Cell Stress最新文献_第4页

Building and breaking the gut barrier with bariatric surgery. 通过减肥手术建立并打破肠道屏障。

IF 6.4

Cell Stress Pub Date : 2021-12-22 eCollection Date: 2022-02-01 DOI: 10.15698/cst2022.02.263

Mohammed K Hankir

引用次数: 1

Evaluation of I-TAC as a potential early plasma marker to differentiate between critical and non-critical COVID-19. I-TAC作为区分重症和非重症新冠肺炎的潜在早期血浆标志物的评估。

IF 6.4

Cell Stress Pub Date : 2021-12-21 eCollection Date: 2022-01-01 DOI: 10.15698/cst2022.01.262

Yushan Zhang, Chao Xu, Nelson I Agudelo Higuita, Resham Bhattacharya, Jennifer Holter Chakrabarty, Priyabrata Mukherjee

{"title":"Evaluation of I-TAC as a potential early plasma marker to differentiate between critical and non-critical COVID-19.","authors":"Yushan Zhang, Chao Xu, Nelson I Agudelo Higuita, Resham Bhattacharya, Jennifer Holter Chakrabarty, Priyabrata Mukherjee","doi":"10.15698/cst2022.01.262","DOIUrl":"10.15698/cst2022.01.262","url":null,"abstract":"The COVID-19 pandemic has led to significant global health and economic consequences. There is an unmet need to define a molecular fingerprint of severity of the disease that may guide an early, rational and directed intervention preventing severe illness. We collected plasma from patients with moderate (nine cases), severe (22 cases) and critical (five cases) COVID-19 within three days of hospitalization (approximately one week after symptom onset) and used a cytokine antibody array to screen the 105 cytokines included in the array. We found that I-TAC, IP-10, ST2 and IL-1ra were significantly upregulated in patients with critical disease as compared to the non-critical (moderate and severe combined). ELISA further quantified I-TAC levels as 590.24±410.89, 645.35±517.59 and 1613.53±1010.59 pg/ml in moderate, severe and critical groups, respectively. Statistical analysis showed that I-TAC levels were significantly higher in patients with critical disease when compared with moderate (p = 0.04), severe (p = 0.03) or the combined non-critical (p = 0.02) group. Although limited by the low sample numbers, this study may suggest a role of I-TAC as a potential early marker to discriminate between critical and non-critical COVID-19 cases. Such knowledge is urgently needed for appropriate allocation of resources and to serve as a platform for future research towards early interventions that could mitigate disease severity and save lives.","PeriodicalId":36371,"journal":{"name":"Cell Stress","volume":"6 1","pages":"6-16"},"PeriodicalIF":6.4,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10671009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway. p38 通过 TSC-mTORC1 通路调节肿瘤抑制因子 PDCD4。

IF 6.4

Cell Stress Pub Date : 2021-11-23 eCollection Date: 2021-12-01 DOI: 10.15698/cst2021.12.260

Clarissa Braun, Karl Katholnig, Christopher Kaltenecker, Monika Linke, Nyamdelger Sukhbaatar, Markus Hengstschläger, Thomas Weichhart

引用次数: 0

Mechanisms of YAP/TAZ transcriptional control. YAP/TAZ转录调控机制。

IF 6.4

Cell Stress Pub Date : 2021-10-29 eCollection Date: 2021-11-01 DOI: 10.15698/cst2021.11.258

Giusy Battilana, Francesca Zanconato, Stefano Piccolo

引用次数: 18

GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome. 掌握非常规的分泌机制，以桥梁细胞应激信号到细胞外蛋白质组。

IF 6.4

Cell Stress Pub Date : 2021-10-15 eCollection Date: 2021-11-01 DOI: 10.15698/cst2021.11.259

Constantinos Demetriades, Julian Nüchel, Markus Plomann

引用次数: 0

Macroautophagy and normal aging of the nervous system: Lessons from animal models. 巨噬和神经系统的正常衰老:来自动物模型的教训。

IF 6.4

Cell Stress Pub Date : 2021-10-06 eCollection Date: 2021-10-01 DOI: 10.15698/cst2021.10.257

Emmanouela Kallergi, Vassiliki Nikoletopoulou

引用次数: 5

Host upregulation of lipid droplets drives antiviral responses. 宿主脂滴的上调驱动抗病毒反应。

IF 6.4

Cell Stress Pub Date : 2021-08-25 eCollection Date: 2021-09-01 DOI: 10.15698/cst2021.09.256

Ebony A Monson, Karla J Helbig

{"title":"Host upregulation of lipid droplets drives antiviral responses.","authors":"Ebony A Monson, Karla J Helbig","doi":"10.15698/cst2021.09.256","DOIUrl":"https://doi.org/10.15698/cst2021.09.256","url":null,"abstract":"When a host cell is infected by a virus, it activates the innate immune response, setting off a cascade of signalling events leading to the production of an antiviral response. This immune response is typically robust and in general works well to clear viral infections, however, viruses have evolved evasion strategies to combat this, and therefore, a better understanding of how this response works in more detail is needed for the development of novel and effective therapeutics. Lipid droplets (LDs) are intracellular organelles and have historically been thought of simply as cellular energy sources, however, have more recently been recognised as critical organelles in signalling events. Importantly, many viruses are known to take over host cellular production of LDs, and it has traditionally been assumed the sole purpose of this is to supply energy for viral life cycle events. However, our recent work positions LDs as important organelles during the first few hours of an antiviral response, showing that they underpin the production of important antiviral cytokines following viral infection. Following infection of cells with either RNA viruses (Zika, Dengue, Influenza A) or a DNA (Herpes Simplex Virus-1) virus, LDs were rapidly upregulated, and this response was also replicated following stimulation with viral mimic agonists. This upregulation of LDs following infection was transient, and interestingly, did not follow the well described homeostatic mechanism of LD upregulation, instead being controlled by EGFR. The cell's ability to mount an effective immune response was greatly diminished when inhibiting EGFR, thus inhibiting LD upregulation during infection, also leading to an increase in viral replication. In this microreview, we extrapolate our recent findings and discuss LDs as an important organelle in the innate immune response.","PeriodicalId":36371,"journal":{"name":"Cell Stress","volume":"5 9","pages":"143-145"},"PeriodicalIF":6.4,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39420927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Atg8ylation as a general membrane stress and remodeling response. Atg8ylation 是一种普遍的膜应激和重塑反应。

IF 6.4

Cell Stress Pub Date : 2021-08-12 eCollection Date: 2021-09-01 DOI: 10.15698/cst2021.09.255

Suresh Kumar, Jingyue Jia, Vojo Deretic

引用次数: 0

PDLIM1: Structure, function and implication in cancer. PDLIM1:结构、功能及其在癌症中的意义。

IF 6.4

Cell Stress Pub Date : 2021-07-26 eCollection Date: 2021-08-01 DOI: 10.15698/cst2021.08.254

Jian-Kang Zhou, Xin Fan, Jian Cheng, Wenrong Liu, Yong Peng

引用次数: 9

Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health. 更好地理解自噬在疾病和健康中对神经发育的作用。

IF 4.1

Cell Stress Pub Date : 2021-06-29 eCollection Date: 2021-07-01 DOI: 10.15698/cst2021.07.253

Juan Zapata-Muñoz, Beatriz Villarejo-Zori, Pablo Largo-Barrientos, Patricia Boya

引用次数: 0