Clinical and Experimental Pediatrics最新文献_第8页

Impact of COVID-19 pandemic on clinical features of benign convulsions with mild gastroenteritis. COVID-19 大流行对伴有轻微肠胃炎的良性惊厥临床特征的影响。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-09-01 Epub Date: 2024-03-25 DOI: 10.3345/cep.2024.00108

Jon Soo Kim

引用次数: 0

Comparison and review of international guidelines for treating asthma in children. 国际儿童哮喘治疗指南的比较与回顾。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-09-01 Epub Date: 2024-08-20 DOI: 10.3345/cep.2022.01466

Eui Jeong Roh

{"title":"Comparison and review of international guidelines for treating asthma in children.","authors":"Eui Jeong Roh","doi":"10.3345/cep.2022.01466","DOIUrl":"10.3345/cep.2022.01466","url":null,"abstract":"Asthma, the most common chronic disease, is characterized by airway inﬂammation and airﬂow obstruction. The World Health Organization estimates that approximately 300 million people worldwide have asthma, 30% of whom are pediatric patients. Asthma is a major cause of morbidity that can lead to hospitalization or death in severe pediatric cases. Therefore, it is necessary to provide children with objective and reliable treatment according to consistent guidelines. Several institutes, such as the Global Institute for Asthma, National Heart, Lung, and Blood Institute, British Thoracic Society, Japanese Society of Pediatric Allergy and Clinical Immunology, and Korean Academy of Asthma, Allergy, and Clinical Immunology have published and revised asthma guidelines. However, since recommendations diﬀer among them, confusion persists regarding drug therapy for pediatric asthma patients. Additionally, some guidelines have changed significantly in recent years. This review investigated the latest changes in each guideline, compared and analyzed the recommendations, and identified the international trends in pediatric asthma drug therapy. The findings of this review may aid determinations of the future direction of the Korean guidelines for childhood asthma.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":"67 9","pages":"447-455"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive evaluation of the child with global developmental delays or intellectual disability. 对有全面发育迟缓或智力障碍的儿童进行全面评估。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-09-01 Epub Date: 2024-05-29 DOI: 10.3345/cep.2023.01697

Abdullah Nasser Aldosari, T Saeed Aldosari

{"title":"Comprehensive evaluation of the child with global developmental delays or intellectual disability.","authors":"Abdullah Nasser Aldosari, T Saeed Aldosari","doi":"10.3345/cep.2023.01697","DOIUrl":"10.3345/cep.2023.01697","url":null,"abstract":"Global developmental delay (GDD) and intellectual disability (ID) are relatively common neurodevelopmental disorders that significantly impact affected children, their families, and society. The etiology of GDD/ID is notably diverse, encompassing both genetic and acquired factors. Although the precise cause of most GDD/ID cases remains unclear, an estimated half of all cases can be attributed to genetic factors. Thus, a detailed medical history and comprehensive physical examination remain pivotal for guiding diagnostic investigations into the underlying causes of GDD/ID. Advancements in genetic testing have supplanted traditional methods such as karyotyping and fluorescence in situ hybridization with chromosomal micro arrays, which are now the primary genetic tests for children with idiopathic GDD/ID. Moreover, the evaluation of Fragile X and Rett syndrome should be an integral component of initial diagnostic assessments. In recent years, whole-exome sequencing and whole-genome sequ-encing have emerged as important diagnostic tools for evaluating children with GDD/ID and have substantially enhanced the diagnostic yield rates. Gene therapy has emerged as a promising avenue and is poised to become a cornerstone in addressing various genetic developmental and epilepsy disorders. Early intervention facilitated by a proficient multidisciplinary team can markedly enhance the prognosis and outcomes of GDD/ID, particularly when parents or caregivers are actively engaged in the interventional process. This review discusses risk factors and common underlying causes, explores recent evidence and recommendations for genetic evaluation, and offers management strategies for children with GDD/ID.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"435-446"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric abdominal ultrasound training program for pediatricians. 面向儿科医生的小儿腹部超声波培训计划。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-09-01 Epub Date: 2024-08-20 DOI: 10.3345/cep.2024.00451

Soon Chul Kim

引用次数: 0

Neonatal risk factors associated with autism spectrum disorders: an umbrella review. 与自闭症谱系障碍相关的新生儿风险因素：综述。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-09-01 Epub Date: 2024-07-19 DOI: 10.3345/cep.2024.00136

Amir Mohammad Salehi, Erfan Ayubi, Salman Khazaei, Ensiyeh Jenabi, Saeid Bashirian, Zohreh Salimi

