{"title":"Assessment of Insulin Secretion and Insulin Resistance","authors":"S. Park","doi":"10.4093/jkd.2023.24.2.66","DOIUrl":"https://doi.org/10.4093/jkd.2023.24.2.66","url":null,"abstract":"Impaired insulin secretion and increased insulin resistance are major contributors to the pathogenesis of diabetes mellitus (DM). Because pancreatic β-cell function and insulin resistance play an important role in the prevention, diagnosis, treatment, and prognosis of DM, several methods for measuring them have been developed based on dynamic and static tests. Because dynamic tests are time consuming and labor intensive, they are not suitable for use in practice. Static tests are simple and less invasive but do not reflect the complex processes of glucose and insulin metabolism. To easily measure insulin secretion capacity, insulinogenic index calculated from oral glucose tolerance test or mixed meal tolerance test and HOMA-β (homeostasis model assessment for β-cell function) can be used. To assess insulin resistance, HOMA-IR (homeostasis model assessment for insulin resistance) can be used. To measure insulin secretion and insulin resistance more accurately, efficiently, and easily, standardized insulin assay should be establishment and new tests should be continuously developed.","PeriodicalId":366252,"journal":{"name":"The Journal of Korean Diabetes","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114888997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Paradigm Shift in Management of Hyperglycemia in Patients with Type 2 Diabetes: Glucocentric versus Organ Protection","authors":"J. Won","doi":"10.4093/jkd.2023.24.2.59","DOIUrl":"https://doi.org/10.4093/jkd.2023.24.2.59","url":null,"abstract":"The first research for managing patients with type 2 diabetes (T2DM) was the UK Prospective Diabetes Study. Subsequent studies have investigated the effects of intensive glucose control on diabetes-associated morbidities and mortality. Study results were intended to change a paradigm to control glycated hemoglobin and prevent diabetes-associated complications, but limited in microvascular diseases rather than diabetes-associated cardio-renal diseases and deaths. Comprehensive management of risk factors other than hyperglycemia (hypertension, dyslipidemia, chronic kidney disease) was emphasized to prevent atherosclerotic cardiovascular (CV) diseases and end-stage renal disease in T2DM. Since 2008, based clinical trials demonstrating CV safety, sodium-glucose transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists have shown beneficial effects on macrovascular and renal complications in patients with T2DM. A recent new paradigm of diabetes care focuses on cardio-renal outcome-oriented care, namely organ-protection, instead of the typical glucocentric view endorsed by major societies across the world including the Korean Diabetes Association and disseminated into clinical practice even in primary care. Although there are many mechanisms by which those glucose-lowering agents protect CV and renal disease in patients with T2DM to be clarified, it is time to redefine diabetes care and to verify the CV effect of anti-diabetic medications beyond glucose lowering.","PeriodicalId":366252,"journal":{"name":"The Journal of Korean Diabetes","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129176877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Screening Test for Evaluation of Cardiovascular Disease in Patients with Diabetes","authors":"J. Mok, C. Jung","doi":"10.4093/jkd.2023.24.2.76","DOIUrl":"https://doi.org/10.4093/jkd.2023.24.2.76","url":null,"abstract":"Diabetes mellitus (DM) per se confers a two-fold excess risk of vascular outcomes, but the risk is subject to wide variation depending on the population and contemporary prophylactic medical therapy. Although patients with DM have a high rate of asymptomatic coronary heart disease (CHD), routine screening for CHD has not been shown to improve clinical outcomes in asymptomatic DM patients being treated with intensive medical therapy for cardiovascular risk factors. Therefore, professional societies do not recommend routine screening for CHD in asymptomatic patients. However, they recommend additional imaging such as coronary calcium score or carotid ultrasonography to provide risk reclassification and reason for treatment intensification. In this review, we provide recent guidelines regarding screening for cardiovascular disease in asymptomatic DM patients and updated the discussion of the role of electrocardiography, coronary calcium score, and carotid ultrasonography.","PeriodicalId":366252,"journal":{"name":"The Journal of Korean Diabetes","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131511537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dietary Management after Bariatric Surgery in Patients with Obesity and