Current Psychiatry Research and Reviews最新文献_第4页

Anxiety, Depression and Quality of Life among Parents Attending School Counseling Programs: Are they Effected by Sociodemographic Characteristics? 参加学校咨询项目的家长的焦虑、抑郁和生活质量：它们受到社会地理特征的影响吗？

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Current Psychiatry Research and Reviews Pub Date : 2023-03-16 DOI: 10.2174/2666082219666230316144225

P. Theofilou

{"title":"Anxiety, Depression and Quality of Life among Parents Attending School Counseling Programs: Are they Effected by Sociodemographic Characteristics?","authors":"P. Theofilou","doi":"10.2174/2666082219666230316144225","DOIUrl":"https://doi.org/10.2174/2666082219666230316144225","url":null,"abstract":"\u0000\u0000Parental stress and depression are factors that significantly affect the exercise of the parental role and have an impact on the upbringing of children and their quality of life. The purpose of this study is to investigate the differences between the dependent variables of quality of life, anxiety and depression in relation to the demographic characteristics, as an independent variable, in the entire sample before the implementation of parent counseling. A sample of 160 parents was collected to participate. The psychometric tools have been used are: The Spielberger Stress Trait Anxiety Inventory (STAI), the Beck depression Inventory (BDI), and the Health and well-being Questionnaire (The RAND 36-Item Healthy Survey, SF-36, Version 1.0). It was found that men have better quality of life in both physical and emotional health, lower anxiety and depression. A positive correlation between age and emotional health was found. Younger parents have more anxiety, depression and generally poorer emotional health than older parents.\u0000\u0000\u0000\u0000It was found that men have better quality of life in both physical and emotional health, lower anxiety and depression. A positive correlation between age and emotional health was found. Younger parents have more anxiety, depression and generally poorer emotional health than older parents.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42962967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Glutathione S Transferase Theta1 and Mu1 (GSTT1 and GSTM1 ) deletion among autistic population of India 谷胱甘肽S转移酶Theta1和Mu1 (GSTT1和GSTM1)在印度自闭症人群中的缺失

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Current Psychiatry Research and Reviews Pub Date : 2023-03-02 DOI: 10.2174/2666082219666230302142608

Rajat Hegde, P. Gai, Smita Hegde, S. Kulkarni, Kusal K. Das

{"title":"Glutathione S Transferase Theta1 and Mu1 (GSTT1 and GSTM1 ) deletion among autistic population of India","authors":"Rajat Hegde, P. Gai, Smita Hegde, S. Kulkarni, Kusal K. Das","doi":"10.2174/2666082219666230302142608","DOIUrl":"https://doi.org/10.2174/2666082219666230302142608","url":null,"abstract":"\u0000\u0000Oxidative stress is an imbalance between an organism's reactive oxygen species [ROS] production and antioxidant defence capacity. Long-term oxidative stress contributes to cellular ageing and plays a role in the pathogenesis of several diseases. Several investigations indicated that oxidative stress has a role in the pathogenesis of ASD.\u0000\u0000\u0000\u0000Present study was undertaken to record the association of GSTTT1 and GSTM1 null genotype among the autistic population of India.\u0000\u0000\u0000\u0000Genomic DNA was isolated from 108 autistic children along with healthy age-matched control. The quality and quantity of the isolated genomic DNA were analysed. GSTT1 and GSTM1 null genotype was analysed using polymerase chain reaction with internal positive control. Statistical analysis was performed using SPSS 15.0.\u0000\u0000\u0000\u0000Present study included 85 males and 23 females with a mean age of 11.7±3.5 and 75 males and 33 females with a mean age of 11±2.0 in the control group. 32 (29.6%) autistic cases showed null genotypes for GSTT1 and 21(19.4%) autistic children showed null genotypes for GSTM1. 3 (2.85%) control children showed a null genotype for GSTT1 and 5 (4.6%) control children showed a null genotype for GSTM1. The GSTT1 and GSTM1 null genotypes were observed to be significantly associated with the risk of autism (p value-0.0001, OR-14.73, 95% CI 4.35-49.90) and (p value-0.003, OR-4.731, 95% CI 1.71-13.08) respectively.\u0000\u0000\u0000\u0000The findings of our study suggested that GSTT1 and GSTM1 null genotype is one of the potential risk factors for autism through oxidative stress mechanism in our population.\u0000\u0000\u0000\u0000None\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41984551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Meet the Section Editor 见栏目编辑

