Journal of Translational Autoimmunity最新文献

{"title":"Autoimmunity in centenarians. A paradox","authors":"Juan-Manuel Anaya ,&nbsp;Ivan David Lozada-Martinez ,&nbsp;Isaura Torres ,&nbsp;Yehuda Shoenfeld","doi":"10.1016/j.jtauto.2024.100237","DOIUrl":"https://doi.org/10.1016/j.jtauto.2024.100237","url":null,"abstract":"<div><p>Autoimmune diseases (ADs) are one of the groups of chronic illnesses that impose a significant burden of disease and health costs worldwide. Age is a crucial risk factor for the onset of ADs. Theoretically, it is inferred that with organic and immune system aging, the loss of immune tolerance and specificity of immune activity becomes more intense, the probability of autoimmunity is increasing. However, there is a group of individuals whose prevalence of ADs is very low or non-existent, despite the biological aging. This paradox in autoimmunity raises questions. Centenarians, individuals who are over 100 years old, are possibly the most successful model of biological aging in humans. Most of these individuals exhibit a favorable health phenotype. To date, primary data evidence and potential hypotheses explaining this phenomenon are lacking globally, even though this paradox could provide valuable, original, and relevant information regarding the understanding of risk or protective factors, biological drivers, and biomarkers related to autoimmunity. Herein we discuss some hypothesis that may explain the absence of ADs in centenarians, including inflammaging, immunosenescence and immune resilience, immune system hyperstimulation, proteodynamics, and genetics.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":"8 ","pages":"Article 100237"},"PeriodicalIF":3.9,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589909024000078/pdfft?md5=d73ac460af023a75956b96beaf06a48e&pid=1-s2.0-S2589909024000078-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of omega-3 fatty acids supplementation on hemoglobin, hematocrit, and platelet levels of patients with ESRD condition undergoing dialysis","authors":"Zahra Mahmoudi ,&nbsp;Zahra Roumi ,&nbsp;Seyed Ali Askarpour ,&nbsp;Zahra Mousavi ,&nbsp;Hanieh Shafaei ,&nbsp;Neda Valisoltani ,&nbsp;Mahsa Shapouri ,&nbsp;Seyed Reza Mirshafaei ,&nbsp;Pouya Mirzaee ,&nbsp;Khadijeh Abbasi Mobarakeh ,&nbsp;Elahe Taghavi Sufiani ,&nbsp;Zeinab Motiee Bijarpasi ,&nbsp;Zeynab Motiei ,&nbsp;Masoud Khosravi ,&nbsp;Saeid Doaei ,&nbsp;Maryam Gholamalizadeh","doi":"10.1016/j.jtauto.2024.100233","DOIUrl":"https://doi.org/10.1016/j.jtauto.2024.100233","url":null,"abstract":"<div><h3>Background</h3><p>Concomitant inflammation may boost the cardiovascular complications in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Omega-3 fatty acids may have certain health benefits in HD patients. The aim of this study was to investigate the effects of omega-3 fatty acids supplementation on hematocrit (HCT), hemoglobin (HB) level and platelet (PLT) counts of HD patients.</p></div><div><h3>Methods</h3><p>A randomized controlled trial was conducted on HD patients at a private dialysis center in Rasht, Iran. Three omega-3 fatty acid supplement capsules (3 g/d) were administered daily for two months to patients in the intervention group (n = 55). The control group (n = 60) were given three placebo capsules containing medium chain triglyceride (MCT) oil, similar to the supplemental dose of the intervention group at the same period. Three parameters of HCT, HB and PLT were measured at baseline and after the intervention.</p></div><div><h3>Results</h3><p>The PLT count decreased in the intervention group compared to the control group (173.38 ± 74.76 vs. 227.68 ± 86.58 10³/mm³, F = 4.83, P = 0.03). No significant change was found on the levels of HCT and HB parameters between the two groups after the intervention.</p></div><div><h3>Conclusion</h3><p>Omega-3 supplementation in HD patients may decrease the risk of forming blood clots in the blood vessels. Further studies are warranted.