Chinese Neurosurgical Journal最新文献

{"title":"Endoscopy-assisted purely total outer wall excision for pediatric Sylvian arachnoid cysts.","authors":"Mingxing Wu,&nbsp;Fei Di,&nbsp;Mingle Ma,&nbsp;Jiye Li,&nbsp;Yanbin Li,&nbsp;Bingke Zhang","doi":"10.1186/s41016-023-00330-7","DOIUrl":"https://doi.org/10.1186/s41016-023-00330-7","url":null,"abstract":"<p><strong>Background: </strong>To present a novel endoscopy-assisted surgical strategy of Sylvian arachnoid cysts (ACs).</p><p><strong>Case presentation: </strong>Endoscopy-assisted surgery was performed on 9 children (May 2019-December 2021). All patients were evaluated with CT and/or MRI and had regular follow-up examinations. The procedure consisted of performing a small temporal craniotomy (2 cm) behind the hairline. After dural opening, the surgery was performed with the assistance of a rigid 30-degree transcranial endoscope, self-irrigating bipolar forceps, and other standard endoscopic instruments. Steps included total excision of the AC outer wall and dissection of arachnoid adhesion around the cystic edge to communicate the residual cyst cavity with subdural space. Compared with the microscopical procedure, a 30-degree transcranial endoscope provides a wider view, especially for the lateral part exposure of the outer wall. The average age of the patients was 27.7 months (range 13-44 months). The Sylvian AC was in the right hemisphere in three patients and six in the left, respectively. 1 patient suffered transient postoperative epilepsy. There was no mortality or additional postoperative neurological deficit in this series. All of the patients achieved significant clinical improvement after surgery. Radiological examination after the operation showed a significant reduction in all cases (100%, 9/9) and disappearance in one case (11.1%, 1/9). Postoperative subdural fluid collection occurred in six cases and completely resolved spontaneously in 9 months.</p><p><strong>Conclusion: </strong>The study demonstrated the minimally invasive, safety, and effectivity of the endoscopy-assisted purely total outer wall excision.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"9 1","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9807762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and management of pituitary apoplexy: a Tunisian data.","authors":"Faten Hadj Kacem,&nbsp;Oumeyma Trimeche,&nbsp;Imen Gargouri,&nbsp;Dhoha Ben Salah,&nbsp;Nadia Charfi,&nbsp;Nabila Rekik,&nbsp;Fatma Mnif,&nbsp;Mouna Mnif,&nbsp;Mouna Elleuch,&nbsp;Mohammed Abid","doi":"10.1186/s41016-023-00331-6","DOIUrl":"https://doi.org/10.1186/s41016-023-00331-6","url":null,"abstract":"<p><strong>Background: </strong>Pituitary apoplexy (PA) is defined as the hemorrhage or the infraction of a pituitary adenoma. Aiming to determine the epidemiological, clinical, paraclinical characteristics as well as management and outcomes of PA in our population, we conducted this cross-sectional study.</p><p><strong>Methods: </strong>This cross-sectional study was conducted at the Department of Endocrinology of Hedi chaker university hospital, Sfax. Data was collected from medical charts of patients with pituitary apoplexy admitted in our department between 2000 and 2017.</p><p><strong>Results: </strong>We included 44 patients with PA. Their mean age was 50 ± 12.6 years. Among them, 31.8% had a known pituitary adenoma, and it was in all cases a macroadenoma, predominantly a prolactin secreting tumor (42.8%). A triggering factor of PA was encountered in 31.8% of cases and it was mainly: head trauma, dopamine antagonists, and hypertension. The clinical presentation of PA encompassed headaches (84.1%), visual disturbances (75%), and neurological signs (40.9%). Gonadotropin deficiency was the most frequent form of hypopituitarism noted (59.1%), followed by corticotropin deficiency (52.3%), thyrotropin deficiency (47.7%), and somatotropin deficiency (2.3%). Hormonal assessment at PA onset, concluded that 23 had a secreting adenoma: 18 prolactinomas, 3 ACTH-secreting adenomas, and 2 GH-secreting adenomas. In the 21 remaining cases, the tumor was non-functioning (47.7%). Pituitary MRI was performed in 42 cases (95.5%), revealing infraction and or hemorrhage in the pituitary gland in 33 cases; a heterogenous signal or a fluid level within the adenoma, in nine cases. Urgent administration of intra venous hydrocortisone was required in 19 cases. Mannitol administration was mandatory in a patient who had severe intracranial hypertension. Surgical management of the PA was imperative in 24 patients (54.5%): 15 suffered from severe visual impairment, 4 had an intracranial hypertension, 2 cases demonstrated an impaired consciousness, 2 patients experienced a tumor enlargement and one case had a severe Cushing's