Clinical and Experimental Pediatrics最新文献

{"title":"Value of demographic factors in early identification of pediatric malignant vasovagal syncope in head-up tilt test.","authors":"Shuo Wang, Yuwen Wang, Hong Cai, Ping Liu, Fang Li, Chuan Wen, Liqun Liu, Runmei Zou, Cheng Wang","doi":"10.3345/cep.2025.02397","DOIUrl":"10.3345/cep.2025.02397","url":null,"abstract":"<p><strong>Background: </strong>Malignant vasovagal syncope (VVS) is characterized by cardiac arrest lasting more than 3 seconds during a syncope episode or head-up tilt test (HUTT). We aim to conduct a risk assessment for potential malignant VVS before the HUTT by using economic, simple and convenient demographic data, in order to prevent adverse outcomes for pediatric VVS.</p><p><strong>Purpose: </strong>To explore the correlation between demographic factors and pediatric malignant VVS, and verify the value of these factors in early risk assessment for malignant VVS before HUTT, so as to optimize test safety and reduce adverse events.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of the clinical data of 3,734 children who were initially diagnosed with VVS due to unexplained syncope and presyncope. Finally, 122 children who met the diagnostic criteria for malignant VVS were included in the malignant VVS group, and 661 children who did not meet the criteria during the same period were matched as the control group. By analyzing demographic data and other factors, we attempted to clarify the association between these factors and malignant VVS.</p><p><strong>Results: </strong>Linear relationship: age and body mass index (BMI) have independent protective effects on malignant VVS. For every 1-year increase in age and every 1 kg/m2 increase in BMI, the risk of malignant VVS decreases by 12% and 9%, respectively. Nonlinear relationship: When the age is <12.9 years old, for every additional year of age, the risk of malignant VVS decreases by 20%. For ages 12.9 years and above, the efficacy is not significant. There is no significant nonlinear relationship between BMI and malignant VVS.</p><p><strong>Conclusion: </strong>Age and BMI are independent protective factors for pediatric malignant VVS. Before the age of 12.9 years, the incidence of malignant VVS gradually decreases with the increase in age, and thereafter there is no significant impact.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"353-361"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply: a commentary on \"Assessing kidney outcomes in childhood-onset lupus nephritis: role of National Institutes of Health-modified histological indices\".","authors":"Pornpimol Rianthavorn","doi":"10.3345/cep.2026.00192","DOIUrl":"10.3345/cep.2026.00192","url":null,"abstract":"","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"364-365"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving toward meaningful shared decision-making in neonatal care: clinical practice and policy implications in Korea.","authors":"In Gyu Song, Trisha M Prentice, Lynn Gillam","doi":"10.3345/cep.2025.02929","DOIUrl":"10.3345/cep.2025.02929","url":null,"abstract":"<p><p>Shared decision-making (SDM), which has become a core principle of patient-clinician communication, emphasizes respect for autonomy, partnership, and transparency. In neonatal practice-where decisions often carry profound ethical and emotional weight-SDM helps align medical recommendations with the family's values, fosters trust, and may reduce moral distress for both parents and clinicians. However, in Korea, the systematic recognition and formalization of SDM remains limited, underscoring the need for practical guidance and institutional support in neonatal and pediatric care. This review discusses key principles of SDM and illustrates their application in real clinical communication through hypothetical neonatal case vignettes. SDM is best understood not as a single model but as a continuum shaped by the balance between medical judgment and parental values. Drawing on Opel's stepwise framework, SDM is most appropriate when more than one medically reasonable option exists and value considerations meaningfully influence the choice. Physicians must also remain aware of personal biases that can shape how options are framed and discussed. Building on this conceptual foundation, this paper describes how meaningful SDM can be practiced