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":"8 ","pages":"Article 100233"},"PeriodicalIF":3.9,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589909024000030/pdfft?md5=5bcba8760b794c6c65baed779d81fc5c&pid=1-s2.0-S2589909024000030-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140030333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation and progression of MPO-ANCA interstitial lung disease","authors":"Lorenzo Salvati ,&nbsp;Boaz Palterer ,&nbsp;Elena Lazzeri ,&nbsp;Emanuele Vivarelli ,&nbsp;Marina Amendola ,&nbsp;Marco Allinovi ,&nbsp;Leonardo Caroti ,&nbsp;Alessio Mazzoni ,&nbsp;Laura Lasagni ,&nbsp;Giacomo Emmi ,&nbsp;Edoardo Cavigli ,&nbsp;Marco Del Carria ,&nbsp;Linda Di Pietro ,&nbsp;Mariangela Scavone ,&nbsp;Daniele Cammelli ,&nbsp;Federico Lavorini ,&nbsp;Sara Tomassetti ,&nbsp;Elisabetta Rosi ,&nbsp;Paola Parronchi","doi":"10.1016/j.jtauto.2024.100235","DOIUrl":"https://doi.org/10.1016/j.jtauto.2024.100235","url":null,"abstract":"<div><p>The association between MPO-ANCA-associated vasculitis (AAV) and interstitial lung disease (ILD) has been well established. Pulmonary fibrosis may coexist with, follow, or even precede the diagnosis of AAV, and its presence adversely affects the prognosis. The optimal approach to investigating ANCA in patients with ILD remains a subject of ongoing debate. Here we aim to describe presentation and progression of MPO-ANCA ILD. We conducted a retrospective evaluation of a cohort of individuals diagnosed with MPO-ANCA ILD, with or without accompanying renal impairment, at the Immunology and Cell Therapy Unit, Careggi University Hospital, Florence, Italy, between June 2016 and June 2022. Clinical records, imaging studies, pathologic examinations, and laboratory test results were collected. Among the 14 patients identified with MPO-ANCA ILD, we observed a significant association between MPO-ANCA titers assessed at the time of ILD diagnosis and renal involvement. Renal impairment in these cases often manifested as subclinical or slowly progressive kidney damage. Interestingly, complement C3 deposits were consistently found in all renal biopsy specimens, thereby suggesting the potential for novel therapeutic targets in managing renal complications associated with MPO-ANCA ILD. The presentation of MPO-ANCA vasculitis as ILD can be the first and only clinical manifestation. MPO-ANCA levels at ILD diagnosis could warn on the progression to renal involvement in patients with MPO-ANCA ILD, hence caution is needed because renal disease can be subclinical or smoldering.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":"8 ","pages":"Article 100235"},"PeriodicalIF":3.9,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589909024000054/pdfft?md5=9a7374416762e09d66959b84f16dd0ea&pid=1-s2.0-S2589909024000054-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139992559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcoidosis and lymphoma mortality risk: An observational study from the Spanish National Registry","authors":"Víctor Moreno-Torres ,&nbsp;María Martínez-Urbistondo ,&nbsp;Pedro Durán-del Campo ,&nbsp;Pablo Tutor ,&nbsp;Begoña Rodríguez ,&nbsp;Raquel Castejón ,&nbsp;Susana Mellor-Pita","doi":"10.1016/j.jtauto.2024.100236","DOIUrl":"https://doi.org/10.1016/j.jtauto.2024.100236","url":null,"abstract":"<div><h3>Introduction</h3><p>Patients with sarcoidosis have a lower survival rate than the general population, in part due to cardiovascular disease, infections and neoplasms. Our objective was to evaluate the impact of haematological neoplasms (HN) and lymphomas on sarcoidosis patient mortality in a nation-wide analysis conducted in Spain, a country with a population of 47 million.</p></div><div><h3>Methods</h3><p>Retrospective and observational comparison of the HN related deaths in sarcoidosis patients and the general Spanish population reported in the Spanish Hospital Discharge Database. To determine the impact of sarcoidosis on the risk of dying from each HN lineage, a binary logistic regression considering age, female sex, tobacco and alcohol consumption, was performed.