disease. Operative complications found were rhinorrhea attributable to cerebral spinal fluid leakage, insipidus diabetes associated with rhinorrhea, isolated insipidus diabetes, and hydrocephalus in one case each. Long-term follow-up concluded that headaches persisted in five cases, owing to the tenacity of a macroprolactinoma regardless of cabergoline treatment in one case, the recurrence of an adenoma in two cases and its persistence despite the medical and the surgical treatment in two patients. Concerning the visual acuity defects, only two patients had persistent diminished visual acuity at long-term follow-up. Among 25 patients, 13 were diagnosed with definitive thyrotropin deficiency. Similarly, 14 patients had persistent corticotropin deficiency (CD). Additionally, CD was de novo diagnosed in two patients. Otherwise, gonadotropin deficiency p","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"9 1","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9735422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of lordosis recovery after lumbar arthrodesis and its clinical impact.","authors":"Gabriel Tchachoua Jiembou,&nbsp;Hermann Adonis Nda,&nbsp;Meleine Landry Konan","doi":"10.1186/s41016-023-00333-4","DOIUrl":"https://doi.org/10.1186/s41016-023-00333-4","url":null,"abstract":"<p><strong>Background: </strong>Posterior lumbar arthrodesis has become a widely used therapeutic option to correct sagittal imbalances in patients suffering from degenerative lumbar conditions. However, in western Africa, there is no study have reported long-term outcome of posterior lumbar arthrodesis. The aim of this study was to investigate the relationship between the restoration of adequate lordosis and the patient's postoperative quality of life.</p><p><strong>Method: </strong>The study was retrospective. From January 2012 to December 2019, 80 patients who underwent posterior lumbar arthrodesis for lumbar degenerative diseases were included with a mean follow-up of 43.2 months. Mean age was 50.8 years (SD = 12.2). Preoperative and postoperative patients' symptoms were assessed by the visual analog scale (VAS), Oswestry Disability Index (ODI), and 12-item Short Form (SF-12). Pre- and post-operative radiographic evaluation included lumbar lordosis measured (LLm), pelvic incidence (PI), sacral slope (SS), and pelvic stilt (PS). Theoretical lumbar lordosis (LLt) was defined by the following: LL = 0.54 × PI + 27.6. Data analysis was done using the statistical software \"R.\" The risk of error was 5% (p < 0.05).</p><p><strong>Result: </strong>The mean pelvic incidence was 57.23°. There was no statistically significant difference between preoperative and postoperative lumbar lordosis (p = 0.2567). There was no statistical difference between preoperative and postoperative PI-LL (p = 0.179). There was a statistically significant difference between the pre and postoperative clinical scores (p < 0.001). Statistical analysis showed a correlation between recovery of lumbar lordosis and improvement in physical component of SF-12 (PCS) (p < 0.05) and lumbar and radicular VAS (p < 0.05) for the subgroup of narrow lumbar spine. There was a statistical relationship between the restoration of lumbar lordosis and improvement in PCS (p = 0.004) and VAS (p = 0.003) for the subgroup of isthmic lysis spondylolisthesis.</p><p><strong>Discussion: </strong>The root decompression performed in most patients could explain the clinical improvement regardless of recovery of lordosis. The failure to consider spinal parameters and sagittal balance of patients in the surgery could explain no restoration of lumbar lordosis. Our study had limitations inherent to its retrospective character such as the classic selection bias.</p><p><strong>Conclusion: </strong>Satisfactory correction of spinopelvic alignment may improve long-term clinical signs.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"9 1","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9719659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-traditional cognitive brain network involvement in insulo-Sylvian gliomas: a case series study and clinical experience using Quicktome.","authors":"Zhiqiang Wu,&nbsp;Guanjie Hu,&nbsp;Bowen Cao,&nbsp;Xingdong Liu,&nbsp;Zifeng Zhang,&nbsp;Nicholas B Dadario,&nbsp;Qinyu Shi,&nbsp;Xiao Fan,&nbsp;Yao Tang,&nbsp;Zhangchun Cheng,&nbsp;Xiefeng Wang,&nbsp;Xia Zhang,&nbsp;Xiaorong Hu,&nbsp;Junxia Zhang,&nbsp;Yongping You","doi":"10.1186/s41016-023-00325-4","DOIUrl":"https://doi.org/10.1186/s41016-023-00325-4","url":null,"abstract":"<p><strong>Background: </strong>Patients with insulo-Sylvian gliomas continue to present with severe morbidity in cognitive functions primarily due to neurosurgeons' lack of familiarity with non-traditional brain networks. We sought to identify the frequency of invasion and proximity of gliomas to portions of these networks.