using the 4 conversational phases outlined by Madrigal and Kelly: (1) acknowledging the need for a decision and inviting participation; (2) sharing information while listening; (3) uncovering values, hopes, and fears; and (4) reaching a balanced and ethically grounded decision. Through clinical examples, these phases demonstrate how empathy, pacing, and reflective dialogue can transform information exchange into shared moral reasoning. Finally, structural and cultural barriers continue to hinder the implementation of SDM in Korea, including time constraints, limited training, and restrictive legal frameworks. Policy reform, education, and team-based strategies are essential to support its broader adoption. SDM ultimately offers an ethically robust and relational framework for navigating complex, value-laden decisions in neonatal and pediatric care that is grounded in communication that recognizes bias and engages families as true partners.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"282-292"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147445155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal risk factors for hemodynamically significant patent ductus arteriosus in very low birth weight infants.","authors":"Jie Hee Jue, So Young Shin, Jae Hyun Park, Chun Soo Kim, Hee Joung Choi","doi":"10.3345/cep.2025.01893","DOIUrl":"10.3345/cep.2025.01893","url":null,"abstract":"<p><strong>Background: </strong>Multiple perinatal factors influence hemodynamically significant patent ductus arteriosus (HS PDA) in preterm infants.</p><p><strong>Purpose: </strong>This study aimed to identify the risk factors associated with HS PDA in very low birth weight infants (VLBWIs) and determine the predictors of surgical ligation.</p><p><strong>Methods: </strong>This retrospective study included VLBWIs born at 23-32 weeks' gestation whose HS PDA properties could be identified using echocardiography. The infants were stratified into 2 groups based on gestational age (23-27 and 28-32 weeks).</p><p><strong>Results: </strong>Among the 496 included VLBWIs, 171 had no PDA, 90 had non-HS PDA, and 235 had HS PDA. In infants born at 23-27 weeks' gestation, risk factors for HS PDA included low birth weight, the absence of histological chorioamnionitis, and premature rupture of membranes. For VLBWIs born at 28-32 weeks' gestation, HS PDA was associated with lower birth weight, frequent surfactant treatment, and maternal hypertension. Within the HS PDA group, infants with a lower birth weight or who received incomplete antenatal steroid administration had an increased likelihood of requiring surgical ligation, whereas those with a small-for-gestational-age status had a decreased need for surgical ligation.</p><p><strong>Conclusion: </strong>Recognizing these risk factors can aid the development of targeted treatment strategies for HS PDA in VLBWIs, enabling early ligation and potentially reducing the need for surgical management.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"313-321"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of atrial septal defect on mitral valve growth after repair of coarctation of the aorta or an interrupted aortic arch in infants.","authors":"Yi-Chia Wang, Heng-Wen Chou, Chi-Hsiang Huang, Hsing-Hao Huang, Yih-Sharng Chen, En-Ting Wu, Shyh-Jye Chen, Ming-Tai Lin, Shuenn-Nan Chiu, Shu-Chien Huang","doi":"10.3345/cep.2025.02110","DOIUrl":"10.3345/cep.2025.02110","url":null,"abstract":"<p><strong>Background: </strong>Patients with coarctation of the aorta (CoA) and an interrupted aortic arch (IAA) may present with small mitral valves (MVs) and a reduced left ventricular (LV) volume. Biventricular repair (BVR) in these patients is dependent on adequate size of the left cardiac structures.</p><p><strong>Purpose: </strong>This study evaluated the impact of the hemodynamic characteristics of atrial septal defects (ASDs) on MV growth following surgical repair.</p><p><strong>Methods: </strong>We retrospectively reviewed the data of patients diagnosed with CoA or IAA between 2007 and 2024. The z score for MV size measured 6 months postoperatively (Z2) was compared with the preoperative MV size (Z1). The factors associated with MV growth were also studied.