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Electrophoresis Testing in the Follow-up of Multiple Myeloma Patients with a Measurable M Protein in Gamma Region: Good Laboratory Practice for the Laboratory Specialist 多发性骨髓瘤患者γ区可测M蛋白的电泳检测随访:实验室专家的良好实验室规范
LLM Dergi Pub Date : 2023-08-22 DOI: 10.5578/llm.20229806
Özgür Aydın, İ. Ertürk
{"title":"Electrophoresis Testing in the Follow-up of Multiple Myeloma Patients with a Measurable M Protein in Gamma Region: Good Laboratory Practice for the Laboratory Specialist","authors":"Özgür Aydın, İ. Ertürk","doi":"10.5578/llm.20229806","DOIUrl":"https://doi.org/10.5578/llm.20229806","url":null,"abstract":"","PeriodicalId":354438,"journal":{"name":"LLM Dergi","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127455247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stepwise Testing in the Diagnosis of Monoclonal Gammopathies 逐步检测在单克隆伽玛病诊断中的应用
LLM Dergi Pub Date : 2023-03-16 DOI: 10.5578/llm.20229906
Özgür Aydın, İ. Ertürk
{"title":"Stepwise Testing in the Diagnosis of Monoclonal Gammopathies","authors":"Özgür Aydın, İ. Ertürk","doi":"10.5578/llm.20229906","DOIUrl":"https://doi.org/10.5578/llm.20229906","url":null,"abstract":"","PeriodicalId":354438,"journal":{"name":"LLM Dergi","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128385759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Darbepoietin Alfa Treatment in Myelodysplastic Syndrome: Single Center Data Darbepoietin治疗骨髓增生异常综合征:单中心数据
LLM Dergi Pub Date : 2023-03-16 DOI: 10.5578/llm.20229905
F. Can, I. Dilek
{"title":"Darbepoietin Alfa Treatment in Myelodysplastic Syndrome: Single Center Data","authors":"F. Can, I. Dilek","doi":"10.5578/llm.20229905","DOIUrl":"https://doi.org/10.5578/llm.20229905","url":null,"abstract":"","PeriodicalId":354438,"journal":{"name":"LLM Dergi","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128475522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective Analysis of 27 Patients Diagnosed with Primary Central Nervous System Lymphoma: A Single Center Experience 27例原发性中枢神经系统淋巴瘤患者的回顾性分析:单中心经验
LLM Dergi Pub Date : 2022-12-20 DOI: 10.5578/llm.20229702
Z. Güven, Davut Eren, S. Çelik, M. Keklik, A. Ünal
{"title":"Retrospective Analysis of 27 Patients Diagnosed with Primary Central Nervous System Lymphoma: A Single Center Experience","authors":"Z. Güven, Davut Eren, S. Çelik, M. Keklik, A. Ünal","doi":"10.5578/llm.20229702","DOIUrl":"https://doi.org/10.5578/llm.20229702","url":null,"abstract":"","PeriodicalId":354438,"journal":{"name":"LLM Dergi","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116292514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Culture Positivity on Treatment Response and Survival in Patients with Acute Myeloid Leukemia; Single Center Data, Retrospective Analysis 培养阳性对急性髓系白血病患者治疗反应及生存的影响单中心数据，回顾性分析
LLM Dergi Pub Date : 2022-12-20 DOI: 10.5578/llm.20229701
Nevin Alayvaz Aslan, Özde Elver, Veysel Erol, İsmail Can Kendir, H. Şenol, Nilay Güler
{"title":"The Effect of Culture Positivity on Treatment Response and Survival in Patients with Acute Myeloid Leukemia; Single Center Data, Retrospective Analysis","authors":"Nevin Alayvaz Aslan, Özde Elver, Veysel Erol, İsmail Can Kendir, H. Şenol, Nilay Güler","doi":"10.5578/llm.20229701","DOIUrl":"https://doi.org/10.5578/llm.20229701","url":null,"abstract":"","PeriodicalId":354438,"journal":{"name":"LLM Dergi","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129329343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of ATRA-Arsenic Trioxide and ATRAIdarubicin in Patients with Acute Promyelocytic Leukemia 阿特拉-三氧化二砷与阿特拉达柔比星治疗急性早幼粒细胞白血病的比较