</p></div><div><h3>Results</h3><p>In the period 2016 and 2019, 139,531 in-hospital deaths from neoplasms were certified in Spain (77 in patients with sarcoidosis). Patients with sarcoidosis died at younger age than the general Spanish population (72.9 vs 77.6, p&lt;0.001). Sarcoidosis patients presented a higher mortality risk from HN (20.8% vs 8.9%, p=0.001, OR=2.64, 95% CI 1.52-4.59), attributable to the higher proportion of deaths from non-Hodgkin lymphoma (NHL), (9.2% vs 2.9%, p=0.006, OR= 3.33, 95% CI 1.53-7.25) from both B cell (6.6% vs 2.5%, p=0.044, OR= 2.62, 95% 1.06-6.5) and T/NK cell lineages (2.6% vs 0.3%, p=0.024, OR= 7.88, 95% CI 1.92-32.29) as well as HN with uncertain behavior and myeloproliferative disorders (2.6% vs 0.3%, p=0.018, OR= 11.88, 95% CI 2.88-49.02). The mean age of sarcoidosis patients who died from HN (63.6 vs 71.9, p=0.032) and non-Hodgkin lymphoma (56.9 vs 71, p=0.009) was lower than that of the general population</p></div><div><h3>Conclusion</h3><p>Patients with sarcoidosis present a higher risk of premature death from HN, including NHL from B, T/NK cell lineage and myeloproliferative disorders in comparison with the general Spanish population. In addition to developing strategies that might help to attenuate their occurrence and impact, such as decreasing the immunosuppressive burden, specific early-detection programs for these conditions should be investigated and considered carefully.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":"8 ","pages":"Article 100236"},"PeriodicalIF":3.9,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589909024000066/pdfft?md5=aee45af346db935182d22e523806b9a0&pid=1-s2.0-S2589909024000066-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139935800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of CCR6 functional polymorphisms with Primary Biliary Cholangitis","authors":"Mingming Zhang ,&nbsp;Zhuye Qin ,&nbsp;Yexi Huang ,&nbsp;Wenyan Tian ,&nbsp;You Li ,&nbsp;Chan Wang ,&nbsp;Weifeng Zhao ,&nbsp;Yaping Dai ,&nbsp;Xingjuan Shi ,&nbsp;M. Eric Gershwin ,&nbsp;Xiong Ma ,&nbsp;Meilin Wang ,&nbsp;Xiangdong Liu ,&nbsp;Weichang Chen ,&nbsp;Fang Qiu","doi":"10.1016/j.jtauto.2024.100234","DOIUrl":"10.1016/j.jtauto.2024.100234","url":null,"abstract":"<div><p>The biliary epithelial cells release CC chemokine receptor 6 (<em>CCR6</em>) ligand 20 (<em>CCL20</em>), leading to recruitment of CCR6⁺ T cells and subsequent infiltration into the biliary epithelium in primary biliary cholangitis patients. Previous genome-wide multi-national meta-analysis, including our Han Chinese cohort, showed significant association of <em>CCR6</em> and <em>CCL20</em> single nucleotide polymorphisms (SNP) with PBC. We report here that significantly associated SNPs, identified in the <em>CCR6</em> locus based on our Han Chinese genome-wide association study, can be separated into “protective” and “risk” groups, but only “risk” SNPs were confirmed using a separate Han Chinese PBC cohort. Only weak association of <em>CCL20</em> SNPs was observed in Han Chinese PBC cohorts. Fine-mapping and logistical analysis identified a previously defined functional variant that, leads to increased <em>CCR6</em> expression, which contributed to increased genetic susceptibility to PBC in Han Chinese cohort.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":"8 ","pages":"Article 100234"},"PeriodicalIF":3.9,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589909024000042/pdfft?md5=bde0fac6bd5f49d1477123acbe1d46a0&pid=1-s2.0-S2589909024000042-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139824762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the inhibition of IL-17A and TNFα in a cartilage explant model cultured with Th17-derived cytokines","authors":"Solveig Skovlund Groen ,&nbsp;Anne-Christine Bay-Jensen ,&nbsp;Christian S. Thudium ,&nbsp;Morten H. Dziegiel ,&nbsp;Marie Skougaard ,&nbsp;Simon Francis Thomsen ,&nbsp;Signe Holm Nielsen","doi":"10.1016/j.jtauto.2024.100231","DOIUrl":"https://doi.org/10.1016/j.jtauto.2024.100231","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;p&gt;T-helper 17 (Th17) cells produce IL-17A playing a critical role in activating the pathogenic chain leading to joint tissue inflammation and destruction. Elevated levels of Th17 cells and IL-17A have been detected in skin lesions, blood, and synovial fluid from patients with psoriatic arthritis (PsA) and ankylosing spondylitis (AS). Moreover, IL-17A inhibitors suppress disease activity in psoriasis, PsA and AS, supporting the evidence of IL-17A contributing to the disease pathogenesis. Although, IL-17A inhibitors are widely approved, it remains unclear how the inhibitory effect of IL-17A alters the extracellular matrix (ECM) of the joint in a Th17-conditioned inflammatory milieu. Therefore, the aim of this study was to establish a cartilage model cultured with conditioned medium from Th17 cells and inhibitors to explore the effect of IL-17A inhibition on joint tissue remodeling.