 g, weeks 3–8; and 9 g, weeks 9–13) or placebo. Mean sleep latency on the MWT was measured across 5 trials of ≤30 min each. Post hoc assessments included percentage of participants whose sleep latency improved ≥5, ≥10, ≥15, and ≥20 min and with a mean sleep latency of 30 min.</p></div><div><h3>Results</h3><p>Significantly more participants receiving ON-SXB vs placebo experienced increased mean sleep latency ≥5 min (all doses <em>P</em> &lt; 0.001), ≥10 min (all doses <em>P</em> &lt; 0.001), ≥15 min (6 and 7.5 g, <em>P</em> &lt; 0.001; 9 g, <em>P</em> &lt; 0.01), and ≥20 min (6 g, <em>P</em> &lt; 0.01; 7.5 g, <em>P</em> &lt; 0.001; 9 g, <em>P</em> &lt; 0.05). More participants receiving ON-SXB had mean sleep latency of 30 min vs placebo (6 g, 5.7 % vs 0 %, respectively [<em>P</em> &lt; 0.05]; 7.5 g, 10.5 % vs 1.3 % [<em>P</em> &lt; 0.05]; 9 g, 13.2 % vs 5.1 % [<em>P</em> = 0.143]).</p></div><div><h3>Conclusions</h3><p>Significantly more participants who received ON-SXB experienced increased mean sleep latency ≥5 to ≥20 min; at the 2 highest doses, &gt;10 % remained awake for the entirety of the MWT. ON-SXB offers a once-at-bedtime treatment option for adults with narcolepsy.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"7 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142724000119/pdfft?md5=b9d301802075b761e2f987d477a38f42&pid=1-s2.0-S2590142724000119-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"May home cardiorespiratory polygraphy be considered a realistic alternative to polysomnography for catathrenia screening?","authors":"Sameh Msaad ,&nbsp;Sourour Abid ,&nbsp;Issraa Wadhane ,&nbsp;Rahma Gargouri ,&nbsp;Nesrine Kallel ,&nbsp;Fatma Triki ,&nbsp;Nadia Moussa ,&nbsp;Samy Kammoun","doi":"10.1016/j.sleepx.2023.100097","DOIUrl":"10.1016/j.sleepx.2023.100097","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"7 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259014272300037X/pdfft?md5=cc39cf3a575dc2fdebb82bb659ded77f&pid=1-s2.0-S259014272300037X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139022000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transitioning insomnia patients from zolpidem to lemborexant: A multicenter, open-label study evaluating a next-dose transition approach to insomnia pharmacotherapy","authors":"Maha Ahmad ,&nbsp;James Kelly ,&nbsp;C. Brendan Montano ,&nbsp;Dinesh Kumar ,&nbsp;Carlos Perdomo ,&nbsp;Manoj Malhotra ,&nbsp;Jess Amchin ,&nbsp;Margaret Moline","doi":"10.1016/j.sleepx.2023.100098","DOIUrl":"10.1016/j.sleepx.2023.100098","url":null,"abstract":"<div><h3>Objective</h3><p>Few clinical studies have assessed real-world abrupt transitioning between insomnia medications. This study assessed strategies for directly transitioning patients from zolpidem tartrate (ZOL) immediate/extended release to the dual orexin receptor antagonist, lemborexant (LEM).</p></div><div><h3>Methods</h3><p>This randomized, open-label, multicenter study (Study 312; E2006-A001-312) enrolled 53 adults age ≥18 years with insomnia disorder and ≥1-month history of intermittent (3–4 nights/week) or frequent (≥5 nights/week) ZOL use. Subjects recorded their ZOL use in a 3-week Pretreatment Phase, followed by a 2-week Treatment Phase (TRT; Titration) during which ZOL was discontinued. Intermittent ZOL users transitioned to LEM 5 mg (LEM5), Cohort 1, and frequent ZOL users were randomized 1:1 to LEM5, Cohort 2A, or LEM 10 mg (LEM10), Cohort 2B. One dose adjustment was permitted during the TRT. Subjects completing the TRT could continue LEM in the 12-week Extension Phase (EXT). The primary outcome was proportion of subjects who successfully transitioned and remained on LEM at the end of the TRT.</p></div><div><h3>Results</h3><p>Most subjects (43 [81.1 %]) successfully transitioned to LEM (9 [90 %], 17 [81.0 %], and 17 [77.3 %] in Cohorts 1, 2A, and 2B, respectively). By the end of the EXT, 66.7 % in Cohort 1 and 60.0 % in Cohort 2A up-titrated to LEM10, whereas 41.2 % in Cohort 2B down-titrated to LEM5; 61.0 % were receiving LEM10 at study end. At the end of the TRT, more subjects taking LEM reported that it helped them return to sleep after waking, compared with those taking ZOL (71.7 % vs. 49.1 %). There were no important differences between treatments regarding how subjects reported feeling as they fell asleep. Most of the treatment-emergent adverse events with LEM were mild in severity.</p></div><div><h3>Conclusions</h3><p>Most subjects transitioned successfully to LEM from ZOL (intermittent or frequent use). LEM was well tolerated.