Human Genome Variation最新文献

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Partial monosomy 18p and 21q due to a paternal reciprocal translocation leading to holoprosencephaly. 部分单体18p和21q由于父本互惠易位导致前脑畸形。
IF 1
Human Genome Variation Pub Date : 2025-05-30 DOI: 10.1038/s41439-025-00314-2
Hiroko Wakabayashi, Ayumi Matsumoto, Sakiko Komori, Masahide Goto, Toshihiro Tajima, Aiko Sasaki, Takayoshi Matsumura, Takanori Yamagata
{"title":"Partial monosomy 18p and 21q due to a paternal reciprocal translocation leading to holoprosencephaly.","authors":"Hiroko Wakabayashi, Ayumi Matsumoto, Sakiko Komori, Masahide Goto, Toshihiro Tajima, Aiko Sasaki, Takayoshi Matsumura, Takanori Yamagata","doi":"10.1038/s41439-025-00314-2","DOIUrl":"https://doi.org/10.1038/s41439-025-00314-2","url":null,"abstract":"<p><p>Here we report a patient with holoprosencephaly (HPE) associated with 45, XY,der(18)t(18;21)(p11.2;q21.3),-21 derived from a paternal balanced reciprocal translocation. Array comparative genomic hybridization analysis revealed 18p11.32-p11.21 and 21q11.2-q21.3 deletions. So far, nine cases of monosomy 18p with an unbalanced translocation (18;21) have been reported, four of which presented with HPE. Our case provides a detailed long-term clinical course and helps us to better understand these rare genetic events.</p>","PeriodicalId":36861,"journal":{"name":"Human Genome Variation","volume":"12 1","pages":"10"},"PeriodicalIF":1.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
De novo CDKN1C variant in Beckwith-Wiedermann spectrum with atypical complications. Beckwith-Wiedermann综合征伴非典型并发症的新发CDKN1C变异。
IF 1
Human Genome Variation Pub Date : 2025-05-28 DOI: 10.1038/s41439-025-00316-0
Yuri Moriura, Yosuke Nishio, Shintaro Ichimura, Haruka Noda, Yoshihiro Tanahashi, Hikaru Yamamoto, Yuka Nakazawa, Taichi Oso, Yoshiaki Sato, Toshiki Takenouchi, Shinji Saitoh, Yukako Muramatsu, Tomoo Ogi
{"title":"De novo CDKN1C variant in Beckwith-Wiedermann spectrum with atypical complications.","authors":"Yuri Moriura, Yosuke Nishio, Shintaro Ichimura, Haruka Noda, Yoshihiro Tanahashi, Hikaru Yamamoto, Yuka Nakazawa, Taichi Oso, Yoshiaki Sato, Toshiki Takenouchi, Shinji Saitoh, Yukako Muramatsu, Tomoo Ogi","doi":"10.1038/s41439-025-00316-0","DOIUrl":"10.1038/s41439-025-00316-0","url":null,"abstract":"<p><p>Beckwith-Wiedemann spectrum (BWSp) is a genomic imprinting disorder characterized by a wide range of clinical features. Here we report an infant with BWSp and atypical features, for whom long-read sequencing confirmed a de novo CDKN1C variant that occurred on the maternally inherited allele and excluded other genetic etiologies. These findings not only expand the BWSp concept but also highlight the potential value of allelic origin analysis in cases with atypical presentations.</p>","PeriodicalId":36861,"journal":{"name":"Human Genome Variation","volume":"12 1","pages":"9"},"PeriodicalIF":1.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two novel pathogenic PDX1 variants in two Japanese patients with maturity-onset diabetes of the young. 两名日本青年成熟型糖尿病患者的两种新型致病性PDX1变异
IF 1
Human Genome Variation Pub Date : 2025-05-16 DOI: 10.1038/s41439-025-00312-4
Satoshi Tanaka, Hiroyuki Akagawa, Michiyo Hase, Naoko Iwasaki
{"title":"Two novel pathogenic PDX1 variants in two Japanese patients with maturity-onset diabetes of the young.","authors":"Satoshi Tanaka, Hiroyuki Akagawa, Michiyo Hase, Naoko Iwasaki","doi":"10.1038/s41439-025-00312-4","DOIUrl":"10.1038/s41439-025-00312-4","url":null,"abstract":"<p><p>Maturity-onset diabetes of the young type 4 (MODY4, PDX1-MODY) is a monogenic diabetes caused by the PDX1 gene. Here we detected two novel heterozygous missense variants, NM_000209.4(NP_000200.1):c.443G>T, p.(Arg148Leu) and c.442C>G p.(Arg148Gly), in two Japanese patients. Pathogenicity testing revealed a loss of function in both variants. Family members had severe diabetic complications, including proliferative retinopathy and overt nephropathy such as end-stage renal disease. Laboratory testing indicated persistently high glucose levels, at least partially caused by reduced postprandial insulin secretion.</p>","PeriodicalId":36861,"journal":{"name":"Human Genome Variation","volume":"12 1","pages":"8"},"PeriodicalIF":1.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful birth after preimplantation genetic testing for rare mitochondrial DNA mutation m.10197G>A. 罕见线粒体DNA突变m.10197G>A胚胎植入前基因检测成功分娩。
