M. Tavakoli, J. N. Taylor, Chun-Biu Li, T. Komatsuzaki, S. Press'e
{"title":"Single Molecule Data Analysis: An Introduction","authors":"M. Tavakoli, J. N. Taylor, Chun-Biu Li, T. Komatsuzaki, S. Press'e","doi":"10.1002/9781119324560.CH4","DOIUrl":"https://doi.org/10.1002/9781119324560.CH4","url":null,"abstract":"This chapter considers statistical data-driven analysis methods, and focuses on parametric as well as more recent information theoretic and nonparametric statistical approaches to biophysical data ...","PeriodicalId":360136,"journal":{"name":"arXiv: Biological Physics","volume":"173 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125752615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of a stochastic model for bacterial growth and the lognormality of the cell-size distribution","authors":"K. Yamamoto, J. Wakita","doi":"10.7566/JPSJ.85.074004","DOIUrl":"https://doi.org/10.7566/JPSJ.85.074004","url":null,"abstract":"This paper theoretically analyzes a phenomenological stochastic model for bacterial growth. This model comprises cell division and the linear growth of cells, where growth rates and cell cycles are drawn from lognormal distributions. We find that the cell size is expressed as a sum of independent lognormal variables. We show numerically that the quality of the lognormal approximation greatly depends on the distributions of the growth rate and cell cycle. Furthermore, we show that actual parameters of the growth rate and cell cycle take values that give a good lognormal approximation; thus, the experimental cell-size distribution is in good agreement with a lognormal distribution.","PeriodicalId":360136,"journal":{"name":"arXiv: Biological Physics","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131691978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dark States in Quantum Photosynthesis","authors":"S. Kozyrev, I. Volovich","doi":"10.1007/978-3-319-91092-5_2","DOIUrl":"https://doi.org/10.1007/978-3-319-91092-5_2","url":null,"abstract":"","PeriodicalId":360136,"journal":{"name":"arXiv: Biological Physics","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114156435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Active Matter Clusters at Interfaces","authors":"K. Copenhagen, A. Gopinathan","doi":"10.3389/fmats.2016.00013","DOIUrl":"https://doi.org/10.3389/fmats.2016.00013","url":null,"abstract":"Collective and directed motility or swarming is an emergent phenomenon displayed by many self-organized assemblies of active biological matter such as clusters of embryonic cells during tissue development, cancerous cells during tumor formation and metastasis, colonies of bacteria in a biofilm, or even flocks of birds and schools of fish at the macro-scale. Such clusters typically encounter very heterogeneous environments. What happens when a cluster encounters an interface between two different environments has implications for its function and fate. Here we study this problem by using a mathematical model of a cluster that treats it as a single cohesive unit that moves in two dimensions by exerting a force/torque per unit area whose magnitude depends on the nature of the local environment. We find that low speed (overdamped) clusters encountering an interface with a moderate difference in properties can lead to refraction or even total internal reflection of the cluster. For large speeds (underdamped), where inertia dominates, the clusters show more complex behaviors crossing the interface multiple times and deviating from the predictable refraction and reflection for the low velocity clusters. We then present an extreme limit of the model in the absense of rotational damping where clusters can become stuck spiraling along the interface or move in large circular trajectories after leaving the interface. Our results show a wide range of behaviors that occur when collectively moving active biological matter moves across interfaces and these insights can be used to control motion by patterning environments.","PeriodicalId":360136,"journal":{"name":"arXiv: Biological Physics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130976591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyoohyun Kim, Jonghee Yoon, Seungwoo Shin, Sangyun Lee, Su-A Yang, Yongkeun Park
{"title":"Optical diffraction tomography techniques for the study of cell pathophysiology","authors":"Kyoohyun Kim, Jonghee Yoon, Seungwoo Shin, Sangyun Lee, Su-A Yang, Yongkeun Park","doi":"10.18287/JBPE16.02.020201","DOIUrl":"https://doi.org/10.18287/JBPE16.02.020201","url":null,"abstract":"Three-dimensional imaging of biological cells is crucial for the investigation of cell biology, provide valuable information to reveal the mechanisms behind pathophysiology of cells and tissues. Recent advances in optical diffraction tomography (ODT) have demonstrated the potential for the study of various cells with its unique advantages of quantitative and label-free imaging capability. To provide insight on this rapidly growing field of research and to discuss its applications in biology and medicine, we present the summary of the ODT principle and highlight recent studies utilizing ODT with the emphasis on the applications to the pathophysiology of cells.","PeriodicalId":360136,"journal":{"name":"arXiv: Biological Physics","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134489037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Scholz, S. Burov, Kimberly L. Weirich, B. Scholz, S. Tabei, M. Gardel, A. Dinner
