Modulation of Inflammatory Dynamics by Insulin to Promote Wound Recovery of Diabetic Ulcers

P. Kaur, D. Choudhury
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引用次数: 2

Abstract

About 5% of the world population is diabetic and are at a risk of slow nonrecoverable wound formation. Estimated 15–25% of diabetic patients develop foot ulcers, 6% among them needing clinical attention among which 15–20% will need an amputation. This counts for around 50% of all traumatic amputation. Wound leads to activation of dynamic inflammatory cascade responsible for the healing process. But in diabetes, a persistent rise of pro-inflammatory cytokines and low anti-inflammatory cytokines blocks the dynamic cascade. Wounding induces various pro-inflammatory cytokines such as IL-1, IL-6, IL-12, IL-18, IFN-γ, and TNFs causing accumulation of free radicals leading to inflammation which become persistent in diabetes. Inhibition of proinflammatory cytokines drives the equilibrium towards the expression of anti-inflammatory cytokines such as IL4, IL-10, IL-11, IL-13, IFN-α, and TGF-β, which is necessary for the wound recovery process. Here in this chapter, the inflammatory modulatory roles of different drugs/formulations have been discussed to unravel their significance to promote wound recovery.
胰岛素调节炎症动力学促进糖尿病溃疡创面恢复
世界上约有5%的人口患有糖尿病,并面临缓慢的不可恢复的伤口形成的风险。估计15-25%的糖尿病患者会出现足部溃疡,其中6%需要临床治疗,其中15-20%需要截肢。这占所有创伤性截肢的50%左右。伤口导致负责愈合过程的动态炎症级联反应的激活。但在糖尿病中,促炎细胞因子的持续上升和抗炎细胞因子的低水平阻碍了这种动态级联反应。损伤诱导各种促炎细胞因子,如IL-1、IL-6、IL-12、IL-18、IFN-γ和tnf,引起自由基积累,导致糖尿病患者持续炎症。促炎细胞因子的抑制使抗炎细胞因子如il - 4、IL-10、IL-11、IL-13、IFN-α和TGF-β的表达趋于平衡,这是伤口恢复过程所必需的。在本章中,我们讨论了不同药物/配方的炎症调节作用,以揭示它们对促进伤口恢复的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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