Journal of Traditional Chinese Medical Sciences最新文献

{"title":"Can Tibetan medicine Honghua Ruyi pills relieve endometriosis-associated dysmenorrhea? Protocol for a randomized placebo-controlled trial","authors":"Mei Han, Jiahui Cao, Jiali Wei, Hui Luo, Chaoqin Yu, Xuefang Liang, Nyangmotse, Guoyan Yang, Huilan Du, Jianping Liu","doi":"10.1016/j.jtcms.2023.12.010","DOIUrl":"https://doi.org/10.1016/j.jtcms.2023.12.010","url":null,"abstract":"","PeriodicalId":36624,"journal":{"name":"Journal of Traditional Chinese Medical Sciences","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138615829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herbal medicine combined with Western medicine for Mycoplasma pneumoniae pneumonia in children: an overview of systematic reviews","authors":"Si Zhang, Xuan Zhang, Yuehua Cui, Juan Huang, Fei Fan, Simeng Wang, Fei Han","doi":"10.1016/j.jtcms.2023.12.004","DOIUrl":"https://doi.org/10.1016/j.jtcms.2023.12.004","url":null,"abstract":"","PeriodicalId":36624,"journal":{"name":"Journal of Traditional Chinese Medical Sciences","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138621376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective mechanism of Paeoniae Radix Alba against chemical liver injury based on network pharmacology, molecular docking, and in vitro experiments","authors":"Shuangqiao Liu, Xin Liu, Sijia Jiang, Min Fu, Jinxi Hu, Jiaqi Liu, Xiaoxu Fan, Yingtong Feng, Shujing Zhang, Jingxia Wang","doi":"10.1016/j.jtcms.2023.12.005","DOIUrl":"https://doi.org/10.1016/j.jtcms.2023.12.005","url":null,"abstract":"","PeriodicalId":36624,"journal":{"name":"Journal of Traditional Chinese Medical Sciences","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138611420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"iTRAQ-based proteomics reveals the mechanism of action of Yinlai decoction in treating pneumonia in mice consuming a high-calorie diet","authors":"Qianqian Li, Tiegang Liu, Chen Bai, Xueyan Ma, Hui Liu, Zian Zheng, Yuxiang Wan, He Yu, Yuling Ma, Xiaohong Gu","doi":"10.1016/j.jtcms.2023.12.003","DOIUrl":"https://doi.org/10.1016/j.jtcms.2023.12.003","url":null,"abstract":"","PeriodicalId":36624,"journal":{"name":"Journal of Traditional Chinese Medical Sciences","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138620613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of Wendan decoction in preventing obesity by regulating multiple signal pathway networks based on gene promoter methylation","authors":"Haiyan Yang, Meiling Ren, Ziting Wu, Jinchao Li, Ping Wang","doi":"10.1016/j.jtcms.2023.12.009","DOIUrl":"https://doi.org/10.1016/j.jtcms.2023.12.009","url":null,"abstract":"","PeriodicalId":36624,"journal":{"name":"Journal of Traditional Chinese Medical Sciences","volume":"59 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated analyses of transcriptomics and network pharmacology reveal leukocyte characteristics and functional changes in subthreshold depression, elucidating the curative mechanism of Danzhi Xiaoyao powder","authors":"Kunyu Li, Leiming You, Jianhua Zhen, Guangrui Huang, Ting Wang, Yanan Cai, Yunan Zhang, Anlong Xu","doi":"10.1016/j.jtcms.2023.12.001","DOIUrl":"https://doi.org/10.1016/j.jtcms.2023.12.001","url":null,"abstract":"","PeriodicalId":36624,"journal":{"name":"Journal of Traditional Chinese Medical Sciences","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138614731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant effects of Peiyuan Jieyu formula in a mouse model of chronic stress in conjunction with lipopolysaccharide-induced depression","authors":"Qin Tang, Yu Li, Tao Yang, Xiaoxu Fan, Lina Li, Hongsheng Chang","doi":"10.1016/j.jtcms.2023.12.007","DOIUrl":"https://doi.org/10.1016/j.jtcms.2023.12.007","url":null,"abstract":"","PeriodicalId":36624,"journal":{"name":"Journal of Traditional Chinese Medical Sciences","volume":" 1248","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138610149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GPCR-Gs mediates the protective effects of ginsenoside Rb1 against oxygen-glucose deprivation/re-oxygenation-induced astrocyte injury","authors":"Xi Wang, Ying Liu, Juan Li, Jiayu Xie, Yi Dai, Minke Tang","doi":"10.1016/j.jtcms.2023.11.002","DOIUrl":"https://doi.org/10.1016/j.jtcms.2023.11.002","url":null,"abstract":"","PeriodicalId":36624,"journal":{"name":"Journal of Traditional Chinese Medical Sciences","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between red blood cell levels and emotional regulation through the miR191-Riok3-Mxi1 pathway","authors":"Da Zhang, Xiaoqing Zhang, Li Yang, Yan Zhao, Xingang Hu","doi":"10.1016/j.jtcms.2023.11.001","DOIUrl":"https://doi.org/10.1016/j.jtcms.2023.11.001","url":null,"abstract":"To assess emotional fluctuations, physical and mental health status, and indicators closely related to red blood cells, such as RIO kinase 3 (Riok3), MAX interactor 1 (Mxi1), and microRNA 191 (miR191), in participants with different levels of red blood cells. Participants who underwent physical examinations at Dongfang Hospital between April and October 2019 