Current Psychiatry Research and Reviews Pub Date : 2023-03-01 DOI: 10.2174/266608221901230124145026

Domenico De Berardis

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Preface 前言

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Current Psychiatry Research and Reviews Pub Date : 2023-03-01 DOI: 10.2174/266608221901230124143557

R. Badgaiyan

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Conceivable Mechanisms of Clozapine Propagated Dyslipidemia- A Short Review 氯氮平传播血脂异常的可设想机制——综述

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Current Psychiatry Research and Reviews Pub Date : 2023-02-24 DOI: 10.2174/2666082219666230224141323

Louis Cojandaraj, Pearl Pinto, Sivaprakasam Chinnarasu, M. Sadasivam

{"title":"Conceivable Mechanisms of Clozapine Propagated Dyslipidemia- A Short Review","authors":"Louis Cojandaraj, Pearl Pinto, Sivaprakasam Chinnarasu, M. Sadasivam","doi":"10.2174/2666082219666230224141323","DOIUrl":"https://doi.org/10.2174/2666082219666230224141323","url":null,"abstract":"\u0000\u0000Clozapine is the most effective drug for the treatment of refractory schizophrenia, showing a good response in the treatment of patients with resistant schizophrenia, especially in reducing violent, aggressive, and suicidal tendencies. However, treatment with clozapine has been associated with hyperlipidemia especially high triglycerides, obesity, diabetes, and cardiovascular disease. An elevated level of lipids has a direct impact on the improvement of symptoms in schizophrenics treated with clozapine. Although the mechanism is not clear, there is a possibility of serum lipids play a major part in enhancing clozapine's therapeutic activity. The effect of clozapine on phospholipids might indicate that this rise is related to its therapeutic benefit as well. Moreover, increased fatty acids accompanied by a sharp rise in triglycerides, point towards the possible involvement of lipases, which are involved in the storage and release of fatty acids and triglycerides in the adipose tissue. An increase in hepatic lipid synthesis can be another cause of hyperlipidemia and lead to weight gain over a certain period. Lipogenesis and myelin synthesis can also become targets in schizophrenia since myelination and synaptogenesis are essential in the central nervous system. Hence, the upregulation of several genes involved in cholesterol and fatty acid biosynthesis focused, which are proven to be controlled by Sterol regulating element-binding protein transcription factors (SREBP). The antipsychotic drug Clozapine activates this SREBP system. This activation increases lipogenesis which can be one of the mechanisms of action, which in turn could explain the metabolic side effects produced by clozapine.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47798690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A Narrative Systematic Review of the Effectiveness of repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment and Management of Borderline Personality Disorder 重复经颅磁刺激(rTMS)治疗和管理边缘型人格障碍有效性的叙述系统综述

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Current Psychiatry Research and Reviews Pub Date : 2023-01-20 DOI: 10.2174/2666082219666230120104856

Georgios Kafas, K. Umla-Runge

{"title":"A Narrative Systematic Review of the Effectiveness of repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment and Management of Borderline Personality Disorder","authors":"Georgios Kafas, K. Umla-Runge","doi":"10.2174/2666082219666230120104856","DOIUrl":"https://doi.org/10.2174/2666082219666230120104856","url":null,"abstract":"\u0000\u0000Borderline Personality Disorder (BPD)is a psychiatric condition that affects approximately 2% of the population worldwide. It can present many challenges and can therefore be difficult to treat successfully by mental health professionals.\u0000\u0000\u0000\u0000The aim of this systematic review was to detect whether repetitive Transcranial Magnetic Stimulation (rTMS] is an effective intervention for the management of BPD to the point where there would be a reduction of the BPD symptoms and challenging behaviour.\u0000\u0000\u0000\u0000A literature search was conducted systematically using the following databases: PROSPERO, PUBMED, GOOGLE SCHOLAR, WEB OF SCIENCE, COCHRANE LIBRARY, SCOPUS, EMBASE and CLINICALTRIALS.GOV. Included studies were primary research studies of adult patients with a diagnosis of BPD who received rTMS treatment.\u0000\u0000\u0000\u0000Nine studies were identified which ranged from a case report to a randomised controlled trial (RCT). While rTMS improved certain symptoms of BPD patients, such as affective instability, impulsivity and outbursts of anger; overall, some results lacked statistical significance and, due to the lack of robust evidence, it is uncertain if rTMS is an effective intervention for BPD.\u0000\u0000\u0000\u0000rTMS treatment showed some promising results in reducing the severity of symptoms for a number of patients. Studies varied with regard to the location of the target stimulation site, including different prefrontal brain regions and the cerebellum, as well as other rTMS protocol characteristics. These methodological differences in the application of the intervention and their impact on BPD symptomatology need to be explored more systematically in future research. Higher quality studies with larger sample sizes are needed in order to assess further the effectiveness of rTMS interventions on BPD symptoms.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48813843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Psycho-neuroendocrine-immune aspects of COVID-19 and its relationship with post-traumatic stress disorder COVID-19的心理-神经内分泌-免疫方面及其与创伤后应激障碍的关系

