Medical Journal of Dr. D.Y. Patil University最新文献_第5页

Phenytoin-induced changes in the bone mineral metabolism in young males 苯妥英引起的年轻男性骨矿物质代谢的变化

Medical Journal of Dr. D.Y. Patil University Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_56_17

S. Rohatgi, A. Ahluwalia

{"title":"Phenytoin-induced changes in the bone mineral metabolism in young males","authors":"S. Rohatgi, A. Ahluwalia","doi":"10.4103/MJDRDYPU.MJDRDYPU_56_17","DOIUrl":"https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_56_17","url":null,"abstract":"Background: Antiepileptic drugs (AEDs) have an adverse effect on the bone mineral metabolism. Patients and Methods: The objective of the study was to determine the bone loss and change in bone mineral parameters in patients treated with phenytoin sodium. We prospectively studied 36 young males aged 20–30 years, with new-onset epilepsy, and treated with phenytoin. Patients were clinically examined and subjected to determination of the bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) at the femur neck, spine, and lower third of radius. We also assessed Vitamin 25-OH-Vitamin D3, parathyroid hormone (PTH), and osteocalcin at the onset and after 1 year of treatment. Results: There were no significant changes noted in the 25-OH-Vitamin D3, (20.7 ± 10 ng/dl before and 18.5 ± 7.3 ng/dl after therapy, P = 0.198), and serum parathyroid levels (8.8 ± 6.8 pg/ml before and 14.2 ± 11.5 pg/ml, P = 0.114) at the end of 1-year therapy. There was declines in BMD at all the three sites; the spine (0.943 ± 0.11 vs. 0.943 ± 0.12 g/cm2, P = 0.15), femur neck (0.912 ± 0.0.12 vs. 0.896 ± 0.124 g/cm2, P = 0.093), and a statistically significant decline lower third of radius (0.659 ± 0.07 vs. 0.644 ± 0.073 g/cm2, P ≤ 0.001). We did not find any significant change in levels of 25-OH-Vitamin D3, PTH, and serum alkaline phosphatase, but found significant elevation in levels of osteocalcin. Conclusions: Phenytoin therapy in young male patients for 1-year causes a bone loss at femur and spine in the absence of Vitamin D deficiency and significant bone loss in the cortical bone radius. DXA should be done in patients during the treatment with AEDs to identify patients who are susceptible to increased risk of fractures.","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"412"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48518440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aggressive angiomyxoma of scrotum in a young male: A rare entity 年轻男性阴囊侵袭性血管粘液瘤:罕见病例

Medical Journal of Dr. D.Y. Patil University Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_297_16

K. Tadepalli, Vijaya Gattu

引用次数: 0

Gastrointestinal stromal tumor of the anal canal: An unusual presentation 肛管胃肠道间质瘤：一种不寻常的表现

Medical Journal of Dr. D.Y. Patil University Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_293_16

C. Das, M. Mukhopadhyay, M. Kumari, Bikram Halder

引用次数: 1

Chloroma in a child with T-cell acute lymphoblastic leukemia 儿童T细胞急性淋巴细胞白血病的绿瘤

Medical Journal of Dr. D.Y. Patil University Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_7_17

A. Mandal, Amitabh Singh, Vijay Gnanaguru, R. Seth

引用次数: 0

Giant brenner tumor of ovary 卵巢巨大布伦纳瘤

Medical Journal of Dr. D.Y. Patil University Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_261_16

Rupali R. Bavikar, S. Bamanikar, H. Kumar, M. Jha, Y. Ingale

引用次数: 0

Unilateral multicystic dysplastic kidney with ipsilateral grade V vesicoureteral reflux: A case report of a rare association 单侧多囊发育不良肾伴同侧V级膀胱输尿管反流1例

Medical Journal of Dr. D.Y. Patil University Pub Date : 2017-09-01 DOI: 10.4103/0975-2870.218185

S. Agarwal, B. Badhe, P. Pandey, M. Ralli

引用次数: 1

Measles outbreak in adults: A changing epidemiological pattern 成人麻疹暴发:不断变化的流行病学模式

Medical Journal of Dr. D.Y. Patil University Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_43_17