</p><p><strong>Results: </strong>A total of 161 patients with CoA or IAA were included. Transthoracic echocardiography was used to assess the MV and LV dimensions preoperatively and 6 months postoperatively. Of the cohort, 155 (96.3%) underwent initial BVR and 6 underwent single-ventricle palliation. MV z scores significantly increased following BVR (mean change: +0.45±1.35; P<0.001) but decreased after single-ventricle repair (-0.56±0.49, P=0.04). Multivariate analysis identified the initial MV z score and ASD pressure gradient as independent predictors of MV growth (R2=0.39).</p><p><strong>Conclusion: </strong>Annular growth of the MV was not observed in patients who underwent single-ventricle palliation. In contrast, among patients who achieved BVR, those with a small preoperative MV annulus and low ASD pressure gradient demonstrated subsequent catch-up MV growth, suggesting that adequate left-sided preload is essential for MV development.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"322-329"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged cerebral oxygenation surveillance with algorithm-based management: a neurocritical care bundle for extremely preterm infants.","authors":"Kai-Hsiang Hsu, Wei-Hung Wu, Shu-Yu Lin, Chih-Chen Chang, Mei-Yin Lai, I-Hsyuan Wu, Shih-Ming Chu, Ming-Chou Chiang, Reyin Lien","doi":"10.3345/cep.2025.02117","DOIUrl":"10.3345/cep.2025.02117","url":null,"abstract":"<p><strong>Background: </strong>Cerebral hypoxia-ischemia impairs brain development in extremely preterm infants and is associated with poor neurological outcomes. Near-infrared spectroscopy (NIRS) is a noninvasive continuous monitoring method for regional cerebral oxygen saturation (rcSO2).</p><p><strong>Purpose: </strong>This study evaluated the clinical feasibility and neurological impact of a neurocritical care bundle that incorporates prolonged multidisciplinary hemodynamic monitoring and a stepwise management algorithm.</p><p><strong>Methods: </strong>Preterm infants with a gestational age (GA) ≤28 weeks or birth weight (BW) ≤1,000 g were prospectively enrolled in a bundle group subjected to NIRS for rcSO2, electrical cardiometry for cardiac output, and daily brain and cardiac echography during the first 72 hours of life. Monitoring was repeated weekly in the first month and then monthly until discharge or the term-equivalent age (TEA) was reached. We implemented a stepwise management algorithm for treating cerebral hypoxia. The primary outcome was a composite of mortality and adverse neurological events (structural abnormalities or electroencephalogram-confirmed seizures) before discharge. The secondary outcomes were the physiological pattern of rcSO2 within the initial 72 hours and up to discharge or TEA.</p><p><strong>Results: </strong>Thirty preterm infants (GA, 27.1±2.0 weeks; BW, 830±225 g) were enrolled in the bundle group. The mean time-averaged rcSO2 (66.8%±10.3%) was not associated with GA or BW. However, postnatal age appeared to influence physiological rcSO2 changes, given that rcSO2 values were higher during the initial 72 hours than at subsequent intervals. Seven infants (23.3%) had poor outcomes and significantly lower time-averaged rcSO2 (51.1% [50.0%-65.2%] vs. 71.8% [67.1%-73.1%], P=0.002). Multivariate regression indicated that a lower rcSO2 was an independent risk factor, and a 65% threshold showed an optimal predictive value for poor outcomes.</p><p><strong>Conclusion: </strong>The neurocritical care bundle helped identify preterm infants at risk of cerebral hypoxia, and lower rcSO2 was an independent risk factor for composite mortality and adverse neurological outcomes.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"304-312"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granulocyte transfusion improves survival in pediatric febrile neutropenia: a 15-year cohort study.","authors":"Witsanu Phetsai, Kleebsabai Sanpakit, Jassada Buaboonnam, Kamon Phuakpet, Nassawee Vathana, Nattee Narkbunnam, Fon Kladed, Chayamon Takpradit","doi":"10.3345/cep.2025.01186","DOIUrl":"10.3345/cep.2025.01186","url":null,"abstract":"<p><strong>Background: </strong>Febrile neutropenia (FN) remains a leading cause of morbidity and mortality in pediatric patients with high-risk hematologic disorders, particularly in low- and middle-income countries (LMICs), where antimicrobial resistance limits treatment options. Granulocyte transfusion (GT) is considered an adjunctive therapy; however, pediatric data from LMICs are limited.