AIDS (London, England)最新文献

{"title":"Primary HIV infection during chronic treatment with imatinib: impact on infection dynamics","authors":"Giorgio Bozzi, Matteo Centazzo, Susanna Scaglioni, Giacomo M. Butta, Paola Saltini, Arianna Liparoti, Elena Trombetta, D. Prati, Andrea Gori, A. Bandera, Lara Manganaro","doi":"10.1097/QAD.0000000000003942","DOIUrl":"https://doi.org/10.1097/QAD.0000000000003942","url":null,"abstract":"","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"128 38","pages":"1601 - 1604"},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141656345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus disease 2019 outcomes in a population-based cohort of people with HIV and a matched cohort of people without HIV during Omicron variant waves","authors":"Catharine Chambers, Curtis L. Cooper, Abigail E. Kroch, S. Buchan, Claire E. Kendall, Jeffrey C. Kwong, Rahim Moideddin, Lena Nguyen, Gordon Arbess, Anita C. Benoit, Cecilia T. Costiniuk, Muluba Habanyama, N. Janjua, Marc-André Langlois, John McCullagh, Lawrence Mbuagbaw, N. Moqueet, Devan Nambiar, Sergio Rueda, H. Samji, Vanessa Tran, Sharon Walmsley, Aslam H Anis, A. Burchell","doi":"10.1097/QAD.0000000000003922","DOIUrl":"https://doi.org/10.1097/QAD.0000000000003922","url":null,"abstract":"We found that rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing and reverse transcriptase (RT)-PCR-confirmed infection were approximately 50% higher in a population-based cohort of people with HIV compared with a matched cohort of people without HIV during the Omicron era (2 January 2022 to 31 March 2023) in Ontario, Canada, after controlling for age, sex, residential census tract, and country of birth. Rates of coronavirus disease 2019 (COVID-19)-related hospitalization and/or death were more than double. Differences persisted independent of vaccination, healthcare access, and COVID-19 diagnosis.","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"85 22","pages":"1597 - 1600"},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vespers: A nursing origin story set in the dawn of the HIV pandemic","authors":"Emily Anne Barr","doi":"10.1097/QAD.0000000000003873","DOIUrl":"https://doi.org/10.1097/QAD.0000000000003873","url":null,"abstract":"","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"12 26","pages":"925 - 927"},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presence of the M184I mutation after short-term exposure to azvudine for COVID-19 in people living with HIV","authors":"Rui Jiang, Jianjun Sun, Bihe Zhao, Ren-fang Zhang, Li Liu, Jun Chen","doi":"10.1097/QAD.0000000000003564","DOIUrl":"https://doi.org/10.1097/QAD.0000000000003564","url":null,"abstract":"Azvudine is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase and is also an agent against SARS-CoV-2 [1]. It was first approved in China in July 2022 as the treatment for COVID-19 [2] and then approved in Russia in February 2023. The reverse transcriptase M184V/I mutation has historically been common in regimens that contain lamivudine (3TC) or emtricitabine (FTC) [3]. An in-vitro study demonstrated that M184I is the key mutation in azvudine treatment [4]. Here, we report M184I mutation in five HIV-1 individuals who take azvudine before initiating antiretroviral therapy (ART) in Shanghai Public Health Clinical Center (SPHCC), China, as summarized in Table 1. Genotypic resistance testing (GRT) was performed in these individuals according to our previously established protocols [5].","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"118533782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glottic Kaposi's sarcoma","authors":"Yong Xie, Chuan-Hui Wang, Qi An, Dongmei Wang","doi":"10.1097/QAD.0000000000003559","DOIUrl":"https://doi.org/10.1097/QAD.0000000000003559","url":null,"abstract":"Kaposi’s sarcoma was first described by the Hungarian dermatologist Moritz Kaposi in 1872. This mysterious vascular tumor has since received increasing attention, especially after its association with AIDS was discovered in 1981. Kaposi’s sarcoma is an indicative disease of AIDS, which is clinically divided into four forms: the classic (Mediterranean), endemic (African), epidemic (HIV/ AIDS-associated), and iatrogenic (transplant-related). All four types share the same causative virus but have distinct epidemiological and clinical presentations [1,2]. Kaposi’s sarcoma is now considered as a low-grade vascular tumor and is caused by Kaposi’s sarcoma herpesvirus/human herpesvirus-8 (KSHV/HHV-8) infection [3,4]. It usually involves