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Current Psychiatry Research and Reviews Pub Date : 2023-01-18 DOI: 10.2174/2666082219666230118142926

Masoomeh Dadkhah, S. Shafia, Sahand Talei, Soheila Molaei, Vahid Asghariazar

{"title":"Psycho-neuroendocrine-immune aspects of COVID-19 and its relationship with post-traumatic stress disorder","authors":"Masoomeh Dadkhah, S. Shafia, Sahand Talei, Soheila Molaei, Vahid Asghariazar","doi":"10.2174/2666082219666230118142926","DOIUrl":"https://doi.org/10.2174/2666082219666230118142926","url":null,"abstract":"\u0000\u0000A large body of literature indicates that the novel coronavirus disease (COVI D-19) was, and still is, a stressful and traumatic experience for different groups of people. Exposure to unexpected deaths or fear of death increases the risk of developing post-traumatic stress disorder (PTSD) anxiety disorder. Understanding the relationship between PTSD and SARS-CoV-2 infection can help reduce the risk of developing psychiatric diseases, especially anxiety disorders. Here, we used the central mega databases of PubMed, Google Scholar, Scopus, Springer, and Science Direct. We explored the articles based on keywords and related articles. Social isolation stress during quarantine and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis via increased cortisol synthesis and release seems to be key findings in current literature. Evidence shows that induced neuroendocrine changes in patients with COVID-19 can cause psychiatric diseases related to fear and anxiety. Studies suspect that angiotensin-converting enzyme 2 (ACE2) expressed in the hypothalamus and pituitary gland can be targeted by the infection and thereby could be a player in inducing psychiatric disorders. Here, we discuss the relationship between Covid-19 and post-traumatic stress disorder from psycho-neuroendocrine-immune aspects and highlight the pro-inflammatory cytokines as mediators in the CNS-related processes, hoping to provide insights into the pathophysiology of PTSD.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42557878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Current State of Application of Formal Thought Disorder Screening Methods in First-Degree Relatives of Patients With Schizophrenia: A Narrative Review 形式思维障碍筛查方法在精神分裂症患者一级亲属中的应用现状：叙述性综述

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Current Psychiatry Research and Reviews Pub Date : 2023-01-16 DOI: 10.2174/2666082219666230116100934

Jes Sebastian Völker, I. Micluția, Adela Hanga

{"title":"Current State of Application of Formal Thought Disorder Screening Methods in First-Degree Relatives of Patients With Schizophrenia: \u0000A Narrative Review","authors":"Jes Sebastian Völker, I. Micluția, Adela Hanga","doi":"10.2174/2666082219666230116100934","DOIUrl":"https://doi.org/10.2174/2666082219666230116100934","url":null,"abstract":"Historically, formal thought disorder (FTD) has been considered one of the distinctive key symptoms of schizophrenia and is still regarded as an important early warning sign and a marker of illness severity with solid predictive value. Recent studies found that the presence of FTD is predictive of the subsequent diagnosis of schizophrenia and often precedes the frank clinical picture by several months. Much effort has been put into developing scales that can reliably detect FTD and can be readily applied in routine clinical practice. This narrative review investigated the use of FTD as a screening tool to assess risk in first-degree relatives of patients with schizophrenia. The results show that the use of these scales in first-degree relatives of schizophrenic individuals during clinical contact and counseling is still an exception, despite their uniquely heightened vulnerability profile. To our knowledge, this is the first time that the application of FTD screening methods in first-degree relatives of schizophrenic individuals has been reviewed in a structured way.","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48652314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Factors Influencing Quetiapine Pharmacokinetic Variability: a Review of Population Pharmacokinetics 奎硫平药代动力学变异性的影响因素——群体药代动力学综述

