Journal of Advanced Pediatrics and Child Health最新文献_第4页

Predictors of mortality in neonatal sepsis in a resource-limited setting 资源有限环境下新生儿败血症死亡率的预测因素

Journal of Advanced Pediatrics and Child Health Pub Date : 2021-06-16 DOI: 10.29328/journal.japch.1001034

Nyenga Adonis Muganza, Mukuku Olivier, Mutombo André Kabamba, Mpoy Charles Wembonyama, Luboya Numbi, W. Okitotsho

{"title":"Predictors of mortality in neonatal sepsis in a resource-limited setting","authors":"Nyenga Adonis Muganza, Mukuku Olivier, Mutombo André Kabamba, Mpoy Charles Wembonyama, Luboya Numbi, W. Okitotsho","doi":"10.29328/journal.japch.1001034","DOIUrl":"https://doi.org/10.29328/journal.japch.1001034","url":null,"abstract":"Introduction: Sepsis remains a major cause of death in neonatal period. Although significant advances in diagnosis, therapeutic and prevention strategies have been noted, sepsis remains a common concern in clinical practice especially in low-resource countries. The aim of this study was to determine the predictors of mortality in neonatal sepsis in Lubumbashi city (Democratic Republic of Congo). Methods: The records of newborns with sepsis managed in Neonatal Intensive Care Units in two University Hospitals between November 2019 and October 2020 were studied. Binary and multiple logistic regressions have been used to observe the association between independent variables and dependent variable. Results: A total of 162 cases of neonatal sepsis were reviewed. The mortality rate of neonatal sepsis was 21% of babies admitted. Very low birth weight (< 1500 grams) and primiparity were significantly associated with mortality in neonatal sepsis (AOR = 12.66; 95% CI 2.40 to 66.86; p = 0.003 and AOR = 3.35; 95% Cl 1.31 to 8.59; p = 0.012, respectively). Conclusion: The mortality rate of neonatal sepsis was 21%. Very low birth weight and primiparity were significantly associated with mortality in neonatal sepsis.","PeriodicalId":365976,"journal":{"name":"Journal of Advanced Pediatrics and Child Health","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114427350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A rare cause of neonatal diarrhoea: Microvillositary inclusion disease: about a case report 新生儿腹泻的罕见病因:微村庄包涵病1例报告

Journal of Advanced Pediatrics and Child Health Pub Date : 2021-05-20 DOI: 10.29328/JOURNAL.JAPCH.1001033

M. Akhrif, M. Sabib, L. Rouas, T. Meskini, N. Mouane

{"title":"A rare cause of neonatal diarrhoea: Microvillositary inclusion disease: about a case report","authors":"M. Akhrif, M. Sabib, L. Rouas, T. Meskini, N. Mouane","doi":"10.29328/JOURNAL.JAPCH.1001033","DOIUrl":"https://doi.org/10.29328/JOURNAL.JAPCH.1001033","url":null,"abstract":"Microvillositary inclusion disease also known as microvillositary atrophy is a rare congenital enteropathy containing a border abnormality in the brushes of enterocytes, manifesting as severe rebellious diarrhea in newborns and infants. It was first described in 1978 by Davidson, et al. The autosomal recessive mode of transmission is suggested because of the frequency of familial cases and inbreeding. Histopathology plays an essential role in establishing the diagnosis. In 2008, a common mutation was identified in most of the patients studied in the MYO5B gene that codes for the Myosin Vb protein, which helped in understanding the etiopathogeny of this pathology poorly described in the literature. The prognosis for this pathology is extremely bleak, requiring total parenteral nutrition for child survival. Intestinal transplantation is for the moment the only long-term solution. Materials and methods: We report the case of an infant aged 6 months, with no perinatal antecedent. There is 1st degree consanguinity, the mother has a history of deaths in younger siblings in undetermined circumstances. Who since the age of 3 days presents profuse liquid diarrhoea with malnutrition, dehydration and enormous abdominal distension? Several diagnoses were suspected before the jejune biopsy was carried out, which led to the diagnosis of a microvilliositary inclusion disease. The aim of our work is to highlight the rarest cause of neonatal rebel diarrhoea and to know how to include it among other differential diagnoses.","PeriodicalId":365976,"journal":{"name":"Journal of Advanced Pediatrics and Child Health","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129639780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapidly involuting congenital hemangioma associated with Kasabach-Merritt Syndrome 与卡萨巴赫-梅里特综合征相关的先天性血管瘤

Journal of Advanced Pediatrics and Child Health Pub Date : 2021-05-17 DOI: 10.29328/JOURNAL.JAPCH.1001032

R. Ballona, J. Zevallos, J. Núñez

引用次数: 0

Clinical picture of pulmonary plague observed in the paediatric wards of antananarivo 在塔那那利佛儿科病房观察到肺鼠疫的临床图像

