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Impact of HIV and antiretroviral drug exposure on lung growth and function over 2 years in an African Birth Cohort 艾滋病毒和抗逆转录病毒药物暴露对非洲出生队列2年以上肺生长和功能的影响
AIDS (London, England) Pub Date : 2019-11-08 DOI: 10.1097/QAD.0000000000002444
D. Gray, C. Wedderburn, R. MacGinty, Lauren McMillan, C. Jacobs, J. A. Stadler, G. Hall, H. Zar
{"title":"Impact of HIV and antiretroviral drug exposure on lung growth and function over 2 years in an African Birth Cohort","authors":"D. Gray, C. Wedderburn, R. MacGinty, Lauren McMillan, C. Jacobs, J. A. Stadler, G. Hall, H. Zar","doi":"10.1097/QAD.0000000000002444","DOIUrl":"https://doi.org/10.1097/QAD.0000000000002444","url":null,"abstract":"Supplemental Digital Content is available in the text","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133573839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
HIV viral load algorithm: what are the needs in the field? HIV病毒载量算法:该领域的需求是什么?
AIDS (London, England) Pub Date : 2019-11-05 DOI: 10.1097/QAD.0000000000002382
G. Breton, G. Laborde-Balen, F. Guilavogui, Saidi Karemangino, Daniel K. Zana, Edith M. Temgoua, C. Rouzioux, Louis Pizarro, R. Tubiana
{"title":"HIV viral load algorithm: what are the needs in the field?","authors":"G. Breton, G. Laborde-Balen, F. Guilavogui, Saidi Karemangino, Daniel K. Zana, Edith M. Temgoua, C. Rouzioux, Louis Pizarro, R. Tubiana","doi":"10.1097/QAD.0000000000002382","DOIUrl":"https://doi.org/10.1097/QAD.0000000000002382","url":null,"abstract":"Guillaume Breton, Gabrièle Laborde-Balen, Foromo Guilavogui, Saidi Karemangino, Daniel K. Zana, Edith M. Temgoua, Christine Rouzioux, Louis Pizarro, Roland Tubiana, the ‘let’s talk about failure’ working group Solthis, Bagnolet, IRD UMI 233 TransVIHMI-INSERM U1175, Montpellier University, Montpellier, France, Centre r egional de Recherche et de formation à la prise en charge Clinique de Fann, Dakar, Senegal, PNLSH, Conakry, Guinea, PNLS/ IST, Bujumbura, Burundi, PNLS, Abidjan, Côte d’Ivoire, CNLS, Yaound e, Cameroun, Department of Virology, Necker Hospital, and Department of Infectious and Tropical Diseases, Piti e-Salpêtrière Hospital, Paris, France.","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122715134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Altered monocyte phenotype and dysregulated innate cytokine responses among people living with HIV and opioid-use disorder HIV和阿片类药物使用障碍患者单核细胞表型改变和先天细胞因子反应失调
AIDS (London, England) Pub Date : 2019-11-04 DOI: 10.1097/QAD.0000000000002416
M. Underwood, Thuan Nguyen, Luke S. Uebelhoer, L. Kunkel, P. Korthuis, C. Lancioni
{"title":"Altered monocyte phenotype and dysregulated innate cytokine responses among people living with HIV and opioid-use disorder","authors":"M. Underwood, Thuan Nguyen, Luke S. Uebelhoer, L. Kunkel, P. Korthuis, C. Lancioni","doi":"10.1097/QAD.0000000000002416","DOIUrl":"https://doi.org/10.1097/QAD.0000000000002416","url":null,"abstract":"Supplemental Digital Content is available in the text","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"79 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122693800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Comorbidities of HIV infection: role of Nef-induced impairment of cholesterol metabolism and lipid raft functionality HIV感染的合并症:nef诱导的胆固醇代谢和脂质筏功能损害的作用
AIDS (London, England) Pub Date : 2019-10-01 DOI: 10.1097/QAD.0000000000002385
D. Sviridov, N. Mukhamedova, A. Makarov, A. Adzhubei, M. Bukrinsky
{"title":"Comorbidities of HIV infection: role of Nef-induced impairment of cholesterol metabolism and lipid raft functionality","authors":"D. Sviridov, N. Mukhamedova, A. Makarov, A. Adzhubei, M. Bukrinsky","doi":"10.1097/QAD.0000000000002385","DOIUrl":"https://doi.org/10.1097/QAD.0000000000002385","url":null,"abstract":"Combination antiretroviral therapy has dramatically changed the outcome of HIV infection, turning it from a death sentence to a manageable chronic disease. However, comorbidities accompanying HIV infection, such as metabolic and cardio-vascular diseases, as well as cognitive impairment, persist despite successful virus control by combination antiretroviral therapy and pose considerable challenges to clinical