LLM Dergi Pub Date : 2022-12-20 DOI: 10.5578/llm.20229703
Serhat Çelik, A. Ünal, Ruveyda Şahin, Z. Güven, M. Baydar, M. Keklik, M. Çetin, L. Kaynar
{"title":"Comparison of ATRA-Arsenic Trioxide and ATRAIdarubicin in Patients with Acute Promyelocytic Leukemia","authors":"Serhat Çelik, A. Ünal, Ruveyda Şahin, Z. Güven, M. Baydar, M. Keklik, M. Çetin, L. Kaynar","doi":"10.5578/llm.20229703","DOIUrl":"https://doi.org/10.5578/llm.20229703","url":null,"abstract":"","PeriodicalId":354438,"journal":{"name":"LLM Dergi","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124727411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ruxolitinib in Acute and Chronic Graft Versus Host Disease: A Single Center Experience 鲁索利替尼治疗急性和慢性移植物抗宿主病:单中心经验
LLM Dergi Pub Date : 2022-12-20 DOI: 10.5578/llm.20229704
M. Merter, A. Uysal
{"title":"Ruxolitinib in Acute and Chronic Graft Versus Host Disease: A Single Center Experience","authors":"M. Merter, A. Uysal","doi":"10.5578/llm.20229704","DOIUrl":"https://doi.org/10.5578/llm.20229704","url":null,"abstract":"","PeriodicalId":354438,"journal":{"name":"LLM Dergi","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114473107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allojeneik Kök Hücre Nakli Sürecinde COVID-19 Sıklığı ve Seyri
LLM Dergi Pub Date : 2022-08-25 DOI: 10.5578/llm.20229805
Uğur Şahin, Aykut İlker Arslan, Selin Merih Urlu, Ayla Gökmen, Ender Soydan
{"title":"Allojeneik Kök Hücre Nakli Sürecinde COVID-19 Sıklığı ve Seyri","authors":"Uğur Şahin, Aykut İlker Arslan, Selin Merih Urlu, Ayla Gökmen, Ender Soydan","doi":"10.5578/llm.20229805","DOIUrl":"https://doi.org/10.5578/llm.20229805","url":null,"abstract":"Objective: This study aimed to retrospectively investigate the frequency and course of COVID-19 and evaluate the factors that may affect the prognosis of COVID-19, including vaccination status, patient and donor characteristics among patients who underwent allogeneic stem cell transplantation (ASCT) in our center one year before and after the COVID-19 pandemic. Patients and Methods: Demographic characteristics, diagnoses, donor characteristics, COVID-19 and vaccination status, COVID-19-related mortality (CRM), non-relapse mortality (NRM) and overall survival (OS) of patients who underwent ASCT in our center between January 2019 and July 2022 were investigated. Results: After exclusion of cases from the 236 consecutive ASCTs, 204 patients had a median age of 50 (18-76), and a median follow-up of 21.2 months [%95 confidence interval (CI): 18.5-23.9] after ASCT. The common diagnoses were acute leukemia and myelodysplastic syndrome (72.6%, 6.4% (n= 13) had CRM. Unvaccinated patients constituted 39.7% (n= 81). Patients vaccinated at least once before ASCT were 22.1% (n= 45). Cumulative CRM was 3.0% (95% CI: 1.04-4.96), 5.0% (95% CI: 1.08-8.92), 7.0% (95% CI: 3.08-10.92) and 7.0% (95% CI: 3.08-10.92) at the 1 st , 3 rd , 6 th , and 12 th months after ASCT, respectively. NRM was higher and OS was lower in patients with less than two doses of vaccination (p< 0.001 and p< 0.001, respectively). Being unvaccinated was an independent risk factor for OS, NRM and CRM. Transplantation from an HLA-matched unrelated donor was an independent risk factor for OS and NRM. Conclusion: COVID-19 is an important cause of mortality in the post-ASCT period. The mortality risk is higher during the first six months following ASCT. Patients who received at least two doses of vaccine has significantly improved mortality and survival rates. The negative survival outcomes observed in transplants from HLA-matched unrelated donors may be due to the restricted access to international marrow registries and the use of frozen stem cells.","PeriodicalId":354438,"journal":{"name":"LLM Dergi","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123680897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yüksek Riskli Diffüz Büyük B Hücreli Lenfoma Olgularında DA-EPOCH-R Deneyimi