Journal of Advanced Pediatrics and Child Health Pub Date : 2021-05-13 DOI: 10.29328/JOURNAL.JAPCH.1001031

R. Rakotomalala, Lovasoa R. Randriamanga, Mihary Soa Karol, Mioramalala Sedera Aurélien, A. Robinson

{"title":"Clinical picture of pulmonary plague observed in the paediatric wards of antananarivo","authors":"R. Rakotomalala, Lovasoa R. Randriamanga, Mihary Soa Karol, Mioramalala Sedera Aurélien, A. Robinson","doi":"10.29328/JOURNAL.JAPCH.1001031","DOIUrl":"https://doi.org/10.29328/JOURNAL.JAPCH.1001031","url":null,"abstract":"Introduction: In Madagascar, plague is a highly contagious acute endemic infectious disease. The diagnosis of the most severe form of pneumonic plague remains difficult in children, hence the objectives of the present study; which is to identify the clinical signs of this clinical form in children and to describe its epidemiological and evolutionary profile. Methods: A retrospective case-control study was conducted in four pediatric wards in Antananarivo during the urban pneumonic plague outbreak from September 2017 to January 2018. Those cases were defined as children aged 0-15 years old suspected of having plague with positive RDT and PCR, and they were defined as children aged 0-15 years old with negative RDT and PCR. Results: Fifty-two cases of pneumonic plague were identified, half of which (50%) were under 24 months of age. A male predominance was noted with a sex ratio of 1.23 and 86.54% of the patients were from urban areas. Several clinical signs were found but none was specific for pneumonic plague: cough (59.62% p: 0.5), dyspnea (3.85% p: 0.16), chest pain (3.85% p: 0.26%), hemoptysis (7.69% p: 0.17), vomiting (9.62% p: 0.14), diarrhea (11.54% p: 0.45), altered general condition (38.46% p: 0.24%). Two deaths were noted (3.8%). Conclusion: No specific clinical warning signs have been identified in childhood pneumonic plague. In the event of an epidemic of urban pneumonic plague, any bacterial pneumonia should at least initially include active treatment against Yersinia pestis.","PeriodicalId":365976,"journal":{"name":"Journal of Advanced Pediatrics and Child Health","volume":"52 7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130332408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with diagnostic delay in children with Wilms’ tumor 儿童肾母细胞瘤诊断延迟的相关因素

Journal of Advanced Pediatrics and Child Health Pub Date : 2021-04-15 DOI: 10.29328/JOURNAL.JAPCH.1001030

Gutierrez Francisca Norma, de Aguiar Moraes Guilherme, Grabois Marilia Fornaciari, Ferman Sima Ester, Barbosa Adauto Dutra Moraes

{"title":"Factors associated with diagnostic delay in children with Wilms’ tumor","authors":"Gutierrez Francisca Norma, de Aguiar Moraes Guilherme, Grabois Marilia Fornaciari, Ferman Sima Ester, Barbosa Adauto Dutra Moraes","doi":"10.29328/JOURNAL.JAPCH.1001030","DOIUrl":"https://doi.org/10.29328/JOURNAL.JAPCH.1001030","url":null,"abstract":"Background: In Wilms’ tumor, the time elapsed between clinical diagnosis and the start of treatment is clearly associated with morbidity and mortality. As treatment delay can influence patient survival, identification of possible causes can mitigate the consequences arising from prolonged diagnostic uncertainty. Objective: To ascertain whether an initial diagnosis of Wilms’ tumor in the emergency department influences patient prognosis depending on the type of referral for definitive treatment. Patients and methods: Retrospective chart review of 98 children receiving treatment for Wilms’ tumor at the Brazilian National Cancer Institute (INCA) between April 2003 and December 2016. Patients were categorized into two groups: those referred directly from an emergency public department to INCA and those first transferred to another hospital before being referred to INCA. Results: Of the 98 cases included in the study, 42.9% were direct referrals and 57.1% were indirect referrals. Presence of an abdominal mass was the most common presenting complaint, followed by abdominal pain. In cases with larger tumors, the mean tumor volume was greater than reported elsewhere in the literature, suggesting longer disease duration. Significantly higher tumor volumes were observed in patients with a palpable abdominal mass as compared to those with the second most frequent complaint (abdominal pain). Conclusion: The findings of this study support the hypothesis that patients diagnosed with kidney masses in the emergency department are at greater risk of delayed diagnosis when they are referred first to a non-specialized outside hospital than when referred directly to a specialized cancer treatment unit.","PeriodicalId":365976,"journal":{"name":"Journal of Advanced Pediatrics and Child Health","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124943608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of influence of IL-6 C-572G gene polymorphism and clinical factors on positive platelet antibody test 白细胞介素-6 C-572G基因多态性及临床因素对血小板抗体阳性检测的影响