IF 1
Human Genome Variation Pub Date : 2025-04-01 DOI: 10.1038/s41439-025-00311-5
Yuki Mizuguchi, Kou Sueoka, Suguru Sato, Mamoru Tanaka
{"title":"Successful birth after preimplantation genetic testing for rare mitochondrial DNA mutation m.10197G>A.","authors":"Yuki Mizuguchi, Kou Sueoka, Suguru Sato, Mamoru Tanaka","doi":"10.1038/s41439-025-00311-5","DOIUrl":"10.1038/s41439-025-00311-5","url":null,"abstract":"<p><p>Here we report the first successful birth after preimplantation genetic testing for m.10197G>A mutation, a rare variant responsible for Leigh encephalopathy. Preimplantation genetic testing diagnosed the embryo with a mutant load of <5%, and transfer resulted in a live birth. The mutant load of embryos diagnosed in this case was skewed to the extremes. Skewed segregation patterns have been observed in common mutations, but this case suggests that the same phenomenon may be seen in this rare mutation.</p>","PeriodicalId":36861,"journal":{"name":"Human Genome Variation","volume":"12 1","pages":"7"},"PeriodicalIF":1.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonrecurrent 17p duplications in two patients with developmental and neurological abnormalities. 2例发育和神经异常患者的非复发性17p重复。
IF 1
Human Genome Variation Pub Date : 2025-03-26 DOI: 10.1038/s41439-025-00310-6
Ah Jin Lee, Byung Kwon Pi, Soo Hyun Nam, Hyun Su Kim, Byung-Ok Choi, Ki Wha Chung
{"title":"Nonrecurrent 17p duplications in two patients with developmental and neurological abnormalities.","authors":"Ah Jin Lee, Byung Kwon Pi, Soo Hyun Nam, Hyun Su Kim, Byung-Ok Choi, Ki Wha Chung","doi":"10.1038/s41439-025-00310-6","DOIUrl":"10.1038/s41439-025-00310-6","url":null,"abstract":"<p><p>Variable copy number variations (CNVs) in the short arm of chromosome 17 are associated with many neurodevelopmental disorders, including Charcot-Marie-Tooth disease type 1A, Potocki-Lupski syndrome and Yuan-Harel-Lupski syndrome. Here we examined CNVs in two sporadic cases of developmental abnormalities, brain impairment and peripheral neuropathy. We identified novel duplications of approximately 14.1 Mb at 17p11.2-p13.1 (containing PMP22 and RAI1) and 17.6 Mb at 17p11.2-p13.3 (YWHAE, PAFAH1B and PMP22) in each patient. Both duplications were suggested to be produced by de novo mutations of paternal origin. This study suggests that CNVs at 17p should be examined in patients with peripheral neuropathy as well as developmental and brain abnormalities.</p>","PeriodicalId":36861,"journal":{"name":"Human Genome Variation","volume":"12 1","pages":"6"},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-frame deletion variant of ABCD1 in a sporadic case of adrenoleukodystrophy. ABCD1帧内缺失变体在散发性肾上腺脑白质营养不良病例中的表现。
IF 1
Human Genome Variation Pub Date : 2025-02-28 DOI: 10.1038/s41439-025-00309-z
Takashi Matsukawa, Atsushi Sudo, Toshiyuki Kakumoto, Akihito Hao, Mitsuhiro Kainaga, Hyangri Chang, Tatsuo Mano, Hiroyuki Ishiura, Jun Mitsui, Toshihiro Hayashi, Shinichi Morishita, Shoji Tsuji, Tatsushi Toda
{"title":"In-frame deletion variant of ABCD1 in a sporadic case of adrenoleukodystrophy.","authors":"Takashi Matsukawa, Atsushi Sudo, Toshiyuki Kakumoto, Akihito Hao, Mitsuhiro Kainaga, Hyangri Chang, Tatsuo Mano, Hiroyuki Ishiura, Jun Mitsui, Toshihiro Hayashi, Shinichi Morishita, Shoji Tsuji, Tatsushi Toda","doi":"10.1038/s41439-025-00309-z","DOIUrl":"10.1038/s41439-025-00309-z","url":null,"abstract":"<p><p>Adrenoleukodystrophy (ALD), an X-linked leukodystrophy caused by pathogenic variants in ABCD1, exhibits a broad range of phenotypes from childhood-onset cerebral forms to adult-onset adrenomyeloneuropathy (AMN). We report a rare in-frame ABCD1 deletion c.1469_71delTGG (p.Val490del) in a man with AMN. Although this variant has been interpreted as 'uncertain significance' in ClinVar, biochemical analysis along with clinical evaluation confirmed the pathogenicity of this variant, underscoring the importance of functional assessment of in-frame deletions.