International Journal on Magnetic Particle Imaging最新文献

Temperature-Dependent Changes in Resolution and Coercivity of Superparamagnetic and Superferromagnetic Iron Oxide Nanoparticles. 超顺磁性和超铁磁性氧化铁纳米粒子的分辨率和矫顽力随温度的变化。

International Journal on Magnetic Particle Imaging Pub Date : 2023-01-01 Epub Date: 2023-03-19 DOI: 10.18416/IJMPI.2023.2303056

Owen Doyle, Jacob Bryan, Melissa Kim, Chinmoy Saayujya, Sophie Nazarian, Javier Mokkarala-Lopez, Renesmee Kuo, Mariam Yousuf, Prashant Chandrasekharan, Benjamin Fellows, Steven Conolly

{"title":"Temperature-Dependent Changes in Resolution and Coercivity of Superparamagnetic and Superferromagnetic Iron Oxide Nanoparticles.","authors":"Owen Doyle, Jacob Bryan, Melissa Kim, Chinmoy Saayujya, Sophie Nazarian, Javier Mokkarala-Lopez, Renesmee Kuo, Mariam Yousuf, Prashant Chandrasekharan, Benjamin Fellows, Steven Conolly","doi":"10.18416/IJMPI.2023.2303056","DOIUrl":"https://doi.org/10.18416/IJMPI.2023.2303056","url":null,"abstract":"Magnetic Particle Imaging (MPI) is a tracer-based imaging modality with immense promise as a radiation-free alternative to nuclear medicine imaging techniques. Nuclear medicine requires \"hot chemistry\" wherein radioactive tracers must be synthesized on-site, requiring expensive infrastructure and labor costs. MPI's magnetic nanoparticles, superparamagnetic iron oxide nanoparticles (SPIOs), have no significant signal decay over time which removes cost barriers associated with nuclear medicine studies such as FDG-PET. While SPIOs are the current industry standard MPI tracer, recent developments in synthesizing superferromagnetic iron oxide nanoparticles (SFMIOs) and high resolution SPIOs (HR-SPIOs), a new class of nanoparticle with almost zero coercivity, have yielded a 30-fold improvement in resolution (0.4 mT) and SNR. To better understand the long-term performance of these new nanoparticles, this investigation reports changes in SPIO (VivoTrax Plus), HR-SPIO, and SFMIO resolution, along with SFMIO coercivity, at low temperatures (-2, 2 °C) and room temperature (18-22 °C) over 12 weeks. We find that changes in HR-SPIO resolution are more sensitive to storage temperature than SFMIOs. Additionally, we observe no appreciable difference in SFMIO coercivity between the two temperatures over time. These results can inform research on optimizing tracer synthesis while lending practical information to future hospitals about the highly accessible conditions for the transit and storage of tracers.","PeriodicalId":36734,"journal":{"name":"International Journal on Magnetic Particle Imaging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2D projection image reconstruction for field free line single-sided magnetic particle imaging scanner: simulation studies. 无场线单面磁粉成像扫描仪二维投影图像重建:仿真研究。

International Journal on Magnetic Particle Imaging Pub Date : 2021-01-01 DOI: 10.18416/ijmpi.2021.2104001

Carlos Chinchilla, Chris McDonough, Amanuel Negash, Jason Pagan, Alexey Tonyushkin

引用次数: 1

Design and engineering colloidal magnetic particles for nanoscale thermometry. 纳米尺度测温胶体磁性粒子的设计与工程。

International Journal on Magnetic Particle Imaging Pub Date : 2020-01-01 DOI: 10.18416/IJMPI.2020.2009068

A J Biacchi, T Q Bui, C L Dennis, S I Woods, A R Hight Walker

引用次数: 1

Sensitivity Limits for in vivo ELISA Measurements of Molecular Biomarker Concentrations. 体内酶联免疫吸附法测定分子生物标志物浓度的灵敏度极限。

International Journal on Magnetic Particle Imaging Pub Date : 2017-01-01 Epub Date: 2017-06-22 DOI: 10.18416/ijmpi.2017.1706003