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"7 ","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142723000381/pdfft?md5=7109a2f1da83bc58b53f511379193c5d&pid=1-s2.0-S2590142723000381-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139191679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sleep quality with physical and psychological health indicators in overweight and obese rural Indians","authors":"Sakshi Arora,&nbsp;Pravin Sahadevan,&nbsp;Jonas S. Sundarakumar","doi":"10.1016/j.sleepx.2024.100112","DOIUrl":"https://doi.org/10.1016/j.sleepx.2024.100112","url":null,"abstract":"<div><h3>Objective</h3><p>To measure the association of sleep quality with physical (i.e., grip strength, functional mobility, balance) and psychological (depression, anxiety) health indicators in an overweight/obese population.</p></div><div><h3>Methods</h3><p>Baseline data of 2337 participants (1382 overweight/obese and 955 normal weight) from an aging cohort in rural southern India (CBR-SANSCOG) was analyzed retrospectively. Assessment tools included the Pittsburgh Sleep Quality Index (PSQI) for sleep quality, dynamometry for Hand Grip Strength (HGS), Timed Up-and-Go (TUG) for functional mobility, Chair Stand Test (CST) for lower limb strength, Geriatric Depression scale (GDS-30) for depressive symptoms and Generalized Anxiety Disorder scale (GAD-7) for anxiety symptoms. Linear regression models, adjusted for known confounders, were used to examine the association of sleep quality with the health parameters in overweight/obese and normal-weight groups.</p></div><div><h3>Results</h3><p>In the fully adjusted model, higher global PSQI score was associated with higher TUG time (β = 0.06, 95 % CI: 0.004,0.12), higher scores on GDS (β = 1.08, 95 % CI: 0.96,1.20) and GAD (β = 0.71, 95 % CI: 0.62,0.79), and lower scores on CST (β = -0.12, 95 % CI: -0.19,-0.06) in overweight/obese individuals. The sleep disturbance sub-component of PSQI was associated with most of the physical (TUG, CST) and psychological (GDS and GAD) health indicators. Sleep duration and use of sleep medication showed no significant association with any of the health indicators.</p></div><div><h3>Conclusion</h3><p>The concurrent presence of poor sleep quality and overweight/obesity could worsen physical and psychological health in middle-aged and older adults. We highlight the importance of early detection and timely management of sleep problems in this population to reduce physical and psychological morbidities.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"7 ","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142724000107/pdfft?md5=4423250c2c60013e04bac44d8afbc6ff&pid=1-s2.0-S2590142724000107-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140952197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are circadian rhythms in disarray in patients with chronic critical illness?","authors":"Mikhail Kanarskii ,&nbsp;Julia Nekrasova ,&nbsp;Ekaterina Kondratieva ,&nbsp;Ilya Borisov ,&nbsp;Elena Simenel ,&nbsp;Yurii Sviryaev ,&nbsp;Pranil Pradhan ,&nbsp;Kirill Gorshkov ,&nbsp;Alexander Shestopalov ,&nbsp;Marina Petrova","doi":"10.1016/j.sleepx.2023.100101","DOIUrl":"https://doi.org/10.1016/j.sleepx.2023.100101","url":null,"abstract":"<div><h3>Aim</h3><p>The aim of our study is to assess circadian rhythms in patients with chronic critical illness due to severe brain injury in intensive care unit by establishing the relation between melatonin and cortisol secretion, considering astronomical time and the sleep-wake cycle in chronic critical illness.</p></div><div><h3>Materials and methods</h3><p>The study included 54 adult patients with chronic critical illness who resided in the intensive care unit for at least 30 days. The level of consciousness was determined using the CRS-R scale. We did the continuous electroencephalographic (EEG) monitoring with polygraphic leads for 24 h. Also, we determined the serum levels of cortisol and melatonin using the tandem mass spectrometry method with ultra-performance liquid chromatography.</p></div><div><h3>Results</h3><p>90.74 % of patients had one acrophase in melatonin secretion curve, which suggests the preservation of the rhythmic secretion of melatonin. These acrophases of the melatonin rhythm occurred during the night time in 91.8 % of patients. Most of the patients (69.3 %) slept during the period from 2:00 to 4:00 a.m. The evening levels of cortisol and melatonin had an inverse relation (<em>r</em>_<em>s</em><em>=0.61</em>, <em>p&lt;0.05</em>), i.e., a decrease in the level of cortisol secretion accompanies an increase in melatonin.</p></div><div><h3>Conclusions</h3><p>We concluded from our study that the rhythmic secretion of melatonin and cortisol is preserved in patients with chronic critical illness that resulted from severe brain injury. No statistically significant discrepancy between melatonin and cortisol secretion, day-and-night time and the sleep-wake cycle are found. We may focus our future work on finding more reliable methods to stabilize the preservation of circadian rhythms to protect vital organ functions.