</p>","PeriodicalId":36861,"journal":{"name":"Human Genome Variation","volume":"12 1","pages":"5"},"PeriodicalIF":1.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-coverage whole-genome sequencing of a Jakun individual from the "Orang Asli" Proto-Malay subtribe from Peninsular Malaysia. 来自马来西亚半岛原始马来亚部落“Orang Asli”的Jakun个体的高覆盖全基因组测序。
IF 1
Human Genome Variation Pub Date : 2025-01-08 DOI: 10.1038/s41439-024-00308-6
Wai-Sum Yap, Alvin Cengnata, Woei-Yuh Saw, Thuhairah Abdul Rahman, Yik-Ying Teo, Renee Lay-Hong Lim, Boon-Peng Hoh
{"title":"High-coverage whole-genome sequencing of a Jakun individual from the \"Orang Asli\" Proto-Malay subtribe from Peninsular Malaysia.","authors":"Wai-Sum Yap, Alvin Cengnata, Woei-Yuh Saw, Thuhairah Abdul Rahman, Yik-Ying Teo, Renee Lay-Hong Lim, Boon-Peng Hoh","doi":"10.1038/s41439-024-00308-6","DOIUrl":"https://doi.org/10.1038/s41439-024-00308-6","url":null,"abstract":"<p><p>Jakun, a Proto-Malay subtribe from Peninsular Malaysia, is believed to have inhabited the Malay Archipelago during the period of agricultural expansion approximately 4 thousand years ago (kya). However, their genetic structure and population history remain inconclusive. In this study, we report the genome structure of a Jakun female, based on whole-genome sequencing, which yielded an average coverage of 35.97-fold. We identified approximately 3.6 million single-nucleotide variations (SNVs) and 517,784 small insertions/deletions (indels). Of these, 39,916 SNVs were novel (referencing dbSNP151), and 10,167 were nonsynonymous (nsSNVs), spanning 5674 genes. Principal Component Analysis (PCA) revealed that the Jakun genome sequence closely clustered with the genomes of the Cambodians (CAM) and the Metropolitan Malays from Singapore (SG_MAS). The ADMIXTURE analysis further revealed potential admixture from the EA and North Borneo populations, as corroborated by the results from the F3, F4, and TreeMix analyses. Mitochondrial DNA analysis revealed that the Jakun genome carried the N21a haplogroup (estimated to have occurred ~19 kya), which is commonly found among Malays from Malaysia and Indonesia. From the whole-genome sequence data, we identified 825 damaging and deleterious nonsynonymous single-nucleotide polymorphisms (nsSNVs) affecting 720 genes. Some of these variants are associated with age-related macular degeneration, atrial fibrillation, and HDL cholesterol level. Additionally, we located a total of 3310 variants on 32 core adsorption, distribution, metabolism, and elimination (ADME) genes. Of these, 193 variants are listed in PharmGKB, and 21 are nsSNVs. In summary, the genetic structure identified in the Jakun individual could enhance the mapping of genetic variants for disease-based population studies and further our understanding of the human migration history in Southeast Asia.</p>","PeriodicalId":36861,"journal":{"name":"Human Genome Variation","volume":"12 1","pages":"4"},"PeriodicalIF":1.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel UBA1 gene mutation in a patient with infantile respiratory distress syndrome. 一个新的UBA1基因突变的患者与婴儿呼吸窘迫综合征。
IF 1
Human Genome Variation Pub Date : 2025-01-06 DOI: 10.1038/s41439-024-00307-7
Masafumi Miyata, Arisa Kojima, Yuri Kawai, Hidetoshi Uchida, Hiroko Boda, Naoko Ishihara, Hidehito Inagaki, Tetsushi Yoshikawa, Hiroki Kurahashi