John B Weaver, Yinpeng Shi, Dylan B Ness, Hafsa Khurshid, Anna Cristina S Samia

{"title":"Sensitivity Limits for in vivo ELISA Measurements of Molecular Biomarker Concentrations.","authors":"John B Weaver, Yinpeng Shi, Dylan B Ness, Hafsa Khurshid, Anna Cristina S Samia","doi":"10.18416/ijmpi.2017.1706003","DOIUrl":"https://doi.org/10.18416/ijmpi.2017.1706003","url":null,"abstract":"The extremely high sensitivity that has been suggested for magnetic particle imaging has its roots in the unique signal produced by the nanoparticles at the frequencies of the harmonics of the drive field. That sensitivity should be translatable to other methods that utilize magnetic nanoparticle probes, specifically towards magnetic nanoparticle spectroscopy that is used to measure molecular biomarker concentrations for an \"in vivo ELISA\" assay approach. In this paper, we translate the predicted sensitivity of magnetic particle imaging into a projected sensitivity limit for in vivo ELISA. The simplifying assumptions adopted are: 1) the limiting noise in the detection system is equivalent to the minimum detectable mass of nanoparticles; 2) the nanoparticle's signal arising from Brownian relaxation is completely eliminated by the molecular binding event, which can be accomplished by binding the nanoparticle to something so massive that it can no longer physically rotate and is large enough that Neel relaxation is minimal. Given these assumptions, the equation for the minimum concentration of molecular biomarker we should be able to detect is obtained and the in vivo sensitivity is estimated to be in the attomolar to zeptomolar range. Spectrometer design and nonspecific binding are the technical limitations that need to be overcome to achieve the theoretical limit presented.","PeriodicalId":36734,"journal":{"name":"International Journal on Magnetic Particle Imaging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39220689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Design analysis of an MPI human functional brain scanner. MPI人脑功能扫描仪的设计分析。

International Journal on Magnetic Particle Imaging Pub Date : 2017-01-01 Epub Date: 2017-03-23 DOI: 10.18416/ijmpi.2017.1703008

Erica E Mason, Clarissa Z Cooley, Stephen F Cauley, Mark A Griswold, Steven M Conolly, Lawrence L Wald

{"title":"Design analysis of an MPI human functional brain scanner.","authors":"Erica E Mason, Clarissa Z Cooley, Stephen F Cauley, Mark A Griswold, Steven M Conolly, Lawrence L Wald","doi":"10.18416/ijmpi.2017.1703008","DOIUrl":"https://doi.org/10.18416/ijmpi.2017.1703008","url":null,"abstract":"MPI's high sensitivity makes it a promising modality for imaging brain function. Functional contrast is proposed based on blood SPION concentration changes due to Cerebral Blood Volume (CBV) increases during activation, a mechanism utilized in fMRI studies. MPI offers the potential for a direct and more sensitive measure of SPION concentration, and thus CBV, than fMRI. As such, fMPI could surpass fMRI in sensitivity, enhancing the scientific and clinical value of functional imaging. As human-sized MPI systems have not been attempted, we assess the technical challenges of scaling MPI from rodent to human brain. We use a full-system MPI simulator to test arbitrary hardware designs and encoding practices, and we examine tradeoffs imposed by constraints that arise when scaling to human size as well as safety constraints (PNS and central nervous system stimulation) not considered in animal scanners, thereby estimating spatial resolutions and sensitivities achievable with current technology. Using a projection FFL MPI system, we examine coil hardware options and their implications for sensitivity and spatial resolution. We estimate that an fMPI brain scanner is feasible, although with reduced sensitivity (20×) and spatial resolution (5×) compared to existing rodent systems. Nonetheless, it retains sufficient sensitivity and spatial resolution to make it an attractive future instrument for studying the human brain; additional technical innovations can result in further improvements.","PeriodicalId":36734,"journal":{"name":"International Journal on Magnetic Particle Imaging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35206611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44