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;Naïve CD4&lt;sup&gt;+&lt;/sup&gt; T cells from healthy human buffy coat were differentiated into Th17 cells, followed by Th17 cell activation to secrete Th17-related cytokines and molecules into media. The activated Th17 cells were isolated from the conditioned media (CM) and analyzed using flow cytometry to verify Th17 cell differentiation. The CM were assessed with ELISA to quantify the concentrations of cytokines secreted into the media by the Th17 cells. Healthy bovine cartilage explants were cultured with the Th17-CM and treated with IL-17A and TNFα inhibitors for 21 days. In harvested supernatant from the cartilage cultures, MMP- and ADAMTS-mediated biomarker fragments of type II collagen, aggrecan, and fibronectin were measured by ELISA to investigate the ECM remodeling within the cartilage tissue.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Th17-CM stimulated a catabolic response in the cartilage. Markers of type II collagen and aggrecan degradation were upregulated, while anabolic marker of type II collagen formation remained on similar levels as the untreated explants. The addition of IL-17A inhibitor to Th17-CM decreased the elevated type II collagen and aggrecan degradation, however, degenerative levels were still elevated compared to untreated group. The addition of TNFα inhibitor completely reduced both type II collagen and aggrecan degradation compared to untreated explants. Moreover, the TNFα inhibitor treatment did not alter the type II collagen formation compared to untreated group.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;This study suggests that inhibition of IL-17A in Th17-conditioned cartilage tissue only partially reduced the MMP-mediated type II collagen degradation and ADAMTS-mediated aggrecan degradation, while the TNFα inhibitor treatment fully reduced both MMP- and ADAMTS-mediated ECM degradation. This exploratory study where ECM biomarkers are combined with Th17-conditioned &lt;em&gt;ex vivo&lt;/em&gt; model may hold great potential as output for describing joint disease mechanisms and predicting structural effects of trea","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":"8 ","pages":"Article 100231"},"PeriodicalIF":3.9,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589909024000017/pdfft?md5=61ffc6f0ec57f666cac3c55f9b5c7838&pid=1-s2.0-S2589909024000017-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139436568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymoma with immunodeficiency, combined diffuse panbronchiolitis, and latent autoimmune diabetes in adults- case report and systematic review","authors":"Yijiao Xu ,&nbsp;Lumin Wang ,&nbsp;Zhisheng Chen ,&nbsp;Qingwei Zhang ,&nbsp;Yun Shen ,&nbsp;Yanrong Ye ,&nbsp;Jiaxin Liu ,&nbsp;Huijun Zhang","doi":"10.1016/j.jtauto.2023.100230","DOIUrl":"https://doi.org/10.1016/j.jtauto.2023.100230","url":null,"abstract":"<div><p>Thymoma with Immunodeficiency (Good's Syndrome, GS) is a rare association between thymoma and immunodeficiency, first described over 60 years ago. Patients with GS typically present with thymomas, reduced or absent B cells in the peripheral blood, hypogammaglobulinemia, and defects in cell-mediated immunity. We report the case of a 67-year-old woman diagnosed with GS following the development of a progressive, severe, refractory pulmonary infection and diffuse panbronchiolitis (DPB). She also had diabetes, characterized by anti-glutamic acid decarboxylase antibody positivity, leading to a diagnosis of latent autoimmune diabetes in adults (LADA). A thorough review of existing literature revealed that GS is often confirmed after multiple episodes of opportunistic infections or autoimmune diseases post-thymoma surgery. Due to their immunodeficiency, GS patients frequently suffer from recurrent infections over extended periods, and some succumb to severe infections. Regular immunoglobulin infusions may be effective in treating GS.