Saratov Journal of Medical Scientific Research最新文献

{"title":"Changes in tension of immunity to pertussis by time of immunization","authors":"I. V. Demurcheva, Svetlana M. Bezrodnov, V. Baturin, O. O. Kravchenko","doi":"10.15275/ssmj1901051","DOIUrl":"https://doi.org/10.15275/ssmj1901051","url":null,"abstract":"Objective: to identify the features of post-vaccination immunity to whooping cough, the state of immuno-logical reactivity in children of the Stavropol Territory. Material and methods. A comprehensive clinical and laboratory examination of 242 children aged 1 to 17 years was carried out. Serological examination of children was carried out at different times after revaccination, as well as an analysis of the parameters of the immune system in children of this age group. Results. A study of the level of immunity tension in children of early and school age showed that a low level of anti-pertussis antibodies was detected in 55% of children already 2-3 years after immunization, meaning that these children were at risk of pertussis, while protective titers of anti-pertussis antibodies were detected only in 34%, and high titers 11% of children. Conclusion. Children vaccinated in anamnesis in Stavropol Territory lose specific antibodies 3 years after the initial vaccination complex.","PeriodicalId":354475,"journal":{"name":"Saratov Journal of Medical Scientific Research","volume":"137 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115943469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the characteristics of the oral fluid in smokers of electronic cigarettes and tobacco heating systems","authors":"Alexey A. Kishkan","doi":"10.15275/ssmj1901013","DOIUrl":"https://doi.org/10.15275/ssmj1901013","url":null,"abstract":"Objective: to evaluate the effect of smoking electronic (SE) cigarettes and tobacco heating systems (THS) on the characteristics of changes in the characteristics of the oral fluid. Material and methods. The results of analysis of oral fluid samples of 150 persons were studied: smoking ES/THS — 50 people each in the group; control group — 50 clinically healthy non-users of ES/THS. Results. Patients in the THS group have a lower salivary secretion rate, a higher oral fluid viscosity at a more neutral salivary pH than control group (p=0.002); whereas patients of the ES group in comparison with the THS group are characterized by a higher saliva secretion rate, a lower viscosity index of the oral fluid at a neutral saliva pH level (p>0.05). Differences were observed in biochemical parameters of total protein concentration (p=0.001), oral fluid calcium concentration (p=0.005), malonic dialdehyde (p=0.007), alkaline phosphatase, and salivary catalase concentration (p=0.004 and p=0.006, respectively) between THS smokers and control group. Conclusion. Smoking THS to a greater extent in comparison with ES and especially with control group reduces the rate of salivation, increases the viscosity of the oral fluid; in this group of smokers, in comparison with ES smokers, a more neutral value of oral fluid acidity was revealed, the concentration of total protein, malonic dialdehyde, phosphates and calcium in saliva was increased with a decrease in alkaline phosphatase and catalase concentrations.","PeriodicalId":354475,"journal":{"name":"Saratov Journal of Medical Scientific Research","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130789102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professor Vladimir M. Popkov (to the 65th birth anniversary)","authors":"A. N. Ponukalin, A. N. Rossolovsky, R. N. Fomkin, G. Maslyakova, A. Bucharskaya, A. Fedonnikov, Andrey V. Eremin","doi":"10.15275/ssmj1901105","DOIUrl":"https://doi.org/10.15275/ssmj1901105","url":null,"abstract":"The article presents the creative biography of the famous doctor, scientist, teacher, rector and president of the Saratov State Medical University n. a. V. I. Razumovsky — one of the oldest and most advanced medical universities in Russia, Head of the Department of Urology and Director of the Research Institute of Fundamental and Clinical Uronephrology of One-Name University, a worthy successor of the Saratov Urological School, a member of the Presidium of the Russian Society of Urologists, Doctor of Medical Sciences, Professor, Honored Doctor of the Russian Federation Vladimir Mikhailovich Popkov.","PeriodicalId":354475,"journal":{"name":"Saratov Journal of Medical Scientific Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128830844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary glaucoma associated with idiopathic dilation of the episcleral veins (clinical case)","authors":"Ekaterina S. Makarevich, G. A. Fedyashev, E. Eliseeva, E. A. Poddubny","doi":"10.15275/ssmj1901007","DOIUrl":"https://doi.org/10.15275/ssmj1901007","url":null,"abstract":"The ophthalmic community does not have specific