Diabetes","authors":"Jun-O Heo","doi":"10.4093/jkd.2023.24.2.95","DOIUrl":"https://doi.org/10.4093/jkd.2023.24.2.95","url":null,"abstract":"Weight loss is a key therapeutic goal of glycemic control in obese diabetic patients. Bariatric surgery is an effective method for weight loss and diabetes remission, but weight regain is not uncommon after surgery. Based on safe blood glucose control before and after bariatric surgery, appropriate dietary management should be implemented to minimize nutritional deficiencies due to changes in the gastrointestinal tract after surgery. Long-term dietary management is necessary to prevent weight regain, and the role of a dietitian is very important.","PeriodicalId":366252,"journal":{"name":"The Journal of Korean Diabetes","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117295441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patient Education to Prevent Hypoglycemia","authors":"Woo Kyung Do","doi":"10.4093/jkd.2023.24.2.90","DOIUrl":"https://doi.org/10.4093/jkd.2023.24.2.90","url":null,"abstract":"Hypoglycemia in diabetic patients is an obstacle to self-management of diabetes. Severe hypoglycemia reduces quality of life and increases the risk of death in diabetic patients. Factors associated with hypoglycemia include older age, insulin use, inadequate diet, excessive exercise, and alcohol consumption. Patients who experience severe hypoglycemia may require adjustment of glycemic target and insulin dosage. Patients who frequently suffer from severe hypoglycemia may need to prepare glucagon in advance and use a continuous glucose monitor system or sensor augmented insulin pump. All diabetic patients should receive education on how to prevent and manage hypoglycemia. Healthcare professionals should identify the cause of hypoglycemia in patients visiting hospitals with severe hypoglycemia and provide appropriate patient education to prevent recurrence.","PeriodicalId":366252,"journal":{"name":"The Journal of Korean Diabetes","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126317845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Importance of Early Diagnosis for Gestational Diabetes Mellitus","authors":"Min Jin Lee","doi":"10.4093/jkd.2023.24.2.55","DOIUrl":"https://doi.org/10.4093/jkd.2023.24.2.55","url":null,"abstract":"Recently, there has been an increase in the number of young individuals with obesity, as well as an increase in the number of older pregnant women, resulting in a higher incidence not only of gestational diabetes, but also of diabetes during the first trimester. In addition, there has been an increase in the number of pregnant women with higher-than-normal glucose tolerance that do not meet the diagnostic criteria for diabetes at their first prenatal examination. In such cases, it is important to consider whether it is appropriate to wait until gestational age of 24 weeks to diagnose gestational diabetes via the oral glucose tolerance test or whether early diagnosis and management should be pursued. There is a lack of high-quality research on the appropriate timing and methods for early diagnosis of gestational diabetes. The upcoming results of the ongoing the Treatment of Booking Gestational Diabetes Mellitus (TOBOGM) study will provide an opportunity to evaluate the appropriate timing for gestational diabetes diagnosis.","PeriodicalId":366252,"journal":{"name":"The Journal of Korean Diabetes","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121564698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autonomic Nerve Function Tests in Patients with Diabetes","authors":"H. Jin, Tae Sun Park","doi":"10.4093/jkd.2023.24.2.71","DOIUrl":"https://doi.org/10.4093/jkd.2023.24.2.71","url":null,"abstract":"The autonomic nervous system (ANS) regulates the internal functions of the body organs, such as heart rate, digestion, respiratory rate, pupil response, urination, and sexual arousal. The ANS is divided into two parts: the sympathetic and parasympathetic nervous systems. However, the ANS can be damaged or degenerated by metabolic problems including hyperglycemia, leading to diabetic autonomic neuropathy (DAN), which is a prevalent complication among diabetic patients. Cardiac autonomic neuropathy is an important form of DAN that results from an imbalance between the sympathetic and parasympathetic nerve responses. This imbalance can lead to symptoms such as resting tachycardia, postural hypotension, and orthostatic tachycardia along with other types of autonomic neuropathy. Special tests can be performed to evaluate and diagnose this condition, including cardiovascular autonomic function tests. The aim of this review is to discuss the various tests used to diagnose and monitor autonomic neuropathy in diabetic patients and how to use and interpret them effectively.","PeriodicalId":366252,"journal":{"name":"The Journal of