Optical diffraction tomography techniques for the study of cell pathophysiology

Kyoohyun Kim, Jonghee Yoon, Seungwoo Shin, Sangyun Lee, Su-A Yang, Yongkeun Park
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引用次数: 143

Abstract

Three-dimensional imaging of biological cells is crucial for the investigation of cell biology, provide valuable information to reveal the mechanisms behind pathophysiology of cells and tissues. Recent advances in optical diffraction tomography (ODT) have demonstrated the potential for the study of various cells with its unique advantages of quantitative and label-free imaging capability. To provide insight on this rapidly growing field of research and to discuss its applications in biology and medicine, we present the summary of the ODT principle and highlight recent studies utilizing ODT with the emphasis on the applications to the pathophysiology of cells.
用于细胞病理生理学研究的光学衍射断层扫描技术
生物细胞的三维成像对细胞生物学的研究至关重要,为揭示细胞和组织的病理生理机制提供了有价值的信息。光学衍射层析成像技术(optical diffraction tomography, ODT)以其独特的定量和无标记成像能力,在研究各种细胞方面具有很大的潜力。为了深入了解这一快速发展的研究领域,并讨论其在生物学和医学中的应用,我们总结了ODT原理,并重点介绍了最近利用ODT的研究,重点是ODT在细胞病理生理学中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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