Wound HealingPub Date : 2020-06-10DOI: 10.5772/intechopen.90792
J. Escrivá-Machado, Eduardo Camacho-Quintero, A. Maciel-Miranda, Samuel Almeida-Navarro, Julia De la Luz-Hernandez
{"title":"Hypertrophic Scarring","authors":"J. Escrivá-Machado, Eduardo Camacho-Quintero, A. Maciel-Miranda, Samuel Almeida-Navarro, Julia De la Luz-Hernandez","doi":"10.5772/intechopen.90792","DOIUrl":"https://doi.org/10.5772/intechopen.90792","url":null,"abstract":"","PeriodicalId":360714,"journal":{"name":"Wound Healing","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127825199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wound HealingPub Date : 2020-06-10DOI: 10.5772/intechopen.89105
Felipe Domingos de Sousa, Francisco Rogênio da Silva Mendes, Jose Jovanny Bermudez-Sierra, Ayrles Fernanda Brandão da Silva, Mirele da Silveira Vasconcelos, Tamiris de Fátima Goebel de Souza, Marília de Oliveira Nunes, Antônio Eufrásio Vieira-Neto, Marcos Roberto Lourenzoni, Rosueti Diógenes de Oliveira-Filho, Adriana Rolim Campos, R. de Azevedo Moreira, Ana Cristina de Oliveira Monteiro-Moreira
{"title":"Plant Macromolecules as Biomaterials for Wound Healing","authors":"Felipe Domingos de Sousa, Francisco Rogênio da Silva Mendes, Jose Jovanny Bermudez-Sierra, Ayrles Fernanda Brandão da Silva, Mirele da Silveira Vasconcelos, Tamiris de Fátima Goebel de Souza, Marília de Oliveira Nunes, Antônio Eufrásio Vieira-Neto, Marcos Roberto Lourenzoni, Rosueti Diógenes de Oliveira-Filho, Adriana Rolim Campos, R. de Azevedo Moreira, Ana Cristina de Oliveira Monteiro-Moreira","doi":"10.5772/intechopen.89105","DOIUrl":"https://doi.org/10.5772/intechopen.89105","url":null,"abstract":"Natural biomolecules are increasingly relevant for biomedical applications and tissue engineering for being able to produce an effect on chemical signals, organization of cells, and restitution of extracellular matrix in lesioned tissues. In this chapter, we will address the potential of plant macromolecules, in particular, carbohydrates and proteins such as hemicelluloses and lectins. While lectins are mostly carbohydrate-binding proteins, which can interact with cell surfaces to initiate anti-inflammatory pathways, as well as immunomodulatory functions, hemicelluloses are remarkably known by their ability to form viscous solutions even at low concentrations, which makes them an excellent candidate as vehicle to carry different sorts of biomolecules. Taking into account the complexity of the whole healing process, as an overlapping and coordinated cascade of events, most of the properties presented here by those materials may be of interest to the wound-care market.","PeriodicalId":360714,"journal":{"name":"Wound Healing","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127233557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wound HealingPub Date : 2020-04-23DOI: 10.5772/intechopen.92096
P. Kaur, D. Choudhury
{"title":"Modulation of Inflammatory Dynamics by Insulin to Promote Wound Recovery of Diabetic Ulcers","authors":"P. Kaur, D. Choudhury","doi":"10.5772/intechopen.92096","DOIUrl":"https://doi.org/10.5772/intechopen.92096","url":null,"abstract":"About 5% of the world population is diabetic and are at a risk of slow nonrecoverable wound formation. Estimated 15–25% of diabetic patients develop foot ulcers, 6% among them needing clinical attention among which 15–20% will need an amputation. This counts for around 50% of all traumatic amputation. Wound leads to activation of dynamic inflammatory cascade responsible for the healing process. But in diabetes, a persistent rise of pro-inflammatory cytokines and low anti-inflammatory cytokines blocks the dynamic cascade. Wounding induces various pro-inflammatory cytokines such as IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNFs causing accumulation of free radicals leading to inflammation which become persistent in diabetes. Inhibition of proinflammatory cytokines drives the equilibrium towards the expression of anti-inflammatory cytokines such as IL4, IL-10, IL-11, IL-13, IFN-α, and TGF-β, which is necessary for the wound recovery process. Here in this chapter, the inflammatory modulatory roles of different drugs/formulations have been discussed to unravel their significance to promote wound recovery.","PeriodicalId":360714,"journal":{"name":"Wound Healing","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114790432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wound HealingPub Date : 2020-03-06DOI: 10.5772/intechopen.91034
E. Afonso, D. Borges, K. Furtado, Maria do Céu Mendes Pinto Marques, Margarida Pedro, Inês Reis, R. Morais
{"title":"Managing Patients with Pressure Ulcers","authors":"E. Afonso, D. Borges, K. Furtado, Maria do Céu Mendes Pinto Marques, Margarida Pedro, Inês Reis, R. Morais","doi":"10.5772/intechopen.91034","DOIUrl":"https://doi.org/10.5772/intechopen.91034","url":null,"abstract":"This study describes care for the person and the informal caregiver with pressure ulcers. The qualitative methodological approach was used, and case study research and the data collection techniques used were the semi-structured interview and the questionnaire. The following scales were applied to the patient: Braden Pressure Ulcer Risk Assessment, Resvesch 2.0, Malnutrition Universal Screening Nutritional Assessment. Modified Barthel and direct observation of wounds, use of the acronym Tissues, Inflammation/infection, Moisture, Edges/Epithelium. The nursing intervention at the patient’s home was positive in the evolution of the pressure ulcer healing and in the management of the caregiver’s emotions. Providing nursing home care to the injured person is a balm for patients and caregivers. It is an excel-lent response to aging and consequent complications, for example, wounds. They promote gains in health and in the management of human and economic resources.","PeriodicalId":360714,"journal":{"name":"Wound Healing","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115542081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wound HealingPub Date : 2019-10-10DOI: 10.5772/intechopen.88658
