Fabad Journal of Pharmaceutical Sciences最新文献_第6页

Novel (p-tolyl)-3(2H)-pyridazinone derivatives containing substituted-1,2,3-triazole moiety as new anti-Alzheimer agents: Synthesis, in vitro and in silico assays 新型含取代1,2,3-三唑的(对甲基)-3(2H)-吡嗪酮衍生物抗阿尔茨海默病新药物:合成、体外和硅检测

Fabad Journal of Pharmaceutical Sciences Pub Date : 2022-08-04 DOI: 10.55262/fabadeczacilik.1128446

İrem Bozbey, Gülce Taşkor Önel, B. Türkmenoğlu, S. Gürsoy, Esra Dilek

引用次数: 2

Glycosides Isolated from Leaf Extract of Phyllanthus muellerianus (Kuntze) Excell (Phyllanthaceae) Upregulated Cell-mediated Innate Immunity 江蓠叶提取物中分离的糖苷上调细胞介导的先天免疫

Fabad Journal of Pharmaceutical Sciences Pub Date : 2022-08-01 DOI: 10.55262/fabadeczacilik.1083066

Martha N. Ofokansi, O. Isiogugu, I. E. Peter, Matthas Agbo, F. C. Okoye, P. Akah

引用次数: 0

The Role of Carbon Monoxide and Their Donor (CORM-2) in Skin Wound Healing in Mice 一氧化碳及其供体(CORM-2)在小鼠皮肤伤口愈合中的作用

Fabad Journal of Pharmaceutical Sciences Pub Date : 2022-07-10 DOI: 10.55262/fabadeczacilik.1095369

S. Beschasnyi, Olena Hasiuk

{"title":"The Role of Carbon Monoxide and Their Donor (CORM-2) in Skin Wound Healing in Mice","authors":"S. Beschasnyi, Olena Hasiuk","doi":"10.55262/fabadeczacilik.1095369","DOIUrl":"https://doi.org/10.55262/fabadeczacilik.1095369","url":null,"abstract":"Carbon monoxide, which is a toxic gas, has a beneficial effect on cells in low doses. It is known that low concentrations of this gas are produced in the body during the decay of heme-containing proteins and have pro-apoptotic, anti-inflammatory, anti-allergic, vasodilator effects, stimulating angiogenesis. The danger of using this gas is the difficulty of its dosage. CO donors are used to controlling the amount and gradual release of carbon monoxide. This study studied the effect of treatment with CO and donor CORM-2 on wound healing processes in laboratory mice. Treatment with CO and CORM-2 reduced the healing rate of skin wounds in laboratory mice. The greatest delay in healing was observed in animals whose wounds were treated with CO. In this group, aquaporin-3 mRNA expression was decreased to the smallest degree among all other animals. This most likely caused the appearance of crusts. CORM-2 treatment also led to a decrease in AQP3 mRNA expression, but no crusts were formed. This can be explained by the fact that CO is released slowly. Having a dry crust on the wound increases the healing time. But, the formation of a dry crust is useful in the healing of burns, because with a dry scab, pus cannot appear; with some degrees of burns, it prevents suppuration and creates a protective barrier. The study confirmed the hypothesis that CO and CORM-2 reduce AQP3 expression after treatment of damaged skin.","PeriodicalId":36004,"journal":{"name":"Fabad Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81476354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of 2-Substitutedbenzimidazolium Tetrachloroplatinate(II) Compounds and Their Cytotoxic Activities on Different Cell Lines 2-取代苯并咪唑四氯铂酸酯类化合物的合成及其对不同细胞系的细胞毒活性

Fabad Journal of Pharmaceutical Sciences Pub Date : 2022-07-01 DOI: 10.55262/fabadeczacilik.1134520

Mahmut Gözelle, A. Kılıç Süloğlu

{"title":"Synthesis of 2-Substitutedbenzimidazolium Tetrachloroplatinate(II) Compounds and Their Cytotoxic Activities on Different Cell Lines","authors":"Mahmut Gözelle, A. Kılıç Süloğlu","doi":"10.55262/fabadeczacilik.1134520","DOIUrl":"https://doi.org/10.55262/fabadeczacilik.1134520","url":null,"abstract":"The aim of the study was the synthesis of novel platinum compounds\u0000having benzimidazole ligands and screening for their in vitro cytotoxic\u0000activity on human cervical carcinoma HeLa, human lung carcinoma\u0000A549, and human lung epithelial Beas-2B cell lines. 2-Substituted\u0000benzimidazole ligands were synthesized by using appropriate\u0000aldehydes and o-phenylenediamine. Subsequently, 2-substituted\u0000benzimidazole ligands and potassium tetrachloroplatinate(II)\u0000(K2PtCl4) were used to synthesize 2-isopropylbenzimidazole\u0000tetrachloroplatinate(II) (K1) and 2-(1-methylpropyl)benzimidazole\u0000tetrachloroplatinate(II) monohydrate (K2). HRMS, IR, elemental\u0000analysis, 1H-NMR, and melting point were used to characterize\u0000the synthesized compounds. Cytotoxic activities against HeLa,\u0000A549, and Beas-2B cells after 48 h and 72 h incubation of the\u0000platinum compounds were investigated via MTT assay. Cisplatin\u0000and carboplatin were used as reference drugs. The cytotoxic activity\u0000results showed that K2 platinum compound displayed 53.42%±2.21\u0000(at 160 μM) on HeLa, 88.16%±0.22 (at 160 μM) on A549 and\u000092.09%±0.57 (at 160 μM) on Beas-2B after 48 h incubation, K2\u0000displayed 27.42%±2.03 (at 160 μM) on HeLa, 93.95%±0.53\u0000(at 160 μM) on A549 and 91.99±0.22 (at 160 μM) on Beas-2B\u0000after 72 h incubation. Both of the platinum compounds have higher\u0000cell inhibitory effects than reference drug carboplatin after 48 h incubation for tested cells.","PeriodicalId":36004,"journal":{"name":"Fabad Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84590508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hastaların İlaç Uyumunun Arttırılmasında Toplum Eczacılarının Rolü