{"title":"Neonatal risk factors associated with autism spectrum disorders: an umbrella review.","authors":"Amir Mohammad Salehi, Erfan Ayubi, Salman Khazaei, Ensiyeh Jenabi, Saeid Bashirian, Zohreh Salimi","doi":"10.3345/cep.2024.00136","DOIUrl":"10.3345/cep.2024.00136","url":null,"abstract":"Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by severe social communication deficits and stereotypical repetitive behaviors.Purpose: This umbrella review assessed neonatal risk factors associated with ASD using meta-analyses and systematic reviews.Methods: We conducted a systematic search of interna- tional databases including PubMed, Scopus, and Web of Science for studies published through April 2022 utilizing pertinent keywords. A random-eﬀects model was used to calculate the odds ratio (OR) and 95% confidence interval (CI). Substantial heterogeneity was considered at values of I2≥50%. A quality assessment of the included studies was performed using the A MeaSurement Tool to Assess Systematic Reviews (AMSTAR2) checklist.Results: A total of 207,221 children with ASD and 22,993,128 neurotypical children were included. Six meta- analyses were included in this umbrella review. The factors of congenital heart disease (OR, 1.35; 95% CI, 1.17-1.52), macrosomia (OR, 1.11; 95% CI, 1.05-1.18), low birth weight (OR, 1.63; 95% CI, 1.48-1.81), very low birth weight (OR, 2.25; 95% CI, 1.79-2.83), small for gestational age (OR, 1.17; 95% CI, 1.09-1.24), jaundice (OR, 1.74; 95% CI, 1.42- 2.12), male sex (OR, 1.47; 95% CI, 1.39-1.55) and 1-minute Apgar score <7 (OR, 1.40; 95% CI, 1.26-1.55) were graded as suggestive evidence (class III). Only 3 studies reported heterogeneity (I2<50%). Based on the AMSTAR2 analysis, the methodological quality was critically low in 3 meta- analyses, low in 2, and moderate in 1.Conclusion: Based on these results, clinicians should consider the risk factors for ASD and screen children in clinics.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"459-464"},"PeriodicalIF":3.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction and validation of predictive models for intravenous immunoglobulin-resistant Kawasaki disease using an interpretable machine learning approach. 利用可解释的机器学习方法构建和验证静脉注射免疫球蛋白耐药川崎病的预测模型。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-08-01 Epub Date: 2024-07-23 DOI: 10.3345/cep.2024.00549

Linfan Deng, Jian Zhao, Ting Wang, Bin Liu, Jun Jiang, Peng Jia, Dong Liu, Gang Li

{"title":"Construction and validation of predictive models for intravenous immunoglobulin-resistant Kawasaki disease using an interpretable machine learning approach.","authors":"Linfan Deng, Jian Zhao, Ting Wang, Bin Liu, Jun Jiang, Peng Jia, Dong Liu, Gang Li","doi":"10.3345/cep.2024.00549","DOIUrl":"10.3345/cep.2024.00549","url":null,"abstract":"Background: Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease is associated with coronary artery lesion development.Purpose: This study aimed to explore the factors associated with IVIG-resistance and construct and validate an interpretable machine learning (ML) prediction model in clinical practice.Methods: Between December 2014 and November 2022, 602 patients were screened and risk factors for IVIG-resistance investigated. Five ML models are used to establish an optimal prediction model. The SHapley Additive exPlanations (SHAP) method was used to interpret the ML model.Results: Na+, hemoglobin (Hb), C-reactive protein (CRP), and globulin were independent risk factors for IVIG-resistance. A nonlinear relationship was identified between globulin level and IVIG-resistance. The XGBoost model exhibited excellent performance, with an area under the receiver operating characteristic curve of 0.821, accuracy of 0.748, sensitivity of 0.889, and specificity of 0.683 in the testing set. The XGBoost model was interpreted globally and locally using the SHAP method.Conclusion: Na+, Hb, CRP, and globulin levels were independently associated with IVIG-resistance. Our findings demonstrate that ML models can reliably predict IVIG-resistance. Moreover, use of the SHAP method to interpret the established XGBoost model's findings would provide evidence of IVIG-resistance and guide the individualized treatment of Kawasaki disease.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"405-414"},"PeriodicalIF":3.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is it possible to provide palliative care to pediatric patients with neurological diseases? 能否为患有神经系统疾病的儿科患者提供姑息关怀？

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-08-01 Epub Date: 2024-02-15 DOI: 10.3345/cep.2023.01032

Young-Hoon Kim

引用次数: 0

Effects of diethylene glycol contamination of pharmaceutical products on unexplained acute kidney injury in children: a systematic review. 药品中的二甘醇污染对儿童不明原因急性肾损伤的影响：系统综述。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-08-01 Epub Date: 2024-01-04 DOI: 10.3345/cep.2023.01039

Sani Rachman Soleman, Muhammad Luthfi Adnan, Hilmi Ardian Sudiarto, Satria Bintang Mahathma, Alya Ayu Tazkia, Hana Afifah Firdaus, Alfreda Amelia Khotijah, Miranti Dewi Pramaningtyas, Emi Azmi Choironi