management of people living with HIV. These comorbidities involve a number of pathological processes affecting a variety of different tissues and cells, making it challenging to identify a common cause(s) that would link these different diseases to HIV infection. In this article, we will present evidence that impairment of cellular cholesterol metabolism may be a common factor driving pathogenesis of HIV-associated comorbidities. Potential implications for therapeutic approaches are discussed.","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"4 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113939755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
HIV surveillance based on routine testing data from antenatal clinics in Malawi (2011–2018): measuring and adjusting for bias from imperfect testing coverage 基于马拉维产前诊所常规检测数据的艾滋病毒监测(2011-2018年):测量和调整检测覆盖率不完善造成的偏差
AIDS (London, England) Pub Date : 2019-09-06 DOI: 10.1097/QAD.0000000000002356
M. Maheu-Giroux, A. Jahn, T. Kalua, A. Mganga, J. Eaton
{"title":"HIV surveillance based on routine testing data from antenatal clinics in Malawi (2011–2018): measuring and adjusting for bias from imperfect testing coverage","authors":"M. Maheu-Giroux, A. Jahn, T. Kalua, A. Mganga, J. Eaton","doi":"10.1097/QAD.0000000000002356","DOIUrl":"https://doi.org/10.1097/QAD.0000000000002356","url":null,"abstract":"Supplemental Digital Content is available in the text","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124173597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Updates to the Spectrum/AIM model for estimating key HIV indicators at national and subnational levels 更新用于估计国家和国家以下各级主要艾滋病毒指标的Spectrum/AIM模型
AIDS (London, England) Pub Date : 2019-09-05 DOI: 10.1097/QAD.0000000000002357
J. Stover, R. Glaubius, L. Mofenson, C. Dugdale, M. Davies, G. Patten, C. Yiannoutsos
{"title":"Updates to the Spectrum/AIM model for estimating key HIV indicators at national and subnational levels","authors":"J. Stover, R. Glaubius, L. Mofenson, C. Dugdale, M. Davies, G. Patten, C. Yiannoutsos","doi":"10.1097/QAD.0000000000002357","DOIUrl":"https://doi.org/10.1097/QAD.0000000000002357","url":null,"abstract":"Supplemental Digital Content is available in the text","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130939491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 46
Global, regional and country-level 90–90–90 estimates for 2018: assessing progress towards the 2020 target 2018年全球、区域和国家一级的90-90-90估计数:评估实现2020年目标的进展情况
AIDS (London, England) Pub Date : 2019-09-03 DOI: 10.1097/QAD.0000000000002355
K. Marsh, J. Eaton, M. Mahy, K. Sabin, Christine S. Autenrieth, I. Wanyeki, Juliana Daher, P. Ghys
{"title":"Global, regional and country-level 90–90–90 estimates for 2018: assessing progress towards the 2020 target","authors":"K. Marsh, J. Eaton, M. Mahy, K. Sabin, Christine S. Autenrieth, I. Wanyeki, Juliana Daher, P. Ghys","doi":"10.1097/QAD.0000000000002355","DOIUrl":"https://doi.org/10.1097/QAD.0000000000002355","url":null,"abstract":"Supplemental Digital Content is available in the text","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127435194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 127
Pharmacokinetics of maraviroc in plasma and breastmilk in a treatment-experienced perinatally HIV-1-infected woman 马拉维洛克在围产期hiv -1感染妇女血浆和母乳中的药代动力学
AIDS (London, England) Pub Date : 2019-09-02 DOI: 10.1097/QAD.0000000000002360
C. Feiterna-Sperling, R. Krüger, A. Amara, S. Khoo, C. Waitt
{"title":"Pharmacokinetics of maraviroc in plasma and breastmilk in a treatment-experienced perinatally HIV-1-infected woman","authors":"C. Feiterna-Sperling, R. Krüger, A. Amara, S. Khoo, C. Waitt","doi":"10.1097/QAD.0000000000002360","DOIUrl":"https://doi.org/10.1097/QAD.0000000000002360","url":null,"abstract":"Maraviroc (MVC), a C-C chemokine receptor type five (CCR5) antagonist, was approved as part of combination antiretroviral therapy (cART) in 2007, for use in treatment-experienced adults infected with CCR5tropic HIV-1 [1]. Whilst, with current treatment strategies, such as maternal cART, low rates of mother-to-child transmission (MTCT) have been reported, in high-income countries, breastfeeding is not recommended