LLM Dergi Pub Date : 2022-08-25 DOI: 10.5578/llm.20229803
Seval Akpınar, Burhan Turgut
{"title":"Yüksek Riskli Diffüz Büyük B Hücreli Lenfoma Olgularında DA-EPOCH-R Deneyimi","authors":"Seval Akpınar, Burhan Turgut","doi":"10.5578/llm.20229803","DOIUrl":"https://doi.org/10.5578/llm.20229803","url":null,"abstract":"Anahtar Kelimeler: ABSTRACT Objective: We aimed to evaluate the impact of dose-adjusted EPOCH-R (DA-EPOCH-R) regimen on outcome parameters in high-risk, newly diagnosed diffuse large B-cell lymphoma (DLBCL) patients. Patients and Methods: Demographic and clinical features, response and survival parameters of patients presenting with DLBCL were retrospectively analyzed. Results: The study included a total of 33 patients (15 women, 18 men) with a median age of 49 (26-71). Seventeen, fourteen and eight patients had stage III/IV, high-intermediate/high risk IPI and double expressor lymphoma, respectively. Twenty six patients achieved complete remission. Two patients died as a result of sepsis. Estimated progression-free and overall survival were 79.7 ± 8.418 (63.21-96.2%; 95% CI) and 90.87 ± 6.74 (77.65-104.08%; 95% CI) months, respectively. Conclusion: DA-EPOCH-R is an effective but toxic regimen in DLBCL patients presenting with high-risk features.","PeriodicalId":354438,"journal":{"name":"LLM Dergi","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121414707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Türk Akut Lenfoblastik Lösemili Erişkin Hastalarda İdame Tedavisi Toksisiteleri, MTHFR ve TPMT Genetik Polimorfizm Analizi ve Doz Manipülasyonlarının Sağkalım Sonuçlarına Etkisi
LLM Dergi Pub Date : 2022-08-25 DOI: 10.5578/llm.20229801
Merve Ecem Erdoğan Yön, Zübeyde Nur Özkurt, Sanem Gökçen, Ramazan Öcal, Zeynep Arzu Yeğin, Münci Yağcı
{"title":"Türk Akut Lenfoblastik Lösemili Erişkin Hastalarda İdame Tedavisi Toksisiteleri, MTHFR ve TPMT Genetik Polimorfizm Analizi ve Doz Manipülasyonlarının Sağkalım Sonuçlarına Etkisi","authors":"Merve Ecem Erdoğan Yön, Zübeyde Nur Özkurt, Sanem Gökçen, Ramazan Öcal, Zeynep Arzu Yeğin, Münci Yağcı","doi":"10.5578/llm.20229801","DOIUrl":"https://doi.org/10.5578/llm.20229801","url":null,"abstract":"Objective: The aim of this study was to determine the side effects and their related factors, and to investigate the effect of toxicity on adult ALL prognosis during maintenance treatment. in eight patients. Among the three groups of patients, OS and DFS (disease free survival) were similar (p> 0.05). There was no relationship between MTHFR polymorphisms and side effects. TPMT polymorphism was not detected among patients receiving maintenance therapy. Conclusion: During maintenance treatment, drug doses should be reduced/delayed. In patients with severe side effects in maintenance therapy, especially in patients with severe mucositis and infection should be treated effectively. In patients with severe toxicity, the appro-priate dose reduction/delay or treatment cessation may have not adverse impact on survival outcomes.","PeriodicalId":354438,"journal":{"name":"LLM Dergi","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128890934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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