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":"8 ","pages":"Article 100230"},"PeriodicalIF":3.9,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589909023000436/pdfft?md5=e058759fb69c79be34e773d370a73337&pid=1-s2.0-S2589909023000436-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139041218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANKRD22 aggravates sepsis-induced ARDS and promotes pulmonary M1 macrophage polarization","authors":"Shi Zhang ,&nbsp;Yao Liu ,&nbsp;Xiao-Long Zhang ,&nbsp;Yun Sun ,&nbsp;Zhong-Hua Lu","doi":"10.1016/j.jtauto.2023.100228","DOIUrl":"10.1016/j.jtauto.2023.100228","url":null,"abstract":"<div><p>Acute respiratory distress syndrome (ARDS) is independently associated with a poor prognosis in patients with sepsis. Macrophage M1 polarization plays an instrumental role in this process. Therefore, the exploration of key molecules affecting acute lung injury and macrophage M1 polarization may provide therapeutic targets for the treatment of septic ARDS. Here, we identified that elevated levels of Ankyrin repeat domain-containing protein 22 (ANKRD22) were associated with poor prognosis and more pronounced M1 macrophage polarization in septic patients by analyzing high-throughput data. ANKRD22 expression was also significantly upregulated in the alveolar lavage fluid, peripheral blood, and lung tissue of septic ARDS model mice. Knockdown of ANKRD22 significantly attenuated acute lung injury in mice with sepsis-induced ARDS and reduced the M1 polarization of lung macrophages. Furthermore, deletion of ANKRD22 in macrophages inhibited M1 macrophage polarization and reduced levels of phosphorylated IRF3 and intracellular interferon regulatory factor 3 (IRF3) expression, while re-expression of ANKRD22 reversed these changes. Further experiments revealed that ANKRD22 promotes IRF3 activation by binding to mitochondrial antiviral-signaling protein (MAVS). In conclusion, these findings suggest that ANKRD22 promotes the M1 polarization of lung macrophages and exacerbates sepsis-induced ARDS.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":"8 ","pages":"Article 100228"},"PeriodicalIF":3.9,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589909023000412/pdfft?md5=92cf84ecd305ce892f8bc331cdac5b55&pid=1-s2.0-S2589909023000412-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138986392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel insights into the complex interplay of immune dysregulation and inflammatory biomarkers in preeclampsia and fetal growth restriction: A two-step Mendelian randomization analysis","authors":"Chumei Zeng ,&nbsp;Huiying Liu ,&nbsp;Zilian Wang ,&nbsp;Jingting Li","doi":"10.1016/j.jtauto.2023.100226","DOIUrl":"https://doi.org/10.1016/j.jtauto.2023.100226","url":null,"abstract":"<div><h3>Background</h3><p>The relationship between genetic immune dysregulation and the occurrence of preeclampsia (PE) or PE with fetal growth restriction (PE with FGR) has yielded inconsistent findings, and the underlying mediators of this association remain elusive. We aimed to explore the causal impact of genetic immune dysregulation on the risk of PE or PE with FGR and to elucidate the role of specific transcriptomes in mediating this relationship.</p></div><div><h3>Methods</h3><p>A two-step Mendelian randomization (MR) analysis was performed to explore the link between immune dysregulation and PE or PE with FGR, as well as to identify potential inflammatory biomarkers that act as mediators. GWAS summary data for outcomes were obtained from the FinnGen dataset. The analyses encompassed five systemic immune-associated diseases, four chronic genital inflammatory diseases, and thirty-one inflammatory biomarkers. Summary-data-based MR (SMR) and HEIDI analysis were conducted to test whether the effect size of single nucleotide polymorphisms (SNPs) on outcomes was mediated by the expression of immune-associated genes.