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"7 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142723000411/pdfft?md5=f90b4a3f5e62678b5dc9ab7ef15e0260&pid=1-s2.0-S2590142723000411-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139109130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are nocturnal awakenings at age 1 predictive of sleep duration and efficiency at age 6: Results from two birth cohorts","authors":"Ina S. Santos ,&nbsp;Priscila Echevarria ,&nbsp;Luciana Tovo-Rodrigues ,&nbsp;Alicia Matijasevich ,&nbsp;Marlos R. Domingues ,&nbsp;Pedro C. Hallal","doi":"10.1016/j.sleepx.2024.100105","DOIUrl":"10.1016/j.sleepx.2024.100105","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the association of nighttime awakenings at 12 months with the duration and efficiency of nighttime sleep at 6 years of age.</p></div><div><h3>Methods</h3><p>Data from two population-based prospective studies (The Pelotas 2004 and The Pelotas 2015 Birth Cohorts) were used. Information on nighttime awakenings was provided by mothers during the 12-month follow-up interview. Infants who awakened &gt;3 times after sleep onset at 12 months were considered frequent wakeners. Sleep duration and sleep efficiency were obtained by actigraphy at the 6-year follow-up. Children wore the device at the wrist of the non-dominant arm continuously for 3–7 days, including at least one weekend day. Unadjusted and adjusted beta coefficients were obtained by linear regression for each cohort separately.</p></div><div><h3>Results</h3><p>2500 children from the 2004 and 2793 from the 2015 cohort had full information on nighttime awakenings at 12 months and actigraphy at 6 years and were analyzed. Prevalence of frequent wakeners was 6.3 % and 5.9 % in the 2004 and 2015 cohort, respectively. Mean bedtime and wake-up time at 6 years were, respectively, 23:23 and 08:41 h in the 2004 cohort, and 00:10 and 09:00 h int the 2015 cohort. Nighttime sleep lasted on average 7.54 and 7.24 h respectively in the 2004 and the 2015 cohort, and the sleep efficiency was 81.1 and 82.5 % respectively. In adjusted analyses, no associations were found between awakening at 12 months and sleep duration or sleep efficiency at 6 years of age.</p></div><div><h3>Conclusion</h3><p>In both cohorts sleep duration and efficiency were below the recommendation for school-age children (respectively 9–11 h and 85 %). There was no relationship between the number of nighttime awakenings at 12 months and sleep duration or efficiency at 6 years.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"7 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259014272400003X/pdfft?md5=b21201cb0e5c8a37c97665c73a21df39&pid=1-s2.0-S259014272400003X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Registry and survey of circadian rhythm sleep-wake disorder patients","authors":"Peter Mansbach,&nbsp;James S.P. Fadden,&nbsp;Lynn McGovern","doi":"10.1016/j.sleepx.2023.100100","DOIUrl":"10.1016/j.sleepx.2023.100100","url":null,"abstract":"<div><h3>Objective</h3><p>Circadian Sleep Disorders Network has created a registry of circadian rhythm sleep-wake disorder (CRSWD) patients, and a survey of their experiences. The purpose of the registry is to provide volunteers willing to participate in research; the purpose of the survey is to fill some of the knowledge gaps on these disorders, including information on subjective patient experience and the efficacy and durability of treatments.</p><p>Researchers are invited to contact Circadian Sleep Disorders Network for permission to use the registry to find potential research participants, and to further analyze the survey data.</p></div><div><h3>Patients</h3><p>Over 1627 patients have participated; 1298 have completed the entire survey. Here we present results based on the 479 clinically diagnosed CRSWD patients.</p></div><div><h3>Methods</h3><p>The survey covers a variety of topics relating to CRSWDs, including diagnosis, comorbidities, treatments, and work/educational accommodations.</p></div><div><h3>Conclusions</h3><p>Results of this survey diverged from much of the literature. More than half the participants reported tiredness even when sleeping on their preferred schedule. While depression may cause sleep problems, our data suggests that sleep/circadian problems often precede depression.</p><p>There were more people suffering from sighted non-24-hour sleep-wake rhythm disorder than some of the literature would lead us to expect.</p><p>Current treatments did not appear to be helpful to a large percentage of our participants. Most of them did not find light therapy helpful and nearly all participants who tried phase-delay chronotherapy reported at best only short-term improvement. A sizable proportion of people who tried phase-delay chronotherapy subsequently developed non-24-hour sleep-wake rhythm disorder.