the skin, lymphatic system and viscera, most notably the respiratory and gastrointestinal tracts [5–7], whereas involvement of the glottis alone is rare. In particular, acute laryngeal obstruction occurs when Kaposi’s sarcoma completely obstructs the glottis, which is life-threatening. This report summarized the clinical diagnosis and treatment of a case of AIDS complicated with glottic Kaposi’s sarcoma.","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120437900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switching from tenofovir alafenamide to tenofovir disoproxil fumarate improves lipid profile and protects from weight gain.","authors":"Kai Juhani Kauppinen, Inka Aho, Jussi Sutinen","doi":"10.1097/QAD.0000000000003245","DOIUrl":"10.1097/QAD.0000000000003245","url":null,"abstract":"<p><strong>Background: </strong>Switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) increases low-density lipoprotein cholesterol (LDL-C) and body weight. Metabolic effects of the opposite TAF-to-TDF switch are unknown.</p><p><strong>Objectives: </strong>To investigate the effect of TAF-to-TDF switch on plasma lipids, body weight, and atherosclerotic cardiovascular disease (ASCVD) risk score.</p><p><strong>Design: </strong>A retrospective chart review.</p><p><strong>Methods: </strong>One hundred and forty-six patients with TAF-to-TDF switch (Switch group) were compared with 146 patients matched for sex, age, and third antiretroviral agent class who continued unchanged TAF-containing regimen (Control group). Data were collected at approximately 1 year (follow-up FU-1) and 2 years (follow-up FU-2) after baseline values.</p><p><strong>Results: </strong>In Switch group at FU-1, total cholesterol (TC) and LDL-C decreased 12.1% and 12.4% ( P  < 0.001 in both), respectively. High-density lipoprotein cholesterol (HDL-C) also decreased 8.2% ( P  < 0.001) in Switch group, but TC/HDL-C ratio did not change. No statistically significant changes were observed in Control group in any lipid values. TC remained similarly decreased through FU-2 in Switch group, but LDL-C increased from FU-1 to FU-2 in both groups. ASCVD risk score decreased from 6.3% at baseline to 6.0% at FU-2 ( P  = 0.012) in Switch group but increased from 8.4 to 9.1% ( P  = 0.162) in Control group. Body weight increased from 83.4 kg at baseline to 84.9 kg at FU-2 ( P  = 0.025) in Control group but remained stable in Switch group (83.1-83.7 kg, P  = 0.978).</p><p><strong>Conclusions: </strong>TAF-to-TDF switch improved plasma lipid profile and ASCVD risk score, as well as prevented weight gain, when compared with ongoing TAF-based antiretroviral therapy.</p>","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":" ","pages":"1337-1344"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40122550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-lasting adaptive immune memory specific to SARS-CoV-2 in convalescent coronavirus disease 2019 stable people with HIV.","authors":"Laura Donadeu, Juan Manuel Tiraboschi, Sofía Scévola, Alba Torija, Maria Meneghini, Thomas Jouve, Alexandre Favà, Laura Calatayud, Carmen Ardanuy, Ignacio Cidraque, Rosemarie Preyer, Kevin Strecker, Juan J Lozano, Daniel Podzamczer, Elena Crespo, Oriol Bestard","doi":"10.1097/QAD.0000000000003276","DOIUrl":"10.1097/QAD.0000000000003276","url":null,"abstract":"<p><strong>Objective: </strong>While the course of natural immunization specific to SARS-CoV-2 has been described among convalescent coronavirus disease 2019 (COVID-19) people without HIV (PWOH), a thorough evaluation of long-term serological and functional T- and B-cell immune memory among people with HIV (PWH) has not been reported.</p><p><strong>Methods: </strong>Eleven stable PWH developing mild ( n  = 5) and severe ( n  = 6) COVID-19 and 39 matched PWOH individuals with mild (MILD) ( n  = 20) and severe (SEV) ( n  = 19) COVID-19 infection were assessed and compared at 3 and 6 months after infection for SARS-CoV-2-specific serology, polyfunctional cytokine (interferon-γ [IFN-γ], interleukin 2 [IL-2], IFN-γ/IL-2, IL-21) producing T-cell frequencies against four main immunogenic antigens and for circulating SARS-CoV-2-specific immunoglobulin G (IgG)-producing memory B-cell (mBc).