because of the potential MTCT risk. However, since 2017, European [2] and United States [3] guidelines have acknowledged that some HIV-infected women may wish to breastfeed, and should be given appropriate support in this decision. Whilst data exist describing the transfer of NRTI, NNRTI, and protease inhibitors to breastfed infants [4,5], the pharmacokinetics and safety of MVC in lactating women and their breastfed infants have not been reported. Here, we present the first case of MVC in a breastfeeding mother.","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117147877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Impact of early antiretroviral treatment on sexual behaviour: a randomised comparison 早期抗逆转录病毒治疗对性行为的影响:随机比较
AIDS (London, England) Pub Date : 2019-09-02 DOI: 10.1097/QAD.0000000000002359
F. Lampe, A. Rodger, W. Burman, A. Grulich, G. Friedland, W. E. Sadr, J. Neaton, G. Corbelli, S. Emery, J. Molina, C. Orkin, J. Gatell, J. Gerstoft, K. Ruxrungtham, M. Barbosa de Souza, A. Phillips
{"title":"Impact of early antiretroviral treatment on sexual behaviour: a randomised comparison","authors":"F. Lampe, A. Rodger, W. Burman, A. Grulich, G. Friedland, W. E. Sadr, J. Neaton, G. Corbelli, S. Emery, J. Molina, C. Orkin, J. Gatell, J. Gerstoft, K. Ruxrungtham, M. Barbosa de Souza, A. Phillips","doi":"10.1097/QAD.0000000000002359","DOIUrl":"https://doi.org/10.1097/QAD.0000000000002359","url":null,"abstract":"Background: Antiretroviral treatment (ART) reduces HIV infectiousness but the effect of early ART on sexual behaviour is unclear. Methods: We assessed, within the START randomized trial that enrolled HIV-positive adults with CD4+ cell count greater than 500 cells/μl, the effect of early (immediate) versus deferred ART on: condomless sex with HIV-serodifferent partners (CLS-D); all condomless sex (CLS); HIV transmission-risk sex (CLS-D-HIV risk, defined as CLS-D and: not on ART or started ART <6 months ago or viral load greater than 200 copies/ml or no viral load in past 6 months), during 2-year follow-up. Month-12 CLS-D (2010–2014) was the primary outcome. Results: Among 2562 MSM, there was no difference between immediate and deferred arms in CLS-D at month 12 [12.6 versus 13.1%; difference (95% CI): −0.4% (−3.1 to 2.2%), P = 0.75] or month 24, or in CLS. Among 2010 heterosexual men and women, CLS-D at month 12 tended to be higher in the immediate versus deferred arm [10.8 versus 8.3%; difference:2.5% (−0.1 to 5.2%), P = 0.062]; the difference was greater at month 24 [9.3 versus 5.6%; difference: 3.7% (1.0 to 6.4%), P = 0.007], at which time CLS was higher in the immediate arm (20.7 versus 15.7%, P = 0.013). CLS-D-HIV risk at month 12 was substantially lower in the immediate versus deferred arm for MSM [0.2 versus 11%; difference: −10.7% (−12.5 to −8.9%), P < 0.001] and heterosexuals [0.6% versus 7.7%; difference: −7.0% (−8.8 to −5.3%), P < 0.001], because of viral suppression on ART. Conclusion: A strategy of early ART had no effect on condomless sex with HIV-serodifferent partners among MSM, but resulted in modestly higher prevalence among heterosexuals. However, among MSM and heterosexuals, early ART resulted in a substantial reduction in HIV-transmission-risk sex, to a very low absolute level.","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129920520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The use of molecular markers for cervical screening of women living with HIV in South Africa 南非使用分子标记对感染艾滋病毒的妇女进行子宫颈筛查
AIDS (London, England) Pub Date : 2019-08-02 DOI: 10.1097/QAD.0000000000002325
W. Kremer, M. van Zummeren, E. Breytenbach, K. Richter, R. Steenbergen, C. Meijer, G. Dreyer
{"title":"The use of molecular markers for cervical screening of women living with HIV in South Africa","authors":"W. Kremer, M. van Zummeren, E. Breytenbach, K. Richter, R. Steenbergen, C. Meijer, G. Dreyer","doi":"10.1097/QAD.0000000000002325","DOIUrl":"https://doi.org/10.1097/QAD.0000000000002325","url":null,"abstract":"Supplemental Digital Content is available in the text","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121223069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
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