PatternsPub Date : 2026-04-10DOI: 10.1016/j.patter.2026.101539
Alec D MacCall
{"title":"Navigating the manifold: A transformative approach to AI image generation.","authors":"Alec D MacCall","doi":"10.1016/j.patter.2026.101539","DOIUrl":"10.1016/j.patter.2026.101539","url":null,"abstract":"<p><p>Using an external starting image and sparse action prompts, Transformative AI treats image generation as iterative navigation through an irregular, high-dimensional manifold. This user-guided process preserves expressive development and explores regions apparently inaccessible to text-to-image workflows. I illustrate this with an example and compare it to a text-to-image equivalent.</p>","PeriodicalId":36242,"journal":{"name":"Patterns","volume":"7 4","pages":"101539"},"PeriodicalIF":7.4,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PatternsPub Date : 2026-04-10DOI: 10.1016/j.patter.2026.101513
Victor Gimenez-Abalos, Sergio Alvarez-Napagao, Adrian Tormos, Sara Montese, Ulises Cortés, Javier Vázquez-Salceda
{"title":"Intentional policy graphs: A pipeline for explaining agent behavior through intentions.","authors":"Victor Gimenez-Abalos, Sergio Alvarez-Napagao, Adrian Tormos, Sara Montese, Ulises Cortés, Javier Vázquez-Salceda","doi":"10.1016/j.patter.2026.101513","DOIUrl":"10.1016/j.patter.2026.101513","url":null,"abstract":"<p><p>Agents increasingly operate in complex environments, where coherent behavior often emerges from opaque decision-making processes. While such systems can be highly effective, this lack of transparency limits trust, auditing, and meaningful human understanding. We introduce intentional policy graphs, a post hoc, model-agnostic framework that explains agent behavior in terms of intentions: probabilistic commitments to desired outcomes inferred from partial observations. By extending policy graphs with a formal notion of intention, we move beyond action-level descriptions toward telic explanations of why agents pursue particular trajectories. The framework provides a complete construction pipeline, design principles, and quantitative metrics that explicitly characterize the trade-off between interpretability and reliability. Intentions support structured answers to what, how, and why questions, enabling both local and global explanations of behavior. We demonstrate the approach in a cooperative multi-agent game and on real-world human driving data, highlighting its generality and explanatory power without access to internal reasoning models.</p>","PeriodicalId":36242,"journal":{"name":"Patterns","volume":"7 4","pages":"101513"},"PeriodicalIF":7.4,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PatternsPub Date : 2026-04-10DOI: 10.1016/j.patter.2026.101518
Wojtek Treyde, Aleksy Kwiatkowski, Jascha Achterberg, Danyal Akarca, Martin Buttenschoen, Rory T Byrne, Kieran Didi, Kristina Kordova, Jakub Lála, Jonathon Langford, Austin M Mroz, Puria Radmard, Filip T Szczypiński, Eva Sevenster, Inga Van den Bossche, Michał Wójcik
{"title":"Organizing across disciplines to tackle shared computational challenges.","authors":"Wojtek Treyde, Aleksy Kwiatkowski, Jascha Achterberg, Danyal Akarca, Martin Buttenschoen, Rory T Byrne, Kieran Didi, Kristina Kordova, Jakub Lála, Jonathon Langford, Austin M Mroz, Puria Radmard, Filip T Szczypiński, Eva Sevenster, Inga Van den Bossche, Michał Wójcik","doi":"10.1016/j.patter.2026.101518","DOIUrl":"https://doi.org/10.1016/j.patter.2026.101518","url":null,"abstract":"<p><p>The Science through Computation Initiative unites sixteen early-career computational scientists spanning physics, biology, chemistry, and neuroscience. Over nine months of workshops and hackathons, they agreed on \"computational motifs,\" fundamental challenges that recur across their scientific disciplines, built prototype tools tackling them, and distilled actionable recommendations for the wider research community.</p>","PeriodicalId":36242,"journal":{"name":"Patterns","volume":"7 4","pages":"101518"},"PeriodicalIF":7.4,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PatternsPub Date : 2026-04-10DOI: 10.1016/j.patter.2026.101541
Yuhao Zhou, María Óskarsdóttir, Cristián Bravo
{"title":"Breaking the glass ceiling: An interview with Yuhao (Jet) Zhou, María Óskarsdóttir, and Cristián Bravo.","authors":"Yuhao Zhou, María Óskarsdóttir, Cristián Bravo","doi":"10.1016/j.patter.2026.101541","DOIUrl":"10.1016/j.patter.2026.101541","url":null,"abstract":"<p><p>Despite years of attention to gender equality, women remain underrepresented on corporate boards. Zhou et al. explore how professional connections influence access to these positions and the reasons behind the underrepresentation.<sup>1</sup> In this interview, three authors reflect on the inspiration behind their research, the teamwork that shaped the project, and the key ideas underlying their analysis of gender disparities on corporate boards.</p>","PeriodicalId":36242,"journal":{"name":"Patterns","volume":"7 4","pages":"101541"},"PeriodicalIF":7.4,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PatternsPub Date : 2026-03-13DOI: 10.1016/j.patter.2026.101497