data on the epidemiology of secondary glaucoma against the background of idiopathic expansion of the episcleral veins, risk factors for the development of this disease. There are no generally accepted guidelines for the management and treatment of such patients. Based on our own observation, this paper presents data on the diagnostic tactics and tactics of treating a patient with secondary glaucoma against the background of idiopathic expansion of the episcleral veins.","PeriodicalId":354475,"journal":{"name":"Saratov Journal of Medical Scientific Research","volume":"151 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124221096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Russian and foreign experience of cultural and leisure activities of older citizens as a way of active longevity (review)","authors":"Lyudmila V. Maksimenko, Ekaterina D. Vitkovskaya","doi":"10.15275/ssmj1901071","DOIUrl":"https://doi.org/10.15275/ssmj1901071","url":null,"abstract":"Objective: to analyze the impact of existing cultural and leisure activities in Russia and foreign countries on the lives of older people. 34 sources were used to write the review article, including scientific publications presented on the following Internet resources: eLibrary, Google Scholar, Cyberleninka, published in the period from 2012 to 2022. As a result of the review, it was concluded that there is a wide variety of active longevity programs around the world for the elderly, which help to maintain an active lifestyle, maintain mental and physical activity and be adapted to social life.","PeriodicalId":354475,"journal":{"name":"Saratov Journal of Medical Scientific Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117149496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of astrocytes in neuroinflammation (review)","authors":"A. I. Mordovina, E. E. Rudenko, T. Demura","doi":"10.15275/ssmj1901089","DOIUrl":"https://doi.org/10.15275/ssmj1901089","url":null,"abstract":"Objective: to present up-to-date scientific information concerning the role of astrocytes in neuroinflammation. A total of 63 publications were analyzed, obtained from Cochrane Library and PubMed using the following search queries: \"astrocytes and neuroinflammation\", \"reactive astrocytes\", \"neuroglia and neuroinflammation\". 45 publications were selected for the review. The analyzed literature was published in the year range of 2000 to 2020. It comes to a conclusion that the role of astrocytes in neuroinflammation is controversial. The cells have both protective and destructive effects. It is important to understand that the activity of reactive astrocytes depends on their topographic location and microenvironment, as well as mediators that are secreted by CNS resident and non-resident cells. Understanding the role of astrocytes in neuroinflammation and their regulatory mechanisms is necessary for the implementation of their therapeutic potential.","PeriodicalId":354475,"journal":{"name":"Saratov Journal of Medical Scientific Research","volume":"226 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132315622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of the Professor Daniil M. Puchinyan to the hemostaseology challenges development","authors":"V. V. Ostrovskiy, V. Ulyanov, S. E. Grishin, A. Fedonnikov, I. Norkin","doi":"10.15275/ssmj1901098","DOIUrl":"https://doi.org/10.15275/ssmj1901098","url":null,"abstract":"This research follows the scientific career of Professor Daniil M. Puchinyan, who made a significant contribution to the development of Russian theoretical and practical hemostaseology. His name is associated with the designing of a new hemostaseology direction — adaptive (preventive) coagulology focused on considering the reserve capacities of hemostasis system in antithrombotic prophylaxis in patients at risk of postoperative thrombotic complications.","PeriodicalId":354475,"journal":{"name":"Saratov Journal of Medical Scientific Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125823266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-stage removal of craniopharyngioma of the sellar/chiasmatic region and clipping of multiple cerebral aneurysms in the acute period of hemorrhage (clinical case)","authors":"Dmitry V. Litvinenko, E. I. Zyablova, V. V. Tkachev, G. G. Muzlaev","doi":"10.15275/ssmj1901030","DOIUrl":"https://doi.org/10.15275/ssmj1901030","url":null,"abstract":"This clinical case demonstrates a rare phenomenon in neurosurgical practice — a combination of multiple cerebral aneurysms in the acute period of subarachnoid hemorrhage with craniopharyngioma. A clinical case of an aneurysm of the anterior communicating artery (АСА), intact aneurysms of both middle cerebral arteries (MCA) and craniopharyngioma of cell localization in a 52-year-old patient is presented. A decision was made on one-stage surgical treatment — clipping of a ruptured АСА aneurysm, an intact aneurysm of the right MCA (aneurysm of the left MCA did not require surgical treatment due to its small size) and removal of a craniopharyngioma of cell localization. The postoperative course is smooth, there is no increase in neurological symptoms and the appearance of endocrine disorders, the patient was discharged under the supervision of a neurologist at the place of residence.","PeriodicalId":354475,"journal":{"name":"Saratov Journal of Medical Scientific Research","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124178270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional status and quality of life in young adults with cerebral palsy","authors":"Savaş Kapruz, Ramazan Yılmaz, A. A. Izki, M. F. Akkurt, Burcu Akkurt, H. Akkurt, İlknur Albayrak Gezer, H. Yılmaz","doi":"10.15275/ssmj1901057","DOIUrl":"https://doi.org/10.15275/ssmj1901057","url":null,"abstract":"Objective: To identify the sociodemographic characteristics, pain level, quality of life, functional state, mobility, and depression level in adults with cerebral palsy (CP). Material and methods. Our study included 78 adults with CP (mean age 24.75±7.66 years, 40.5% males) and 79 control subjects (mean age 26.74±6.72 years, 38.5% males). The quality of life, depression, and mobility of all participants were evaluated. In addition, functional status, functional independence and activity level were evaluated in the adult CP group. The depression level was determined by the Beck Depression Inventory (BDI), the mobility level was identified via Rivermead Mobility Index (RMI), and the quality of life was evaluated by the Short Form-36 (SF-36). The functional level of adults with CP was assessed with Gross Motor Function Classification System. Functional independence and activity level were evaluated using the Functional Independence Measure scale (FIM). Pain level was assessed with Visual Analogue Scale (VAS). Results. The patient and control groups were statistically different in terms of their educational status, marital status, duration of marriage, employment status, and monthly income (p<0.05). SF-36 summary scale scores and subgroup scores, as well as RMI and FIM scores of CP patients, were lower than in the control group. In addition, we revealed a statistically significant positive correlation of FIM scores with SF-36 physical and mental components, along with a statistically significant negative correlation of VAS with FIM, and of FIM with GMFCS: p<0.001, r= 0.450; p=0.013, ^0.279; p=0.022, r= -0.257; p<0.001, r= -0.741, respectively. Conclusion. We established that the quality of life, along with the mobility and functional levels, were lower in young adults with CP than in the control group, while the depression and pain levels were higher vs. control group. Hence, pain, depression, mobility, functional level, and quality of life should be assessed during the follow-up of adult patients with CP","PeriodicalId":354475,"journal":{"name":"Saratov Journal of Medical Scientific Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131067824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of bone defect substitution in revision knee arthroplasty","authors":"M. Girkalo, I. Shchanitsyn, V. V. Ostrovskiy, M. N. Kozadaev, Alexander V. Derevyanov","doi":"10.15275/ssmj1901018","DOIUrl":"https://doi.org/10.15275/ssmj1901018","url":null,"abstract":"Objective: to evaluate the immediate and long-term outcomes of revision knee replacement using porous metaphysical sleeves and cones. Material and methods. The research involved 134 patients who underwent revision arthroplasty of their knee joints. The patients were divided into two groups according to the type of metaphyseal fixator: sleeves (Group 1) — 97 patients, and cones (Group 2) — 37 patients. The evaluation of the surgical outcomes was carried out at discharge from the hospital (in 7-12 days) as well as 6, 12, and 24 months after their surgeries. The survival rate of the implants was analyzed by the Kaplan — Meyer method. A revision with total replacement of the implant or its components was considered to be a critical event. Results. The analysis of the survival rate of the implants using various metaphysical fixators showed that the groups with metaphyseal sleeves and cones do not differ statistically (Log Rank criterion (Mantel — Cox) p=0.108). Conclusion. The medium term follow-up revealed no difference in clinical, functional or radiological outcomes of revision knee arthroplasty using porous cones or metaphyseal sleeves in 2A, 2B, and 3 (by Anderson Orthopaedic Research Institute classification) bone loss replacements.","PeriodicalId":354475,"journal":{"name":"Saratov Journal of Medical Scientific Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114698398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}