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Ecletica Quimica最新文献

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Development and validation of a new spectrophotometric method for simultaneous determination of sitagliptin and metformin hydrochloride in tablet pharmaceutical dosage forms using chemometrics technique in comparison with HPLC 化学计量学与高效液相色谱法同时测定片剂剂型中西格列汀和盐酸二甲双胍的方法的建立与验证
Ecletica Quimica Pub Date : 2023-01-01 DOI: 10.26850/1678-4618eqj.v48.1.2023.p72-94
Maher Ali Almaqtari, N. Al-Odaini, F. Alarbagi, Hussein Al-Maydama
{"title":"Development and validation of a new spectrophotometric method for simultaneous determination of sitagliptin and metformin hydrochloride in tablet pharmaceutical dosage forms using chemometrics technique in comparison with HPLC","authors":"Maher Ali Almaqtari, N. Al-Odaini, F. Alarbagi, Hussein Al-Maydama","doi":"10.26850/1678-4618eqj.v48.1.2023.p72-94","DOIUrl":"https://doi.org/10.26850/1678-4618eqj.v48.1.2023.p72-94","url":null,"abstract":"A new, quick, easy, affordable and eco-friendly simultaneous spectrophotometric method for determining a combined sitagliptin and metformin hydrochloride in pharmaceutical formulations was developed and validated using two chemometrics technique. These two methods are the partial least square (PLS) and principal component regression (PCR). They do not need to do a sample preparation or separation before analysis. Various drug concentrations and instrumental spectra of 25 mixed solutions of a combination of sitagliptin and metformin hydrochloride were used for model construction in the range of 200�270 nm. The R2 values of 0.9994 and 0.9996 assigned for the PLS of the sitagliptin and metformin hydrochloride and that of 0.9987 and 0.9996 for the PCR of the sitagliptin and metformin hydrochloride, respectively. It is noteworthy that these two models were successfully and effectively used with the commercial pharmaceutical formulations. Finally, the statistical comparison revealed no significant differences with the results of the HPLC reference method. The proposed method is dependable to be adopted as an alternative analytical method in the pharmaceutical industry�s quality control.","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87716806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative Structure-Activity relationship, Molecular Docking and ADMET Screening of Tetrahydroquinoline Derivatives as Anti-Small Cell Lung Cancer Agents 四氢喹啉类抗小细胞肺癌药物的定量构效关系、分子对接及ADMET筛选
Ecletica Quimica Pub Date : 2023-01-01 DOI: 10.26850/1678-4618eqj.v48.1.2023.p55-71
E. A. Erazua, A. Oyebamiji, S. Akintelu, P. Adewole, Adedayo Adelakun, B. B. Adeleke
{"title":"Quantitative Structure-Activity relationship, Molecular Docking and ADMET Screening of Tetrahydroquinoline Derivatives as Anti-Small Cell Lung Cancer Agents","authors":"E. A. Erazua, A. Oyebamiji, S. Akintelu, P. Adewole, Adedayo Adelakun, B. B. Adeleke","doi":"10.26850/1678-4618eqj.v48.1.2023.p55-71","DOIUrl":"https://doi.org/10.26850/1678-4618eqj.v48.1.2023.p55-71","url":null,"abstract":"Lung carcinoma (LC) is responsible for almost one-third of all cancer fatalities worldwide. Tetrahydroquinoline is an organic molecule that is the semi-hydrogenated derivative of quinoline and could be found in several naturally occurring compounds such as flindersine, oricine etc. Some tetrahydroquinoline derivatives with pyrazole and hydrazide moieties were evaluated in silico against A549 (human lung cancer cell lines). The quantitative structural-activity relationship (QSAR) model created was statistically significant with validation metrics of R2 (0.9525), R2adj (0.9314), and CV.R (0.9719). The molecular docking analysis revealed that compound C14 demonstrated the best binding affinity towards the studied protein with binding affinity value of –10.1 kcal mol–1 (4LRM). This is in accordance with the experimental result (IC50 = 0.69). The factors observed for ADME&T correlated well with the factors observed for the referenced drug. This study indicates that compounds C1 and C9 can be further developed as anti-epidermal growth factor receptor (EGFR) compounds. Thus, our findings may open door for the design and development of library of efficient Tetrahydroquinoline-based drug-like compounds as potential anti-LC agents.","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88813809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Antioxidant property of secondary metabolites from Garcinia genus: A short review 藤黄属次生代谢产物的抗氧化性研究进展
Ecletica Quimica Pub Date : 2023-01-01 DOI: 10.26850/1678-4618eqj.v48.1.2023.p41-54
Elton Kazmierczak, C�ssia Gon�alves Magalh�es, Romaiana Picada Pereira
