Neurological Surgery最新文献_第2页

[History and Current Situation of Indirect Bypass Surgery for Moyamoya Disease]. [烟雾病间接搭桥手术的历史与现状]。

Neurological Surgery Pub Date : 2025-05-01 DOI: 10.11477/mf.030126030530030509

Tomohito Hishikawa

引用次数: 0

[Severity Classification of Moyamoya Disease]. [烟雾病严重程度分级]。

Neurological Surgery Pub Date : 2025-05-01 DOI: 10.11477/mf.030126030530030463

Jun C Takahashi

引用次数: 0

[Cognitive Dysfunction of Pediatric Moyamoya Disease]. [小儿烟雾病认知功能障碍]。

Neurological Surgery Pub Date : 2025-05-01 DOI: 10.11477/mf.030126030530030552

Shoko Hara, Tadashi Nariai

{"title":"[Cognitive Dysfunction of Pediatric Moyamoya Disease].","authors":"Shoko Hara, Tadashi Nariai","doi":"10.11477/mf.030126030530030552","DOIUrl":"https://doi.org/10.11477/mf.030126030530030552","url":null,"abstract":"Moyamoya disease is rare and affects children and young adults. A substantial proportion of children with this disease experience cognitive dysfunction in some domains even in the absence of ischemic or hemorrhagic stroke. A characteristic feature is a decline in working memory, which is believed to be associated with reduced blood flow and disrupted microstructure in the frontal and parietal lobes. However, the involvement of the temporo-parietal-occipital lobes has also been reported. While successful bypass surgery can improve cognitive decline in some domains, especially the visual-motor processing ability, some patients still suffer from cognitive decline, which negatively affects school learning. As a primary physician of pediatric patients with moyamoya disease, it is essential to assess not only neurological symptoms but also their educational situation and need for support at each school stage. Furthermore, since children with moyamoya disease will have a long life after initial treatment, it is crucial to transmit our knowledge and current challenges to healthcare providers in the next generation to ensure appropriate support throughout the patients' lives.","PeriodicalId":35984,"journal":{"name":"Neurological Surgery","volume":"53 3","pages":"552-562"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[History and Current Status of Direct or Combined Revascularization Surgery for Moyamoya Disease]. [烟雾病直接或联合血管重建术的历史与现状]。

Neurological Surgery Pub Date : 2025-05-01 DOI: 10.11477/mf.030126030530030514

Atsushi Kanoke, Hidenori Endo

{"title":"[History and Current Status of Direct or Combined Revascularization Surgery for Moyamoya Disease].","authors":"Atsushi Kanoke, Hidenori Endo","doi":"10.11477/mf.030126030530030514","DOIUrl":"https://doi.org/10.11477/mf.030126030530030514","url":null,"abstract":"We reviewed the history and development of revascularization surgery for moyamoya disease, particularly STA-MCA bypass. In the early stages, medical treatments, such as vasodilators, were ineffective. In the 1970s, indirect surgical methods were introduced but have shown limited success. Direct bypass techniques have evolved with advancements in microsurgery, and STA-MCA bypass has become the standard treatment. Surgery improves the collateral blood flow and reduces the risk of stroke, especially in patients with ischemia. Despite being generally safe, perioperative complications, such as cerebral infarction and hyperperfusion syndrome, may occur. Adult and pediatric patients show different hemodynamic responses that require tailored postoperative care. Long-term studies have shown high graft patency and reduced risk of stroke, although late cerebrovascular events may occur. Meta-analyses support revascularization, especially in cases of hemorrhage. The optimal timing of surgery remains controversial. The risk factors for postoperative stroke include age < 5 years, diabetes, and a higher Suzuki grade. Continued research is needed to refine individual treatment strategies.","PeriodicalId":35984,"journal":{"name":"Neurological Surgery","volume":"53 3","pages":"514-521"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Adult Hemorrhagic Moyamoya Disease: Physiopathology and Treatment]. 成人出血性烟雾病：生理病理与治疗

Neurological Surgery Pub Date : 2025-05-01 DOI: 10.11477/mf.030126030530030576

Takeshi Funaki, Hideo Chihara

引用次数: 0

[Brief History of the Search for Susceptibility Loci for Moyamoya Disease]. [烟雾病易感位点的研究简史]。

