Journal of Advances in Medical and Biomedical Research最新文献_第6页

Association between Polymorphisms of X-ray Repair Cross Complementing 5 and 6 Promoter Genes and the Risk of Metastatic Breast Cancer X射线修复交叉互补5、6启动子基因多态性与癌症转移风险的相关性研究

Journal of Advances in Medical and Biomedical Research Pub Date : 2023-01-01 DOI: 10.30699/jambs.31.144.46

Zhaleh Karimi Moghaddam, Samaneh Karimkhanilouei, Golnaz Asaadi Tehrani

引用次数: 0

Protective Effect of Pomegranate Seed Oil against D-Galactose-Induced Aging in Rats 石榴籽油对d -半乳糖诱导大鼠衰老的保护作用

Journal of Advances in Medical and Biomedical Research Pub Date : 2023-01-01 DOI: 10.30699/jambs.31.144.80

A. Hosseini, Leila Ziaee, Arezoo Rajabian, M. Boroushaki

引用次数: 1

Evaluation of S Gene Mutations in Children with Maternally Transmitted Hepatitis B 母婴传播乙型肝炎患儿S基因突变的评估

Journal of Advances in Medical and Biomedical Research Pub Date : 2023-01-01 DOI: 10.30699/jambs.31.144.57

I. Shahramian, P. Ostadrahimi, M. Sheikh, S. Nazari, Hadi Mirzarie, A. Moradi, A. Aminisefat, A. Bazi, F. Parooie, M. Tahani

引用次数: 0

Comparison of the Success Rate of Treatment with Primary Percutaneous Coronary Intervention PCI versus Thrombolytic Treatment in Patients with ST-Elevation Myocardial Infarction in Local Hospitals in Iran 伊朗地方医院经皮冠状动脉介入治疗与溶栓治疗st段抬高型心肌梗死成功率的比较

Journal of Advances in Medical and Biomedical Research Pub Date : 2023-01-01 DOI: 10.30699/jambs.31.144.32

Soleiman Gharanjik, Morteza Motedayen, Reza Hasanzadeh Makoui, N. Motamed, Minoo Emami, Armin Bordbar, Mohammad Reza Jamshidi, Reza Madadi

引用次数: 0

Suppressive Effects of the Aerial Parts of Datura Stramonium L. Extract on Naloxone-Precipitated Morphine Withdrawal Signs in Mice 曼陀罗地上部分提取物对纳洛酮诱发小鼠吗啡戒断症状的抑制作用

Journal of Advances in Medical and Biomedical Research Pub Date : 2022-10-01 DOI: 10.30699/jambs.30.143.561

Sobhan Kasraeifar, Amin Mokhtari-Zaer, Narges Marefati, H. Rakhshandeh, M. Hosseini

{"title":"Suppressive Effects of the Aerial Parts of Datura Stramonium L. Extract on Naloxone-Precipitated Morphine Withdrawal Signs in Mice","authors":"Sobhan Kasraeifar, Amin Mokhtari-Zaer, Narges Marefati, H. Rakhshandeh, M. Hosseini","doi":"10.30699/jambs.30.143.561","DOIUrl":"https://doi.org/10.30699/jambs.30.143.561","url":null,"abstract":"10.30699/jambs.30.143.561 Background & Objective: Datura stramonium L. is a medicinal herb from the family of Solanaceae. It has been used in herbal remedies for promoting health and treating several diseases. The current study was set up to compare the effects of Datura stramonium L. extract on the naloxone-precipitated opiate-withdrawal in mice. Materials & Methods: Male BALB/c mice (30– 35 g, n = 40) were arbitrarily separated into 4 groups. The control group received morphine and normal saline and other groups received three doses of D. stramonium extract (10, 20, or 30 mg/kg, intraperitoneally, i.p.). Physically dependent was made by the administration of morphine in increasing doses (50-75 mg/kg, i.p.). The withdrawal signs were elicited by intraperitoneal injections of naloxone (5 mg/kg) 2 h after the last injection of morphine. Results: Administration of D. stramonium extract in doses of 20 and 30 mg/kg markedly diminished the jumping numbers compared to the control group (P<0.05). All three doses of D. stramonium extract could significantly suppress the increase in climbing (P<0.05, P<0.001, and P<0.001, respectively) and diarrhea (P<0.001). D. stramonium in higher doses (20 or 30 mg/kg) significantly decreased rearing and itching (P<0.001). Conclusion: The study findings suggest that D. stramonium extract is effective in alleviating the signs of morphine withdrawal. Additional research is needed to determine the exact mechanisms underlying D. stramonium for inhibiting morphine withdrawal syndrome.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47341543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Salivary Antioxidants in Patients with Oral Squamous Cell Carcinoma: Systematic Review Study and Meta-Analysis 口腔鳞状细胞癌患者唾液抗氧化剂的变化：系统回顾性研究和Meta分析

Journal of Advances in Medical and Biomedical Research Pub Date : 2022-10-01 DOI: 10.30699/jambs.30.143.471