</p><p><strong>Methods: </strong>We retrospectively analyzed data from 45 patients undergoing glioma surgery centered in the insular lobe. Tumors were categorized based on their proximity and invasiveness of non-traditional cognitive networks and traditionally eloquent structures. Diffusion tensor imaging tractography was completed by creating a personalized brain atlas using Quicktome to determine eloquent and non-eloquent networks in each patient. Additionally, we prospectively collected neuropsychological data on 7 patients to compare tumor-network involvement with change in cognition. Lastly, 2 prospective patients had their surgical plan influenced by network mapping determined by Quicktome.</p><p><strong>Results: </strong>Forty-four of 45 patients demonstrated tumor involvement (< 1 cm proximity or invasion) with components of non-traditional brain networks involved in cognition such as the salience network (SN, 60%) and the central executive network (CEN, 56%). Of the seven prospective patients, all had tumors involved with the SN, CEN (5/7, 71%), and language network (5/7, 71%). The mean scores of MMSE and MOCA before surgery were 18.71 ± 6.94 and 17.29 ± 6.26, respectively. The two cases who received preoperative planning with Quicktome had a postoperative performance that was anticipated.</p><p><strong>Conclusions: </strong>Non-traditional brain networks involved in cognition are encountered during surgical resection of insulo-Sylvian gliomas. Quicktome can improve the understanding of the presence of these networks and allow for more informed surgical decisions based on patient functional goals.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"9 1","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9901878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-inflicted penetrating brain injuries with preserved neurological function: a case series.","authors":"Shuja Shaukat,&nbsp;Syeda Mahrukh Fatima Zaidi,&nbsp;Adil Khatri,&nbsp;Mishal Shan Siddiqui,&nbsp;Muhammad Sameer Khulsai,&nbsp;Abdul Basit Ansari,&nbsp;Shabih Ayesha,&nbsp;Atiq Ahmed Khan,&nbsp;Muhammad Imran","doi":"10.1186/s41016-023-00328-1","DOIUrl":"https://doi.org/10.1186/s41016-023-00328-1","url":null,"abstract":"<p><strong>Background: </strong>Penetrating trauma to the brain is a rare mode of self-harm in individuals with depressive psychosis. It may have variable presentations ranging from intact neurological status to non-survivable damage and the subjects may be surprisingly apathetic to pain. It is even unusual for such an injury to have an excellent prognosis despite coming late to clinical attention.</p><p><strong>Case presentations: </strong>We report two cases of patients with psychotic depression who attempted suicide by hammering nails into their heads. On imaging, deep penetration within the brain parenchyma was noted; however, neither case had any neurological deficit or symptoms attributable to brain trauma.</p><p><strong>Conclusions: </strong>Self-inflicted penetrating brain injuries with peculiar objects such as nails are rarely encountered in practice. They need prompt management for their removal and addressing the underlying mental health illnesses.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"9 1","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9526073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial pressure monitoring in neurosurgery: the present situation and prospects.","authors":"Chenqi He,&nbsp;Chubei Teng,&nbsp;Zujian Xiong,&nbsp;Xuelei Lin,&nbsp;Hongbo Li,&nbsp;Xuejun Li","doi":"10.1186/s41016-023-00327-2","DOIUrl":"https://doi.org/10.1186/s41016-023-00327-2","url":null,"abstract":"<p><p>Intracranial pressure (ICP) is one of the most important indexes in neurosurgery. It is essential for doctors to determine the numeric value and changes of ICP, whether before or after an operation. Although external ventricular drainage (EVD) is the gold standard for monitoring ICP, more and more novel monitoring methods are being applied clinically.Invasive wired ICP monitoring is still the most commonly used in practice. Meanwhile, with the rise and development of various novel technologies, non-invasive types and invasive wireless types are gradually being used clinically or in the testing phase, as a complimentary approach of ICP management. By choosing appropriate monitoring methods, clinical neurosurgeons are able to obtain ICP values safely and effectively under particular conditions.This article introduces diverse monitoring methods and compares the advantages and disadvantages of different monitoring methods. Moreover, this review may enable clinical neurosurgeons to have a broader view of ICP monitoring.