{"title":"Antioxidant property of secondary metabolites from Garcinia genus: A short review","authors":"Elton Kazmierczak, C�ssia Gon�alves Magalh�es, Romaiana Picada Pereira","doi":"10.26850/1678-4618eqj.v48.1.2023.p41-54","DOIUrl":"https://doi.org/10.26850/1678-4618eqj.v48.1.2023.p41-54","url":null,"abstract":"Species from the Garcinia genus (Clusiaceae family) are used in the treatment of many diseases and metabolic disorders frequently associated with the oxidative stress. The characteristic metabolites found in this genus are xanthones and benzophenones, which have antioxidant properties, among relevant biological potentials. This review provides a specific vision about antioxidant activity of Garcinia species, reporting in vitro and in vivo assays, described from the last five years. The research about antioxidant properties of Garcinia species and their constituents can be directed in the development of new medicines and drugs.","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87611991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinetics and mechanisms of the reaction between the pentaamine(dimethylsulfoxide)cobalt(III) complex and the reducing agents chromium(III), vanadium(II) and europium(II) in aqueous solution 五胺(二甲亚砜)钴(III)配合物与还原剂铬(III)、钒(II)、铕(II)在水溶液中的反应动力学及机理
Ecletica Quimica Pub Date : 2018-10-05 DOI: 10.26850/1678-4618eqj.v15.1.1990.p9-15
Luiz Antonio Andrade de Oliveira
{"title":"Kinetics and mechanisms of the reaction between the pentaamine(dimethylsulfoxide)cobalt(III) complex and the reducing agents chromium(III), vanadium(II) and europium(II) in aqueous solution","authors":"Luiz Antonio Andrade de Oliveira","doi":"10.26850/1678-4618eqj.v15.1.1990.p9-15","DOIUrl":"https://doi.org/10.26850/1678-4618eqj.v15.1.1990.p9-15","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69144644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinação de boro em fertilizantes pela colorimetria de azometina-H modificada 用改性氮甲胺-H比色法测定肥料中硼
Ecletica Quimica Pub Date : 2018-09-13 DOI: 10.26850/1678-4618eqj.v21.1.1996.p61-69
Assunta Maria Marques da Silva
{"title":"Determinação de boro em fertilizantes pela colorimetria de azometina-H modificada","authors":"Assunta Maria Marques da Silva","doi":"10.26850/1678-4618eqj.v21.1.1996.p61-69","DOIUrl":"https://doi.org/10.26850/1678-4618eqj.v21.1.1996.p61-69","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69144319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies of adsorptive interaction between Aspergillus niger and the reactive azo dye procion blue MX-G 黑曲霉与活性偶氮染料产蓝MX-G吸附相互作用的研究
Ecletica Quimica Pub Date : 2018-09-13 DOI: 10.26850/1678-4618eqj.v21.1.1996.p97-102
Ivonete Marcanti Contato
{"title":"Studies of adsorptive interaction between Aspergillus niger and the reactive azo dye procion blue MX-G","authors":"Ivonete Marcanti Contato","doi":"10.26850/1678-4618eqj.v21.1.1996.p97-102","DOIUrl":"https://doi.org/10.26850/1678-4618eqj.v21.1.1996.p97-102","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69144327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Preparação, caracterização e estudo do comportamento térmico dos selanatos duplos de cálcio, de berílio e de amônio 钙、铍、铵双硒酸盐的制备、表征及热行为研究
Ecletica Quimica Pub Date : 2018-09-13 DOI: 10.26850/1678-4618eqj.v21.1.1996.p49-60
Ademir Geraldo Cavalari Costalonga
{"title":"Preparação, caracterização e estudo do comportamento térmico dos selanatos duplos de cálcio, de berílio e de amônio","authors":"Ademir Geraldo Cavalari Costalonga","doi":"10.26850/1678-4618eqj.v21.1.1996.p49-60","DOIUrl":"https://doi.org/10.26850/1678-4618eqj.v21.1.1996.p49-60","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69144784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
L'importance des methodes autoconsistentes dans la definition d'un modele de l'aromaticite chimique 自一致方法在定义化学芳香化模型中的重要性
Ecletica Quimica Pub Date : 2018-08-07 DOI: 10.26850/1678-4618EQJ.V10.1.1986.P1-6
J. Gastmans, D. F. Gastmans, J. M. Lopes
{"title":"L'importance des methodes autoconsistentes dans la definition d'un modele de l'aromaticite chimique","authors":"J. Gastmans, D. F. Gastmans, J. M. Lopes","doi":"10.26850/1678-4618EQJ.V10.1.1986.P1-6","DOIUrl":"https://doi.org/10.26850/1678-4618EQJ.V10.1.1986.P1-6","url":null,"abstract":"","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41919973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sobre a recuperação de prata: etapa eletrolítica 关于银的回收：电解步骤
Ecletica Quimica Pub Date : 2018-08-07 DOI: 10.26850/1678-4618eqj.v7.1.1982.p43-48
Eikite Tengnon
{"title":"Sobre a recuperação de prata: etapa eletrolítica","authors":"Eikite Tengnon","doi":"10.26850/1678-4618eqj.v7.1.1982.p43-48","DOIUrl":"https://doi.org/10.26850/1678-4618eqj.v7.1.1982.p43-48","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69144534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Algumas estruturas internas do diamante, ao redor de inclusões minerais 矿物夹杂物周围的一些金刚石内部结构
Ecletica Quimica Pub Date : 2018-08-07 DOI: 10.26850/1678-4618eqj.v7.1.1982.p59-63
Cirano Rocha Leite
{"title":"Algumas estruturas internas do diamante, ao redor de inclusões minerais","authors":"Cirano Rocha Leite","doi":"10.26850/1678-4618eqj.v7.1.1982.p59-63","DOIUrl":"https://doi.org/10.26850/1678-4618eqj.v7.1.1982.p59-63","url":null,"abstract":"<jats:p>.</jats:p>","PeriodicalId":35894,"journal":{"name":"Ecletica Quimica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69144540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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