S. Bajaj, Pranjal Bobdey, Neha Singh

{"title":"Measles outbreak in adults: A changing epidemiological pattern","authors":"S. Bajaj, Pranjal Bobdey, Neha Singh","doi":"10.4103/MJDRDYPU.MJDRDYPU_43_17","DOIUrl":"https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_43_17","url":null,"abstract":"Background: Thirty-one cases of fever with rash were reported among students of a college in Pune, India, from March to May 2014. The clinical profile was similar to that of measles and 7 of them tested positive for measles-specific immunoglobulin M (IgM). An outbreak of measles was declared, and epidemiological investigation was carried out to assess the situation and suggest preventive measures. Methods: An epidemiological case sheet filled for each case to identify the source and likely contacts. Medical and administrative authorities were sensitized about the increase in incidence and clustering of cases. A surveillance system was set up for detection of new cases and follow-up of contacts. Throat swabs and blood samples from 12 cases were tested by ELISA method for commonly occurring viral exanthematous fevers to confirm the diagnosis and 7 were positive for measles-specific IgM antibody. Preventive measures were advised to control the outbreak. Results: A total of 31 cases of fever with rashes were reported among students of a college in Pune, India, during the months of March–May 2014. Most of the students were in the age group of 18–24 years. Samples from 12 cases were sent for testing and 7 tested positive for measles-specific IgM antibodies. Seven cases were epidemiologically linked to a lab-confirmed case. All cases had fever, maculopapular rash, and sore throat and gave a history of vaccination for measles in childhood. Conclusion: An epidemiological investigation was carried out for outbreak of measles in a young adult population of college students from Pune. It is reported that, with increase in overall coverage of vaccination, there is a rise in incidence of measles in vaccinated individuals. The age profile also shifts to higher age groups. Investigation of such outbreaks provides an opportunity to identify high-risk groups, changes in measles epidemiology and weaknesses in the routine immunization programs.","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"447"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45439677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Nanotechnology for health: A new useful technology in medicine 纳米技术促进健康:医学上一项有用的新技术

Medical Journal of Dr. D.Y. Patil University Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_32_17

B. Joob, V. Wiwanitkit

引用次数: 12

Quantification of vulnerability to Type 2 diabetes: A study among shopkeepers in Kolkata 2型糖尿病易感性的量化:加尔各答店主的研究

Medical Journal of Dr. D.Y. Patil University Pub Date : 2017-09-01 DOI: 10.4103/MJDRDYPU.MJDRDYPU_63_17

A. Dasgupta, B. Biswas, B. Paul, L. Bandyopadhyay, Ayon Ghosh, Sembagamuthu Sembiah

{"title":"Quantification of vulnerability to Type 2 diabetes: A study among shopkeepers in Kolkata","authors":"A. Dasgupta, B. Biswas, B. Paul, L. Bandyopadhyay, Ayon Ghosh, Sembagamuthu Sembiah","doi":"10.4103/MJDRDYPU.MJDRDYPU_63_17","DOIUrl":"https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_63_17","url":null,"abstract":"Context: Urban people are more prone to develop diabetes due to their sedentary lifestyle and high-calorie food intake. Shopkeepers with their long sitting hours, unhealthy food habits, and lack of regular physical activity are one of the high-risk groups for developing diabetes. Hence, it is necessary to detect this large pool of undiagnosed people with diabetes to offer them early treatment. Aims: The present study aimed at assessing people with a high risk of developing type 2 diabetes and its correlation with some known risk factors. Materials and Methods: The study was a cross-sectional community-based study conducted from May to July among 152 shopkeepers in a permanent market with a structured schedule. Statistical Analysis Used: Data were analyzed using appropriate statistical methods by SPSS software (version 16). Results: Thirty-five (23.02%) out of 152 shopkeepers were found having high blood sugar (>140 mg/dl). In univariate analysis, the study participants with higher age, perceived stress score, Indian Diabetic Risk Score (IDRS), body weight, centrally obese, and less physically active had shown significantly greater odds of having high blood sugar level. In multivariable model, PSS (adjusted odds ratio [AOR]-1.90), waist circumference (AOR-3.34), and physical activity (AOR-3.09) remained significantly adjusted with other significant variables in univariate analysis excepting IDRS. Sensitivity and specificity of IDRS were 68.6% and 65.8%, respectively, with diagnostic accuracy of 72.3% calculated using receiver operating characteristic curve. Conclusions: The study revealed that shopkeepers are indeed at high risk of developing diabetes. There is an urgent need for increasing awareness regarding diabetes among them.","PeriodicalId":36033,"journal":{"name":"Medical Journal of Dr. D.Y. Patil University","volume":"10 1","pages":"417"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42204042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Uterine intramural lipoma: A benign but rare entity 子宫壁内脂肪瘤:一种少见的良性肿瘤

Medical Journal of Dr. D.Y. Patil University Pub Date : 2017-07-01 DOI: 10.4103/0975-2870.213931

V. Pathak, Deepti Sukheeja, Rakesh K. Singh

引用次数: 5