Türk Akut Lenfoblastik Lösemili Erişkin Hastalarda İdame Tedavisi Toksisiteleri, MTHFR ve TPMT Genetik Polimorfizm Analizi ve Doz Manipülasyonlarının Sağkalım Sonuçlarına Etkisi

Objective: The aim of this study was to determine the side effects and their related factors, and to investigate the effect of toxicity on adult ALL prognosis during maintenance treatment. in eight patients. Among the three groups of patients, OS and DFS (disease free survival) were similar (p> 0.05). There was no relationship between MTHFR polymorphisms and side effects. TPMT polymorphism was not detected among patients receiving maintenance therapy. Conclusion: During maintenance treatment, drug doses should be reduced/delayed. In patients with severe side effects in maintenance therapy, especially in patients with severe mucositis and infection should be treated effectively. In patients with severe toxicity, the appro-priate dose reduction/delay or treatment cessation may have not adverse impact on survival outcomes.