Georgia Channing, Avijit Ghosh
{"title":"AI for scientific discovery is a social problem.","authors":"Georgia Channing, Avijit Ghosh","doi":"10.1016/j.patter.2026.101497","DOIUrl":"https://doi.org/10.1016/j.patter.2026.101497","url":null,"abstract":"<p><p>AI is being increasingly applied to scientific research, but its benefits remain unevenly distributed across different communities and disciplines. While technical challenges such as limited data, fragmented standards, and unequal access to computational resources are already well known, social and institutional factors are often the primary constraints. Narratives emphasizing autonomous \"AI scientists,\" the underrecognition of data and infrastructure work, misaligned incentives, and gaps between domain experts and machine-learning researchers all limit the impact of AI on scientific discovery. Four interconnected challenges are highlighted in this paper: community coordination, the misalignment of research priorities with upstream needs, data fragmentation, and infrastructure inequities. We argue that addressing these challenges requires not only technical innovations but also intentional community-building efforts, cross-disciplinary education, shared benchmarks, and accessible infrastructure. We call for reframing AI for science as a collective social project, where sustainable collaboration and equitable participation are treated as prerequisites for achieving technical progress.</p>","PeriodicalId":36242,"journal":{"name":"Patterns","volume":"7 3","pages":"101497"},"PeriodicalIF":7.4,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PatternsPub Date : 2026-03-13DOI: 10.1016/j.patter.2026.101496
Anand K Gavai, Miranda P M Meuwissen
{"title":"Agentic AI as a coordination paradigm in digital health and agri-food systems.","authors":"Anand K Gavai, Miranda P M Meuwissen","doi":"10.1016/j.patter.2026.101496","DOIUrl":"https://doi.org/10.1016/j.patter.2026.101496","url":null,"abstract":"<p><p>Digital health and agri-food data systems increasingly rely on sophisticated machine learning and data-sharing infrastructures. Yet persistent challenges in scalability, accountability, and public trust indicate that technical capability alone does not resolve systemic failure. This perspective argues that these limitations primarily arise from architectural misalignment with governance rather than from algorithmic insufficiency. Through a comparative examination of federated learning, blockchain-based infrastructures, and FAIR-aligned platforms, recurring coordination bottlenecks are identified across both health and agricultural domains. Building on these observations, this perspective introduces an agentic coordination model in which task-bounded agentic components operate under explicit institutional and regulatory constraints. The model context protocol (MCP) is presented as a reference mechanism for mediating policy, provenance, and accountability across distributed agents without centralizing control. Rather than prescribing a universal solution, this work frames agentic architectures as a governance-aware design space for future digital health and food systems.</p>","PeriodicalId":36242,"journal":{"name":"Patterns","volume":"7 3","pages":"101496"},"PeriodicalIF":7.4,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PatternsPub Date : 2026-03-13DOI: 10.1016/j.patter.2026.101516
Lizhen Zhu, Chaewan Chun, Kathryn Brown, James Z Wang
{"title":"Mapping the flow of painterly gesture.","authors":"Lizhen Zhu, Chaewan Chun, Kathryn Brown, James Z Wang","doi":"10.1016/j.patter.2026.101516","DOIUrl":"https://doi.org/10.1016/j.patter.2026.101516","url":null,"abstract":"<p><p>We introduce streamline-based visualizations that manifest the detailed directional structures of painted surfaces by integrating local gradient information into continuous flow representations. Using Impressionist paintings as a primary case study, we position these visualizations as interpretive instruments that render the gestural production of artworks perceptible, comparable, and accessible to both scholars and non-specialist audiences.</p>","PeriodicalId":36242,"journal":{"name":"Patterns","volume":"7 3","pages":"101516"},"PeriodicalIF":7.4,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147782910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PatternsPub Date : 2026-03-12eCollection Date: 2026-04-10DOI: 10.1016/j.patter.2026.101495
Yuhao Zhou, Wenhao Chen, María Óskarsdóttir, Matt Davison, Cristián Bravo