</p><p><strong>Purpose: </strong>This study evaluates the effectiveness, timing, and safety of GT in a real-world LMIC setting.</p><p><strong>Methods: </strong>This 15-year retrospective cohort study included pediatric patients (≤18 years) with severe neutropenic infections treated at a national tertiary referral center in Thailand in 2009-2023. The patients received GT plus antimicrobial therapy or antimicrobial therapy alone. The primary outcome measure was 30-day survival. The analyses included multivariate logistic regression, Cox regression, propensity score matching (PSM), and inverse probability of treatment weighting (IPTW).</p><p><strong>Results: </strong>Among the 54 patients (26 GT recipients; 28 controls), GT was associated with improved 30-day survival in the full cohort (odds ratio [OR], 0.105; 95% confidence interval [CI], 0.016-0.700; P=0.020). IPTW confirmed this association (OR, 0.099; P=0.001), with consistent results in the PSM analysis (OR, 0.157; P=0.028). In the high-risk hematologic condition subgroup (n=48), GT was associated with increased survival (95.2% vs. 61.9%; hazard ratio [HR], 0.105; P=0.034). GT also accelerated the resolution of fever (HR, 2.24; P=0.028), FN recovery (HR, 2.35; P=0.017), and absolute neutrophil count recovery (HR, 2.10; P=0.047). No serious transfusion-related adverse events were observed.</p><p><strong>Conclusion: </strong>GT was associated with improved survival and faster clinical recovery in pediatric patients with FN. These real-world LMIC data support its use as a feasible adjunctive therapy and warrant prospective validation.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"236-246"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a new Japanese classification for predicting severe bronchopulmonary dysplasia in preterm infants.","authors":"Masato Ito, Shinya Hirano, Fumihiko Namba","doi":"10.3345/cep.2025.02642","DOIUrl":"10.3345/cep.2025.02642","url":null,"abstract":"<p><strong>Background: </strong>Bronchopulmonary dysplasia (BPD) is the most prevalent chronic lung disease in very preterm infants; however, conventional classifications have limited ability to predict severity before 36 weeks' postmenstrual age (PMA). A new Japanese classification, based on small for gestational age (SGA), bubbly/cystic chest radiographic findings, and chorioamnionitis (CAM), was proposed to enable earlier risk stratification. However, its validation in homogeneous cohorts is warranted.</p><p><strong>Purpose: </strong>This study aimed to examine the association between this new Japanese classification and severe BPD development at 36 weeks' PMA in a secondary analysis of a randomized controlled trial (RCT).</p><p><strong>Methods: </strong>A retrospective secondary analysis of a multicenter, double-blind RCT of inhaled corticosteroids in 12 tertiary neonatal intensive care units in Japan (2006-2009) was performed. Infants with a birth weight (BW)<1,000 g and requiring mechanical ventilation were enrolled. Of those 211 infants, 194 survivors were analyzed. Severe BPD was defined by National Institute of Child Health and Human Development criteria as requiring supplemental oxygen (fraction of inspired O2 >0.30) or positive pressure ventilation at 36 weeks' PMA. Logistic regression analyses were adjusted for gestational age, BW, sex, Apgar score, maternal steroid use, respiratory distress syndrome, and patent ductus arteriosus.</p><p><strong>Results: </strong>Among the 194 infants, 25 were SGA, 45 had bubbly/cystic findings, and 86 had CAM. Severe BPD occurred in 80 infants. A multivariate analysis identified SGA (adjusted odds ratio [aOR], 3.32; 95% confidence interval [CI], 1.16-9.48; P=0.032) and bubbly/cystic findings (aOR, 10.88; 95% CI, 4.43-26.72; P<0.01) as independent risk factors. Compared with type II (non-CAM, no bubbly/cystic findings), type I (bubbly/cystic only: aOR, 6.21; 95% CI, 1.93-14.36) and type III (CAM plus bubbly/cystic: aOR, 15.32; 95% CI, 2.48-46.32) were significantly associated with severe BPD.</p><p><strong>Conclusion: </strong>The new Japanese classification demonstrated that SGA and bubbly/cystic findings at day 28 independently predicted severe BPD. Early stratification using this classification may facilitate the early identification of high-risk infants for targeted interventions.