were divided into healthy, blood deficiency, and anemia groups (30 individuals in the healthy and blood deficiency group respectively, and 13 in the anemia group) according to our inclusion and exclusion criteria. The physical and mental conditions of the participants were evaluated through questionnaires, and emotional fluctuations were assessed through an emotion-inducing experiment, in which participants watched video segments designed to induce specific emotions. Relative expression levels of miR191, Riok3, and Mxi1 from venous blood samples were also determined. The main psychological factors identified in the anemia and blood deficiency groups were obsessive-compulsive symptoms, depression, anxiety, and other negative emotions. Relative gene expression levels indicated that miR191 was upregulated and Riok3 and Mxi1 were downregulated in both the blood deficiency and anemia groups. Regarding the emotional score of disgust on video stage, the main effect was significant (F = 335.58, P = .00), which showed that watching the three videos caused participants to have a dominant emotion, and there is a difference on group (F = 5.35, P = .01), with higher disgust scores in the anemia and blood deficiency groups. The symptoms of blood deficiency and anemia, such as weakness in limbs were significantly negatively correlated with Riok3 and Mxi1 expression (r =﹣0.38 and ﹣0.31 respectively), but was significantly positively correlated with miR191 expression (r = 0.29). We determined that a close relationship exists between red blood cell levels and emotional status. Our findings suggest that individuals with anemia and blood deficiency are more likely to experience psychological problems and negative emotions, particularly disgust. We also demonstrate that emotional regulation is related to mir191-Riok3-Mxi1 pathway activity, identifying these pathway components are potential targets for genetic therapies in combination with psychological therapy.","PeriodicalId":36624,"journal":{"name":"Journal of Traditional Chinese Medical Sciences","volume":"19 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135615608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guilu Erxian glue mitigates oxidative damage in mouse GC-1 spermatogonial cells by inhibiting autophagy via the Keap1/Nrf2 pathway","authors":"Jin Ding ,&nbsp;Wen Sheng ,&nbsp;Wei Fu ,&nbsp;Meixin Lin ,&nbsp;Bonan Li ,&nbsp;Xing Zhou ,&nbsp;Qinghu He","doi":"10.1016/j.jtcms.2023.09.002","DOIUrl":"https://doi.org/10.1016/j.jtcms.2023.09.002","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the effects and underlying mechanisms of Guilu Erxian glue (GLEXG) on oxidative damage in a mouse GC-1 spermatogonial (MGS) cell model.</p></div><div><h3>Methods</h3><p>A cellular model for oxidative damage was created using MGS cells exposed to hydrogen peroxide (H₂O₂). Cell viability was assessed using the cell counting kit-8 assay, while reactive oxygen species (ROS) and malondialdehyde (MDA) levels were measured via flow cytometry and enzyme-linked immunosorbent assay, respectively. Western blotting and immunofluorescence techniques were employed to quantify the relative expression levels of sequestosome-1 (p62), nuclear factor erythroid 2-related factor 2 (Nrf2), microtubule-associated protein light chain 3β (LC3B), and Kelch-like ECH-associated protein 1 (Keap1). Quantitative real-time PCR was used to evaluate Keap1 mRNA expression. Transmission electron microscopy (TEM) was conducted to observe structural changes in autophagy-related vesicles.</p></div><div><h3>Results</h3><p>The cellular model of oxidative damage induced by H₂O₂ showed reduced cell viability along with elevated levels of ROS and MDA. Treatment with 10% GLEXG-enriched serum significantly enhanced cell viability (<em>P</em> = .0002) while decreasing ROS and MDA levels (<em>P</em> = .0105 and <em>P</em> = .0033, respectively). In rapamycin-treated MGS cells, GLEXG treatment substantially upregulated the relative protein expression of p-mTOR, Nrf2, and p62 (all <em>P</em> &lt; .01), and downregulated the expression of Keap1 and the LC3B-II/LC3B-I ratio (<em>P</em> = .002 and <em>P</em> = .0043, respectively). It also lowered ROS and MDA levels. TEM analysis revealed that GLEXG treatment considerably reduced the number of abnormally enlarged autolysosomes in rapamycin-treated MGS cells. In Keap1-siRNA-transfected MGS cells, the siRNA-Keap1-2311 knockdown site demonstrated higher efficiency. Furthermore, GLEXG treatment in these Keap1-siRNA-transfected cells notably upregulated the relative protein expression of Nrf2 and p62, decreased Keap1 expression and the LC3B-II/LC3B-I ratio, and reduced ROS and MDA levels.</p></div><div><h3>Conclusion</h3><p>GLEXG effectively mitigated oxidative damage in the MGS cell model by inhibiting autophagy through the Keap1/Nrf2 pathway.</p></div>","PeriodicalId":36624,"journal":{"name":"Journal of Traditional Chinese Medical Sciences","volume":"10 4","pages":"Pages 484-492"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71782977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}