Neurological Surgery Pub Date : 2025-05-01 DOI: 10.11477/mf.030126030530030468

Mitsuhiro Tada

{"title":"[Brief History of the Search for Susceptibility Loci for Moyamoya Disease].","authors":"Mitsuhiro Tada","doi":"10.11477/mf.030126030530030468","DOIUrl":"https://doi.org/10.11477/mf.030126030530030468","url":null,"abstract":"Here, I briefly describe the determination of locus 17q25 on chromosome 17 for a moyamoya disease susceptibility gene, focusing on our study. At the beginning of the study, linkage analysis was challenging. However, our efforts finally achieved statistically significant results at locus 17q25 with a logarithm of odds(LOD) score of 3.11, a maximum LOD score of 4.58, and p-value of 0.00001 with parametric linkage analysis, multipoint analysis, and nonparametric Affected Pedigree Member analysis, respectively. This was due to the good fortune of choosing chromosome 17 as the primary target, given that neurofibromatosis type 1 and moyamoya disease occur simultaneously in some cases. Moreover, our success was largely due to the contributions of our collaborators who precisely determined the disease traits and collected DNA(leukocyte) samples from 103 individuals from 24 families. After our publication in 2000, a research group from Kyoto University searched for the locus 17q25.3 and discovered a mutation in RNF213 gene. Simultaneously, a group from Tohoku University performed a genome-wide association study and determined RNF213 to be a susceptibility gene for moyamoya disease. This occurred 11 years after our first results.","PeriodicalId":35984,"journal":{"name":"Neurological Surgery","volume":"53 3","pages":"468-475"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[History and Recent Advancements of the Research Committee on Moyamoya Disease of the Ministry of Health, Labor and Welfare, Japan]. [日本厚生劳动省烟雾病研究委员会的历史和最新进展]。

Neurological Surgery Pub Date : 2025-05-01 DOI: 10.11477/mf.030126030530030440

Susumu Miyamoto, Satoshi Kuroda

引用次数: 0

[Long-term Outcome of Bypass Surgery for Moyamoya Disease]. [烟雾病搭桥手术的远期疗效]。

Neurological Surgery Pub Date : 2025-05-01 DOI: 10.11477/mf.030126030530030537

Koji Yamaguchi, Takakazu Kawamata

引用次数: 0

[Association between Moyamoya Disease and Autoimmune Thyroid Disorders]. [烟雾病与自身免疫性甲状腺疾病的关系]。

Neurological Surgery Pub Date : 2025-05-01 DOI: 10.11477/mf.030126030530030567

Eika Hamano, Hiroharu Kataoka

{"title":"[Association between Moyamoya Disease and Autoimmune Thyroid Disorders].","authors":"Eika Hamano, Hiroharu Kataoka","doi":"10.11477/mf.030126030530030567","DOIUrl":"https://doi.org/10.11477/mf.030126030530030567","url":null,"abstract":"Moyamoya disease(MMD) is a progressive cerebrovascular disorder characterized by stenosis or occlusion of the terminal portion of the internal carotid arteries and development of abnormal collateral vessels. Recent studies have suggested a clinical association between MMD and autoimmune thyroid disorders or antithyroid antibodies. In patients with concurrent Graves'disease, thyrotoxicosis may precipitate ischemic cerebrovascular events, and normalization of thyroid function is crucial before revascularization surgery. Notably, elevated levels of antithyroid autoantibodies, such as antithyroid peroxidase and anti-thyroglobulin, are frequently observed in patients with MMD, despite the absence of clinically overt thyroid dysfunction. Genetic susceptibility, including RNF213 variants and immunological factors, might contribute to the pathophysiology of MMD and autoimmune thyroid disorders. The presence of thyroid autoantibodies may be associated with the pathological extension and cerebrovascular events in MMD. However, the underlying mechanisms linking thyroid autoimmunity and moyamoya angiopathy remain unclear. Further investigation is warranted to elucidate these associations and establish appropriate diagnostic and therapeutic approaches.","PeriodicalId":35984,"journal":{"name":"Neurological Surgery","volume":"53 3","pages":"567-575"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cognitive Impairment in Adult Patients with Moyamoya Disease]. [成人烟雾病患者的认知障碍]。

Neurological Surgery Pub Date : 2025-05-01 DOI: 10.11477/mf.030126030530030563

Takeshi Miyamoto, Yasushi Takagi

引用次数: 0