{"title":"Effects of diethylene glycol contamination of pharmaceutical products on unexplained acute kidney injury in children: a systematic review.","authors":"Sani Rachman Soleman, Muhammad Luthfi Adnan, Hilmi Ardian Sudiarto, Satria Bintang Mahathma, Alya Ayu Tazkia, Hana Afifah Firdaus, Alfreda Amelia Khotijah, Miranti Dewi Pramaningtyas, Emi Azmi Choironi","doi":"10.3345/cep.2023.01039","DOIUrl":"10.3345/cep.2023.01039","url":null,"abstract":"Unexplained acute kidney injury (AKI) in children owing to diethylene glycol (DEG) contamination during drug production has gained attention in recent years. This qualitative study investigated the effects of DEG exposure on the incidence of unknown AKI in children. A systematic review following the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines was proposed to search for studies using predefined search terms in the PubMed, EBSCO, and Web of Science data-bases without publication date restrictions. The inclusion criteria are observational study, case study, case report, and case series design; and having provided accurate data for DEG poisoning and AKI diagnosis in children. All authors performed the study screening, data extraction, and data synthesis processes. Consensus was reached by mutual agreement. The data synthesis was conducted according to the DEG and unexplained AKI in children by examining the statistical data using Microsoft Excel 2017 and storing the data using the cloud service of Universitas Islam Indonesia. Of the 115 included studies, 21 met the inclusion criteria, including 2 case-control studies, 1 cross-sectional study, 4 case studies, and 14 case reports. DEG-contaminated paracetamol caused unexplained AKI in children. Other drugs including cough expectorants, antihistamines, and sedatives were administered. Chemicals other than DEG, such as propylene glycol and ethylene glycol, also induce AKI owing to overprescription and unintentional exposure. A recent epidemic of unexplained AKI showed contaminated paracetamol as the poisoning agent regardless of formula.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"395-402"},"PeriodicalIF":3.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutropenia following metamizole use in pediatric patients: a multicenter retrospective study. 儿科患者使用甲硝唑后出现的中性粒细胞减少症：一项多中心回顾性研究。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-08-01 Epub Date: 2024-07-23 DOI: 10.3345/cep.2024.00262

Meraj Alam Siddiqui, Arzu Akyay, Fatma Burcu Belen Apak, Özgür Carti, Canan Albayrak, Melek İşik, Zühre Kaya, Sevgi Yetgin, Lale Olcay

引用次数: 0

Association between pre- and postnatal exposure to endocrine-disrupting chemicals and birth and neurodevelopmental outcomes: an extensive review. 产前和产后暴露于某些内分泌干扰化学物质与出生和神经发育结果的关系:一项广泛的综述。

IF 3.2

Clinical and Experimental Pediatrics Pub Date : 2024-07-01 Epub Date: 2023-11-16 DOI: 10.3345/cep.2023.00941

Ozge Yesildemir, Mensure Nur Celik

{"title":"Association between pre- and postnatal exposure to endocrine-disrupting chemicals and birth and neurodevelopmental outcomes: an extensive review.","authors":"Ozge Yesildemir, Mensure Nur Celik","doi":"10.3345/cep.2023.00941","DOIUrl":"10.3345/cep.2023.00941","url":null,"abstract":"Endocrine-disrupting chemicals (EDCs) are natural or synthetic chemicals that mimic, block, or interfere with the hormones in the body. The most common and well- studied EDCs are bisphenol A, phthalates, and persistent organic pollutants including polychlorinated biphenyls, polybrominated diphenyl ethers, per- and polyﬂuoroalkyl substances, other brominated ﬂame retardants, organochlorine pesticides, dioxins, and furans. Starting in embryonic life, humans are constantly exposed to EDCs through air, diet, skin, and water. Fetuses and newborns undergo crucial developmental processes that allow adaptation to the environment throughout life. As developing organisms, they are extremely sensitive to low doses of EDCs. Many EDCs can cross the placental barrier and reach the developing fetal organs. In addition, newborns can be exposed to EDCs through breastfeeding or formula feeding. Pre- and postnatal exposure to EDCs may increase the risk of childhood diseases by disrupting the hormone-mediated processes critical for growth and development during gestation and infancy. This review discusses evidence of the relationship between pre- and postnatal exposure to several EDCs, childbirth, and neurodevelopmental outcomes. Available evidence suggests that pre- and postnatal exposure to certain EDCs causes fetal growth restriction, preterm birth, low birth weight, and neurodevelopmental problems through various mechanisms of action. Given the adverse eﬀects of EDCs on child development, further studies are required to clarify the overall associations.","PeriodicalId":36018,"journal":{"name":"Clinical and Experimental Pediatrics","volume":" ","pages":"328-346"},"PeriodicalIF":3.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0