Chitang J Joshi, Ji-Cheng Hsieh, Abbas M. Hassan, R. Galiano
{"title":"Application of Negative Pressure Wound Therapy on Closed Incisions","authors":"Chitang J Joshi, Ji-Cheng Hsieh, Abbas M. Hassan, R. Galiano","doi":"10.5772/intechopen.88658","DOIUrl":"https://doi.org/10.5772/intechopen.88658","url":null,"abstract":"Negative pressure wound therapy (NPWT) is widely used for chronic and acute open wounds, with clinically proven benefits of faster wound healing by promoting granulation tissue growth and increased perfusion and facilitating epithelialization and contraction. Improved outcomes on open wounds prompted the application of NPWT on closed surgical incisions. The application of NPWT, in the immediate postoperative period, reduces surgical site infections (SSIs) and wound dehiscence by 50% in high-risk patients. The negative pressure reduces wound edema and improves local perfusion and lymphatic f low, thereby minimizing hematoma and seroma rates. The improved perfusion and oxygenation facilitate quicker wound healing as well as minimize ischemic complications like f lap necrosis. Recent literature supports enhanced wound healing and superior scar appearance as well as improved wound maturity, evidenced by 50% more force required to pull apart a sutured incision. Improved outcomes of incisional NPWT are reported from various surgical procedures on abdominal, breast, orthopedic, vascular, cardiac, and plastic surgeries. Further clinical studies and cost-benefit analysis are needed to recommend routine postoperative use of incisional NPWT in high-risk and low-risk patient population.","PeriodicalId":360714,"journal":{"name":"Wound Healing","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130220249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wound HealingPub Date : 2019-08-20DOI: 10.5772/INTECHOPEN.88363
L. Antipova, S. A. Storublevtsev, S. Titov, S. Antipov, M. G. Khatkhokhu, M. S. Bolokov, V. Loboda
{"title":"A Study of the Use of Modified Collagen of Freshwater Fish as a Material for Personal Care Products","authors":"L. Antipova, S. A. Storublevtsev, S. Titov, S. Antipov, M. G. Khatkhokhu, M. S. Bolokov, V. Loboda","doi":"10.5772/INTECHOPEN.88363","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.88363","url":null,"abstract":"The work is devoted to the use of collagen materials produced on the basis of connective tissues of hydrobionts. Their characteristics as potential means of personal hygiene and wound healing are investigated. The results of studies of physical and chemical characteristics of collagen materials from freshwater fish with a modified structure obtained in this paper indicate the prospects of their use as an absorbent layer of personal hygiene products, due to the high moisture absorp-tion capacity, which is an order of magnitude higher than the moisture capacity of untreated collagen and higher moisture capacity of superadsorbing polymers required for use in personal hygiene products. The resulting material meets the requirements of sanitary and epidemiological safety, allergenic action on the skin, as can be concluded from the results of tests on animals, it does not. This material accelerates reparative processes to the same extent as collagen used in standard hemostatic sponges with the simplicity of its production technology, low cost, and availability of raw materials.","PeriodicalId":360714,"journal":{"name":"Wound Healing","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124926824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wound HealingPub Date : 2018-11-05DOI: 10.5772/INTECHOPEN.80875
J. Cherng
{"title":"Calcium Alginate Polysaccharide Dressing as an Accelerated Treatment for Burn Wound Healing","authors":"J. Cherng","doi":"10.5772/INTECHOPEN.80875","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80875","url":null,"abstract":"Patients with burn injuries suffer from pain and an inflammatory response; however, treatment methods are still not satisfactory and remain challenging. Due to the long stage of burn wound rehabilitation, which contributes to the long-term sensory problems, an effective treatment must begin at the outset of burn wound care. The functionalized wound dressing is expected to be a great treatment strategy over the commercialization wound dressing products and engineered skin substi-tutes nowadays. Some studies revealed the use of calcium alginate polysaccharide (CAPS) as an “ active ” dressing due to its calcium richness for wound healing and scar tissue formation. The outstanding outcome of CAPS dressing for severe burn injuries was indicated by natural wound healing and less scarring formation, minimum bacterial infection, cytokine enhancement regulation, and appropriate inflammatory response and pain regulation. These advantages affirmed the phyto-polysaccharide dressing as the next generation of wound dressing materials with highly desirable properties.","PeriodicalId":360714,"journal":{"name":"Wound Healing","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126958327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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