Forooz Keshani, Sara Rashed, M. J. Tarahi, L. Maleki

{"title":"Changes in Salivary Antioxidants in Patients with Oral Squamous Cell Carcinoma: Systematic Review Study and Meta-Analysis","authors":"Forooz Keshani, Sara Rashed, M. J. Tarahi, L. Maleki","doi":"10.30699/jambs.30.143.471","DOIUrl":"https://doi.org/10.30699/jambs.30.143.471","url":null,"abstract":"10.30699/jambs.30.143.471 Background & Objective: Oral cancer is one of the 10 most common cancers in the world and its global outbreak is increasing. Saliva assessment is one of the noninvasive diagnostic methods for this cancer. The aim of the study was to achieve a comprehensive conclusion about changes in salivary antioxidants in patients with squamous cell carcinoma of the mouth (OSCC). Materials & Methods: In the present study, as a systematic review and meta-analysis study, information extracted by searching in external databases (PubMed, Science Direct, Scopus, Web of Science, google scholar) and internal databases (IranMedex, Scientific Information Database, Magiran) between the years 1980 to 2020. Comprehensive meta-analysis version 2 software was used to analyze the data (P <0.05). Results: Of 497 articles, 271 duplicate articles were deleted, and then, after reviewing the titles and abstracts of the articles, another 197 articles were removed. The full text of 26 articles were reviewed and evaluated. Finally, based on the STROB checklist, the data of 10 articles were entered into the meta-analysis. index levels were much higher in patients with OSCC than in healthy people (P = 0.0001). All salivary antioxidant indexes (TAC) (P=0.003) and GSH glutathione (P=0.008) saliva was significantly lower in patients than in the healthy group and regarding the salivary superoxide dismutase (SOD) index was no significant. Conclusion: In general, antioxidant supplements may be able to help prevent, treat, and improve the prognosis of this disease, which requires further research in this area.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47770599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Complete Bed Rest Position In COVID-19 Patient Outcome; Bed Rest And COVID-19 完全卧床姿势对COVID-19患者预后的影响卧床休息与COVID-19

Journal of Advances in Medical and Biomedical Research Pub Date : 2022-10-01 DOI: 10.30699/jambs.30.143.573

M. Taghavi, Salar Poorbarat, S. Mollazadeh

引用次数: 0

Association between Laboratory Findings and Mortality of Hospitalized Patients with Covid-19 in Mashhad, Iran 伊朗马什哈德Covid-19住院患者实验室结果与死亡率之间的关系

Journal of Advances in Medical and Biomedical Research Pub Date : 2022-10-01 DOI: 10.30699/jambs.30.143.519

Zahra Khoshnegah, M. Keramati, Shirin Taraz Jamshidi, Mehdi Karimi-Shahri, Samaneh Boroumand-Noughabi

{"title":"Association between Laboratory Findings and Mortality of Hospitalized Patients with Covid-19 in Mashhad, Iran","authors":"Zahra Khoshnegah, M. Keramati, Shirin Taraz Jamshidi, Mehdi Karimi-Shahri, Samaneh Boroumand-Noughabi","doi":"10.30699/jambs.30.143.519","DOIUrl":"https://doi.org/10.30699/jambs.30.143.519","url":null,"abstract":"Background & Objective: COVID-19 has enforced high burden on health systems universally. To better allocate limited health equipment, we aimed to investigate the prognostic impacts of laboratory parameters. Material(s) and Method(s): All SARS-CoV-2 patients admitted to Imam-Reza University Hospital, Mashhad, Iran, during three COVID19 peak periods in Iran (March to April 2020, July to August, and October to November 2020) were enrolled the study. Demographic and laboratory data were extracted and compared between survivors and non-survivors. Regression analyses and receiver operating characteristic (ROC curve) were used to identify risk factors and assess the ability of laboratory tests in predicting in-hospital mortality. Result(s): A total of 2156 COVID19 patients were included in the analysis, with a mean age of 60.20 (+/-18.8) years. Most patients were male (57%). Multiple regression analysis identified older age (OR=1.01), male sex (OR=2.34), lymphopenia (OR=2.12), LDH >500U/L (OR=2.17), hypernatremia (OR=9.7), urea >45mg/dL (OR=3.6), and BS >200mg/dl (OR=1.93) as significant risk factors for in-hospital death. Using ROC curve analysis, D-dimer (>1000ng/ml) as well as CK-Mb (>28U/L) both with sensitivities and specificities of more than 80% and PPV of about 90% were able to identify patients with higher possibility of in-hospital death. Conclusion(s): Male sex, older age, lymphopenia, hypernatremia, increased Urea, increased LDH, and hyperglycemia may serve as potential risk factors for inhospital death. D-dimer and CK-MB may be used in identifying patients with high probability of in-hospital death. These tests may be used in clinical decision-making in order to improve outcomes of patients with COVID-19. Copyright © 2022, Zahra Khoshnegah.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47181442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proposed Method for Predicting COVID-19 Severity in Chronic Kidney Disease Patients Based on Ant Colony Algorithm and CHAID 基于蚁群算法和CHAID的慢性肾脏病患者新冠肺炎严重程度预测方法