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Current Psychiatry Research and Reviews Pub Date : 2023-01-11 DOI: 10.2174/2666082219666230111145821

Janthima Methaneethorn

{"title":"Factors Influencing Quetiapine Pharmacokinetic Variability: a Review of Population Pharmacokinetics","authors":"Janthima Methaneethorn","doi":"10.2174/2666082219666230111145821","DOIUrl":"https://doi.org/10.2174/2666082219666230111145821","url":null,"abstract":"\u0000\u0000Atypical antipsychotic quetiapine (QTP) exhibits high pharmacokinetic variability and population pharmacokinetic (PopPK) analysis is one of the approaches used to characterize factors influencing QTP pharmacokinetic variability. Though QTP is not regarded as a narrow therapeutic index drug, knowledge of this area is of importance. Thus, this review was conducted to summarize significant predictors for QTP pharmacokinetic variability identified using a PopPK analysis and to explore any knowledge gaps to be investigated. PubMed, Scopus, and CINAHL Complete databases were searched for eligible studies, and 75 articles were identified. Of these, only five studies were included as they were conducted using a nonlinear mixed-effects approach. This review found that only limited predictors for QTP pharmacokinetics were identified, with body weight being a predictor for the volume of distribution and age and γ-glutamyl transpeptidase being predictors for QTP clearance. None of the studies included elderly patients aged >65 years, and thus factors associated with aging were not investigated. Also, most of the participants in the PopPK analyses were from clinical trials which might not reflect real-world patients e.g., the impacts of polypharmacy may not be available. Moreover, while a population pharmacokinetic-pharmacodynamic model explaining QTP exposure and clinical response using the scores of the Brief Psychiatric Rating Scale is available, knowledge relevant to the relationship between exposure and QTP side effects has not been explored. Based on this limited information, future PopPK research encompassing a wide range of patient characteristics is required.\u0000","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49485652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Alternative Approaches For The Management Of Autism: A Narrative Review 自闭症管理的替代方法:叙述性回顾

Current Psychiatry Research and Reviews Pub Date : 2023-01-06 DOI: 10.2174/2666082219666230106143424

Ajit Kumar Thakur, Nikhila Shekhar, Sakshi Tyagi

{"title":"Alternative Approaches For The Management Of Autism: A Narrative Review","authors":"Ajit Kumar Thakur, Nikhila Shekhar, Sakshi Tyagi","doi":"10.2174/2666082219666230106143424","DOIUrl":"https://doi.org/10.2174/2666082219666230106143424","url":null,"abstract":"Background: Autism, a neurodevelopment disorder that was regarded as insignificant in the past is thereby now recognized as a major problem with an increasing prevalence over the past 50 years affecting 1 out of every 160 children worldwide. Recent accumulating evidence indicates that autism is a consequence of the fusion of environmental, genetic, and epigenetic components. Due to the lack of effective pharmacotherapy, alternative approaches are being explored for their beneficial effect on autistic symptoms. Methods: A literature review was performed identifying previously published clinical studies that were set up as an alternative therapy for alleviating the symptoms of autism. The data were collected from PubMed and Google Scholar databases. Results: A total of 13 kinds of interventions including video modelling, play therapy, music therapy, yoga, social skills training, sensory integration (SIT), scalp acupuncture, medical clowning, animal-assisted activity, theatre-based intervention, Tai Chu Chuan training, novel mattress technology, and magnetic resonance imaging were found to be affecting the symptoms associated with autism. Conclusion: From sufficient clinical evidence, it was estimated that alternative approaches such as music therapy and play therapy have the most beneficial effect in mitigating the symptoms to an extent.","PeriodicalId":36711,"journal":{"name":"Current Psychiatry Research and Reviews","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135276447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0