</p></div><div><h3>Results</h3><p>The primary univariable analysis revealed a significant positive correlation between systemic lupus erythematosus (SLE), type 1 diabetes (T1D), type 2 diabetes (T2D), and rheumatoid arthritis (RA) with the risk of PE or PE with FGR. Surprisingly, a counterintuitive finding showed a significant negative association between endometriosis of pelvic peritoneum (EMoP) and the risk of PE with FGR. None of the inflammatory factors had a causal relationship with PE or PE with FGR. However, there was a significant association between lymphocyte count and the risk of PE with FGR. Within the lymphocyte subset, both the proportion of Natural Killer (NK) cells and absolute counts of naïve CD4⁺ T cells demonstrated significant effects on the risk of PE with FGR. Two-step MR analysis underscored the genetically predicted lymphocyte count as a significant mediator between T1D and PE with FGR. Additionally, SMR analysis indicated the potential involvement of SH2B3 in the occurrence of PE with FGR.</p></div><div><h3>Conclusions</h3><p>Our findings provided substantial evidence of the underlying causal relationship between immune dysregulation and PE or PE with FGR and some of these diseases proved to accelerate immune cells disorders and then contribute to the risk of incident PE or PE with FGR.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":"8 ","pages":"Article 100226"},"PeriodicalIF":3.9,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589909023000394/pdfft?md5=cb5e3031edeced63939855c6ddbaa1b3&pid=1-s2.0-S2589909023000394-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139033830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ulcerative colitis with autoimmune thyroid disease results in bilateral auricular ossificans：a case","authors":"Jiaqi Zhao ,&nbsp;Fangxiao Liu ,&nbsp;Lingshuo Bai ,&nbsp;Zheng Jiao ,&nbsp;Zihui Meng ,&nbsp;Bo Jia ,&nbsp;Yu Huang ,&nbsp;Lin Liu","doi":"10.1016/j.jtauto.2023.100225","DOIUrl":"10.1016/j.jtauto.2023.100225","url":null,"abstract":"<div><h3>Background</h3><p>Patients with ulcerative colitis (UC) often exhibit susceptibilities to multiple autoimmune diseases such as Sjogren's syndrome, primary sclerosing cholangitis, systemic lupus erythematosus, and insulin-dependent diabetes mellitus. This propensity likely stems from common pathogenic mechanisms underlying immune-mediated conditions. This report highlights the occurrence of autoimmune thyroid disease during UC exacerbations. Notably, the patient displayed petrified auricles.</p><p>Case Summary.</p><p>A 57-year-old male complained of sustained abdominal pain, diarrhea, hematochezia, and mucus for a duration of 20 days. The diagnosis of UC was confirmed via colonoscopy, histopathological examination, and small bowel MRE. Clinical evaluations revealed bilateral ectopic ossification in his ears, which appeared to develop over an unspecified timeframe. Imaging and histological evaluations substantiated the ectopic ossification diagnosis while eliminating the possibility of adrenal insufficiency. The presented case offers a unique instance of bilateral auricular ossification, which is hypothesized to result from hyperthyroidism.</p></div><div><h3>Conclusion</h3><p>Our case report underscores the necessity of enhancing awareness of the rare complications associated with UC. Medical practitioners should recognize the potential overlap of autoimmune thyroid disorders in UC patients. It is imperative to test for thyroid-related antibodies in such individuals, irrespective of overt thyroid dysfunction.</p></div>","PeriodicalId":36425,"journal":{"name":"Journal of Translational Autoimmunity","volume":"8 ","pages":"Article 100225"},"PeriodicalIF":3.9,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589909023000382/pdfft?md5=974b0c6db587f329ff0226c4277fe947&pid=1-s2.0-S2589909023000382-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139015912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}