Journal of Advances in Medical and Biomedical Research Pub Date : 2022-10-01 DOI: 10.30699/jambs.30.143.507

F. Moeinzadeh, M. Sattari

{"title":"Proposed Method for Predicting COVID-19 Severity in Chronic Kidney Disease Patients Based on Ant Colony Algorithm and CHAID","authors":"F. Moeinzadeh, M. Sattari","doi":"10.30699/jambs.30.143.507","DOIUrl":"https://doi.org/10.30699/jambs.30.143.507","url":null,"abstract":"Background & Objective: The COVID-19 pandemic is a phenomenon that has infected and killed many people worldwide. Underlying diseases such as diabetes mellitus, heart failure, and chronic kidney disease (CKD) can affect the severity of COVID-19 and aggravate patients' condition. This study aimed to predict the severity of the COVID-19 disease in CKD patients by combining feature selection and classification methods. Material(s) and Method(s): This study was conducted between March 2021 and September 2021 in Isfahan University of Medical Sciences. The data set includes 83 traits of 72 kidney transplant patients, 231 kidney failure patients, and 105 dialysis patients. The data set has 77 input attributes, including age, sex, diabetes mellitus, hypertension, ischemic heart disease, chronic lung disease, and kidney transplant In the proposed method, the combination of ant colony algorithm and the CHAID method has been used. Result(s): The combination of the ant colony algorithm and CHAID method leads to better performance than CHAID alone. A total of 22 rules were extracted, of which 6 rules with a confidence of more than 60% were introduced as selected rules. The most reliable rule states that if a person has CKD stage 5, is not undergoing dialysis (5ND), and is short of breath, in 81% of cases the type of COVID-19 disease will be severe. Conclusion(s): In this study the severity of COVID-19 disease in kidney patients was measured using variables including age, diabetes mellitus, blood pressure, CKD stage, etc. The results showed that high levels of kidney disease can lead to severe COVID-19. Copyright © 2022 Firouzeh Moeinzadeh.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44057626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcome of Phlebotomy on Improvement of Liver Enzymes and Steatosis in Non-Alcoholic Fatty Liver Disease: A Randomized, Controlled Trial 静脉切开术改善非酒精性脂肪肝肝肝酶和脂肪变性的疗效：一项随机对照试验

Journal of Advances in Medical and Biomedical Research Pub Date : 2022-10-01 DOI: 10.30699/jambs.30.143.493

A. Hormati, Ali Khanyabi, S. Ahmadpour, F. Alemi, Seyed Saeid Sarkeshikian, Mahboubeh Afifian, Abolfazl Mohammadbeig, M. Ghadir

{"title":"Outcome of Phlebotomy on Improvement of Liver Enzymes and Steatosis in Non-Alcoholic Fatty Liver Disease: A Randomized, Controlled Trial","authors":"A. Hormati, Ali Khanyabi, S. Ahmadpour, F. Alemi, Seyed Saeid Sarkeshikian, Mahboubeh Afifian, Abolfazl Mohammadbeig, M. Ghadir","doi":"10.30699/jambs.30.143.493","DOIUrl":"https://doi.org/10.30699/jambs.30.143.493","url":null,"abstract":"10.30699/jambs.30.143.493 Background & Objective: Iron overload in the liver can potentially induce nonalcoholic fatty liver disease (NAFLD). In this study, we sought to evaluate the phlebotomy in NAFLD, and compare it with modified life style. Materials & Methods: This randomized, single-blind, clinical trial was carried out to evaluate the efficacy of phlebotomy on liver enzymes and steatosis in NAFLD patients. Forty patients diagnosed with NAFLD were enrolled in the study. Patients were randomized into two groups, including twenty patients in the first group who were under daily consumption of 800 IU vitamin E with modified lifestyle, and the second group who administrated 400 ml phlebotomy at the baseline and fifth month of study alongside the modified lifestyle. Transient elastography (TE) was used to evaluate liver transaminases, hemoglobin, ferritin levels, and liver stiffness prior to and following the intervention. Chi-square and paired t-tests were used to analyze the data, using SPSS v18. Results: In each group, there were 14 men and 6 women. There was no statistically significant difference in demographic features. After the intervention, the mean liver stiffness of the control group increased from 10.38±2.65 kPa before the treatment to 11.40±6.58 kPa, which was not significantly different (P=0.463). The liver stiffness was 11.29±4.71 kPa in the intervention group before the treatment, which was reduced to 8.10±2.36 kPa after the treatment; however, the difference between pre and post-treatment values was statistically significant (P = 0.009). Before and after the treatment, there were no significant differences in the levels of liver enzymes between the two groups. Conclusion: Phlebotomy is a useful treatment for NAFLD patients, and decreased liver stiffness as cirrhosis complication.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49417638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0