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"9 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9512872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic recurrence craniopharyngioma: series report and literature review.","authors":"Chenxing Ji,&nbsp;Haixia Cheng,&nbsp;Xiang Zhou,&nbsp;Xiaoyun Cao,&nbsp;Nidan Qiao,&nbsp;Chengzhang Shi,&nbsp;Yichao Zhang,&nbsp;Zhao Ye,&nbsp;Yao Zhao","doi":"10.1186/s41016-023-00326-3","DOIUrl":"https://doi.org/10.1186/s41016-023-00326-3","url":null,"abstract":"<p><strong>Background: </strong>Craniopharyngioma is a common intracranial tumor located in the sellar-suprasellar region. Due to the involvement of adjacent structures, it can lead to increased intracranial pressure, visual impairment, and endocrine deficiencies. Surgical resection is the primary treatment, but it is a tough challenge to achieve total resection, which will led to the frequency of recurrences and progressions. Among them, distant spread is extremely rare, but important complication, identifying and providing proper therapy, is crucial.</p><p><strong>Methods: </strong>We report two cases of ectopic recurrence craniopharyngioma and make a literature review for the published similar case reports.</p><p><strong>Results: </strong>Our literature review revealed 63 cases (including our patient). The onset age in children group and adult group ranges from 2-14 years old (6.70 ± 3.33) to 17-73 years old (40.63 ± 15.58), while the interval year between tumor initiation and ectopic recurrence ranges from 0.17-20 (7.28 ± 6.76) years to 0.3-34 (6.85 ± 7.29). Achieving gross total resection seems not to prevent the ectopic recurrence. The major pathology of ectopic recurrence craniopharyngioma is adamantinomatous type. The most common site of ectopic recurrence is frontal lobe. According to the pathogenesis, 35 cases were seeding along the surgical approach, and 28 cases were seeding via the CSF pathway.</p><p><strong>Conclusion: </strong>Ectopic recurrence craniopharyngioma is rare, but it can lead to serious symptoms. Delicate surgical procedure can help to reduce the risk of ectopic recurrence, and standardized follow-up can provide valuable information for treatment.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"9 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9417701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of antithrombotic therapy with postoperative rebleeding in patients with cerebral amyloid angiopathy.","authors":"Taro Yanagawa,&nbsp;Hiroki Sato,&nbsp;Kaima Suzuki,&nbsp;Hidetoshi Ooigawa,&nbsp;Masaki Takao,&nbsp;Hiroki Kurita","doi":"10.1186/s41016-023-00324-5","DOIUrl":"https://doi.org/10.1186/s41016-023-00324-5","url":null,"abstract":"<p><strong>Background: </strong>Cerebral amyloid angiopathy is a common cause of subcortical hemorrhage in older adults. Although open hematoma removal may be performed for severe subcortical hemorrhage, its safety in patients with cerebral amyloid angiopathy has not been established, and postoperative rebleeding may occur. Therefore, this study aimed to investigate factors associated with postoperative rebleeding.</p><p><strong>Methods: </strong>Out of 145 consecutive patients who had undergone craniotomy for surgical removal of subcortical intracerebral hemorrhage between April 2010 and August 2019 at a single institution in Japan, we examined 109 patients with subcortical hemorrhage who met the inclusion criteria. After excluding 30 patients whose tissue samples were unsuitable for the study, the final study cohort comprised 79 patients.</p><p><strong>Results: </strong>Of the 79 patients, 50 (63%) were diagnosed with cerebral amyloid angiopathy (cerebral amyloid angiopathy group) and 29 (37%) were not diagnosed with noncerebral amyloid angiopathy (noncerebral amyloid angiopathy group). Postoperative rebleeding occurred in 12 patients (24%) in the cerebral amyloid angiopathy group and in 2 patients (7%) in the noncerebral amyloid angiopathy group. Preoperative prothrombin time-international normalized ratio and intraoperative bleeding volume were significantly associated with postoperative rebleeding in the cerebral amyloid angiopathy group (odds ratio = 42.4, 95% confidence interval = 1.14-1578; p = 0.042 and odds ratio = 1.005, 95% confidence interval = 1.001-1.008; p = 0.007, respectively).</p><p><strong>Conclusions: </strong>Patients with cerebral amyloid angiopathy-related cerebral hemorrhage who are receiving antithrombotic therapy, particularly warfarin therapy, are at a high risk of postoperative rebleeding.</p><p><strong>Trial registration: </strong>Registry and Registration Number of the study: 19-220, 2019/12/23, retrospectively registered.