{"title":"A cycling state that can lead to glassy dynamics in intracellular transport","authors":"M. Scholz, S. Burov, Kimberly L. Weirich, B. Scholz, S. Tabei, M. Gardel, A. Dinner","doi":"10.1103/PHYSREVX.6.011037","DOIUrl":"https://doi.org/10.1103/PHYSREVX.6.011037","url":null,"abstract":"Power-law dwell times have been observed for molecular motors in living cells, but the origins of these trapped states are not known. We introduce a minimal model of motors moving on a two-dimensional network of filaments, and simulations of its dynamics exhibit statistics comparable to those observed experimentally. Analysis of the model trajectories, as well as experimental particle tracking data, reveals a state in which motors cycle unproductively at junctions of three or more filaments. We formulate a master equation for these junction dynamics and show that the time required to escape from this vortex-like state can account for the power-law dwell times. We identify trends in the dynamics with the motor valency for further experimental validation. We demonstrate that these trends exist in individual trajectories of myosin II on an actin network. We discuss how cells could regulate intracellular transport and, in turn, biological function, by controlling their cytoskeletal network structures locally.","PeriodicalId":360136,"journal":{"name":"arXiv: Biological Physics","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131302768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kazunori Takamiya, Keisuke Yamamoto, Shuhei Isami, H. Nishimori, A. Awazu
{"title":"Excluded volume effect enhances the homology pairing of model chromosomes","authors":"Kazunori Takamiya, Keisuke Yamamoto, Shuhei Isami, H. Nishimori, A. Awazu","doi":"10.1587/NOLTA.7.66","DOIUrl":"https://doi.org/10.1587/NOLTA.7.66","url":null,"abstract":"To investigate the structural dynamics of the homology pairing of polymers, we mod- eled the scenario of homologous chromosome pairings during meiosis in Schizosaccharomyces pombe, one of the simplest model organisms of eukaryotes. We consider a simple model consist- ing of pairs of homologous polymers with the same structures that are confined in a cylindrical container, which represents the local parts of chromosomes contained in an elongated nucleus of S. pombe. Brownian dynamics simulations of this model showed that the excluded volume effects among non-homological chromosomes and the transitional dynamics of nuclear shape serve to enhance the pairing of homologous chromosomes.","PeriodicalId":360136,"journal":{"name":"arXiv: Biological Physics","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116071711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The radical-pair mechanism as a paradigm for the emerging science of quantum biology","authors":"I. Kominis","doi":"10.1142/S0217984915300136","DOIUrl":"https://doi.org/10.1142/S0217984915300136","url":null,"abstract":"The radical-pair mechanism was introduced in the 1960's to explain anomalously large EPR and NMR signals in chemical reactions of organic molecules. It has evolved to the cornerstone of spin chemistry, the study of the effect electron and nuclear spins have on chemical reactions, with the avian magnetic compass mechanism and the photosynthetic reaction center dynamics being prominent biophysical manifestations of such effects. In recent years the radical-pair mechanism was shown to be an ideal biological system where the conceptual tools of quantum information science can be fruitfully applied. We will here review recent work making the case that the radical-pair mechanism is indeed a major driving force of the emerging field of quantum biology.","PeriodicalId":360136,"journal":{"name":"arXiv: Biological Physics","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130252843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Manrique, F. Caycedo-Soler, A. D. Mendoza, F. Rodr'iguez, L. Quiroga, N. Johnson
{"title":"Exploring the effects of photon correlations from thermal sources on bacterial photosynthesis","authors":"P. Manrique, F. Caycedo-Soler, A. D. Mendoza, F. Rodr'iguez, L. Quiroga, N. Johnson","doi":"10.1016/J.RINP.2016.11.024","DOIUrl":"https://doi.org/10.1016/J.RINP.2016.11.024","url":null,"abstract":"","PeriodicalId":360136,"journal":{"name":"arXiv: Biological Physics","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116606848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Engineering sensorial delay to control phototaxis and emergent collective behaviors","authors":"M. Mijalkov, Austin Mcdaniel, J. Wehr, G. Volpe","doi":"10.1103/PhysRevX.6.011008","DOIUrl":"https://doi.org/10.1103/PhysRevX.6.011008","url":null,"abstract":"Collective motions emerging from the interaction of autonomous mobile individuals play a key role in many phenomena, from the growth of bacterial colonies to the coordination of robotic swarms. For these collective behaviours to take hold, the individuals must be able to emit, sense and react to signals. When dealing with simple organisms and robots, these signals are necessarily very elementary, e.g. a cell might signal its presence by releasing chemicals and a robot by shining light. An additional challenge arises because the motion of the individuals is often noisy, e.g. the orientation of cells can be altered by Brownian motion and that of robots by an uneven terrain. Therefore, the emphasis is on achieving complex and tunable behaviors from simple autonomous agents communicating with each other in robust ways. Here, we show that the delay between sensing and reacting to a signal can determine the individual and collective long-term behavior of autonomous agents whose motion is intrinsically noisy. We experimentally demonstrate that the collective behaviour of a group of phototactic robots capable of emitting a radially decaying light field can be tuned from segregation to aggregation and clustering by controlling the delay with which they change their propulsion speed in response to the light intensity they measure. We track this transition to the underlying dynamics of this system, in particular, to the ratio between the robots' sensorial delay time and the characteristic time of the robots' random reorientation. Supported by numerics, we discuss how the same mechanism can be applied to control active agents, e.g. airborne drones, moving in a three-dimensional space.","PeriodicalId":360136,"journal":{"name":"arXiv: Biological Physics","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132216593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}