Journal of Advanced Pediatrics and Child Health Pub Date : 2021-01-15 DOI: 10.29328/JOURNAL.JAPCH.1001023

Lin Jeong-Shi, Lee Li-Hsuan, Liu Hsueng-Mei, Ying-Ju Chen, Chiou Tzeon-Jye

{"title":"Evaluation of influence of IL-6 C-572G gene polymorphism and clinical factors on positive platelet antibody test","authors":"Lin Jeong-Shi, Lee Li-Hsuan, Liu Hsueng-Mei, Ying-Ju Chen, Chiou Tzeon-Jye","doi":"10.29328/JOURNAL.JAPCH.1001023","DOIUrl":"https://doi.org/10.29328/JOURNAL.JAPCH.1001023","url":null,"abstract":"Background: Interleukin-6 (IL-6) promotes antibody production. The objective of this study was to investigate whether IL-6 C-572G single nucleotide polymorphisms (SNP) and clinical factors are associated with positive platelet antibody test. Materials and methods: Thirty platelet recipients with platelet antibodies (responders) and 20 platelet recipients without platelet antibodies (non-responders) were randomly selected. The -572 C>G (rs 1800796) SNPs in the promoter region of IL-6 gene were genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. Solid phase red cell adherence assay (SPRCA) was used for platelet antibody detection. Results: Age, sex, percentage patients with benign diseases, and percentage of patients with homozygotes for the C allele at position -572 of the IL-6 gene were similar between responders and non-responders. Although the amounts of platelets pheresis transfused to patients with hematologic diseases were higher than those of non-hematologic diseases (47.2 ± 54.2 vs. 17.4 ± 13.8 units, p = 0.019), detection rate of platelet antibodies was lower in patients with hematologic diseases than that in patients with non-hematologic diseases (42.3% vs. 79.2%, p = 0.01). Conclusion: There was no association between IL-6 C-572G gene polymorphism and positive reactivity in solid phase platelet antibody detection method in platelet recipients.","PeriodicalId":365976,"journal":{"name":"Journal of Advanced Pediatrics and Child Health","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127594831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A girl with a stiff neck 一个脖子僵硬的女孩

Journal of Advanced Pediatrics and Child Health Pub Date : 2020-12-08 DOI: 10.29328/JOURNAL.JAPCH.1001019

C. G, P. A, V. F, Barbi E, Carbone M

引用次数: 0

Air pollution and respiratory health 空气污染与呼吸系统健康

Journal of Advanced Pediatrics and Child Health Pub Date : 2020-09-01 DOI: 10.29328/journal.japch.1001015

Raj Kumar

{"title":"Air pollution and respiratory health","authors":"Raj Kumar","doi":"10.29328/journal.japch.1001015","DOIUrl":"https://doi.org/10.29328/journal.japch.1001015","url":null,"abstract":"OPEN ACCESS As per report of WHO [1] (World Health Organization), air pollution (ambient/outdoor and household/indoor air pollution) kills an estimated seven million people worldwide every year largely as a result of increased mortality from stroke, heart disease, chronic obstructive pulmonary disease, lung cancer and acute respiratory infections. Data of WHO shows that 9 out of 10 people breathe air containing high levels of pollutants. World Health Organization is working with countries to monitor air pollution and improve air quality. From smog hanging over cities to smoke inside the home, air pollution poses a major threat to health and climate. More than 80% of people living in urban areas and around 91% of the world’s population live in places where air quality levels exceed WHO limits, with developing and under-developed countries suffering from the highest exposures, both indoors and outdoors [1]. While outdoor air pollution comes from the motor vehicles, burning of fossil fuels and other industrialization activities, indoor air pollution is the result of tobacco smoke and burning fuel for cooking & heating. Furniture and construction materials also emit such pollutants. Both outdoor and indoor air pollution are harmful to the human health","PeriodicalId":365976,"journal":{"name":"Journal of Advanced Pediatrics and Child Health","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124386268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

“Syndrome of Contractures and Deformities” according Prof. Hans Mau. Symptoms, diagnosis, treatment: Recommendations for parents “挛缩及畸形综合症”(毛汉斯教授)症状、诊断、治疗:给父母的建议

Journal of Advanced Pediatrics and Child Health Pub Date : 2020-03-10 DOI: 10.29328/journal.japch.1001012

T. Karski, J. Karski

引用次数: 0

Branchio Oculo Facial Syndrome Branchio眼面部综合症

Journal of Advanced Pediatrics and Child Health Pub Date : 2019-11-29 DOI: 10.29328/journal.japch.1001007

Oudrhiri Maha, L. Toualouth, Oubejja Houda, Ettayebi Fouad, Zerhouni Hicham

引用次数: 8