</p><p><strong>Results: </strong>In all time points, all SARS-COV-2-specific adaptive immune responses were highly driven by the clinical severity of COVID-19 infection, irrespective of HIV disease. Notably, while a higher proportion of mild PWH showed a higher decay on serological detection between the two time points as compared to PWOH, persistently detectable IgG-producing mBc were still detectable in most patients (4/4 (100%) for SEV PWH, 4/5 (80%) for MILD PWH, 10/13 (76.92%) for SEV PWOH and 15/18 (83.33%) for MILD PWOH). Likewise, SARS-CoV-2-specific IFN-γ-producing T-cell frequencies were detected in both PWH and PWOH, although significantly more pronounced among severe COVID-19 (6/6 (100%) for SEV PWH, 3/5 (60%) for MILD PWH, 18/19 (94.74%) for SEV PWOH and 14/19 (73.68%) for MILD PWOH).</p><p><strong>Conclusions: </strong>PWH develop a comparable short and long-term natural functional cellular and humoral immune response than PWOH convalescent patients, which are highly influenced by the clinical severity of the COVID-19 infection.</p>","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":" ","pages":"1373-1382"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40164853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory study of an oral screening dysplasia program for HIV-infected men who have sex with men.","authors":"Angela Callejo,&nbsp;Maria Del Mar Molina,&nbsp;Maria Carme Dinares,&nbsp;Javier Hernández-Losa,&nbsp;Bibiana Planas,&nbsp;Jorge Garcia,&nbsp;Adria Curran,&nbsp;Jordi Navarro,&nbsp;Paula Suanzes,&nbsp;Vicenç Falcó,&nbsp;Joaquin Burgos","doi":"10.1097/QAD.0000000000003287","DOIUrl":"https://doi.org/10.1097/QAD.0000000000003287","url":null,"abstract":"<p><strong>Background: </strong>HIV-infected men who have sex with men (MSM) are at high risk to develop human papilloma virus (HPV)-related oropharyngeal cancer. The aim of our study was to assess the usefulness of a pilot oral dysplasia screening program and its correlation with an anal dysplasia screening program.</p><p><strong>Methods: </strong>This was a prospective study with HIV-infected MSM. Oral and anal screenings were performed based on HPV determination, liquid cytology, direct and microscopy oral examinations, high-resolution anoscopy and biopsies, if necessary.</p><p><strong>Results: </strong>A total of 103 patients were included. The mean age of the patients was 44.6 years, 55.3% were smokers, and 57.3% had a history of previous anal high-grade squamous intraepithelial lesions (HSILs). The prevalence of oral HPV infections was 14% (9% HPV-high risk), the prevalence of abnormal cytology was 25.2%, and in 4.8% of the patients, oral examinations showed suspicious HSILs. Oral microscopy did not detect additional lesions that visual inspection. Five oral biopsies were performed and the results were normal. No risk factors for oral HPV infections were identified. The prevalence of anal HPV infections was 88.3% (76.7% HPV-high risk), 52.9% of the patients had altered cytology, and in 45.6% anoscopy showed changes suggestive of HSILs. Seventy-two anal biopsies were performed, detecting 25 cases of HSILs (24.3%).A poor correlation was observed between oral and anal HPV infections (κ = 0.037).</p><p><strong>Conclusions: </strong>The prevalence of oral HPV infections, abnormal cytology and lesions in HIV-infected MSM was low, and their correlation with anal HPV-related lesions was slight. These results confirm the current barriers to oral dysplasia screening techniques.</p>","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":" ","pages":"1383-1391"},"PeriodicalIF":3.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40164419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenging management of a post-coronavirus disease 2019 invasive Aspergillus sinusitis in a person living with HIV.","authors":"Martina Bottanelli,&nbsp;Emanuela Messina,&nbsp;Maurizio Barbera,&nbsp;Monica Guffanti,&nbsp;Stefano Bondi,&nbsp;Alfio Spina,&nbsp;Antonella Castagna,&nbsp;Camilla Muccini","doi":"10.1097/QAD.0000000000003243","DOIUrl":"https://doi.org/10.1097/QAD.0000000000003243","url":null,"abstract":"","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":" ","pages":"1321-1323"},"PeriodicalIF":3.8,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40615333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunity against measles in people with HIV: the need for more research and surveillance.","authors":"Nancy F Crum,&nbsp;Ali Ahmad","doi":"10.1097/QAD.0000000000003254","DOIUrl":"https://doi.org/10.1097/QAD.0000000000003254","url":null,"abstract":"","PeriodicalId":355297,"journal":{"name":"AIDS (London, England)","volume":" ","pages":"1305-1306"},"PeriodicalIF":3.8,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40615331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}