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"7 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S259014272300040X/pdfft?md5=4cf5c8d0f949b8308fe6a357b7c77bba&pid=1-s2.0-S259014272300040X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of sleep patterns and circadian typology in uruguayan children: The contribution of school shifts","authors":"Andrés Olivera ,&nbsp;Ignacio Estevan ,&nbsp;Bettina Tassino ,&nbsp;Cecilia Rossel ,&nbsp;Ana Silva","doi":"10.1016/j.sleepx.2023.100099","DOIUrl":"10.1016/j.sleepx.2023.100099","url":null,"abstract":"<div><p>Healthy sleep is defined by the combination of adequate duration, good quality, and regular timing. In children, sleep thus depends on the interplay of individual, parental, organizational, community, and social variables, but only a few studies have addressed this issue in a comprehensive way nationwide. Using the Uruguayan nationally representative survey (Nutrition, Child Development, and Health Survey, Encuesta de Nutrición, Desarrollo Infantil y Salud, ENDIS), we present the first epidemiological characterization of chronobiological and sleep parameters in Latin American children. On average, Uruguayan urban children (n = 2437; 5−10-years old) showed quite late chronotypes (MSFsc = 03:53 ± 1:07), moderate misalignment (SJL = 1.0 ± 0.9 h), and adequate sleep duration (SDweek = 9.9 ± 1.0 h). Further, we show the substantial influence of school shift schedules on children's circadian typology and sleep patterns. Our results show that children attending the morning school shift have a higher risk of sleep problems than afternoon-school shift ones. The chronotype and sleep were earlier in morning-school shift children than in children attending the afternoon school shift. However, morning-school shift children had stronger misalignment, shorter sleep on school days, and a higher risk of chronic sleep deficit and non-healthy circadian misalignment (even worse in late chronotypes) than afternoon-shift children. This evidence points to the need of evaluating policies to reorganize school start times to prevent the negative effects that early schooling seems to have on children's sleep health, which has been neglected so far.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"7 ","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142723000393/pdfft?md5=6da92b22cbd9245914856277b45d17aa&pid=1-s2.0-S2590142723000393-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of sleep disturbance and its possible associated factors among iranian medical students: A cross-sectional study with a national meta-analysis","authors":"Arman Shafiee ,&nbsp;Jafar Fili ,&nbsp;Samane Ghafari ,&nbsp;Mohammad Amin Sattari ,&nbsp;Nahid Borna ,&nbsp;Ali Pourramzani","doi":"10.1016/j.sleepx.2024.100107","DOIUrl":"https://doi.org/10.1016/j.sleepx.2024.100107","url":null,"abstract":"<div><h3>Background</h3><p>The aim of this cross-sectional study was to investigate the prevalence of sleep disturbance and its possible associated factors among Iranian medical students. Additionally, a national meta-analysis was conducted to provide a comprehensive overview of sleep disturbance in this population.</p></div><div><h3>Methods</h3><p>A sample of medical students from Guilan University of Medical Sciences, Iran was included in the study. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep disturbance. Demographic and lifestyle factors, as well as academic performance, were collected through a self-administered questionnaire. The data collected from this study were combined with existing studies through a meta-analysis to estimate the overall prevalence of sleep disturbance among Iranian medical students using the random effects model.</p></div><div><h3>Results</h3><p>A total of 249 medical students participated in the study. The prevalence of sleep disturbance among Guilan University of Medical Sciences medical students was found to be 71.1%. A significant difference was observed in total PSQI means regarding medical students’ residency (p &lt; 0.001) and their duration of sleep in the last 24 h (p = 0.006). The national prevalence of sleep disturbances was 59% (95% CI: [51%–66%], I2 = 97%).</p></div><div><h3>Conclusion</h3><p>Sleep disturbance is highly prevalent among Iranian medical students, with various factors contributing to its occurrence. The findings of this study highlight the need for interventions and strategies to improve sleep quality and overall well-being among this population. The national meta-analysis provides valuable insights into the overall burden of sleep disturbance among Iranian medical students and can serve as a reference for future studies and public health initiatives targeting this issue.</p></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"7 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590142724000053/pdfft?md5=436d9616aa74f62c240d2a83527ef42c&pid=1-s2.0-S2590142724000053-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139726939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}