Korean Diabetes","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121396788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment and Diagnosis of Peripheral Artery Disease in Patients with Diabetes","authors":"Seung Min Chung, J. Moon","doi":"10.4093/jkd.2023.24.2.84","DOIUrl":"https://doi.org/10.4093/jkd.2023.24.2.84","url":null,"abstract":"Peripheral artery disease (PAD) is a chronic circulatory condition that occurs when the arteries that supply blood to the legs and feet are narrowed or blocked, leading to reduced blood flow to these areas. PAD is a common complication of type 2 diabetes, affecting up to 1 in 3 individuals with the condition. Assessment of PAD in individuals with diabetes typically involves a physical exam, ankle-brachial index (ABI) measurement, and imaging tests such as Doppler ultrasound or angiography. The ABI is a noninvasive measure that compares the blood pressure in the ankles and arms, with a lower ABI indicating a higher risk of PAD. Management of PAD in type 2 diabetes involves a multifaceted approach, including lifestyle modifications, medication, and revascularization procedures. Lifestyle changes such as smoking cessation and regular exercise can improve PAD symptoms and reduce the risk of disease progression. Medications such as antiplatelet agents, statins, and blood pressure-lowering drugs help to manage PAD and its associated risk factors. Revascularization procedures such as angioplasty or bypass surgery may be necessary in severe cases of PAD to restore blood flow to the affected limbs. In addition, these procedures should be considered in the feet of patients with diabetes if there is evidence of ischemia. Early detection and management of PAD in type 2 diabetes are critical to preventing complications such as non-healing wounds, infections, and amputations. Individuals with type 2 diabetes should undergo regular screening for PAD and work with their healthcare providers to develop a personalized treatment plan.","PeriodicalId":366252,"journal":{"name":"The Journal of Korean Diabetes","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114674403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diabetes and Skin Disease","authors":"J. Lim","doi":"10.4093/jkd.2023.24.1.29","DOIUrl":"https://doi.org/10.4093/jkd.2023.24.1.29","url":null,"abstract":"Skin disorders in patients with diabetes mellitus are common but easy to overlook. The spectrum of diabetes-associated skin disease is wide and ranges from benign to life-threatening conditions. Early detection of skin lesion is important since cutaneous manifestation may precede diagnosis of diabetes mellitus. Skin disease may be a signal of underlying diabetes mellitus in undiagnosed patients or can represent poorly controlled status in diagnosed patients. If some skin disorders such as diabetic foot can be prevented, considerable socioeconomic burden can be avoided. In addition, control of blood glucose level may help treat some diabetic skin diseases. Therefore, clinicians who manage patients with diabetes mellitus should be familiar with diabetic skin diseases since their diagnosis and early treatment can improve quality of life. This review aims to describe the epidemiology, clinical presentations, diagnosis, and treatment of diabetic skin diseases.","PeriodicalId":366252,"journal":{"name":"The Journal of Korean Diabetes","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125535027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review on Community Care for Chronic Disease Management Based on Digital Health Care: For Elderly Living Alone","authors":"Yu Jeong Park","doi":"10.4093/jkd.2023.24.1.48","DOIUrl":"https://doi.org/10.4093/jkd.2023.24.1.48","url":null,"abstract":"In the face of aging, it can be difficult for the elderly to accept and cope with changes. During the coronavirus disease 2019 (COVID-19) pandemic, changes in the medical service market for health care such as non-face-to-face treatment implementation, education and counseling, seminars, and camps have accelerated. Changes in medical use through mobile phones, tablet PCs, wearable devices, etc. were inevitable. It is important to study how the current early elderly population maintains change in daily life and the extent to which elderly people living alone can participate in such change. This review aims to answer the question, “What should we consider when treating and consulting patients regarding use of the vastly changing medical environment?” In particular, the study focuses on digital healthcare and community care and related health and welfare policies with consideration of aging and increasing chronic diseases.","PeriodicalId":366252,"journal":{"name":"The Journal of Korean Diabetes","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114795374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}