{"title":"A novel UBA1 gene mutation in a patient with infantile respiratory distress syndrome.","authors":"Masafumi Miyata, Arisa Kojima, Yuri Kawai, Hidetoshi Uchida, Hiroko Boda, Naoko Ishihara, Hidehito Inagaki, Tetsushi Yoshikawa, Hiroki Kurahashi","doi":"10.1038/s41439-024-00307-7","DOIUrl":"https://doi.org/10.1038/s41439-024-00307-7","url":null,"abstract":"<p><p>UBA1 is an E1 ubiquitin-activating enzyme that initiates the ubiquitylation of target proteins and is thus a key component of the ubiquitin signaling pathway. Three disorders are associated with pathogenic variants of the UBA1 gene: vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome, lung cancer in never smokers (LCINS), and X-linked spinal muscular atrophy (XL-SMA, SMAX2). We here report a case of infantile respiratory distress syndrome followed by continuing neuromuscular symptoms. We identified a de novo hemizygous mutation, c.1660 C > T (p.Pro554Ser), in exon 15 of the UBA1 gene in this baby. This missense mutation was located with the AAD (active adenylation domain) of the protein, a known hotspot of SMAX2 mutations. This case lends support to the genotype-phenotype correlation regarding the UBA1 mutation and its related diseases.</p>","PeriodicalId":36861,"journal":{"name":"Human Genome Variation","volume":"12 1","pages":"2"},"PeriodicalIF":1.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of novel ERLIN2 gene variants with hereditary spastic paraplegia. 新的ERLIN2基因变异与遗传性痉挛性截瘫的关系。
IF 1
Human Genome Variation Pub Date : 2025-01-06 DOI: 10.1038/s41439-024-00305-9
R Bermejo Ramírez, N Villena Gascó, L Ruiz Palmero, G A Ribes Bueno, E S Yamanaka, J Piqueras Flores, J M Flores Barragán, E Buces González, J D Arroyo Andújar
{"title":"Association of novel ERLIN2 gene variants with hereditary spastic paraplegia.","authors":"R Bermejo Ramírez, N Villena Gascó, L Ruiz Palmero, G A Ribes Bueno, E S Yamanaka, J Piqueras Flores, J M Flores Barragán, E Buces González, J D Arroyo Andújar","doi":"10.1038/s41439-024-00305-9","DOIUrl":"https://doi.org/10.1038/s41439-024-00305-9","url":null,"abstract":"<p><p>Two ERLIN2 variants (NM_007175.8:c.660delA and NM_007175.8:c.869C>T) were detected in a Spanish patient with hereditary spastic paraplegia via whole-exome sequencing and software-based pathogenic variant selection. Segregation analysis revealed that the patient's two affected siblings carried both variants, whereas their offspring, carrying only one variant, were asymptomatic, indicating the autosomal recessive nature of the disease. These findings suggest that the identified variants can be classified as pathogenic when they are present as compound heterozygous variants.</p>","PeriodicalId":36861,"journal":{"name":"Human Genome Variation","volume":"12 1","pages":"3"},"PeriodicalIF":1.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical characteristics of the Ala21Val variant in the myelin proteolipid protein 1 (PLP1) gene associated with Pelizaeus-Merzbacher disease in a Brazilian male patient. 巴西男性患者Pelizaeus-Merzbacher病相关髓磷脂蛋白脂蛋白1 (PLP1)基因Ala21Val变异的临床特征
IF 1
Human Genome Variation Pub Date : 2025-01-06 DOI: 10.1038/s41439-024-00306-8
Pedro Manzke, Pedro Renato P Brandão, Talita Balieiro, Diógenes Diego de Carvalho Bispo, Maria Joana Osório, Gustavo Barcelos Barra
{"title":"Clinical characteristics of the Ala21Val variant in the myelin proteolipid protein 1 (PLP1) gene associated with Pelizaeus-Merzbacher disease in a Brazilian male patient.","authors":"Pedro Manzke, Pedro Renato P Brandão, Talita Balieiro, Diógenes Diego de Carvalho Bispo, Maria Joana Osório, Gustavo Barcelos Barra","doi":"10.1038/s41439-024-00306-8","DOIUrl":"https://doi.org/10.1038/s41439-024-00306-8","url":null,"abstract":"<p><p>Here, we report the case of a 29-year-old male with classic Pelizaeus-Merzbacher disease (PMD) harboring the PLP1 variant NM_000533.5:c.62 C > T, leading to an NP_000524.3:p.(Ala21Val) alteration in the first transmembrane domain of the protein. He presented with developmental delays, nystagmus, spastic paraparesis, optic atrophy, dysphagia, appendicular ataxia, and progressive head tremor. Brain MRI revealed hypomyelination, diffuse white matter hyperintensity, and atrophy of the corpus callosum and cerebellum, expanding the known clinical spectrum of PMD.</p>","PeriodicalId":36861,"journal":{"name":"Human Genome Variation","volume":"12 1","pages":"1"},"PeriodicalIF":1.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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