{"title":"Unveiling gender disparities in corporate board career paths using deep learning.","authors":"Yuhao Zhou, Wenhao Chen, María Óskarsdóttir, Matt Davison, Cristián Bravo","doi":"10.1016/j.patter.2026.101495","DOIUrl":"10.1016/j.patter.2026.101495","url":null,"abstract":"<p><p>In this study, we investigate the relationship between professional networks and gender disparities in corporate board appointments, focusing on publicly traded Canadian companies. Using data from over 19,000 senior managers and board members in more than 700 firms from 2000 to 2022, we combine social network analysis with a causal learning framework and long short-term memory (LSTM) models to examine how networks act as both enablers and barriers to achieving gender diversity in leadership. Our findings highlight a clear glass-ceiling effect: female board members must build wider and more influential networks than men to reach similar positions of influence, even when their demographics and career paths are comparable. Gender-specific personalized PageRank further reveals the strong role of female-to-female connections in supporting women's advancement. This research contributes to a broader discussion of corporate governance and gender diversity, highlighting the need for inclusive networking and mentorship initiatives to reduce existing barriers.</p>","PeriodicalId":36242,"journal":{"name":"Patterns","volume":"7 4","pages":"101495"},"PeriodicalIF":7.4,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PatternsPub Date : 2026-03-06eCollection Date: 2026-03-13DOI: 10.1016/j.patter.2026.101512
Irving Torres
{"title":"A call to join a collective effort on AI evaluation.","authors":"Irving Torres","doi":"10.1016/j.patter.2026.101512","DOIUrl":"https://doi.org/10.1016/j.patter.2026.101512","url":null,"abstract":"<p><p>AI evaluations increasingly shape deployment, governance, and trust, but expectations for how they are conducted and reported remain fragmented. We introduce a cross-sector Delphi process to develop community-endorsed guidance for AI evaluation practice and invite researchers, practitioners, ethics organizations, and institutions to participate.</p>","PeriodicalId":36242,"journal":{"name":"Patterns","volume":"7 3","pages":"101512"},"PeriodicalIF":7.4,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PatternsPub Date : 2026-03-04eCollection Date: 2026-03-13DOI: 10.1016/j.patter.2025.101474
Chapin S Korosec, Jessica M Conway, Vitaliy A Matveev, Mario Ostrowski, Jane M Heffernan, Mohammad Sajjad Ghaemi
{"title":"Modeling of longitudinal immune profiles reveals distinct immunogenic signatures following five COVID-19 vaccinations among people living with HIV.","authors":"Chapin S Korosec, Jessica M Conway, Vitaliy A Matveev, Mario Ostrowski, Jane M Heffernan, Mohammad Sajjad Ghaemi","doi":"10.1016/j.patter.2025.101474","DOIUrl":"https://doi.org/10.1016/j.patter.2025.101474","url":null,"abstract":"<p><p>The immune response to vaccination is highly heterogeneous and arises from a dynamic interplay of immune components. Harnessing machine learning (ML) to learn immune interdependencies offers the potential not only to decode immune signatures linked to a specified comorbidity but also to reveal individualized patterns laying the groundwork for precision-guided vaccination and targeted clinical follow-up. We employ a random forest (RF) approach to classify informative differences in immunogenicity between older people living with HIV (PLWH) on antiretroviral therapy (ART) and an age-matched control group who received up to five SARS-CoV-2 vaccinations. RFs identify evidence for T helper 1 (Th1) imprinting and reveal novel distinguishing immune features, such as saliva-based antibody screening, as promising diagnostic tools (whereas serum IgG is not). Our modeling approach reveals a subset of PLWH whose immune signatures are indistinguishable from the HIV- control group, which we interpret as near-complete immune restoration from a longitudinal vaccine-elicited immunogenic perspective. To expand the utility of our findings, we generate privacy-preserving synthetic \"virtual patients\" that accurately approximate the original longitudinal immunologic data and show, via train-on-synthetic/test-on-real evaluation, that RF classifiers trained solely on virtual patients generalize to held-out real patients. Our results highlight the effectiveness in utilizing informative immune feature interdependencies for classification tasks and suggest broad impacts of ML applications for personalized vaccination strategies among high-risk populations.</p>","PeriodicalId":36242,"journal":{"name":"Patterns","volume":"7 3","pages":"101474"},"PeriodicalIF":7.4,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13100683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}