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"274-281"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombocytopenia in preterm infants born to mothers with systemic lupus erythematosus: a retrospective cohort study.","authors":"Ru Xue, Guoqing Zhang, Xiafang Chen, Jun Bu, Lanlan Mi, Fei Bei","doi":"10.3345/cep.2025.01942","DOIUrl":"10.3345/cep.2025.01942","url":null,"abstract":"<p><strong>Background: </strong>Thrombocytopenia in preterm infants born to mothers with systemic lupus erythematosus (SLE) is poorly characterized, despite its potential link to adverse outcomes. Our understanding of platelet dynamics, risk factors, and clinical outcomes in this population is limited, necessitating further investigation.</p><p><strong>Purpose: </strong>This study aimed to characterize the incidence, timing, and severity of thrombocytopenia in this population; to identify associated maternal and neonatal risk factors; and to evaluate its association with adverse outcomes.</p><p><strong>Methods: </strong>We included 154 preterm infants born to mothers with SLE who were admitted to Shanghai Children's Medical Center within 24 hours of birth between 2014 and 2024. Logistic regression was used to identify risk factors and outcomes associated with neonatal thrombocytopenia.</p><p><strong>Results: </strong>Thrombocytopenia (platelet count < 150 ×109/L) occurred in 32.5% of infants, and severe form (< 50 ×109/L) occurred in 4.6%. The condition peaked on postnatal days 4-5, and 16% of affected infants required intervention. Late preterm infants (adjusted odds ratio [aOR], 0.15; 95% confidence interval [CI], 0.05-0.42), moderate preterm infants (aOR, 0.26; 95% CI, 0.09-0.76), and maternal hydroxychloroquine use (aOR, 0.19; 95% CI, 0.07-0.52) were protective factors. In contrast, maternal hypertensive disorders of pregnancy (HDP; aOR, 3.41; 95% CI, 1.06-10.93) increased the risk. Infants with thrombocytopenia had significantly higher risks of intracranial hemorrhage (aOR, 4.27; 95% CI, 1.65-11.00) and late-onset sepsis (aOR, 11.00; 95% CI, 1.23-98.14).</p><p><strong>Conclusion: </strong>Preterm infants exposed to maternal SLE frequently developed thrombocytopenia, but most cases were self-limited. Key risk modulators included gestational age, maternal HDP, and hydroxychloroquine use. Furthermore, thrombocytopenia was significantly associated with neonatal morbidity.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"266-273"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can a basophil activation test of cord blood predict a cow's milk allergy?","authors":"Dilara Fatma Kocacik Uygun, Durmuş Burgucu, Vedat Uygun, Gül Alkan Bulbul, Fulden Duyar, Cem Yasar Sahnal, Aysen Bingöl","doi":"10.3345/cep.2025.01697","DOIUrl":"10.3345/cep.2025.01697","url":null,"abstract":"<p><strong>Background: </strong>Food allergies affect 4%-6% of the pediatric population and are often present within the first 2 years of life. Cord blood cells and cytokines in high-risk infants can predict allergic problems; however, their predictive value remains unclear.</p><p><strong>Purpose: </strong>This study aimed to determine whether a cow's milk allergy in infants can be predicted using a basophil activation test (BAT) of cord blood samples by stimulating basophils with milk protein antigens (cow's milk and casein).</p><p><strong>Methods: </strong>We collected cord blood during the birth of 30 mother-child pairs and immediately analyzed BAT stimulated with milk protein antigens. One year later, we compared the results of those infants who developed an allergy to those who did not.</p><p><strong>Results: </strong>We found that infants with a casein-BAT value ≥2.6 were 33.2 times more likely than those with a casein- BAT value <2.6 to develop food allergy symptoms within the first year of life (P=0.03).</p><p><strong>Conclusion: </strong>High casein-BAT values in cord blood may predict the development of food allergies during the first year of life. Although no association with cow's milk sensitivity has been found, casein sensitivity may indicate food allergy risk. However, further studies are required to confirm this association.</p>","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"257-265"},"PeriodicalIF":3.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12963943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}