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"9 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9751783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramedullary spinal cavernous malformations with high ossification: a case report and review of the literature.","authors":"Weihao Liu,&nbsp;Chong Wang,&nbsp;Bo Wang,&nbsp;Yaowu Zhang,&nbsp;Wenqing Jia","doi":"10.1186/s41016-023-00323-6","DOIUrl":"https://doi.org/10.1186/s41016-023-00323-6","url":null,"abstract":"<p><strong>Background: </strong>Cavernous malformations of the spinal cord are a rare type of vascular malformation, comprising approximately 5 to 16% of all vascular lesions in the spinal cord. Depending on their origin position, these malformations can be distributed in different locations within the spinal canal. Although intramedullary cavernous malformations have been reported in the literature, they are exceedingly rare. Furthermore, highly calcified or ossified intramedullary cavernous spinal malformations are even rarer.</p><p><strong>Case presentation: </strong>Here, we present a case report of a 28-year-old woman diagnosed with a thoracic intramedullary cavernous malformation. The patient had been experiencing progressive numbness in her distal limbs for a period of 2 months. During routine lung computed tomography screening for COVID-19, a hyperdense mass was noted in the patient's spinal canal. Magnetic resonance imaging revealed a mulberry-shaped intramedullary mass at the T1-2 level. The patient underwent surgical treatment, during which the entire lesion was successfully removed, resulting in a gradual improvement of her symptoms. Histological examination confirmed the presence of cavernous malformations with calcification.</p><p><strong>Conclusions: </strong>Intramedullary cavernous malformations with calcification are rare and special type that should be treated surgically in the early stage without significant neurological impairment before rebleeding or enlargement of the lesion can occur.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"9 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9476195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic analysis: the protection of over-expression thioredoxin reductase 1 in Parkinson's disease.","authors":"Zihua Liu,&nbsp;Qiang Ye,&nbsp;Ying Jiang","doi":"10.1186/s41016-023-00319-2","DOIUrl":"https://doi.org/10.1186/s41016-023-00319-2","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is the second most common neurodegenerative disease. The pathologic characteristic feature is the loss of dopaminergic neurons in the substantia nigra (SN). However, the biochemical mechanisms are unclear. A large number of studies have shown that oxidative damage is the primary cause of PD. Hence, antioxidants could become a suitable option to treat PD. The thioredoxin (Trx) system represents a useful, potentially disease-relevant oxidation-reduction system. Thioredoxin reductase 1 (TR1) is a significant component of the Trx system.</p><p><strong>Methods: </strong>The overexpression lentivirus (LV) or LV-TR1 in the TR1-A53T model of PD by the stereotactic brain, and successful overexpression of LV or LV-TR1 in the MPP⁺-induced cellular model by LV or LV-TR1 transfection.</p><p><strong>Results: </strong>We confirmed that interleukin-7 mRNA levels increased in MPP⁺ compared to that in the control and MPP⁺-TR1 groups using quantitative polymerase chain reaction. The γ-H₂AX level was increased in the Tg-A53T group compared to that in the TR1-A53T group by western blotting. The expression of Na⁺-K⁺-ATP was decreased in the MPP⁺ group compared to that in the control and MPP⁺-TR1 groups by high content screening. Tg-A53T(the C57BL/6 mice transferred with mutant human a-syn); TR1-A53T(A53T mice which were injected TR1-LV 2 µl in SNc on two sides with minipump).The mice were fed for 10 months. control (the N2a cells cultivated with DMEM); MPP⁺(the N2a cells dealt with MPP⁺(1 mM) 48 h), MPP⁺-LV (the N2a cells over-expressed LV for 24 h then dealt with MPP⁺(1 mM) 48 h). MPP⁺-TR1(the N2a cell over-expressed TR1-LV for 24 h then dealt with MPP⁺(1 mM) 48 h). From the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, we confirmed that the overexpression of TR1 in SN pars compacta cells decreased oxidative stress, apoptosis, DNA damage, and inflammatory response and increased NADPH, Na⁺-K⁺-ATP, and immune response in this PD model.</p><p><strong>Conclusions: </strong>Our study shows that overexpressed TR1 can be developed as a neuroprotective agent for PD. Therefore, our findings demonstrate a new targeted protein for the treatment of PD.</p>","PeriodicalId":36700,"journal":{"name":"Chinese Neurosurgical Journal","volume":"9 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9302121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}