Fabad Journal of Pharmaceutical Sciences Pub Date : 2022-06-22 DOI: 10.55262/fabadeczacilik.1092310

Felat Çelebi̇, Muammer Çalikuşu, Gülbin Özçeli̇kay

{"title":"Hastaların İlaç Uyumunun Arttırılmasında Toplum Eczacılarının Rolü","authors":"Felat Çelebi̇, Muammer Çalikuşu, Gülbin Özçeli̇kay","doi":"10.55262/fabadeczacilik.1092310","DOIUrl":"https://doi.org/10.55262/fabadeczacilik.1092310","url":null,"abstract":"In this study, the importance of compliance to treatment for the patient to benefit from the treatment, and the effects of patient compliance were determined. The study is a decisive type of research. The forms with 5-point Likert-type questions created by the researchers were asked to community pharmacists via the Internet. 110 pharmacists from different parts of Turkey participated in the survey. The data obtained in the research were analyzed with the SPSS ver. 25.0 program. The significance level (α) was determined as 0.05 in the analyzes made in the study. The Cronbach-alpha reliability coefficient for the developed scale was found to be 0.847. In this study, it is found that community pharmacists make an effort to increase the drug compliance of patients. There was no significant difference between the age and professional experience of the pharmacist in improving patient compliance. Pharmacists need to work more systematically to improve patients' drug compliance. It is thought that the concept of drug compliance is frequently included in the education curriculum of Pharmacy Schools. Still, the necessary educational content and learning opportunities are not sufficient to increase it.","PeriodicalId":36004,"journal":{"name":"Fabad Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73388531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leukotriene D4 Levels in Patıents With Breast Cancer Patıents乳腺癌患者体内白三烯D4水平

Fabad Journal of Pharmaceutical Sciences Pub Date : 2022-06-16 DOI: 10.55262/fabadeczacilik.1086291

S. Akaydin, Sümeyye Ramazanoğlu, Ece MİSER SALİHOĞLU, H. Karanlık, S. Demokan

引用次数: 0

Development of Innovative Cosmetic Formulations to Help Fungal Treatment and Testing the Efficiency of Formulations 创新化妆品配方的开发，以帮助真菌治疗和测试配方的效率

Fabad Journal of Pharmaceutical Sciences Pub Date : 2022-06-16 DOI: 10.55262/fabadeczacilik.1100973

G. Yener, Caner Acar

{"title":"Development of Innovative Cosmetic Formulations to Help Fungal Treatment and Testing the Efficiency of Formulations","authors":"G. Yener, Caner Acar","doi":"10.55262/fabadeczacilik.1100973","DOIUrl":"https://doi.org/10.55262/fabadeczacilik.1100973","url":null,"abstract":"In the fungus of hands and toenails, the thickening of the nail and its yellow color are the first signs of attention. Fungus on the nails of the hands and feet is often caused by Trichophyton rubrum dermatophyte. They have antifungal properties due to the components found in lavender oil, geranium oil and tea tree oil structures. Oral antifungal agents used for treatment of nail fungi have serious side effects especially on liver. Therefore, topical applications have been given importance in recent years. However, in topical applications antifungal agents have difficulties in sending to the target area. For this reason, nanoemulsion technology was preferred in the study. Nanoemulsion formulations of essential oils were prepared using ultrasonication method. Centrifugal and thermal test were applied as preliminary stability to the formulations and the pH value, viscosity, droplet size and polidispersity index of the formulations passing this step were measured and organoleptic controls were performed. Antifungal efficacy and release studies were performed on the formulations F4P3-I (pelargonium), F4P3-L (lavender), F4P3-C (tea tree) and F4P3-K (mixture) which were successful as a result of all the tests. According to the study, it was concluded that F4P3-I, F4P3-L, F4P3-Ç, F4P3-K formulations may help in the treatment of fungi.","PeriodicalId":36004,"journal":{"name":"Fabad Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83311133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin Based Standardization Of Polyherbal Anti-Gout Remedy And İts Molecular Docking Study Against Anti-Gout And Anti-İnflammatory Protein Targets 基于槲皮素的多药抗痛风药物标准化及抗痛风与抗-İnflammatory蛋白靶点的İts分子对接研究

Fabad Journal of Pharmaceutical Sciences Pub Date : 2022-06-08 DOI: 10.55262/fabadeczacilik.1085825

Ayisha Shaukat, K. Hussain

引用次数: 2

Conductor of the Astrocyte-Neuron Metabolic Orchestra 星形细胞-神经元代谢乐团指挥

Fabad Journal of Pharmaceutical Sciences Pub Date : 2022-03-01 DOI: 10.55262/fabadeczacilik.1078905

M. Welcome

引用次数: 0

Recent Advancements in Antipsoriatic Therapy: An Update 抗银屑病治疗的最新进展

Fabad Journal of Pharmaceutical Sciences Pub Date : 2022-03-01 DOI: 10.55262/fabadeczacilik.1078882

Shaik Shafiulla, S. Dhaneshwar

引用次数: 1